Motif ID: PRRX1,2.p2

Z-value: 4.047


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX1chr1_+_1688988980.761.1e-03Click!
PRRX2chr9_+_131467740-0.253.6e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_17599438 8.906 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr20_+_5935897 7.201 NM_001127458
CRLS1
cardiolipin synthase 1
chr12_-_15706340 7.139 EPS8
epidermal growth factor receptor pathway substrate 8
chr5_+_147775652 7.031 FBXO38
F-box protein 38
chr8_-_82557956 7.009 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr9_+_124835608 6.831 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr5_-_88155360 6.768 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_+_160408447 6.466 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr2_-_133145539 6.396 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr9_+_674193 6.173


chr2_-_175170674 5.880 WIPF1
WAS/WASL interacting protein family, member 1
chr10_+_126620681 5.867 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr4_-_152366970 5.832 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr3_+_69895310 5.829 NM_001184967
MITF
microphthalmia-associated transcription factor
chr10_+_69539255 5.750 NM_032578
MYPN
myopalladin
chr9_-_15240113 5.709 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr6_-_87861492 5.658 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr8_+_42671718 5.645 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr4_+_146820805 5.623 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr11_-_128399218 5.587 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_+_69895651 5.477 NM_006722
MITF
microphthalmia-associated transcription factor
chr7_+_115650240 5.465 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_-_139654807 5.309 NM_153235
TXLNB
taxilin beta
chr2_-_162808123 5.302 NM_004460
FAP
fibroblast activation protein, alpha
chr4_-_152368492 5.209 SH3D19
SH3 domain containing 19
chr2_-_206790871 5.151 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr17_-_1211263 5.079 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr2_+_36777406 5.004 VIT
vitrin
chr6_+_136214495 4.967 NM_018945
PDE7B
phosphodiesterase 7B
chr12_+_14429499 4.903 ATF7IP
activating transcription factor 7 interacting protein
chr3_-_116272911 4.864 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_242283129 4.849 NM_006352
ZNF238
zinc finger protein 238
chr3_-_115585178 4.716 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_143230124 4.628 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr11_-_114593838 4.550 CADM1
cell adhesion molecule 1
chr13_-_59223074 4.504


chr7_-_87180499 4.454 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr15_-_70838703 4.376


chr7_+_18501876 4.349 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr4_+_3341521 4.235 NM_198227
RGS12
regulator of G-protein signaling 12
chrX_-_19727828 4.230 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr21_+_29439768 4.200 C21orf7
chromosome 21 open reading frame 7
chr10_-_29963906 4.175 NM_021738
SVIL
supervillin
chr2_+_108571209 4.094 LIMS1
LIM and senescent cell antigen-like domains 1
chr13_-_37070862 4.039 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chrX_-_19727775 4.039 SH3KBP1
SH3-domain kinase binding protein 1
chr17_+_36515166 4.033 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chrX_+_114734074 3.981 NM_001136025
NM_001172335
PLS3

plastin 3

chr21_+_39117064 3.954 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr3_-_11598829 3.949 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr4_-_39199527 3.938 UGDH
UDP-glucose 6-dehydrogenase
chr2_+_108571336 3.927 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr13_+_47948586 3.878 RB1
retinoblastoma 1
chr1_+_213245507 3.858 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_+_133798770 3.846 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr13_+_100902942 3.828 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr4_-_87989291 3.729 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr7_-_30032649 3.657 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr1_+_194887630 3.649 NM_000186
NM_001014975
CFH

complement factor H

chr8_+_32698892 3.647 NM_001159996
NRG1
neuregulin 1
chr12_-_52281050 3.639 NM_001130059
ATF7
activating transcription factor 7
chr4_+_71142893 3.587 NM_005212
CSN3
casein kappa
chr19_-_46504831 3.578


chr7_+_90177082 3.567 CDK14
cyclin-dependent kinase 14
chr4_-_90197140 3.552 NM_014883
FAM13A
family with sequence similarity 13, member A
chr8_-_122722674 3.503 NM_005328
HAS2
hyaluronan synthase 2
chr16_+_85169615 3.478 NM_005250
FOXL1
forkhead box L1
chr4_+_86918870 3.457 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr5_+_6799100 3.456 NM_001171806
PAPD7
PAP associated domain containing 7
chr6_+_144654565 3.455 NM_007124
UTRN
utrophin
chr3_-_49372584 3.433 RHOA
ras homolog gene family, member A
chr4_-_122304925 3.431 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr1_-_197173159 3.401 LOC100131234
familial acute myelogenous leukemia related factor
chrX_-_19598912 3.385 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_168898898 3.334 PRRX1
paired related homeobox 1
chr2_-_202271598 3.332 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr4_+_86918882 3.297 ARHGAP24
Rho GTPase activating protein 24
chr7_+_102340579 3.292 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr3_+_138132006 3.287 NM_001190796
NCK1
NCK adaptor protein 1
chr3_-_11585264 3.277 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr5_-_169340321 3.276 NM_001129891
FAM196B
family with sequence similarity 196, member B
chr11_-_128217550 3.250 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr2_-_231697999 3.230 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr3_+_174598937 3.222 NM_014932
NLGN1
neuroligin 1
chr7_+_17349425 3.152 AHR
aryl hydrocarbon receptor
chr7_-_81237162 3.151 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr7_-_115458010 3.143 NM_001018058
NM_012252
TFEC

transcription factor EC

chr6_+_153060722 3.134 NM_025107
MYCT1
myc target 1
chr3_+_190147633 3.106 TPRG1
tumor protein p63 regulated 1
chr2_+_210152399 3.084 MAP2
microtubule-associated protein 2
chr11_-_104421240 3.064 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr6_-_33862690 3.058 NM_001143944
LEMD2
LEM domain containing 2
chr5_+_55182963 3.054 NM_139017
IL31RA
interleukin 31 receptor A
chr17_+_75971305 3.053 RNF213
ring finger protein 213
chr18_+_30544193 3.052 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr5_-_94442941 3.032 MCTP1
multiple C2 domains, transmembrane 1
chr7_-_41709191 3.023 NM_002192
INHBA
inhibin, beta A
chr21_-_35174742 3.014 RUNX1
runt-related transcription factor 1
chr13_+_51933228 3.014 CKAP2
cytoskeleton associated protein 2
chr2_-_183095308 3.014 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr15_+_55298908 2.999 NM_207040
TCF12
transcription factor 12
chr17_+_25292748 2.988 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr11_+_33306652 2.980 HIPK3
homeodomain interacting protein kinase 3
chr9_+_27099138 2.973 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr12_-_13139848 2.965 NM_031289
NM_153823
GSG1

germ cell associated 1

chr20_+_56369012 2.955


chr17_+_36493927 2.954 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr3_+_161040343 2.945 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr4_-_38710376 2.934 NM_024943
TMEM156
transmembrane protein 156
chr3_+_153468518 2.906 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr2_-_203484445 2.895 WDR12
WD repeat domain 12
chr7_+_111908143 2.893 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr7_-_115458064 2.892 TFEC
transcription factor EC
chr4_+_86968069 2.884 ARHGAP24
Rho GTPase activating protein 24
chr4_-_140443061 2.883 NM_001184987
NM_001184988
NM_001184989
NM_001184990
NDUFC1



NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa



chr4_-_153820535 2.883 NM_152680
TMEM154
transmembrane protein 154
chr11_-_104411065 2.879 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr8_-_120720200 2.857 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr8_-_93181091 2.857 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_81544432 2.846 LPHN2
latrophilin 2
chr3_+_190831909 2.842 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr11_-_58099884 2.840 NM_004811
LPXN
leupaxin
chr6_+_118976134 2.838 NM_002667
PLN
phospholamban
chr9_-_116920232 2.837 NM_002160
TNC
tenascin C
chr4_-_83566045 2.835


chr20_-_7869068 2.815 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_83566246 2.810 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr12_-_10464308 2.783 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr2_+_33514896 2.757 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_15757114 2.751 EPS8
epidermal growth factor receptor pathway substrate 8
chr17_-_36436979 2.717 NM_031957
KRTAP1-5
keratin associated protein 1-5
chrX_+_135058402 2.716 NM_001159700
FHL1
four and a half LIM domains 1
chr12_-_90029328 2.706 LUM
lumican
chr21_-_35153664 2.702 RUNX1
runt-related transcription factor 1
chr4_+_169250281 2.698 NM_007193
ANXA10
annexin A10
chr6_-_56824672 2.693 DST
dystonin
chr10_+_94584449 2.672 NM_001013848
EXOC6
exocyst complex component 6
chr12_-_90029672 2.667 NM_002345
LUM
lumican
chr4_+_158361185 2.635 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr10_+_83627422 2.634 NM_001165973
NRG3
neuregulin 3
chr9_-_116608113 2.633 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr4_-_74307637 2.625 ANKRD17
ankyrin repeat domain 17
chr1_-_242073094 2.595 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr11_+_128067598 2.586 NM_001167681
FLI1
Friend leukemia virus integration 1
chr6_-_127882192 2.570 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr7_-_115458047 2.564 TFEC
transcription factor EC
chr8_-_108579270 2.557 NM_001146
ANGPT1
angiopoietin 1
chr9_-_4656665 2.544 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr15_+_37330176 2.542 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr11_-_85115105 2.522 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr18_+_30427279 2.513 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr11_+_12265022 2.495 NM_032867
MICALCL
MICAL C-terminal like
chr10_-_29963847 2.490


chr7_+_90176647 2.487 NM_012395
CDK14
cyclin-dependent kinase 14
chr9_+_18464138 2.482 ADAMTSL1
ADAMTS-like 1
chr8_-_93144039 2.481


chr13_-_35327798 2.473 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr3_-_69254226 2.471 NM_198271
LMOD3
leiomodin 3 (fetal)
chr10_-_98280299 2.461 TM9SF3
transmembrane 9 superfamily member 3
chr3_+_35658852 2.455 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_+_181803649 2.447 TTC14
tetratricopeptide repeat domain 14
chr6_-_79732391 2.428 PHIP
pleckstrin homology domain interacting protein
chr1_+_84402962 2.416 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr15_-_68781662 2.414 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr10_-_98326435 2.414 TM9SF3
transmembrane 9 superfamily member 3
chr7_+_18515488 2.412 HDAC9
histone deacetylase 9
chr13_+_75232797 2.410 NM_015842
LMO7
LIM domain 7
chr11_-_27698800 2.405 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr12_-_90100733 2.402 NM_001920
DCN
decorin
chr7_+_18515440 2.399 HDAC9
histone deacetylase 9
chr10_-_49483002 2.394 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr1_+_158426908 2.381 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr18_+_19826734 2.353 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr5_-_39430180 2.348 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_+_55098280 2.346 CLTC
clathrin, heavy chain (Hc)
chr2_+_36777336 2.342 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr6_-_46401363 2.335 NM_005822
RCAN2
regulator of calcineurin 2
chr3_+_161040439 2.324 SCHIP1
schwannomin interacting protein 1
chr4_+_120029426 2.320 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr4_-_138673014 2.320 PCDH18
protocadherin 18
chr12_-_90100710 2.316 DCN
decorin
chr1_-_203868622 2.295 NM_001973
NM_021795
ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chrX_-_114703273 2.293


chr4_+_106851415 2.285 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr5_-_94443300 2.273 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr1_-_171286634 2.251 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr3_-_158695832 2.249 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_+_174084137 2.248 NM_002449
MSX2
msh homeobox 2
chr3_-_52269467 2.241 WDR82
WD repeat domain 82
chr3_-_69212192 2.236 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr12_+_9871343 2.234 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr8_-_28403652 2.227 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr6_+_134800533 2.198 LOC154092
hypothetical LOC154092
chr2_+_108571177 2.196 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_188021117 2.189 NM_005795
CALCRL
calcitonin receptor-like
chr5_-_111340421 2.176 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr6_-_46997579 2.152 NM_001098518
GPR116
G protein-coupled receptor 116
chr6_-_152681171 2.150 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_129720209 2.143 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr4_+_41234944 2.141 LIMCH1
LIM and calponin homology domains 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 9.95e-04 GO:0048856 anatomical structure development
1.82 1.14e-03 GO:0007517 muscle organ development
1.19 1.79e-03 GO:0048731 system development
1.15 1.32e-02 GO:0007275 multicellular organismal development
1.14 2.00e-02 GO:0032502 developmental process
1.59 2.57e-02 GO:0061061 muscle structure development
1.30 4.01e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter

Nothing significant found in compartment category.

Nothing significant found in function category.