Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 2.734


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFX4chr12_+_1055008140.751.3e-03Click!
RFXAPchr13_+_362913060.675.9e-03Click!
RFXANKchr19_+_191640070.381.6e-01Click!
RFX1chr19_-_13977875-0.342.2e-01Click!
RFX3chr9_-_35157210.312.6e-01Click!
RFX5chr1_-_1495862980.253.7e-01Click!
RFX2chr19_-_60614910.087.9e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_42701460 4.918 CCDC30
coiled-coil domain containing 30
chr2_-_187422141 4.621 NM_182521
ZSWIM2
zinc finger, SWIM-type containing 2
chr18_+_30544193 4.287 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr12_+_120840829 3.530 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr8_+_13468722 2.971 NM_001007090
C8orf48
chromosome 8 open reading frame 48
chr5_-_157031022 2.939 SOX30
SRY (sex determining region Y)-box 30
chr2_+_228444570 2.893 NM_178821
WDR69
WD repeat domain 69
chr8_+_120497732 2.695 NM_002514
NOV
nephroblastoma overexpressed gene
chr3_-_58538110 2.576 FAM107A
family with sequence similarity 107, member A
chr3_-_114643008 2.572 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr19_-_63643400 2.570 NM_003433
ZNF132
zinc finger protein 132
chr7_+_48041632 2.428 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr3_+_120904555 2.412 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr3_-_139315011 2.382 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr5_+_157031138 2.302 NM_001145132
C5orf52
chromosome 5 open reading frame 52
chr12_+_79362256 2.294 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chrX_+_135079120 2.285 NM_001159704
FHL1
four and a half LIM domains 1
chr5_-_142045770 2.280 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chrX_+_135079461 2.256 NM_001167819
FHL1
four and a half LIM domains 1
chr2_+_213857347 2.249 NM_001025436
NM_024532
SPAG16

sperm associated antigen 16

chr18_+_76006795 2.233 LOC100130522
hypothetical LOC100130522
chr13_+_97403929 2.200 NM_002271
IPO5
importin 5
chr1_+_159334774 2.199 NM_001007255
NM_152366
KLHDC9

kelch domain containing 9

chr13_-_95092283 2.165 DZIP1
DAZ interacting protein 1
chr10_+_63092724 2.141 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr9_+_99109730 2.117 NM_020893
C9orf174
chromosome 9 open reading frame 174
chr9_+_111442888 2.077 NM_001037293
PALM2
paralemmin 2
chr10_-_116382089 2.051 ABLIM1
actin binding LIM protein 1
chr5_-_16795336 2.030 MYO10
myosin X
chr11_+_7997366 2.005 TUB
tubby homolog (mouse)
chr13_-_43259032 1.995 NM_017993
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr8_-_49810270 1.989 NM_001142857
NM_024593
EFCAB1

EF-hand calcium binding domain 1

chr3_-_30911156 1.939 NM_207359
GADL1
glutamate decarboxylase-like 1
chr8_+_39084206 1.929 NM_145004
ADAM32
ADAM metallopeptidase domain 32
chr3_+_9826643 1.928 NM_001025930
TTLL3
tubulin tyrosine ligase-like family, member 3
chr4_-_156517423 1.833 MAP9
microtubule-associated protein 9
chr3_+_50281582 1.826 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr10_-_74788508 1.816 NM_145170
TTC18
tetratricopeptide repeat domain 18
chr13_+_30404809 1.816 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr7_-_139987044 1.815 DENND2A
DENN/MADD domain containing 2A
chr3_+_9826930 1.814 TTLL3
tubulin tyrosine ligase-like family, member 3
chr3_-_171013000 1.812 LRRC34
leucine rich repeat containing 34
chr1_-_48710263 1.760 SPATA6
spermatogenesis associated 6
chr18_-_45630154 1.757 MYO5B
myosin VB
chr15_-_70385709 1.749 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr17_-_16413188 1.687 NM_020653
ZNF287
zinc finger protein 287
chr4_-_156517394 1.678 MAP9
microtubule-associated protein 9
chr7_-_35192177 1.661 DPY19L2P1
dpy-19-like 2 pseudogene 1 (C. elegans)
chr16_+_56219802 1.648 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_-_215870935 1.642 NM_018040
GPATCH2
G patch domain containing 2
chr17_+_7199178 1.638 NM_198154
TMEM95
transmembrane protein 95
chr13_+_35904408 1.573 NM_001111045
NM_003914
CCNA1

cyclin A1

chr16_+_4485859 1.571 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr17_-_959007 1.570 NM_001092
ABR
active BCR-related gene
chrX_+_53095230 1.561 NM_018969
GPR173
G protein-coupled receptor 173
chr5_-_142046175 1.544 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr11_+_85763425 1.521 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr3_+_185538998 1.517 FAM131A
family with sequence similarity 131, member A
chr4_-_76774594 1.515 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr5_+_178919298 1.512 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr13_-_59223074 1.509


chr9_-_35093089 1.504 STOML2
stomatin (EPB72)-like 2
chr12_-_52939636 1.504 NM_001127321
CBX5
chromobox homolog 5
chr12_-_62348506 1.502 NM_173812
DPY19L2
dpy-19-like 2 (C. elegans)
chr9_-_35093048 1.502 STOML2
stomatin (EPB72)-like 2
chr8_-_101187346 1.490 RGS22
regulator of G-protein signaling 22
chr1_-_167663278 1.482 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr17_+_17339059 1.456


chr22_-_22646602 1.444 NM_001084392
DDT
D-dopachrome tautomerase
chr17_+_19255083 1.438 NM_007148
RNF112
ring finger protein 112
chr2_+_45022540 1.414 NM_005413
SIX3
SIX homeobox 3
chr9_-_35093144 1.399 NM_013442
STOML2
stomatin (EPB72)-like 2
chr14_-_88087575 1.394 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr1_-_48710378 1.390 NM_019073
SPATA6
spermatogenesis associated 6
chr11_+_101423378 1.386 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr5_+_34720368 1.374 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr1_-_38097811 1.365 NM_005955
MTF1
metal-regulatory transcription factor 1
chr15_+_68971835 1.363 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr11_-_114880275 1.344 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr9_-_35093189 1.340 STOML2
stomatin (EPB72)-like 2
chr4_+_114433551 1.334 ANK2
ankyrin 2, neuronal
chr3_-_27385856 1.330 NM_199347
NEK10
NIMA (never in mitosis gene a)- related kinase 10
chr14_+_99329198 1.322 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr10_+_105243724 1.322 NM_004210
NEURL
neuralized homolog (Drosophila)
chr12_+_46863632 1.312 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr17_-_15185623 1.302 NM_031898
TEKT3
tektin 3
chr15_+_79213660 1.297 NM_173528
C15orf26
chromosome 15 open reading frame 26
chr18_+_52469559 1.293 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr11_+_131285747 1.264 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr6_-_152744143 1.264 SYNE1
spectrin repeat containing, nuclear envelope 1
chr9_-_15240113 1.242 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr10_-_120091795 1.235 NM_001134672
NM_022063
C10orf84

chromosome 10 open reading frame 84

chr2_+_55600220 1.230 NM_080667
CCDC104
coiled-coil domain containing 104
chr1_+_201711505 1.211 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr19_+_40322231 1.206 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_233501069 1.186 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr3_-_171013145 1.181 NM_001172779
NM_001172780
NM_153353
LRRC34


leucine rich repeat containing 34


chr9_-_35818728 1.180 NM_001012446
C9orf128
chromosome 9 open reading frame 128
chr9_-_4656665 1.171 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr1_-_36688556 1.167 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr1_+_15446354 1.162 NM_052929
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr1_+_201711578 1.156 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr12_-_52939584 1.109 NM_001127322
CBX5
chromobox homolog 5
chr4_-_156517544 1.096 NM_001039580
MAP9
microtubule-associated protein 9
chr12_+_83954229 1.095 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr17_-_5344898 1.094 NM_001162371
LOC728392
hypothetical protein LOC728392
chr9_+_123501186 1.092 DAB2IP
DAB2 interacting protein
chr1_+_215871288 1.091 NM_138796
SPATA17
spermatogenesis associated 17
chr8_-_101187519 1.081 NM_015668
RGS22
regulator of G-protein signaling 22
chr9_-_129537372 1.080 NM_001085347
NM_001134430
NM_001134431
NM_130459
TOR2A



torsin family 2, member A



chr5_-_14064846 1.078 DNAH5
dynein, axonemal, heavy chain 5
chr20_-_36322587 1.070 NM_001029864
KIAA1755
KIAA1755
chr14_-_59407103 1.061 NM_021136
RTN1
reticulon 1
chr12_-_83954185 1.051 NM_001100917
TSPAN19
tetraspanin 19
chr11_-_19219000 1.051 NM_024680
E2F8
E2F transcription factor 8
chr14_-_59001603 1.048 GPR135
G protein-coupled receptor 135
chr2_+_128119908 1.047 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr19_+_60543032 1.044 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr4_+_114190233 1.037 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr12_+_54798236 1.036 NM_032786
ZC3H10
zinc finger CCCH-type containing 10
chr12_-_80676562 1.022 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr15_-_68971665 1.013 NM_020147
THAP10
THAP domain containing 10
chr11_-_10671873 1.012 MRVI1
murine retrovirus integration site 1 homolog
chr11_+_26310253 1.010 NM_031418
ANO3
anoctamin 3
chr16_-_66007650 1.009 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr8_+_16929116 1.004 NM_181723
EFHA2
EF-hand domain family, member A2
chr14_+_59628381 1.003 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr20_+_3817485 1.002 NM_024960
PANK2
pantothenate kinase 2
chr14_+_105063975 0.994 NM_025268
TMEM121
transmembrane protein 121
chr1_+_10015577 0.993 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B (UFD2 homolog, yeast)

chr3_+_46717826 0.989 NM_147196
TMIE
transmembrane inner ear
chr3_-_16281287 0.983 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr20_+_43478120 0.973 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr19_-_63584194 0.973 NM_001129730
NM_138466
ZNF837

zinc finger protein 837

chr19_-_6344005 0.967 NM_002096
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr19_-_584474 0.963 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr11_+_28086373 0.963 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr14_+_74539364 0.963 NM_014239
EIF2B2
eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
chr12_-_123568781 0.951


chr10_-_119795663 0.941 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr2_+_220170804 0.940 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr5_-_159730196 0.937 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr16_+_56230707 0.936 NM_001145774
GPR56
G protein-coupled receptor 56
chr17_-_5345167 0.935 LOC728392
hypothetical protein LOC728392
chr13_+_110162970 0.934 NM_198217
ING1
inhibitor of growth family, member 1
chr3_-_49117169 0.929 NM_005051
QARS
glutaminyl-tRNA synthetase
chr19_-_584526 0.920 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr19_+_19500669 0.918 NM_001190328
NM_198537
YJEFN3

YjeF N-terminal domain containing 3

chr9_+_115970599 0.917 COL27A1
collagen, type XXVII, alpha 1
chr2_-_182229977 0.915 NM_001030311
NM_001030312
NM_001030313
NM_001160277
NM_201548
CERKL




ceramide kinase-like




chr3_+_16281670 0.914 NM_138381
OXNAD1
oxidoreductase NAD-binding domain containing 1
chrX_-_44945025 0.912 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr2_-_20053256 0.910 NM_001006657
NM_020779
WDR35

WD repeat domain 35

chr22_-_42539399 0.897 NM_022785
NM_198856
EFCAB6

EF-hand calcium binding domain 6

chr16_+_30681120 0.894 NM_014771
RNF40
ring finger protein 40
chr4_+_166468266 0.888 NM_001017369
NM_006745
SC4MOL

sterol-C4-methyl oxidase-like

chr17_-_6675731 0.887 NM_053285
TEKT1
tektin 1
chr19_-_63301418 0.884 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr8_-_114518194 0.882 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr11_-_85074848 0.882 NM_152723
CCDC89
coiled-coil domain containing 89
chr11_-_65869113 0.881 NM_001024957
NM_015399
BRMS1

breast cancer metastasis suppressor 1

chr2_+_242460553 0.880 NM_173821
C2orf85
chromosome 2 open reading frame 85
chr1_+_165330710 0.880 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr12_+_54798319 0.877 ZC3H10
zinc finger CCCH-type containing 10
chr3_-_122951200 0.875 NM_004487
GOLGB1
golgin B1
chr3_-_49736297 0.870 NM_013334
NM_021971
GMPPB

GDP-mannose pyrophosphorylase B

chr7_-_13997389 0.868 NM_001163149
ETV1
ets variant 1
chr3_+_48482213 0.866 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr1_-_6162669 0.861 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr22_-_29082880 0.861 NM_001005409
NM_005877
SF3A1

splicing factor 3a, subunit 1, 120kDa

chr1_+_63761600 0.860 NM_032437
EFCAB7
EF-hand calcium binding domain 7
chr17_+_9420668 0.859 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr14_-_76856776 0.858 NM_013382
POMT2
protein-O-mannosyltransferase 2
chr2_+_173308880 0.852 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr14_-_47213906 0.849 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr1_+_66990736 0.848 TCTEX1D1
Tctex1 domain containing 1
chr11_-_118716244 0.846 MFRP
membrane frizzled-related protein
chr12_+_99118692 0.842 NM_022496
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chrX_-_99778340 0.836 NM_003270
TSPAN6
tetraspanin 6
chr13_-_29779556 0.833 NM_032116
KATNAL1
katanin p60 subunit A-like 1
chr12_-_88270375 0.828 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr6_-_165643064 0.825 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr13_+_37821964 0.817 UFM1
ubiquitin-fold modifier 1
chr8_-_485330 0.812 NM_175075
C8orf42
chromosome 8 open reading frame 42
chr14_-_59001804 0.809 NM_022571
GPR135
G protein-coupled receptor 135
chr22_+_30222512 0.808 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr1_-_209915443 0.806 NM_002497
NEK2
NIMA (never in mitosis gene a)-related kinase 2
chr2_+_173308841 0.805 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr4_+_87734489 0.800 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr22_-_43272567 0.799 NM_032287
LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr14_+_76856982 0.799 NM_145870
NM_145871
GSTZ1

glutathione transferase zeta 1

chr4_+_123873306 0.798 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr11_-_132318741 0.795 OPCML
opioid binding protein/cell adhesion molecule-like
chr16_-_46052254 0.793 ITFG1
integrin alpha FG-GAP repeat containing 1
chr9_-_35802142 0.792 NM_001039592
NM_172312
SPAG8

sperm associated antigen 8

chr21_+_17807167 0.790 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr4_-_148086413 0.789 NM_031956
TTC29
tetratricopeptide repeat domain 29
chr19_-_63776442 0.785 MZF1
myeloid zinc finger 1
chr8_+_94836247 0.783 NM_001142301
NM_153704
TMEM67

transmembrane protein 67

chr7_+_44110527 0.782 AEBP1
AE binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.43 1.56e-04 GO:0030031 cell projection assembly
2.69 6.83e-04 GO:0007017 microtubule-based process
6.54 7.84e-04 GO:0042384 cilium assembly
4.58 1.13e-03 GO:0010927 cellular component assembly involved in morphogenesis
13.37 1.87e-02 GO:0035082 axoneme assembly
4.61 3.26e-02 GO:0060271 cilium morphogenesis
2.83 4.54e-02 GO:0000226 microtubule cytoskeleton organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.66 7.24e-09 GO:0005930 axoneme
3.97 1.45e-08 GO:0005929 cilium
7.78 1.95e-08 GO:0035085 cilium axoneme
6.07 4.51e-08 GO:0044441 cilium part
2.09 1.00e-05 GO:0015630 microtubule cytoskeleton
1.21 1.27e-05 GO:0005737 cytoplasm
6.32 2.19e-05 GO:0005932 microtubule basal body
2.49 5.18e-04 GO:0005874 microtubule
1.54 2.60e-03 GO:0005856 cytoskeleton
2.22 4.48e-03 GO:0005815 microtubule organizing center
2.07 6.98e-03 GO:0044463 cell projection part
1.60 1.54e-02 GO:0044430 cytoskeletal part
1.67 1.55e-02 GO:0042995 cell projection
1.33 2.85e-02 GO:0043228 non-membrane-bounded organelle
1.33 2.85e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.10 3.09e-02 GO:0005622 intracellular

Nothing significant found in function category.