Motif ID: NANOG.p2

Z-value: 1.270


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_7833292-0.421.2e-01Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17861266 5.613 NM_001105569
MSGN1
mesogenin 1
chr15_+_38849450 3.477 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr10_-_56230953 3.215 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr3_+_161040439 2.879 SCHIP1
schwannomin interacting protein 1
chr14_+_51025604 2.630 NM_001042481
FRMD6
FERM domain containing 6
chr3_+_161040343 2.614 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr4_+_114190233 2.450 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr2_+_170742900 2.409 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr18_+_19826734 2.134 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr12_-_51114372 1.850 NM_004693
KRT75
keratin 75
chr10_+_82290554 1.832 NM_001145719
SH2D4B
SH2 domain containing 4B
chr7_+_2524022 1.814 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_58146721 1.769 NM_000614
CNTF
ciliary neurotrophic factor
chr3_+_89239494 1.719 EPHA3
EPH receptor A3
chr6_+_131613196 1.643 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr2_+_157822355 1.607 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr11_-_58736897 1.539 NM_001039396
MPEG1
macrophage expressed 1
chr4_+_77575276 1.511 NM_020859
SHROOM3
shroom family member 3
chr1_-_116185215 1.508 NM_005599
NHLH2
nescient helix loop helix 2
chr11_-_128217550 1.393 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr2_-_40510923 1.377 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr7_+_18501876 1.303 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chrX_+_66705407 1.300 NM_001011645
AR
androgen receptor
chr13_+_100902942 1.296 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr5_+_127012611 1.280 NM_001048252
CTXN3
cortexin 3
chr11_-_83071084 1.275 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr12_-_14024187 1.270 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr3_-_120861959 1.244 NM_022135
POPDC2
popeye domain containing 2
chr5_-_56814310 1.205 NM_001017992
ACTBL2
actin, beta-like 2
chr18_+_13601664 1.172 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr5_+_152850276 1.132 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr3_-_126325132 1.122 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr17_-_39094787 1.111 NM_001040002
MEOX1
mesenchyme homeobox 1
chr5_-_36337756 1.101 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr7_-_107930170 1.091 PNPLA8
patatin-like phospholipase domain containing 8
chr8_+_32698892 1.087 NM_001159996
NRG1
neuregulin 1
chr2_+_108604111 1.062 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_+_55691179 1.053 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr14_+_77939845 1.012 NM_004796
NRXN3
neurexin 3
chr17_-_45629401 1.011


chr3_+_63859114 0.986 NM_001177387
ATXN7
ataxin 7
chr4_+_3341521 0.955 NM_198227
RGS12
regulator of G-protein signaling 12
chr10_-_90702490 0.952 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_-_145049853 0.944 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr12_-_15706340 0.913 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_116272911 0.909 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr13_-_93929719 0.891 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr9_+_119506446 0.890 TLR4
toll-like receptor 4
chr18_-_26996742 0.890 NM_004948
NM_024421
DSC1

desmocollin 1

chr11_-_56951628 0.885 NM_017611
SLC43A3
solute carrier family 43, member 3
chr3_+_69895310 0.880 NM_001184967
MITF
microphthalmia-associated transcription factor
chr4_-_186815116 0.879 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr12_+_45896511 0.875 FAM113B
family with sequence similarity 113, member B
chr18_+_30427279 0.861 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr9_+_119506428 0.844 TLR4
toll-like receptor 4
chr15_-_75259714 0.841 PEAK1
NKF3 kinase family member
chr4_-_57242492 0.833 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr14_-_79748273 0.828 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr2_+_113542017 0.826 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr1_+_207944807 0.825 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr15_+_56217686 0.816 NM_020980
AQP9
aquaporin 9
chr9_+_119506274 0.808 NM_138554
TLR4
toll-like receptor 4
chr4_-_138673014 0.804 PCDH18
protocadherin 18
chr1_-_42156957 0.794 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr3_-_11598829 0.782 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr17_-_78391178 0.773 NM_024702
ZNF750
zinc finger protein 750
chr1_-_50661716 0.771 NM_032110
DMRTA2
DMRT-like family A2
chr8_+_67201684 0.754 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr1_-_42157077 0.751 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr5_+_140848905 0.746 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr1_-_30977931 0.739 LAPTM5
lysosomal protein transmembrane 5
chr14_-_80934523 0.729 NM_033104
STON2
stonin 2
chr7_+_18502342 0.728 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr8_-_40874485 0.723 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr3_+_2528272 0.718 CNTN4
contactin 4
chr12_+_79634820 0.713 NM_005593
MYF5
myogenic factor 5
chr7_+_128802719 0.702 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chrX_-_19727828 0.698 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_16191159 0.694 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr11_+_7574992 0.689 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_21767819 0.677 NM_024697
ZNF385D
zinc finger protein 385D
chr13_-_83354425 0.677 SLITRK1
SLIT and NTRK-like family, member 1
chr1_+_158426908 0.670 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_+_35696119 0.662 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chrX_+_134482212 0.661 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr3_+_88270951 0.660 NM_018293
ZNF654
zinc finger protein 654
chr1_+_180836050 0.654


chr14_+_99309688 0.652 EML1
echinoderm microtubule associated protein like 1
chr3_-_11585264 0.649 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr12_-_16649211 0.649 LMO3
LIM domain only 3 (rhombotin-like 2)
chr22_+_44828338 0.649


chr12_+_79625538 0.649 NM_002469
MYF6
myogenic factor 6 (herculin)
chr13_-_98708549 0.640 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_-_169392771 0.636


chr12_-_10983072 0.635 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr9_+_674193 0.629


chr6_+_84619703 0.626 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr10_+_24795465 0.625 KIAA1217
KIAA1217
chr5_+_36644187 0.621 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_42156913 0.620


chr13_-_83354474 0.612 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr10_+_24795446 0.610 KIAA1217
KIAA1217
chr10_-_105835609 0.610 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr2_-_206790871 0.605 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr1_-_155336223 0.602 NM_001004341
ETV3L
ets variant 3-like
chr5_+_155686333 0.593 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr9_+_117955890 0.592 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr16_+_55373241 0.586 NUP93
nucleoporin 93kDa
chr10_-_105835525 0.584 COL17A1
collagen, type XVII, alpha 1
chr6_+_88026338 0.584 ZNF292
zinc finger protein 292
chr4_-_138673078 0.582 NM_019035
PCDH18
protocadherin 18
chr8_-_134156353 0.579 SLA
Src-like-adaptor
chr18_+_74841262 0.579 NM_171999
SALL3
sal-like 3 (Drosophila)
chr19_-_46504831 0.578


chr7_+_28692122 0.578 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr9_+_108665168 0.570 NM_021224
ZNF462
zinc finger protein 462
chr8_-_67253234 0.567 NM_000756
CRH
corticotropin releasing hormone
chr1_-_150328153 0.563 NM_001008536
TCHHL1
trichohyalin-like 1
chr3_+_69895651 0.556 NM_006722
MITF
microphthalmia-associated transcription factor
chr18_+_59726183 0.553 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr12_-_51200347 0.546 NM_000424
KRT5
keratin 5
chrX_-_19727775 0.532 SH3KBP1
SH3-domain kinase binding protein 1
chr11_+_123986661 0.528 NM_052959
PANX3
pannexin 3
chr1_+_168898898 0.527 PRRX1
paired related homeobox 1
chr11_-_2149591 0.523 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr1_-_153109349 0.520 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr3_+_101720753 0.520 TMEM45A
transmembrane protein 45A
chr11_+_114054409 0.517 NM_182495
FAM55B
family with sequence similarity 55, member B
chr5_+_170668892 0.514 NM_021025
TLX3
T-cell leukemia homeobox 3
chr15_+_64481270 0.512 MAP2K1
mitogen-activated protein kinase kinase 1
chr3_+_123385219 0.510 NM_000388
CASR
calcium-sensing receptor
chr15_-_70838703 0.506


chr9_-_5294579 0.505 NM_005059
NM_134441
RLN2

relaxin 2

chr3_+_138132006 0.505 NM_001190796
NCK1
NCK adaptor protein 1
chr2_+_96269703 0.504 NM_001037228
LOC285033
hypothetical protein LOC285033
chr6_-_32605898 0.502 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr1_-_150653351 0.502 NM_016190
CRNN
cornulin
chr7_+_150376537 0.500 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr12_+_8167494 0.495 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr8_-_134156437 0.489 SLA
Src-like-adaptor
chr11_-_114593838 0.484 CADM1
cell adhesion molecule 1
chr8_+_32905027 0.476


chr11_-_85108030 0.475 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr10_-_14090459 0.468 FRMD4A
FERM domain containing 4A
chr5_+_125786717 0.466 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr11_+_59979857 0.466 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr4_+_169250281 0.465 NM_007193
ANXA10
annexin A10
chr8_-_108579270 0.460 NM_001146
ANGPT1
angiopoietin 1
chr1_-_154484341 0.458 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr6_+_134800533 0.457 LOC154092
hypothetical LOC154092
chr12_-_15005761 0.457 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr7_+_63411813 0.456 ZNF736
zinc finger protein 736
chr12_+_45896318 0.452 NM_138371
FAM113B
family with sequence similarity 113, member B
chr2_-_110665188 0.449 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr13_+_110637173 0.448 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr10_-_14412813 0.448 NM_018027
FRMD4A
FERM domain containing 4A
chr5_-_150501393 0.447 NM_001193544
ANXA6
annexin A6
chr1_-_32036802 0.447 SPOCD1
SPOC domain containing 1
chr4_-_40631397 0.447 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_-_85107569 0.445 NM_206929
SYTL2
synaptotagmin-like 2
chr17_-_10362583 0.444 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr5_+_76470829 0.444


chr12_+_50981915 0.442 NM_002284
KRT86
keratin 86
chr1_-_6341553 0.441 NM_181866
ACOT7
acyl-CoA thioesterase 7
chr7_+_28418668 0.440 NM_182898
CREB5
cAMP responsive element binding protein 5
chr17_-_46479127 0.439 SPAG9
sperm associated antigen 9
chr17_-_53335748 0.435 NM_017949
CUEDC1
CUE domain containing 1
chrX_+_71280758 0.434 NM_207422
FLJ44635
TPT1-like protein
chr19_+_40632456 0.430 NM_005306
FFAR2
free fatty acid receptor 2
chr2_+_234624084 0.428 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr5_+_169713458 0.426 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr3_-_115960807 0.421 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr14_-_104330982 0.418 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr11_-_110755112 0.418 POU2AF1
POU class 2 associating factor 1
chr11_-_26550243 0.412 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr1_-_32036858 0.409 SPOCD1
SPOC domain containing 1
chr20_+_43691797 0.408 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr2_+_95326753 0.407 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr17_-_9870292 0.406 NM_001130831
GAS7
growth arrest-specific 7
chr10_-_98315090 0.404 TM9SF3
transmembrane 9 superfamily member 3
chr15_-_70385709 0.403 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr22_+_38903825 0.402 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr6_-_32665409 0.402 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr13_+_47948586 0.401 RB1
retinoblastoma 1
chr4_+_114433551 0.400 ANK2
ankyrin 2, neuronal
chr17_+_56843893 0.400 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr3_-_74652952 0.398 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr13_+_30207668 0.397 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_-_93172119 0.392


chr19_-_51829778 0.389 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr1_+_117345894 0.389 NM_004258
CD101
CD101 molecule
chr3_-_110155237 0.388 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr11_-_27637771 0.388 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr17_-_10393664 0.388 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr8_+_70541631 0.388 SULF1
sulfatase 1
chr17_-_45621571 0.387 COL1A1
collagen, type I, alpha 1
chr12_+_49605010 0.387 METTL7A
methyltransferase like 7A
chr7_+_129771865 0.386 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chrX_+_48253007 0.383 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chrX_+_55951280 0.381



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 1.09e-09 GO:0032501 multicellular organismal process
1.61 1.49e-07 GO:0048731 system development
2.43 2.97e-07 GO:0045595 regulation of cell differentiation
1.56 2.98e-07 GO:0048856 anatomical structure development
1.79 1.53e-06 GO:0003008 system process
1.46 6.99e-06 GO:0032502 developmental process
1.70 9.21e-06 GO:0048513 organ development
1.46 3.11e-05 GO:0007275 multicellular organismal development
2.03 4.64e-05 GO:0050793 regulation of developmental process
1.77 6.55e-05 GO:0007399 nervous system development
3.38 1.78e-04 GO:0007517 muscle organ development
1.75 3.59e-04 GO:0050877 neurological system process
2.88 3.60e-04 GO:0061061 muscle structure development
3.15 1.26e-03 GO:0008544 epidermis development
1.94 1.63e-03 GO:0007600 sensory perception
1.94 2.20e-03 GO:0048584 positive regulation of response to stimulus
1.98 2.33e-03 GO:2000026 regulation of multicellular organismal development
2.25 6.85e-03 GO:0051094 positive regulation of developmental process
5.37 8.46e-03 GO:0070848 response to growth factor stimulus
1.51 1.02e-02 GO:0030154 cell differentiation
1.83 1.49e-02 GO:0009888 tissue development
2.91 3.41e-02 GO:0002757 immune response-activating signal transduction
2.54 3.56e-02 GO:0045596 negative regulation of cell differentiation
1.47 3.56e-02 GO:0048869 cellular developmental process
2.35 3.67e-02 GO:0045597 positive regulation of cell differentiation
1.69 4.06e-02 GO:0010646 regulation of cell communication
5.60 4.40e-02 GO:0051149 positive regulation of muscle cell differentiation
2.85 4.79e-02 GO:0002764 immune response-regulating signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 6.03e-08 GO:0005886 plasma membrane
1.43 2.40e-07 GO:0071944 cell periphery
3.28 2.62e-04 GO:0005882 intermediate filament
2.97 8.68e-04 GO:0045111 intermediate filament cytoskeleton
4.36 8.94e-04 GO:0045095 keratin filament
10.67 2.62e-03 GO:0042613 MHC class II protein complex
1.53 8.93e-03 GO:0005856 cytoskeleton
2.14 1.66e-02 GO:0031012 extracellular matrix
2.20 2.97e-02 GO:0005578 proteinaceous extracellular matrix

Nothing significant found in function category.