Motif ID: PBX1.p2

Z-value: 1.212


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PBX1chr1_+_163084934-0.381.6e-01Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_96726415 2.801 MBNL2
muscleblind-like 2 (Drosophila)
chr13_+_96726197 2.604 MBNL2
muscleblind-like 2 (Drosophila)
chr7_-_27108826 1.823 NM_006735
HOXA2
homeobox A2
chr6_+_26307691 1.720 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr11_-_102174032 1.623 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr21_+_29439768 1.599 C21orf7
chromosome 21 open reading frame 7
chr11_-_102174102 1.546 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr5_+_162797149 1.355 NM_004060
NM_199246
CCNG1

cyclin G1

chr10_+_124310170 1.319 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr5_-_89741233 1.283 NM_004365
CETN3
centrin, EF-hand protein, 3
chr13_-_47510033 1.264 SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr3_+_112934016 1.180 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_189752575 1.157 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_+_26153590 1.130 NM_003531
HIST1H3C
histone cluster 1, H3c
chr17_+_8132539 1.095 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr5_-_58607673 1.085 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_26307418 1.056 NM_021065
NM_003530
HIST1H2AD
HIST1H3D
histone cluster 1, H2ad
histone cluster 1, H3d
chr3_-_53139457 1.045 NM_052859
RFT1
RFT1 homolog (S. cerevisiae)
chr13_+_38159172 1.035 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr10_+_63092724 1.030 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr10_+_69539255 1.029 NM_032578
MYPN
myopalladin
chr10_+_102113410 0.980


chr11_+_95163457 0.948 CEP57
centrosomal protein 57kDa
chr17_+_72380323 0.928 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr14_-_75196911 0.918 C14orf1
chromosome 14 open reading frame 1
chr6_+_54281161 0.896 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr1_-_147665783 0.889 HIST2H2BF
histone cluster 2, H2bf
chr5_-_171814026 0.874 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr13_-_32757835 0.872 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_+_79995927 0.842 NM_024560
ACSS3
acyl-CoA synthetase short-chain family member 3
chr16_+_15503623 0.839 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr6_-_27222556 0.823 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr9_+_112470871 0.818 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr14_+_23008742 0.805 NGDN
neuroguidin, EIF4E binding protein
chr3_-_123036526 0.792 IQCB1
IQ motif containing B1
chr1_-_171442937 0.761 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_-_26125939 0.755 NM_005325
HIST1H1A
histone cluster 1, H1a
chr4_-_118226119 0.733 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr13_-_60887210 0.728 PCDH20
protocadherin 20
chr5_-_75048965 0.724 NM_001099271
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr4_+_86968069 0.707 ARHGAP24
Rho GTPase activating protein 24
chr2_+_85676347 0.699 NM_016494
RNF181
ring finger protein 181
chr18_+_30427279 0.698 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr14_+_51025604 0.690 NM_001042481
FRMD6
FERM domain containing 6
chr10_-_101180191 0.673 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr21_-_35174742 0.664 RUNX1
runt-related transcription factor 1
chr8_-_68037378 0.661 NM_001193502
TCF24
transcription factor 24
chr2_-_218843039 0.659 AAMP
angio-associated, migratory cell protein
chr8_-_102034272 0.643 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr6_-_26379567 0.628 NM_003534
HIST1H3G
histone cluster 1, H3g
chr5_+_15553288 0.627 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr3_+_173951163 0.626 ECT2
epithelial cell transforming sequence 2 oncogene
chr14_+_23654161 0.625 DCAF11
DDB1 and CUL4 associated factor 11
chr1_-_148050534 0.624 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr8_+_99145925 0.621 NM_001170806
NM_173549
C8orf47

chromosome 8 open reading frame 47

chr2_-_192767844 0.608 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chrX_-_92815222 0.603 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr3_+_130641840 0.600 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr20_+_56369012 0.599


chr18_+_42780784 0.593 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr11_-_85115105 0.583 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr17_-_36436979 0.576 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr14_+_23008723 0.576 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr5_+_147562531 0.575 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chrX_+_92815667 0.573 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr8_+_69027166 0.561 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr3_+_185762233 0.561 NM_004443
EPHB3
EPH receptor B3
chr16_+_65868913 0.559 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr2_+_218843358 0.554 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr2_+_176680251 0.552 NM_021192
HOXD11
homeobox D11
chr8_+_69027143 0.551 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr12_+_21570457 0.550 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr6_-_26232109 0.548 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr2_+_200031333 0.546


chr4_-_177950658 0.544 NM_005429
VEGFC
vascular endothelial growth factor C
chr5_-_16795336 0.535 MYO10
myosin X
chr5_-_22248630 0.526 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr8_+_69026895 0.512 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr19_-_50912429 0.508


chr2_-_183439515 0.501 NM_001463
FRZB
frizzled-related protein
chr1_-_152162074 0.501 NM_020699
GATAD2B
GATA zinc finger domain containing 2B
chr11_+_95163256 0.501 NM_014679
CEP57
centrosomal protein 57kDa
chr17_+_43540124 0.500 SNX11
sorting nexin 11
chr15_-_73531082 0.498 NM_001145358
SIN3A
SIN3 homolog A, transcription regulator (yeast)
chr1_+_148125090 0.493 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr22_-_37520049 0.488 DNAL4
dynein, axonemal, light chain 4
chr14_+_73621408 0.487 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr4_-_186537145 0.485 NM_018409
LRP2BP
LRP2 binding protein
chr8_+_69027277 0.480 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr6_+_26381122 0.476 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr2_-_192767494 0.473 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr22_+_27468018 0.470 NM_172002
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr5_+_3649167 0.467 NM_024337
IRX1
iroquois homeobox 1
chr3_-_123036597 0.464 NM_001023570
NM_001023571
IQCB1

IQ motif containing B1

chr2_-_218843109 0.462 NM_001087
AAMP
angio-associated, migratory cell protein
chr20_+_43874735 0.461 UBE2C
ubiquitin-conjugating enzyme E2C
chr2_-_154043403 0.461 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr17_+_43480674 0.461 NM_003204
NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr5_-_171813960 0.454 SH3PXD2B
SH3 and PX domains 2B
chr4_+_81325447 0.453 NM_020226
PRDM8
PR domain containing 8
chr2_-_218843088 0.452 AAMP
angio-associated, migratory cell protein
chr13_-_60887655 0.446 NM_022843
PCDH20
protocadherin 20
chr20_+_11846536 0.446 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr17_+_56109940 0.444 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr12_-_54901946 0.443 NM_005785
NM_194358
NM_194359
RNF41


ring finger protein 41


chr3_+_123036719 0.439 NM_018456
EAF2
ELL associated factor 2
chr22_-_28972683 0.439 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr2_-_162808123 0.434 NM_004460
FAP
fibroblast activation protein, alpha
chr8_-_79880095 0.432 NM_000880
IL7
interleukin 7
chr12_+_21059896 0.431 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr13_-_97916768 0.428 STK24
serine/threonine kinase 24
chr6_+_27222839 0.428 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr22_-_37520092 0.426 NM_005740
DNAL4
dynein, axonemal, light chain 4
chr7_-_155297576 0.425 NM_000193
SHH
sonic hedgehog
chr9_-_128910132 0.424 ANGPTL2
angiopoietin-like 2
chr11_-_30562324 0.421 MPPED2
metallophosphoesterase domain containing 2
chr3_+_130641828 0.419 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr6_-_64087806 0.413 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr6_+_26333361 0.404 NM_003532
HIST1H3E
histone cluster 1, H3e
chr17_-_43328141 0.403


chr12_-_54965996 0.401 CS
citrate synthase
chr10_+_115514567 0.400 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr17_+_56884560 0.398 TBX4
T-box 4
chr2_-_200030944 0.393 NM_001172509
SATB2
SATB homeobox 2
chr12_+_49728350 0.393 NM_001024668
NM_015416
LETMD1

LETM1 domain containing 1

chr11_+_15051683 0.390 NM_000728
CALCB
calcitonin-related polypeptide beta
chr6_-_25679197 0.389


chr8_-_23768242 0.386 NM_003155
STC1
stanniocalcin 1
chr3_+_161040343 0.381 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr16_+_80626331 0.377 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_-_148124738 0.376 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr2_-_108972100 0.375 NM_022336
EDAR
ectodysplasin A receptor
chr4_+_69716298 0.375 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr12_+_77782719 0.372 SYT1
synaptotagmin I
chr5_+_43638495 0.368 NM_012343
NNT
nicotinamide nucleotide transhydrogenase
chr20_-_45848043 0.368 NM_018837
SULF2
sulfatase 2
chr7_-_121571472 0.366 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr16_+_81218074 0.359 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr3_-_130641460 0.356 MBD4
methyl-CpG binding domain protein 4
chr1_-_57204208 0.355 NM_000066
C8B
complement component 8, beta polypeptide
chr1_+_15862887 0.355


chr17_-_36456949 0.354 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr14_+_23653745 0.354 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr3_+_150675117 0.353 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr14_-_23653965 0.352 NRL
neural retina leucine zipper
chr3_-_130641365 0.351 MBD4
methyl-CpG binding domain protein 4
chr1_+_109036431 0.351 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr20_+_43874654 0.350 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr10_-_115923874 0.350 C10orf118
chromosome 10 open reading frame 118
chr17_+_43480724 0.350 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr4_-_111777956 0.349 NM_153426
NM_153427
PITX2

paired-like homeodomain 2

chr17_+_20970828 0.349 NM_015510
DHRS7B
dehydrogenase/reductase (SDR family) member 7B
chr1_-_42574116 0.345 NM_001198850
FOXJ3
forkhead box J3
chr5_+_131437383 0.342 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr2_+_62786290 0.341 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr17_+_43480723 0.341 NFE2L1
nuclear factor (erythroid-derived 2)-like 1
chr3_+_138063764 0.335 NCK1
NCK adaptor protein 1
chr16_+_88154582 0.329 NM_000977
NM_033251
RPL13

ribosomal protein L13

chr9_-_72926333 0.329 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr3_+_161040439 0.329 SCHIP1
schwannomin interacting protein 1
chr16_+_80626402 0.327 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_-_102880892 0.326 NM_001085398
TLX1NB
TLX1 neighbor
chr3_+_171621721 0.326 NM_001185056
CLDN11
claudin 11
chr7_-_135083906 0.321 NM_205855
FAM180A
family with sequence similarity 180, member A
chr2_+_191454157 0.320 GLS
glutaminase
chr3_-_113495763 0.316 NM_183061
SLC9A10
solute carrier family 9, member 10
chr20_+_18436525 0.315 SEC23B
Sec23 homolog B (S. cerevisiae)
chr1_+_60053050 0.313 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr10_-_14919973 0.313 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr8_-_114518194 0.310 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr2_+_241944333 0.310 NM_014808
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
chr6_+_26232351 0.309 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr11_+_57121602 0.307 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr8_-_130868315 0.304 NM_031415
GSDMC
gasdermin C
chr3_+_130641779 0.304 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr4_-_84254912 0.304 PLAC8
placenta-specific 8
chr2_+_191453791 0.302 NM_014905
GLS
glutaminase
chr13_-_45577144 0.300 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chrX_+_53139936 0.298 LOC100132984
hypothetical protein LOC100132984
chr14_-_54727958 0.296 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr14_-_53977785 0.293 NM_005776
CNIH
cornichon homolog (Drosophila)
chr6_-_30792830 0.291 MDC1
mediator of DNA-damage checkpoint 1
chr20_-_54400628 0.288 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr20_+_54400812 0.288 NM_001033521
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr2_+_162908828 0.286 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr16_+_81218142 0.286 CDH13
cadherin 13, H-cadherin (heart)
chr3_-_150993299 0.284 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr3_+_138063697 0.282 NM_006153
NCK1
NCK adaptor protein 1
chr12_-_28016182 0.279 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_-_108972048 0.278 EDAR
ectodysplasin A receptor
chr7_+_29569913 0.277 NM_175887
PRR15
proline rich 15
chr18_+_30327243 0.276 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr1_-_226712140 0.276 NM_033445
HIST3H2A
histone cluster 3, H2a
chr11_-_105398118 0.275 NM_032424
KIAA1826
KIAA1826
chr3_-_191322919 0.274 NM_001134418
LEPREL1
leprecan-like 1
chr3_+_174598937 0.270 NM_014932
NLGN1
neuroligin 1
chr9_+_34979674 0.266 NM_001135004
NM_012266
DNAJB5

DnaJ (Hsp40) homolog, subfamily B, member 5

chr4_-_84254873 0.266 PLAC8
placenta-specific 8
chr5_-_94442941 0.266 MCTP1
multiple C2 domains, transmembrane 1
chr21_-_31012965 0.265 NM_001164435
KRTAP21-3
keratin associated protein 21-3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.67 7.74e-13 GO:0065004 protein-DNA complex assembly
6.32 3.59e-12 GO:0071824 protein-DNA complex subunit organization
6.76 6.12e-12 GO:0031497 chromatin assembly
6.85 1.50e-11 GO:0006334 nucleosome assembly
5.40 9.49e-11 GO:0006333 chromatin assembly or disassembly
5.58 1.08e-10 GO:0006323 DNA packaging
6.19 1.95e-10 GO:0034728 nucleosome organization
3.29 4.04e-09 GO:0034622 cellular macromolecular complex assembly
4.79 5.72e-09 GO:0071103 DNA conformation change
1.66 3.17e-08 GO:0071842 cellular component organization at cellular level
2.40 8.03e-08 GO:0071844 cellular component assembly at cellular level
1.62 1.35e-07 GO:0071841 cellular component organization or biogenesis at cellular level
2.76 1.47e-07 GO:0034621 cellular macromolecular complex subunit organization
1.83 6.06e-07 GO:0006996 organelle organization
1.51 1.02e-06 GO:0016043 cellular component organization
1.50 1.40e-06 GO:0071840 cellular component organization or biogenesis
2.28 6.51e-06 GO:0065003 macromolecular complex assembly
2.00 6.60e-06 GO:0022607 cellular component assembly
2.36 1.07e-05 GO:0051276 chromosome organization
1.91 1.75e-05 GO:0044085 cellular component biogenesis
2.08 4.40e-05 GO:0043933 macromolecular complex subunit organization
2.36 6.41e-04 GO:0006325 chromatin organization
1.81 2.30e-03 GO:0007049 cell cycle
2.60 5.89e-03 GO:0000280 nuclear division
2.60 5.89e-03 GO:0007067 mitosis
2.52 1.02e-02 GO:0000087 M phase of mitotic cell cycle
2.51 1.09e-02 GO:0048285 organelle fission
2.23 1.24e-02 GO:0000279 M phase
2.02 1.72e-02 GO:0000278 mitotic cell cycle
1.84 1.84e-02 GO:0022402 cell cycle process
1.92 2.03e-02 GO:0022403 cell cycle phase

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.22 2.57e-11 GO:0000786 nucleosome
5.78 4.07e-09 GO:0032993 protein-DNA complex
1.18 3.28e-06 GO:0043229 intracellular organelle
1.18 4.35e-06 GO:0043226 organelle
1.50 1.54e-05 GO:0043228 non-membrane-bounded organelle
1.50 1.54e-05 GO:0043232 intracellular non-membrane-bounded organelle
2.36 6.96e-05 GO:0044427 chromosomal part
2.22 7.47e-05 GO:0005694 chromosome
2.95 1.14e-04 GO:0000785 chromatin
1.28 1.19e-04 GO:0005634 nucleus
1.12 1.48e-04 GO:0044424 intracellular part
1.12 1.53e-04 GO:0005622 intracellular
1.26 5.45e-04 GO:0044422 organelle part
1.26 7.82e-04 GO:0044446 intracellular organelle part
1.15 2.82e-03 GO:0043231 intracellular membrane-bounded organelle
1.15 3.20e-03 GO:0043227 membrane-bounded organelle
1.50 2.10e-02 GO:0005856 cytoskeleton

Nothing significant found in function category.