Motif ID: HMGA1,2.p2

Z-value: 2.295


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA2chr12_+_64504835-0.611.7e-02Click!
HMGA1chr6_+_34312979-0.562.9e-02Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_64568641 2.254 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_-_157892391 2.181 NM_001009959
ERMN
ermin, ERM-like protein
chr10_+_5976354 1.975 NM_032807
FBXO18
F-box protein, helicase, 18
chr3_+_39346200 1.973 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr2_+_102401580 1.968 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chrX_-_70243362 1.880 NM_001025265
CXorf65
chromosome X open reading frame 65
chr18_-_65766068 1.870 CD226
CD226 molecule
chr1_-_158815895 1.817 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr7_+_77307382 1.780 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr7_-_135263737 1.769 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr1_-_158815850 1.672 CD84
CD84 molecule
chr11_-_5130174 1.628 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr5_-_39238818 1.535 FYB
FYN binding protein
chr3_+_32968069 1.475 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr9_+_139758336 1.463 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr6_+_31690957 1.440 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr4_+_75393053 1.439 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr1_-_143708467 1.393 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_114176401 1.330 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr7_+_123036312 1.328 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr12_+_46802695 1.321 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr4_+_72423633 1.314 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr19_-_43608641 1.280 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chr3_+_153074118 1.267 NM_033050
SUCNR1
succinate receptor 1
chr3_-_46224791 1.250 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr11_-_117600918 1.248 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr5_+_96237399 1.248 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr1_+_148511806 1.247 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr7_+_143043871 1.205 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr2_-_64944214 1.156


chr1_+_242283129 1.153 NM_006352
ZNF238
zinc finger protein 238
chr12_+_9713472 1.146 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr9_-_112139908 1.145 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr14_+_19761708 1.139 NM_001004480
OR11H6
olfactory receptor, family 11, subfamily H, member 6
chr1_-_160648429 1.132 NM_053282
SH2D1B
SH2 domain containing 1B
chr3_-_120761092 1.129 NM_005191
CD80
CD80 molecule
chr4_-_100070808 1.073 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr3_+_122794859 1.071 NM_016298
FBXO40
F-box protein 40
chr7_-_7724762 1.063 NM_002947
RPA3
replication protein A3, 14kDa
chr11_+_59804634 1.060 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr6_-_27988152 1.060 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr1_-_158948176 1.049 NM_001778
CD48
CD48 molecule
chr2_-_65447267 1.048 SPRED2
sprouty-related, EVH1 domain containing 2
chr14_-_106249999 1.027 IGHA1
immunoglobulin heavy constant alpha 1
chr7_+_104468614 1.020 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr10_-_921694 1.017 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr1_-_158759606 1.017 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr14_+_59782222 1.015 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr17_-_30909219 1.008 NM_001129820
SLFN14
schlafen family member 14
chr2_-_85948287 1.004 NM_001042437
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr2_-_169596078 1.002 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr5_+_61910318 1.001 NM_181506
LRRC70
leucine rich repeat containing 70
chr4_+_159350850 1.001 NM_018342
TMEM144
transmembrane protein 144
chr19_+_6838576 0.994 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr2_+_169637255 0.994 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_-_77880731 0.988 LHFPL2
lipoma HMGIC fusion partner-like 2
chr17_-_31231421 0.983 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr12_-_101396459 0.971 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_+_60109319 0.970 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr3_-_42818221 0.969


chr15_-_97607108 0.965 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr1_+_207944807 0.965 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_-_201930311 0.962 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr10_+_91488704 0.959 KIF20B
kinesin family member 20B
chr9_+_129893948 0.954 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr12_+_8167494 0.948 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr9_-_99740243 0.944 NM_197978
HEMGN
hemogen
chr12_-_112326037 0.922 NM_006843
SDS
serine dehydratase
chr1_-_191422346 0.919 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_+_200698493 0.919 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr7_+_21434818 0.916


chr14_-_19867372 0.913 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr20_+_43764068 0.912 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr2_-_158008763 0.896 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_+_97513644 0.888 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr13_+_51933228 0.885 CKAP2
cytoskeleton associated protein 2
chr1_-_151352587 0.885 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr20_-_30703219 0.885 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr12_-_78831821 0.882 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr1_+_109043550 0.875 PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr14_+_20319049 0.874 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr15_+_83467295 0.860 PDE8A
phosphodiesterase 8A
chr11_-_5110383 0.857 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr19_-_7009644 0.856 NM_001164425
MBD3L3
methyl-CpG-binding domain protein 3-like 3-like
chr1_+_144374513 0.847 RNF115
ring finger protein 115
chr1_+_245779018 0.845 NM_145278
C1orf150
chromosome 1 open reading frame 150
chr4_+_100714995 0.834 MTTP
microsomal triglyceride transfer protein
chr1_+_173111306 0.833 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr1_+_205068844 0.832 NM_013371
IL19
interleukin 19
chr18_-_27594696 0.827 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr3_+_46386636 0.823 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr7_+_116447499 0.822 ST7
suppression of tumorigenicity 7
chr1_-_171838802 0.821 NM_178527
SLC9A11
solute carrier family 9, member 11
chr15_-_41195994 0.817 RPS3A
ribosomal protein S3A
chr20_-_45410033 0.816 ZMYND8
zinc finger, MYND-type containing 8
chr12_-_642786 0.813 NM_016533
NINJ2
ninjurin 2
chr3_+_3056307 0.807 NM_175612
CNTN4
contactin 4
chr12_-_53661888 0.806 NM_001098815
KIAA0748
KIAA0748
chr1_-_165326148 0.806 NM_005814
GPA33
glycoprotein A33 (transmembrane)
chr2_+_169645862 0.804 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr15_-_70350609 0.795 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chrX_-_138742050 0.795 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr12_-_9777126 0.794 NM_172004
CLECL1
C-type lectin-like 1
chr1_+_116727514 0.783 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr7_+_116447527 0.782 ST7
suppression of tumorigenicity 7
chr6_+_31081707 0.779 NM_001198815
PBMUCL1
panbronchiolitis related mucin-like 1
chr8_-_95298706 0.772 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr8_+_107529327 0.771 NM_001198532
OXR1
oxidation resistance 1
chr3_-_152585226 0.768 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr5_-_147996769 0.766 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr2_-_37228452 0.764 NM_001135652
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr20_-_55628852 0.762 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr5_+_69356827 0.761 NM_001178087
NM_022978
NM_021967
NM_022968
SERF1B

SERF1A

small EDRK-rich factor 1B (centromeric)

small EDRK-rich factor 1A (telomeric)

chr1_+_239762179 0.760 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_-_107930170 0.759 PNPLA8
patatin-like phospholipase domain containing 8
chr16_+_33168191 0.757 NM_001099687
TP53TG3B
TP53 target 3B
chr9_+_6318348 0.757 NM_001001874
NM_001001875
NM_033516
TPD52L3


tumor protein D52-like 3


chr2_-_65447370 0.754 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr14_+_59934178 0.753


chr16_-_32596378 0.752 NM_001099687
TP53TG3B
TP53 target 3B
chr5_-_88155360 0.749 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr3_+_123526700 0.739 NM_005213
CSTA
cystatin A (stefin A)
chr1_-_151296611 0.733 NM_005988
SPRR2A
small proline-rich protein 2A
chr3_-_195670256 0.730 NM_024524
ATP13A3
ATPase type 13A3
chr12_-_8110268 0.729 C3AR1
complement component 3a receptor 1
chr10_-_50066386 0.727 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr10_+_89257569 0.727 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chrX_+_118598325 0.726 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr8_-_82557956 0.721 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr2_-_175170674 0.720 WIPF1
WAS/WASL interacting protein family, member 1
chr3_-_152517204 0.717 NM_023915
GPR87
G protein-coupled receptor 87
chr12_-_8110196 0.705 NM_004054
C3AR1
complement component 3a receptor 1
chr12_-_120270035 0.705 ANAPC5
anaphase promoting complex subunit 5
chr19_-_60528480 0.701 NM_001085488
TMEM150B
transmembrane protein 150B
chr8_-_38324809 0.701 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr13_+_108079570 0.697 NM_001198950
MYO16
myosin XVI
chr7_+_73826244 0.694 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr15_-_48626193 0.691 NM_203494
USP50
ubiquitin specific peptidase 50
chr6_+_16251260 0.688 MYLIP
myosin regulatory light chain interacting protein
chr6_-_76259976 0.687 NM_015687
FILIP1
filamin A interacting protein 1
chr4_+_71806538 0.683 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr11_+_67133502 0.680 NDUFV1
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
chr12_+_21570457 0.680 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr1_+_156526182 0.679 NM_001765
CD1C
CD1c molecule
chr12_+_9871343 0.678 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr7_+_64136078 0.674 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr1_+_557269 0.673


chr2_+_161701711 0.672 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr6_+_37511383 0.667


chr9_-_21132143 0.666 NM_002177
IFNW1
interferon, omega 1
chr17_+_28342994 0.664 NM_173847
SPACA3
sperm acrosome associated 3
chrX_-_119593646 0.664 NM_003588
CUL4B
cullin 4B
chr6_-_53034445 0.663 ICK
intestinal cell (MAK-like) kinase
chr11_+_10433241 0.657 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr7_+_115650240 0.654 NM_152829
TES
testis derived transcript (3 LIM domains)
chr7_-_132371208 0.650 EEF1G
eukaryotic translation elongation factor 1 gamma
chr1_+_109043711 0.648 PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr8_+_107807415 0.648 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr1_+_234624266 0.647 NM_145861
EDARADD
EDAR-associated death domain
chr21_-_34820916 0.646 NM_203418
RCAN1
regulator of calcineurin 1
chr1_+_84539876 0.646 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr19_-_14750347 0.646 NM_013447
NM_152916
NM_152917
NM_152918
NM_152919
NM_152920
NM_152921
EMR2






egf-like module containing, mucin-like, hormone receptor-like 2






chr10_+_35524060 0.646 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr9_-_85773899 0.640 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_142587973 0.636


chr19_+_14554895 0.635 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr5_-_160211623 0.634 NM_025153
ATP10B
ATPase, class V, type 10B
chr19_-_16111594 0.633


chr1_-_202726068 0.629 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr7_+_28692122 0.625 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr3_+_171112053 0.625 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr13_-_48873735 0.619 NM_030925
CAB39L
calcium binding protein 39-like
chr10_+_74323344 0.616 NM_152635
OIT3
oncoprotein induced transcript 3
chr6_+_31662454 0.616 NM_205837
LST1
leukocyte specific transcript 1
chr6_+_134800533 0.614 LOC154092
hypothetical LOC154092
chr17_-_36232366 0.614 NM_000421
KRT10
keratin 10
chr1_+_40635058 0.613 NM_001198980
SMAP2
small ArfGAP2
chr7_-_143085704 0.611 NM_178561
CTAGE6P
CTAGE family, member 6, pseudogene
chr2_+_114390975 0.610 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr8_+_24297742 0.605 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr3_+_38282301 0.599 NM_004256
SLC22A13
solute carrier family 22 (organic anion transporter), member 13
chr15_+_65217412 0.598 NM_001145103
SMAD3
SMAD family member 3
chr4_+_100957003 0.598 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr19_-_16111695 0.598


chr22_-_39189369 0.597 MKL1
megakaryoblastic leukemia (translocation) 1
chr6_+_27215039 0.595 NM_003495
HIST1H4I
histone cluster 1, H4i
chr7_-_139948780 0.594 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr1_-_21310462 0.593 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr14_-_106064887 0.588 LOC100126583
IGHV3-48
IGHA1
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 3-48
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr22_-_39587944 0.587 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr7_-_92615593 0.584 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr19_-_3013880 0.583 NM_198969
AES
amino-terminal enhancer of split
chr20_-_23014828 0.582 NM_012072
CD93
CD93 molecule
chr6_+_31782618 0.582 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr19_+_61624 0.581 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_+_150013716 0.581 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr4_-_151993422 0.577


chr19_+_52532210 0.577 NM_018485
GPR77
G protein-coupled receptor 77
chr5_-_71838875 0.576 NM_152625
ZNF366
zinc finger protein 366
chr14_-_30927931 0.574 NM_015473
HEATR5A
HEAT repeat containing 5A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.86 2.47e-08 GO:0007606 sensory perception of chemical stimulus
1.50 4.20e-08 GO:0002376 immune system process
1.88 1.18e-07 GO:0007608 sensory perception of smell
1.58 3.90e-06 GO:0006955 immune response
1.66 5.03e-04 GO:0050776 regulation of immune response
1.50 1.23e-03 GO:0002682 regulation of immune system process
1.46 1.28e-03 GO:0006952 defense response
2.05 4.00e-03 GO:0009615 response to virus
1.42 7.76e-03 GO:0007600 sensory perception
2.72 2.44e-02 GO:0006968 cellular defense response
1.77 2.45e-02 GO:0045321 leukocyte activation
2.15 4.20e-02 GO:0070663 regulation of leukocyte proliferation
2.17 4.84e-02 GO:0050670 regulation of lymphocyte proliferation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 2.80e-02 GO:0005886 plasma membrane
1.13 3.01e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.90 4.21e-08 GO:0004984 olfactory receptor activity
1.46 1.58e-04 GO:0004930 G-protein coupled receptor activity
1.27 3.19e-03 GO:0004872 receptor activity
1.29 1.69e-02 GO:0004888 transmembrane receptor activity
1.22 1.78e-02 GO:0004871 signal transducer activity
1.22 1.78e-02 GO:0060089 molecular transducer activity
2.80 4.99e-02 GO:0003823 antigen binding