Motif ID: GLI1..3.p2

Z-value: 2.182


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI3chr7_-_422433180.562.9e-02Click!
GLI1chr12_+_561401840.478.0e-02Click!
GLI2chr2_+_121271336-0.117.0e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_72057755 3.633 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr11_-_60880799 3.540 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr22_+_18090118 3.175 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr16_+_48865521 3.077 ADCY7
adenylate cyclase 7
chr20_-_44612619 2.515 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr16_+_56259657 2.414 NM_170776
GPR97
G protein-coupled receptor 97
chr8_+_21972631 2.403 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr6_+_44076281 2.129 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr18_-_17434811 1.954 ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
chr20_-_42457717 1.952


chr17_+_73738985 1.946 NM_001145529
TMEM235
transmembrane protein 235
chr9_+_130056513 1.889


chr8_+_21972804 1.839 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_-_11909042 1.775 NM_138346
KIAA2013
KIAA2013
chr16_+_2461500 1.773 NM_006181
NTN3
netrin 3
chr17_-_3407780 1.726 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr1_-_180621272 1.680 GLUL
glutamate-ammonia ligase
chr19_+_55844446 1.604 NM_001195076
LOC342918
hypothetical protein LOC342918
chr19_-_48977247 1.599 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr17_-_3408038 1.577 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr17_-_3766441 1.547 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr19_+_2240996 1.480


chr2_-_231498184 1.417 NM_005683
GPR55
G protein-coupled receptor 55
chr11_-_289518 1.407 NM_001025295
IFITM5
interferon induced transmembrane protein 5
chr12_-_53064723 1.372 NM_015481
ZNF385A
zinc finger protein 385A
chr5_-_43448174 1.351 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr17_-_3766708 1.327 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr10_-_105208634 1.324 NM_001001412
CALHM1
calcium homeostasis modulator 1
chr4_-_140696740 1.301 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr7_-_142695392 1.301


chr17_+_23875085 1.288 NM_003593
FOXN1
forkhead box N1
chr8_+_21937533 1.283 NPM2
nucleophosmin/nucleoplasmin 2
chr7_-_150515851 1.259 NM_080871
ASB10
ankyrin repeat and SOCS box containing 10
chr15_-_41879426 1.212 NM_001033517
SERINC4
serine incorporator 4
chr15_+_37660568 1.208 NM_003246
THBS1
thrombospondin 1
chr4_-_164614335 1.205 NM_032136
TKTL2
transketolase-like 2
chr8_-_145671947 1.194 FOXH1
forkhead box H1
chr9_-_97319067 1.189 NM_001083602
NM_001083603
PTCH1

patched 1

chr9_-_138757175 1.184 NM_001001712
LCN10
lipocalin 10
chr19_+_50109416 1.178 APOC1
apolipoprotein C-I
chr16_-_45339605 1.168 NM_182493
MYLK3
myosin light chain kinase 3
chr9_-_97318760 1.158 PTCH1
patched 1
chr19_-_54618410 1.149 NM_178449
PTH2
parathyroid hormone 2
chr7_+_142695570 1.140 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr7_-_150306169 1.128 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_-_45081190 1.112 NM_001166292
NM_003738
PTCH2

patched 2

chr19_+_10404110 1.098 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr3_+_38010081 1.093 NM_015873
VILL
villin-like
chr12_-_53064565 1.089 ZNF385A
zinc finger protein 385A
chr11_+_61943082 1.078 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr1_+_160615319 1.065 NM_001135240
C1orf226
chromosome 1 open reading frame 226
chr5_-_168204430 1.056


chr4_-_176970895 1.055 GPM6A
glycoprotein M6A
chr20_+_61655934 1.055


chr20_+_61654816 1.053 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr1_-_158815850 1.053 CD84
CD84 molecule
chr16_+_87232501 1.050 NM_013278
IL17C
interleukin 17C
chr11_-_118055564 1.050 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr16_+_56134077 1.049 NM_153837
GPR114
G protein-coupled receptor 114
chr16_-_83703496 1.044 NM_198491
FAM92B
family with sequence similarity 92, member B
chr7_+_149699185 1.036 NM_014374
REPIN1
replication initiator 1
chr7_+_142695511 1.023 NM_032982
NM_032983
CASP2

caspase 2, apoptosis-related cysteine peptidase

chr10_-_97040661 1.022 NM_020992
PDLIM1
PDZ and LIM domain 1
chr12_+_45896511 0.994 FAM113B
family with sequence similarity 113, member B
chr19_-_60483302 0.993 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr12_-_56422120 0.992 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr16_+_56134037 0.988 GPR114
G protein-coupled receptor 114
chr7_-_127833231 0.985 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr1_-_38285033 0.979 NM_002699
POU3F1
POU class 3 homeobox 1
chr22_+_38090120 0.974 NM_145738
SYNGR1
synaptogyrin 1
chr1_-_39877928 0.971 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr16_+_55950195 0.954 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr2_-_85490984 0.948 CAPG
capping protein (actin filament), gelsolin-like
chr18_-_17434655 0.947 NM_052911
ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
chr1_-_55039458 0.947 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr2_+_238673689 0.926 NM_194312
ESPNL
espin-like
chr19_-_10900086 0.912 NM_024029
YIPF2
Yip1 domain family, member 2
chr1_+_199259664 0.911


chr8_+_21956335 0.903 NM_003867
FGF17
fibroblast growth factor 17
chr6_+_31647854 0.903 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr12_-_55696542 0.896 NM_001178054
NM_013251
TAC3

tachykinin 3

chr17_-_34607257 0.891 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr22_+_45401321 0.889 NM_015124
GRAMD4
GRAM domain containing 4
chr22_+_18388633 0.887 C22orf25
chromosome 22 open reading frame 25
chr2_-_6923215 0.879 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr22_+_20899155 0.875


chr19_+_50109903 0.869 APOC1
apolipoprotein C-I
chr19_-_48976852 0.862 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_39877883 0.861 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr6_+_34541827 0.852 NM_020804
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr1_+_36394044 0.850 MAP7D1
MAP7 domain containing 1
chr19_-_53868075 0.849 NM_145807
NTN5
netrin 5
chr2_+_96355661 0.849 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr5_-_36277656 0.844 NM_001085411
C5orf33
chromosome 5 open reading frame 33
chr5_+_150206277 0.843 NM_001145805
IRGM
immunity-related GTPase family, M
chr6_-_167491305 0.842 NM_005299
GPR31
G protein-coupled receptor 31
chr14_-_106352471 0.841


chr19_+_10388448 0.841 PDE4A
phosphodiesterase 4A, cAMP-specific
chr15_+_41879912 0.836 NM_016400
C15orf63
chromosome 15 open reading frame 63
chr19_-_40684638 0.834 NM_001035516
DMKN
dermokine
chr16_+_1979959 0.833 NM_004209
SYNGR3
synaptogyrin 3
chrX_+_106336517 0.831 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr1_+_36121382 0.829 NM_012199
EIF2C1
eukaryotic translation initiation factor 2C, 1
chr22_+_21852911 0.828 BCR
breakpoint cluster region
chr7_-_150305933 0.826 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr11_+_58967192 0.825 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr4_+_1764802 0.825 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chrX_-_1615999 0.822 NM_178129
P2RY8
CRLF2
purinergic receptor P2Y, G-protein coupled, 8
cytokine receptor-like factor 2
chr4_-_176970407 0.815 GPM6A
glycoprotein M6A
chr7_+_99809068 0.814 PILRA
paired immunoglobin-like type 2 receptor alpha
chr1_+_36121400 0.814 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr4_-_176970372 0.810 GPM6A
glycoprotein M6A
chr3_+_155321826 0.810 NM_015595
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr21_-_43903755 0.807 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr5_+_169592523 0.806 NM_001102609
C5orf58
chromosome 5 open reading frame 58
chrX_+_49013424 0.806 PPP1R3F
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chrX_-_152591936 0.804 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr11_+_67984758 0.803 NM_001164160
NM_001164161
NM_001164162
NM_001164163
NM_001164164
NM_018312
PPP6R3





protein phosphatase 6, regulatory subunit 3





chr22_+_20316968 0.801 NM_152612
CCDC116
coiled-coil domain containing 116
chr7_-_142369534 0.800 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr11_+_2279932 0.797 TSPAN32
tetraspanin 32
chrX_+_48427103 0.796 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_163780063 0.787 NM_001005214
LRRC52
leucine rich repeat containing 52
chr7_-_142369519 0.787 KEL
Kell blood group, metallo-endopeptidase
chr16_+_29892714 0.786 NM_004783
NM_016151
TAOK2

TAO kinase 2

chr22_+_18388602 0.785 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr7_+_73826244 0.783 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr11_-_118405288 0.781 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr20_+_42417752 0.778 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_+_31799099 0.775 NM_025260
NM_138272
NM_138273
NM_138274
NM_138275
NM_138277
C6orf25





chromosome 6 open reading frame 25





chr17_-_9870292 0.773 NM_001130831
GAS7
growth arrest-specific 7
chr8_-_134653194 0.769 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr2_+_27225362 0.769 NM_175769
TCF23
transcription factor 23
chr3_-_109292444 0.767 NM_001777
NM_198793
CD47

CD47 molecule

chr11_-_83071084 0.767 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr8_+_124264054 0.766 FAM83A
family with sequence similarity 83, member A
chr9_+_135277264 0.766 ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr19_-_60483256 0.764 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr16_+_66236559 0.758 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr21_+_43903803 0.755 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr11_+_19691397 0.747 NM_145117
NM_182964
NAV2

neuron navigator 2

chr19_+_14405100 0.745 NM_002741
PKN1
protein kinase N1
chr3_+_187917791 0.745 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr3_-_39209075 0.740 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr2_-_242096673 0.740 NM_006374
STK25
serine/threonine kinase 25
chr16_+_29581783 0.740 NM_001030288
SPN
sialophorin
chr20_-_43972061 0.738 PLTP
phospholipid transfer protein
chr20_+_34523555 0.737 NM_183006
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr19_-_12802206 0.736 NM_001080997
RTBDN
retbindin
chr2_+_220087135 0.736 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr2_-_242096592 0.735 STK25
serine/threonine kinase 25
chr15_+_65145215 0.731 SMAD3
SMAD family member 3
chr22_+_18388656 0.731 C22orf25
chromosome 22 open reading frame 25
chr3_+_47004457 0.730 NBEAL2
neurobeachin-like 2
chr3_-_185578621 0.729 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr15_+_38923914 0.727 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr20_-_34102250 0.724 LOC647979
hypothetical LOC647979
chr16_+_66236512 0.723 NM_001013838
RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr19_+_3490154 0.720 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chr6_+_3009120 0.715 RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chrX_+_153062918 0.714 NM_020061
OPN1LW
opsin 1 (cone pigments), long-wave-sensitive
chr1_-_158815895 0.701 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr15_-_76313896 0.701 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr16_-_82778071 0.700 NM_005679
NM_139353
TAF1C

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

chr5_-_149515331 0.699 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr7_+_99793561 0.699 NM_178238
PILRB
paired immunoglobin-like type 2 receptor beta
chr7_+_142695584 0.696 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr1_-_159099090 0.691 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr11_+_183079 0.690 NM_145651
SCGB1C1
secretoglobin, family 1C, member 1
chr4_-_176971175 0.690 NM_201591
GPM6A
glycoprotein M6A
chr16_+_28903647 0.687 NM_001014989
LAT
linker for activation of T cells
chr17_-_45617899 0.684 COL1A1
collagen, type I, alpha 1
chr17_-_35975227 0.674 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr10_+_85923473 0.673 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr22_-_49042065 0.668 NM_002969
MAPK12
mitogen-activated protein kinase 12
chr3_-_49701085 0.666 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr10_+_85944383 0.666 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chr19_-_56260135 0.661 NM_015596
KLK13
kallikrein-related peptidase 13
chr7_-_92686773 0.658 NM_198151
HEPACAM2
HEPACAM family member 2
chr2_-_242096122 0.655 STK25
serine/threonine kinase 25
chr17_-_59817575 0.653 PECAM1
platelet/endothelial cell adhesion molecule
chr7_-_102044374 0.652 RASA4
RAS p21 protein activator 4
chr11_+_63030131 0.651 LGALS12
lectin, galactoside-binding, soluble, 12
chr19_-_45611110 0.651 NM_020956
NM_181882
PRX

periaxin

chr12_-_121551424 0.651 NM_017612
ZCCHC8
zinc finger, CCHC domain containing 8
chr1_-_39929654 0.650 NM_016257
HPCAL4
hippocalcin like 4
chr5_-_1647617 0.650 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr7_+_94130752 0.649 PEG10
paternally expressed 10
chr17_-_35331435 0.644 ORMDL3
ORM1-like 3 (S. cerevisiae)
chr2_+_128175066 0.641 NM_032740
SFT2D3
SFT2 domain containing 3
chr17_+_35484204 0.636 THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr16_+_28903870 0.635 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr8_+_145700272 0.634 NM_005309
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr14_+_95222506 0.633 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr20_+_42417502 0.631 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_-_202921103 0.625 NM_006338
NM_201630
LRRN2

leucine rich repeat neuronal 2

chr13_-_40138607 0.624 NM_002015
FOXO1
forkhead box O1
chr7_+_43118721 0.624 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr1_+_159959072 0.623 NM_001002901
FCRLB
Fc receptor-like B
chr12_+_6517600 0.623



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.12 1.89e-04 GO:0065007 biological regulation
1.24 1.69e-03 GO:0048518 positive regulation of biological process
1.28 5.64e-03 GO:0048583 regulation of response to stimulus
1.11 8.55e-03 GO:0050789 regulation of biological process
1.32 1.02e-02 GO:0009966 regulation of signal transduction
1.30 1.03e-02 GO:0023051 regulation of signaling
1.11 2.88e-02 GO:0050794 regulation of cellular process
1.76 3.61e-02 GO:0046578 regulation of Ras protein signal transduction
1.61 4.21e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.78 4.75e-02 GO:0051129 negative regulation of cellular component organization

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.81 2.23e-04 GO:0005083 small GTPase regulator activity
1.10 7.22e-03 GO:0005515 protein binding
1.62 2.21e-02 GO:0016563 transcription activator activity
1.49 4.70e-02 GO:0030695 GTPase regulator activity