Motif ID: NFKB1_REL_RELA.p2

Z-value: 2.323


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_103641854-0.543.8e-02Click!
RELAchr11_-_651824110.468.8e-02Click!
RELchr2_+_609622280.204.6e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35277942 4.099 NM_198844
NM_199321
 ZPBP2

zona pellucida binding protein 2

chr19_+_40632456 3.772 NM_005306
 FFAR2
free fatty acid receptor 2
chr2_+_219453487 3.683 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr20_-_4743768 3.338 NM_170774
 RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr2_-_231498184 3.083 NM_005683
 GPR55
G protein-coupled receptor 55
chr7_+_142723340 2.874 NM_000083
 CLCN1
chloride channel 1, skeletal muscle
chr17_-_33178987 2.700 HNF1B
HNF1 homeobox B
chr1_-_200397300 2.593 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr6_-_30188845 2.544 NM_007028
 TRIM31
tripartite motif containing 31
chr3_-_58175437 2.469 NM_004944
 DNASE1L3
deoxyribonuclease I-like 3
chr17_+_22823151 2.452 NM_014238
 KSR1
kinase suppressor of ras 1
chr19_-_7672978 2.292 NM_002002
 FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr17_-_31231421 2.244 NM_002985
 CCL5
chemokine (C-C motif) ligand 5
chr19_+_17499064 2.242 FAM129C
family with sequence similarity 129, member C
chr3_-_13089547 2.153 NM_001134382
 IQSEC1
IQ motif and Sec7 domain 1
chr16_+_49288550 2.145 NM_022162
 NOD2
nucleotide-binding oligomerization domain containing 2
chr11_-_60880799 2.026 NM_001161452
 CYBASC3
cytochrome b, ascorbate dependent 3
chr14_-_95250155 1.935 NM_001098725
NM_021966
 TCL1A

T-cell leukemia/lymphoma 1A

chr20_-_44370537 1.871 CDH22
cadherin 22, type 2
chr18_-_26996742 1.847 NM_004948
NM_024421
 DSC1

desmocollin 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 52 entries
enrichment   p-value GO term description
4.02 1.83e-02 GO:0060443 mammary gland morphogenesis
3.48 1.46e-02 GO:0034764 positive regulation of transmembrane transport
3.42 3.74e-02 GO:0042307 positive regulation of protein import into nucleus
3.39 1.13e-02 GO:0046824 positive regulation of nucleocytoplasmic transport
3.26 2.14e-02 GO:0090316 positive regulation of intracellular protein transport
3.25 1.17e-02 GO:0032388 positive regulation of intracellular transport
2.71 5.12e-03 GO:0051222 positive regulation of protein transport
2.29 9.35e-03 GO:0034762 regulation of transmembrane transport
2.04 1.13e-02 GO:0051249 regulation of lymphocyte activation
1.93 2.97e-02 GO:0002694 regulation of leukocyte activation
1.75 8.26e-03 GO:0007243 intracellular protein kinase cascade
1.75 8.26e-03 GO:0023014 signal transduction via phosphorylation event
1.67 3.68e-05 GO:0006955 immune response
1.66 2.34e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.65 5.63e-04 GO:0010628 positive regulation of gene expression
1.63 1.13e-02 GO:0006928 cellular component movement
1.63 2.14e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.62 5.34e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.61 2.62e-02 GO:0051253 negative regulation of RNA metabolic process
1.58 1.89e-02 GO:0001932 regulation of protein phosphorylation

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.08 3.50e-02 GO:0009897 external side of plasma membrane
1.32 1.16e-04 GO:0044459 plasma membrane part
1.19 1.47e-03 GO:0071944 cell periphery
1.19 1.81e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.70 4.95e-02 GO:0016563 transcription activator activity
1.45 3.34e-03 GO:0001071 nucleic acid binding transcription factor activity
1.45 3.34e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.14 4.62e-04 GO:0005515 protein binding