Motif ID: SPIB.p2

Z-value: 4.421


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.312.6e-01Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_48443232 8.544 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_-_71838875 7.066 NM_152625
ZNF366
zinc finger protein 366
chr6_+_31661934 6.964 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr6_+_31662454 6.786 NM_205837
LST1
leukocyte specific transcript 1
chr17_+_31455332 6.561 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr17_-_40843530 6.336 ARHGAP27
Rho GTPase activating protein 27
chr4_+_91035025 6.085 NM_007351
MMRN1
multimerin 1
chr5_+_61910318 5.765 NM_181506
LRRC70
leucine rich repeat containing 70
chr12_+_48443588 5.662 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr17_+_31664143 5.060 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr17_+_44643067 4.615 ABI3
ABI family, member 3
chr17_-_18890963 4.576 NM_006613
GRAP
GRB2-related adaptor protein
chr1_-_111848265 4.504 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr2_-_175207521 4.425 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr7_+_149778815 4.395 GIMAP8
GTPase, IMAP family member 8
chr1_+_111818111 4.036 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr2_+_102401580 3.969 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr7_+_149778869 3.961 NM_175571
GIMAP8
GTPase, IMAP family member 8
chr6_-_11490487 3.841 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chrX_-_44945025 3.777 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 48 entries
enrichment   p-value GO term description
1.86 9.39e-05 GO:0050870 positive regulation of T cell activation
1.82 1.19e-05 GO:0051251 positive regulation of lymphocyte activation
1.76 4.01e-05 GO:0002696 positive regulation of leukocyte activation
1.76 4.24e-05 GO:0050867 positive regulation of cell activation
1.70 5.07e-03 GO:0050900 leukocyte migration
1.68 1.98e-03 GO:0050863 regulation of T cell activation
1.61 1.89e-03 GO:0051249 regulation of lymphocyte activation
1.58 4.43e-02 GO:0002764 immune response-regulating signaling pathway
1.55 7.65e-03 GO:0002694 regulation of leukocyte activation
1.52 1.42e-02 GO:0050865 regulation of cell activation
1.50 4.32e-02 GO:0045321 leukocyte activation
1.46 3.91e-02 GO:0006954 inflammatory response
1.45 2.50e-15 GO:0002376 immune system process
1.44 7.74e-04 GO:0050776 regulation of immune response
1.44 9.82e-04 GO:0002684 positive regulation of immune system process
1.42 2.48e-07 GO:0006955 immune response
1.40 3.06e-02 GO:0006397 mRNA processing
1.39 4.82e-03 GO:0007599 hemostasis
1.39 5.01e-03 GO:0007596 blood coagulation
1.39 5.01e-03 GO:0050817 coagulation

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.58 4.83e-02 GO:0009897 external side of plasma membrane
1.16 1.70e-02 GO:0031981 nuclear lumen
1.15 1.71e-02 GO:0044428 nuclear part
1.14 1.49e-02 GO:0031974 membrane-enclosed lumen
1.13 4.67e-02 GO:0043233 organelle lumen
1.09 1.61e-03 GO:0005634 nucleus
1.08 3.45e-02 GO:0044422 organelle part
1.08 4.02e-02 GO:0044446 intracellular organelle part
1.07 4.33e-04 GO:0043227 membrane-bounded organelle
1.07 4.55e-02 GO:0044444 cytoplasmic part
1.06 6.87e-04 GO:0043231 intracellular membrane-bounded organelle
1.06 1.16e-03 GO:0043226 organelle
1.06 1.34e-03 GO:0043229 intracellular organelle
1.06 1.53e-02 GO:0005737 cytoplasm
1.05 4.77e-06 GO:0005622 intracellular
1.05 1.94e-05 GO:0044424 intracellular part
1.03 3.44e-04 GO:0005623 cell
1.03 4.21e-04 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.08 3.92e-02 GO:0003743 translation initiation factor activity
1.59 3.55e-03 GO:0005126 cytokine receptor binding
1.58 2.77e-03 GO:0005125 cytokine activity
1.30 4.06e-04 GO:0003723 RNA binding
1.12 1.09e-11 GO:0005515 protein binding
1.12 1.19e-02 GO:0003676 nucleic acid binding
1.04 8.39e-04 GO:0005488 binding