Motif ID: TFEB.p2

Z-value: 0.971


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41811916-0.185.1e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_160310118 1.570 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr11_-_85457753 1.472 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr1_-_26266571 1.472 NM_032588
TRIM63
tripartite motif containing 63
chr12_-_56432377 1.313 CDK4
cyclin-dependent kinase 4
chr11_-_85457736 1.289 PICALM
phosphatidylinositol binding clathrin assembly protein
chr10_+_69314347 1.265 NM_012238
SIRT1
sirtuin 1
chr12_-_56432375 1.177 CDK4
cyclin-dependent kinase 4
chr7_-_130443379 1.143 FLJ43663
hypothetical LOC378805
chr12_-_56432385 1.110 NM_000075
CDK4
cyclin-dependent kinase 4
chr6_+_87921980 1.017 NM_015021
ZNF292
zinc finger protein 292
chr15_-_71712711 0.970 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr5_+_172415891 0.949 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr1_+_11788889 0.933 CLCN6
chloride channel 6
chr11_-_71492019 0.897 NM_017907
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr12_-_56432292 0.887 CDK4
cyclin-dependent kinase 4
chr19_+_10626106 0.870 ILF3
interleukin enhancer binding factor 3, 90kDa
chr22_-_19543069 0.866 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr1_+_11788827 0.860 CLCN6
chloride channel 6
chr1_-_152797760 0.856 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_-_26105477 0.848 NM_001145454
NM_005563
STMN1

stathmin 1

chr3_+_129927668 0.829 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr1_-_39097904 0.823 NM_022157
RRAGC
Ras-related GTP binding C
chr22_-_19543012 0.786 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr1_-_152797707 0.784 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr17_-_32730804 0.782 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr17_-_33043514 0.773 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr22_-_19543099 0.771 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr16_-_1465021 0.757 CLCN7
chloride channel 7
chr5_-_133734616 0.754 CDKL3
cyclin-dependent kinase-like 3
chr11_+_18300689 0.751 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr11_+_67532592 0.740 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr7_+_36395913 0.730 NM_018685
ANLN
anillin, actin binding protein
chr5_+_133734768 0.721 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr16_-_1465007 0.715 CLCN7
chloride channel 7
chr12_+_52653176 0.703 NM_014212
HOXC11
homeobox C11
chr6_-_151814861 0.702 NM_017909
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr17_-_27210330 0.700 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr5_+_41940216 0.693 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr7_+_116380590 0.691 NM_018412
NM_021908
ST7

suppression of tumorigenicity 7

chr1_-_152797820 0.689 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_-_152797767 0.684 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr11_-_71491983 0.680 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr8_+_17824631 0.655 NM_006197
PCM1
pericentriolar material 1
chr10_-_45410197 0.653 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr2_+_108571177 0.642 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_52618815 0.637 NM_017410
HOXC13
homeobox C13
chr11_-_71491916 0.631 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr9_-_138277467 0.618 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr14_-_19999324 0.616 TMEM55B
transmembrane protein 55B
chr1_+_111215343 0.616 NM_001040033
CD53
CD53 molecule
chr1_+_44213260 0.613 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr7_-_42918013 0.612 NM_001099858
NM_024054
C7orf25

chromosome 7 open reading frame 25

chr8_-_66863841 0.606 NM_002603
PDE7A
phosphodiesterase 7A
chr4_-_47160476 0.603 COMMD8
COMM domain containing 8
chr11_-_71491942 0.596 LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr3_+_129927716 0.595 RAB7A
RAB7A, member RAS oncogene family
chr10_+_50557689 0.593 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr10_-_105442868 0.592 SH3PXD2A
SH3 and PX domains 2A
chr16_-_1464927 0.589 CLCN7
chloride channel 7
chr2_-_55090759 0.588 NM_007008
RTN4
reticulon 4
chr1_+_44870223 0.582 RNF220
ring finger protein 220
chr8_-_54918099 0.580 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr19_-_45546250 0.578 C19orf47
chromosome 19 open reading frame 47
chr19_+_10625987 0.571 ILF3
interleukin enhancer binding factor 3, 90kDa
chr3_+_129927714 0.565 RAB7A
RAB7A, member RAS oncogene family
chr18_+_30875297 0.563 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_-_7078446 0.562 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_-_18300246 0.559 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr3_+_129927726 0.558 RAB7A
RAB7A, member RAS oncogene family
chr12_-_122415708 0.552 SBNO1
strawberry notch homolog 1 (Drosophila)
chr4_-_47160403 0.550 NM_017845
COMMD8
COMM domain containing 8
chr2_+_219751230 0.550 FAM134A
family with sequence similarity 134, member A
chr3_+_129927723 0.532 RAB7A
RAB7A, member RAS oncogene family
chr13_-_49057707 0.529 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr8_+_104102477 0.529 ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr13_-_49057629 0.528 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr5_+_34692124 0.526 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr14_+_20580224 0.526 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr7_-_132417237 0.524 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr4_+_56414565 0.523 NM_001024924
NM_018261
NM_178237
EXOC1


exocyst complex component 1


chr6_+_151815114 0.519 NM_024573
C6orf211
chromosome 6 open reading frame 211
chr2_+_234333653 0.519 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr1_+_151456683 0.517 NM_001195571
PRR9
proline rich 9
chr16_-_28410580 0.515 NM_000086
CLN3
ceroid-lipofuscinosis, neuronal 3
chr15_-_71712605 0.514 NPTN
neuroplastin
chr2_+_108571209 0.512 LIMS1
LIM and senescent cell antigen-like domains 1
chr17_+_23708825 0.512 TMEM199
transmembrane protein 199
chr11_-_116474196 0.498 NM_025164
SIK3
SIK family kinase 3
chr1_-_201162938 0.496 KLHL12
kelch-like 12 (Drosophila)
chr11_-_85457469 0.490 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_26105230 0.488 NM_203401
STMN1
stathmin 1
chr10_+_22649977 0.483 NM_005180
BMI1
BMI1 polycomb ring finger oncogene
chr12_-_121316907 0.474 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr5_+_34692352 0.473 NM_001145520
RAI14
retinoic acid induced 14
chr6_-_33493640 0.471 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr15_+_41871809 0.471 SERF2-C15ORF63
SERF2
SERF2-C15orf63 read-through transcript
small EDRK-rich factor 2
chr9_-_134809774 0.465 TSC1
tuberous sclerosis 1
chr19_-_60611136 0.465 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr17_-_7078304 0.464 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr8_-_74822206 0.461 STAU2
staufen, RNA binding protein, homolog 2 (Drosophila)
chr12_-_63439322 0.456 GNS
glucosamine (N-acetyl)-6-sulfatase
chr7_+_4781784 0.455 NM_014855
KIAA0415
KIAA0415
chr17_-_60346042 0.454 LRRC37A3
leucine rich repeat containing 37, member A3
chr19_+_45546369 0.454 PLD3
phospholipase D family, member 3
chr21_-_37561463 0.451 DSCR3
Down syndrome critical region gene 3
chr7_-_38915306 0.451 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr1_-_205186330 0.450 NM_002644
PIGR
polymeric immunoglobulin receptor
chr4_-_152901542 0.449 NM_004564
PET112L
PET112-like (yeast)
chr9_-_134809816 0.448 NM_000368
NM_001162426
NM_001162427
TSC1


tuberous sclerosis 1


chr5_-_39255335 0.446 NM_001465
NM_199335
FYB

FYN binding protein

chr6_+_151815298 0.443 C6orf211
chromosome 6 open reading frame 211
chr1_-_52936573 0.441 C1orf163
chromosome 1 open reading frame 163
chr8_-_126173055 0.440 KIAA0196
KIAA0196
chr15_-_56829225 0.437 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr1_-_152867007 0.435 ADAR
adenosine deaminase, RNA-specific
chr3_-_4483952 0.432 SUMF1
sulfatase modifying factor 1
chr11_-_61441536 0.430 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chrX_+_49573952 0.429 NM_001127898
NM_001127899
CLCN5

chloride channel 5

chr12_-_63439449 0.427 GNS
glucosamine (N-acetyl)-6-sulfatase
chr7_+_149696792 0.427 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr11_+_120399966 0.426 NM_001130047
NM_152715
TBCEL

tubulin folding cofactor E-like

chr1_+_20385164 0.423 NM_152376
UBXN10
UBX domain protein 10
chr3_+_23961739 0.423 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr17_-_44026042 0.421 NM_002147
HOXB5
homeobox B5
chr15_-_70455153 0.421 HEXA
hexosaminidase A (alpha polypeptide)
chr1_+_179269183 0.421 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr4_+_71806538 0.420 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr9_-_89779413 0.420 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr15_+_41871768 0.419 NM_001018108
SERF2
small EDRK-rich factor 2
chr1_+_15725894 0.419 DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chrX_+_14801447 0.418 NM_152581
MOSPD2
motile sperm domain containing 2
chr7_+_116380790 0.417 ST7
suppression of tumorigenicity 7
chr1_+_109963950 0.417 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chr1_-_151775221 0.416 NM_014624
S100A6
S100 calcium binding protein A6
chr1_+_109963982 0.415 AMPD2
adenosine monophosphate deaminase 2
chrX_+_101862297 0.410 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr7_+_150390566 0.410 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr6_-_37061625 0.409 MTCH1
mitochondrial carrier homolog 1 (C. elegans)
chr9_-_37894098 0.407 MCART1
mitochondrial carrier triple repeat 1
chrX_+_102356659 0.405 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr16_+_1341937 0.403 GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr4_+_128773529 0.401 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr16_-_1465041 0.400 NM_001114331
NM_001287
CLCN7

chloride channel 7

chr17_+_69781980 0.400 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr9_-_130749604 0.400 NM_014908
DOLK
dolichol kinase
chr19_-_45546123 0.400 NM_178830
C19orf47
chromosome 19 open reading frame 47
chr22_-_19180075 0.399 NM_032775
KLHL22
kelch-like 22 (Drosophila)
chr19_-_45016587 0.399 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr12_-_63439415 0.399 GNS
glucosamine (N-acetyl)-6-sulfatase
chr4_+_164484540 0.399 NM_006174
NPY5R
neuropeptide Y receptor Y5
chr12_-_63439456 0.398 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr8_+_26296439 0.396 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr22_+_19543350 0.396 SNAP29
synaptosomal-associated protein, 29kDa
chrX_-_34585287 0.396 NM_031442
TMEM47
transmembrane protein 47
chr1_+_15725935 0.395 NM_015291
DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr17_+_52410466 0.395 NM_021626
SCPEP1
serine carboxypeptidase 1
chr8_-_23371080 0.394 NM_004901
ENTPD4
ectonucleoside triphosphate diphosphohydrolase 4
chr18_+_12397894 0.394 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr3_-_4483939 0.393 SUMF1
sulfatase modifying factor 1
chr10_+_69314714 0.391 SIRT1
sirtuin 1
chr1_-_153477511 0.391 GBA
glucosidase, beta, acid
chr10_+_70553862 0.388 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr3_-_4483955 0.385 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr8_+_126173264 0.385 NM_173685
NSMCE2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr22_+_19543248 0.383 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chr18_+_9904017 0.383 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr17_-_39556535 0.381 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr12_-_121316997 0.379 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr8_-_22145462 0.377 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr1_-_152867070 0.376 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr18_+_9904032 0.373 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr3_-_158700036 0.372 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr2_-_172572993 0.368


chr17_-_8241868 0.368 NM_001146684
RNF222
ring finger protein 222
chr12_-_107551783 0.367 NM_003006
SELPLG
selectin P ligand
chr7_-_132417374 0.367 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr4_-_164473107 0.366 NM_000909
NPY1R
neuropeptide Y receptor Y1
chrX_-_63531968 0.366 MTMR8
myotubularin related protein 8
chr1_+_109221271 0.365 GPSM2
G-protein signaling modulator 2
chr8_+_104102417 0.364 NM_001695
ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr9_-_139128777 0.364 DPP7
dipeptidyl-peptidase 7
chr5_+_34692239 0.363 RAI14
retinoic acid induced 14
chr18_-_41801237 0.362 NM_020964
EPG5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr5_-_154210405 0.361 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr18_+_9904000 0.361 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr3_+_5139032 0.360 ARL8B
ADP-ribosylation factor-like 8B
chr16_+_68353738 0.360 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr6_-_43445103 0.359 NM_014345
ZNF318
zinc finger protein 318
chr1_-_153477673 0.359 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr17_+_63252087 0.358 NM_004459
NM_182641
BPTF

bromodomain PHD finger transcription factor

chr14_-_54948290 0.358 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chr18_+_9903992 0.357 VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr5_-_154210350 0.356 C5orf4
chromosome 5 open reading frame 4
chr1_-_52936602 0.356 C1orf163
chromosome 1 open reading frame 163
chr3_-_196644864 0.355 NM_012287
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr12_-_107551744 0.352 SELPLG
selectin P ligand
chr1_-_11788550 0.352 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr1_-_52604405 0.351 NM_032449
CC2D1B
coiled-coil and C2 domain containing 1B
chrX_-_106846924 0.350 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_-_165112093 0.348 TADA1
transcriptional adaptor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.42 9.25e-06 GO:0007033 vacuole organization
8.37 4.54e-05 GO:0007040 lysosome organization
1.68 6.61e-04 GO:0033036 macromolecule localization
1.72 2.70e-03 GO:0008104 protein localization
1.63 5.15e-03 GO:0051641 cellular localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.59 6.90e-14 GO:0005773 vacuole
1.25 2.04e-10 GO:0043231 intracellular membrane-bounded organelle
1.25 2.56e-10 GO:0043227 membrane-bounded organelle
3.29 3.10e-09 GO:0000323 lytic vacuole
3.29 3.10e-09 GO:0005764 lysosome
1.21 1.03e-08 GO:0043229 intracellular organelle
4.11 1.14e-08 GO:0005774 vacuolar membrane
1.20 1.48e-08 GO:0043226 organelle
3.93 3.75e-08 GO:0044437 vacuolar part
1.15 2.24e-07 GO:0005622 intracellular
1.15 4.45e-07 GO:0044424 intracellular part
1.30 3.03e-06 GO:0044422 organelle part
1.30 3.15e-06 GO:0044446 intracellular organelle part
1.28 5.59e-06 GO:0044444 cytoplasmic part
4.39 1.53e-05 GO:0042470 melanosome
4.39 1.53e-05 GO:0048770 pigment granule
1.20 2.70e-05 GO:0005737 cytoplasm
2.25 6.99e-05 GO:0005768 endosome
3.28 1.71e-04 GO:0005769 early endosome
3.57 2.35e-04 GO:0005765 lysosomal membrane
8.22 8.05e-04 GO:0033176 proton-transporting V-type ATPase complex
2.49 1.51e-03 GO:0010008 endosome membrane
2.47 1.78e-03 GO:0044440 endosomal part
1.42 3.87e-03 GO:0031090 organelle membrane
1.75 5.00e-03 GO:0031410 cytoplasmic vesicle
1.72 7.06e-03 GO:0031982 vesicle
1.22 9.96e-03 GO:0005634 nucleus
1.06 1.37e-02 GO:0044464 cell part
1.06 1.40e-02 GO:0005623 cell
2.99 1.81e-02 GO:0005770 late endosome
1.71 2.12e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.38 2.18e-02 GO:0044428 nuclear part
1.68 3.52e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.74e-05 GO:0005515 protein binding
2.36 3.22e-02 GO:0003713 transcription coactivator activity