Motif ID: TFAP2B.p2

Z-value: 2.392


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50894397-0.332.3e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_48951286 2.384 NM_001160300
NM_052839
 PANX2

pannexin 2

chr20_-_61933012 2.231 ZBTB46
zinc finger and BTB domain containing 46
chr16_+_87047159 1.983 ZFPM1
zinc finger protein, multitype 1
chr3_-_130807865 1.735 NM_015103
 PLXND1
plexin D1
chr20_+_20296744 1.679 NM_002196
 INSM1
insulinoma-associated 1
chr8_-_144583718 1.592 NM_201589
 MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr15_-_62854749 1.548 NM_194272
 RBPMS2
RNA binding protein with multiple splicing 2
chr17_-_34015631 1.524 NM_025248
 SRCIN1
SRC kinase signaling inhibitor 1
chr9_+_123501186 1.487 DAB2IP
DAB2 interacting protein
chr16_+_88169612 1.481 NM_014427
NM_153636
 CPNE7

copine VII

chr14_+_104338423 1.478 ZBTB42
zinc finger and BTB domain containing 42
chr20_-_60963390 1.414 NM_006602
 TCFL5
transcription factor-like 5 (basic helix-loop-helix)
chr10_+_120779217 1.405 NM_199461
 NANOS1
nanos homolog 1 (Drosophila)
chr1_+_39729885 1.398 NM_181809
 BMP8A
bone morphogenetic protein 8a
chr9_+_137511448 1.398 NM_014811
 KIAA0649
KIAA0649
chr4_+_2031036 1.385 NM_178557
 NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr19_+_39664706 1.374 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr10_-_99175685 1.364


chr1_-_38285033 1.360 NM_002699
 POU3F1
POU class 3 homeobox 1
chr7_-_150495799 1.350 NM_001098834
 GBX1
gastrulation brain homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 170 entries
enrichment   p-value GO term description
1.62 7.22e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.61 2.09e-06 GO:0048011 nerve growth factor receptor signaling pathway
1.60 1.07e-02 GO:0022604 regulation of cell morphogenesis
1.57 4.46e-02 GO:0010975 regulation of neuron projection development
1.54 5.76e-04 GO:0045664 regulation of neuron differentiation
1.53 2.54e-04 GO:0045786 negative regulation of cell cycle
1.52 2.65e-04 GO:0048568 embryonic organ development
1.47 2.71e-06 GO:0048598 embryonic morphogenesis
1.47 1.65e-05 GO:0007411 axon guidance
1.46 9.15e-05 GO:0060284 regulation of cell development
1.46 2.73e-03 GO:0050767 regulation of neurogenesis
1.45 1.26e-08 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.45 5.19e-08 GO:0000904 cell morphogenesis involved in differentiation
1.45 4.80e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.45 1.96e-06 GO:0007409 axonogenesis
1.43 3.21e-06 GO:0048812 neuron projection morphogenesis
1.43 4.49e-04 GO:0071495 cellular response to endogenous stimulus
1.43 6.37e-03 GO:0045596 negative regulation of cell differentiation
1.43 3.87e-02 GO:0071375 cellular response to peptide hormone stimulus
1.42 1.64e-08 GO:0000902 cell morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
1.98 4.48e-03 GO:0017053 transcriptional repressor complex
1.72 3.43e-02 GO:0031256 leading edge membrane
1.67 1.80e-02 GO:0009898 internal side of plasma membrane
1.52 4.89e-03 GO:0005912 adherens junction
1.49 2.11e-03 GO:0031252 cell leading edge
1.46 1.80e-02 GO:0070161 anchoring junction
1.33 4.64e-02 GO:0005874 microtubule
1.31 1.16e-04 GO:0044431 Golgi apparatus part
1.31 1.45e-03 GO:0000139 Golgi membrane
1.30 1.02e-05 GO:0044451 nucleoplasm part
1.28 2.60e-10 GO:0005654 nucleoplasm
1.25 3.31e-14 GO:0044428 nuclear part
1.25 1.38e-11 GO:0031981 nuclear lumen
1.25 1.83e-05 GO:0005794 Golgi apparatus
1.24 3.66e-12 GO:0005829 cytosol
1.24 3.63e-02 GO:0005694 chromosome
1.23 1.35e-02 GO:0015630 microtubule cytoskeleton
1.22 1.61e-11 GO:0070013 intracellular organelle lumen
1.21 1.88e-10 GO:0043233 organelle lumen
1.20 5.59e-10 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.55 1.17e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.48 2.36e-02 GO:0004721 phosphoprotein phosphatase activity
1.41 6.09e-04 GO:0008134 transcription factor binding
1.39 9.02e-04 GO:0016563 transcription activator activity
1.39 3.33e-02 GO:0019787 small conjugating protein ligase activity
1.39 4.92e-02 GO:0004842 ubiquitin-protein ligase activity
1.38 4.45e-03 GO:0005083 small GTPase regulator activity
1.38 1.11e-02 GO:0016881 acid-amino acid ligase activity
1.37 2.52e-05 GO:0030695 GTPase regulator activity
1.37 6.18e-05 GO:0004674 protein serine/threonine kinase activity
1.36 4.05e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.35 1.71e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.34 8.03e-04 GO:0019904 protein domain specific binding
1.33 3.96e-02 GO:0016564 transcription repressor activity
1.32 8.24e-06 GO:0043565 sequence-specific DNA binding
1.31 1.82e-06 GO:0016301 kinase activity
1.31 1.88e-02 GO:0008047 enzyme activator activity
1.30 5.49e-06 GO:0019899 enzyme binding
1.30 2.29e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.29 1.34e-07 GO:0001071 nucleic acid binding transcription factor activity