Motif ID: HIF1A.p2

Z-value: 0.799


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_612317950.352.1e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_191357680 0.582 NM_024529
 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr11_+_20341806 0.457 NM_006410
NM_001098521
 HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr1_+_109963950 0.402 NM_139156
 AMPD2
adenosine monophosphate deaminase 2
chr7_+_156624370 0.388 UBE3C
ubiquitin protein ligase E3C
chr1_+_109963982 0.386 AMPD2
adenosine monophosphate deaminase 2
chr3_+_184898234 0.386 NM_018023
 YEATS2
YEATS domain containing 2
chr1_-_37991160 0.382 EPHA10
EPH receptor A10
chr1_+_191357906 0.360 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr22_-_35232979 0.355 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr11_+_20341835 0.348 NM_001098520
 HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr7_+_156624392 0.343 NM_014671
 UBE3C
ubiquitin protein ligase E3C
chr1_+_20385164 0.319 NM_152376
 UBXN10
UBX domain protein 10
chr1_+_191357788 0.312 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr11_+_20341900 0.306 NM_001098522
 HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr1_+_191357819 0.297 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr6_+_44295219 0.294 NM_001078174
NM_004955
 SLC29A1

solute carrier family 29 (nucleoside transporters), member 1

chr3_+_43303005 0.285 NM_001100594
NM_017719
 SNRK

SNF related kinase

chr22_-_35233032 0.277 NM_024955
NM_001102371
 FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr11_-_76059435 0.277 NM_001128922
 LRRC32
leucine rich repeat containing 32
chr20_-_1321744 0.275 NM_000801
NM_054014
 FKBP1A

FK506 binding protein 1A, 12kDa


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.77 2.51e-02 GO:0018193 peptidyl-amino acid modification
1.44 2.15e-02 GO:0032268 regulation of cellular protein metabolic process
1.42 5.59e-06 GO:0043412 macromolecule modification
1.42 9.55e-06 GO:0006464 protein modification process
1.38 1.09e-06 GO:0044267 cellular protein metabolic process
1.30 3.80e-09 GO:0044260 cellular macromolecule metabolic process
1.27 8.53e-04 GO:0019538 protein metabolic process
1.24 1.06e-06 GO:0043170 macromolecule metabolic process
1.22 8.44e-08 GO:0044237 cellular metabolic process
1.19 1.54e-05 GO:0044238 primary metabolic process
1.17 1.23e-05 GO:0008152 metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
2.49 1.34e-02 GO:0001726 ruffle
2.34 2.80e-02 GO:0005788 endoplasmic reticulum lumen
2.05 6.75e-03 GO:0031252 cell leading edge
1.63 3.25e-03 GO:0005730 nucleolus
1.56 2.95e-04 GO:0044432 endoplasmic reticulum part
1.40 5.83e-05 GO:0012505 endomembrane system
1.38 1.04e-06 GO:0031090 organelle membrane
1.38 1.49e-02 GO:0005783 endoplasmic reticulum
1.36 1.53e-05 GO:0005829 cytosol
1.32 9.58e-05 GO:0031974 membrane-enclosed lumen
1.32 1.38e-04 GO:0070013 intracellular organelle lumen
1.31 1.93e-04 GO:0043233 organelle lumen
1.31 4.33e-04 GO:0044428 nuclear part
1.28 1.05e-14 GO:0044444 cytoplasmic part
1.28 1.93e-02 GO:0031981 nuclear lumen
1.26 1.70e-11 GO:0005634 nucleus
1.25 2.28e-24 GO:0043231 intracellular membrane-bounded organelle
1.25 3.78e-24 GO:0043227 membrane-bounded organelle
1.25 1.80e-22 GO:0005737 cytoplasm
1.24 1.68e-09 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.35 3.50e-03 GO:0032559 adenyl ribonucleotide binding
1.34 5.04e-03 GO:0030554 adenyl nucleotide binding
1.33 8.66e-03 GO:0005524 ATP binding
1.30 1.77e-02 GO:0016740 transferase activity
1.26 8.02e-03 GO:0000166 nucleotide binding
1.23 1.52e-03 GO:0003676 nucleic acid binding
1.19 3.03e-09 GO:0005515 protein binding
1.17 6.36e-04 GO:0003824 catalytic activity
1.09 2.12e-05 GO:0005488 binding