Motif ID: SREBF1,2.p2

Z-value: 1.153


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF2chr22_+_40559070-0.381.7e-01Click!
SREBF1chr17_-_17681013-0.224.3e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_73638430 2.715 NM_152468
 TMC8
transmembrane channel-like 8
chr13_+_48582389 2.212 NM_014923
 FNDC3A
fibronectin type III domain containing 3A
chr12_-_56432385 2.033 NM_000075
 CDK4
cyclin-dependent kinase 4
chr6_-_84994032 1.823 NM_014895
 KIAA1009
KIAA1009
chr12_-_56432375 1.728 CDK4
cyclin-dependent kinase 4
chr12_-_56432377 1.709 CDK4
cyclin-dependent kinase 4
chr10_+_69314347 1.662 NM_012238
 SIRT1
sirtuin 1
chr12_+_102982365 1.532 NM_013320
 HCFC2
host cell factor C2
chr8_-_54918099 1.496 NM_213620
 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chrX_+_101862297 1.486 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
 BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr19_+_45546369 1.465 PLD3
phospholipase D family, member 3
chr6_+_160310118 1.347 NM_000876
 IGF2R
insulin-like growth factor 2 receptor
chr5_+_133735004 1.321 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr10_-_45410197 1.315 NM_001002265
NM_145021
 MARCH8

membrane-associated ring finger (C3HC4) 8

chr11_+_125586828 1.276 NM_024556
 FAM118B
family with sequence similarity 118, member B
chr8_-_54918389 1.239 NM_015941
NM_213619
 ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr17_+_69781980 1.221 NM_001172810
NM_023036
 DNAI2

dynein, axonemal, intermediate chain 2

chr11_-_125586733 1.218 NM_001144827
NM_032795
 RPUSD4

RNA pseudouridylate synthase domain containing 4

chr2_-_172675873 1.202 DLX2
distal-less homeobox 2
chr19_+_37528340 1.124 NM_001136156
NM_014910
 ZNF507

zinc finger protein 507


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
5.56 3.44e-04 GO:0015682 ferric iron transport
5.56 3.44e-04 GO:0033572 transferrin transport
2.80 2.30e-02 GO:0000041 transition metal ion transport
1.52 1.12e-03 GO:0051641 cellular localization
1.48 2.64e-02 GO:0044248 cellular catabolic process
1.45 2.06e-02 GO:0033036 macromolecule localization
1.30 9.45e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 1.62e-02 GO:0006807 nitrogen compound metabolic process
1.27 1.91e-02 GO:0034641 cellular nitrogen compound metabolic process
1.21 1.35e-04 GO:0044237 cellular metabolic process
1.18 3.85e-03 GO:0044238 primary metabolic process
1.16 4.53e-03 GO:0008152 metabolic process
1.10 5.81e-03 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
5.77 3.50e-03 GO:0033176 proton-transporting V-type ATPase complex
3.58 3.37e-02 GO:0016469 proton-transporting two-sector ATPase complex
3.19 2.46e-08 GO:0044437 vacuolar part
3.17 9.46e-08 GO:0005774 vacuolar membrane
3.12 1.96e-05 GO:0005765 lysosomal membrane
2.87 3.78e-13 GO:0005773 vacuole
2.74 1.34e-09 GO:0000323 lytic vacuole
2.74 1.34e-09 GO:0005764 lysosome
2.74 2.05e-02 GO:0042470 melanosome
2.74 2.05e-02 GO:0048770 pigment granule
2.63 4.48e-03 GO:0005770 late endosome
1.88 3.95e-04 GO:0005768 endosome
1.62 2.92e-03 GO:0044451 nucleoplasm part
1.60 9.26e-07 GO:0005654 nucleoplasm
1.60 5.47e-03 GO:0031967 organelle envelope
1.57 1.05e-02 GO:0031975 envelope
1.48 1.43e-08 GO:0031974 membrane-enclosed lumen
1.48 3.54e-08 GO:0043233 organelle lumen
1.46 1.71e-07 GO:0070013 intracellular organelle lumen
1.46 1.71e-05 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.22 1.13e-08 GO:0005515 protein binding
1.10 3.99e-05 GO:0005488 binding