Motif ID: SREBF1,2.p2

Z-value: 1.153


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF2chr22_+_40559070-0.381.7e-01Click!
SREBF1chr17_-_17681013-0.224.3e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_73638430 2.715 NM_152468
TMC8
transmembrane channel-like 8
chr13_+_48582389 2.212 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr12_-_56432385 2.033 NM_000075
CDK4
cyclin-dependent kinase 4
chr6_-_84994032 1.823 NM_014895
KIAA1009
KIAA1009
chr12_-_56432375 1.728 CDK4
cyclin-dependent kinase 4
chr12_-_56432377 1.709 CDK4
cyclin-dependent kinase 4
chr10_+_69314347 1.662 NM_012238
SIRT1
sirtuin 1
chr12_+_102982365 1.532 NM_013320
HCFC2
host cell factor C2
chr8_-_54918099 1.496 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chrX_+_101862297 1.486 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr19_+_45546369 1.465 PLD3
phospholipase D family, member 3
chr6_+_160310118 1.347 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr5_+_133735004 1.321 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr10_-_45410197 1.315 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr11_+_125586828 1.276 NM_024556
FAM118B
family with sequence similarity 118, member B
chr8_-_54918389 1.239 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr17_+_69781980 1.221 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr11_-_125586733 1.218 NM_001144827
NM_032795
RPUSD4

RNA pseudouridylate synthase domain containing 4

chr2_-_172675873 1.202 DLX2
distal-less homeobox 2
chr19_+_37528340 1.124 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chr16_-_28411123 1.109 NM_001042432
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_-_26266571 1.105 NM_032588
TRIM63
tripartite motif containing 63
chr20_+_43953606 1.079 CTSA
cathepsin A
chr12_-_56432292 1.077 CDK4
cyclin-dependent kinase 4
chr17_-_27210330 1.069 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr8_-_54918369 1.069 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr20_-_4743768 1.058 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr8_-_54918325 1.043 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_+_62295412 1.029 NM_006473
TAF6L
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr1_-_39097904 0.995 NM_022157
RRAGC
Ras-related GTP binding C
chr11_-_85457753 0.983 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr1_+_20385164 0.973 NM_152376
UBXN10
UBX domain protein 10
chr16_+_1341937 0.970 GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr7_-_42918013 0.954 NM_001099858
NM_024054
C7orf25

chromosome 7 open reading frame 25

chr1_-_152797820 0.946 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr17_-_17816425 0.932 NM_001033551
NM_001082968
TOM1L2

target of myb1-like 2 (chicken)

chr2_+_219751230 0.932 FAM134A
family with sequence similarity 134, member A
chr3_-_20202622 0.931 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
SGOL1





shugoshin-like 1 (S. pombe)





chr10_-_50066386 0.930 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr12_+_67426184 0.927 NM_018656
SLC35E3
solute carrier family 35, member E3
chr6_+_87921980 0.921 NM_015021
ZNF292
zinc finger protein 292
chr2_-_20115269 0.910 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr3_-_123995216 0.899 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr19_-_17236522 0.898 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr10_+_112317401 0.877 NM_005445
SMC3
structural maintenance of chromosomes 3
chr7_-_44496703 0.860 NM_015332
NUDCD3
NudC domain containing 3
chr5_+_41940216 0.857 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr20_+_37024383 0.857 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr13_-_49057707 0.855 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr10_+_25345513 0.827 NM_024838
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr16_+_22124870 0.822 NM_013302
EEF2K
eukaryotic elongation factor-2 kinase
chr10_+_69314714 0.819 SIRT1
sirtuin 1
chr13_-_49057629 0.818 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr3_-_121550767 0.816 NM_001099678
LRRC58
leucine rich repeat containing 58
chr17_+_63252704 0.803 BPTF
bromodomain PHD finger transcription factor
chr2_+_227898163 0.802 MFF
mitochondrial fission factor
chr8_+_17824631 0.777 NM_006197
PCM1
pericentriolar material 1
chr5_+_34692124 0.773 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr12_+_88627601 0.767 LOC338758
hypothetical LOC338758
chr15_+_73415426 0.762 NM_017828
COMMD4
COMM domain containing 4
chr15_+_41871809 0.762 SERF2-C15ORF63
SERF2
SERF2-C15orf63 read-through transcript
small EDRK-rich factor 2
chr18_-_45241014 0.754 NM_017653
DYM
dymeclin
chr11_+_18300689 0.754 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr17_-_39556535 0.752 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr4_-_47160403 0.746 NM_017845
COMMD8
COMM domain containing 8
chr12_-_63439456 0.743 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr12_-_63439449 0.743 GNS
glucosamine (N-acetyl)-6-sulfatase
chr13_-_32757835 0.742 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_+_98725505 0.738 NM_178812
MTDH
metadherin
chr1_-_152797707 0.731 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr19_-_15436333 0.722 NM_022904
RASAL3
RAS protein activator like 3
chr19_-_45546250 0.721 C19orf47
chromosome 19 open reading frame 47
chr19_-_45546123 0.718 NM_178830
C19orf47
chromosome 19 open reading frame 47
chr1_+_109221271 0.711 GPSM2
G-protein signaling modulator 2
chr9_-_37894098 0.707 MCART1
mitochondrial carrier triple repeat 1
chr1_-_159459999 0.704 NM_001643
APOA2
apolipoprotein A-II
chr3_-_4483952 0.701 SUMF1
sulfatase modifying factor 1
chr16_-_87570716 0.697 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr15_+_41871768 0.695 NM_001018108
SERF2
small EDRK-rich factor 2
chr1_+_181871830 0.695 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr11_-_85457736 0.690 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_152797767 0.687 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_123996655 0.686 DIRC2
disrupted in renal carcinoma 2
chr2_+_219751207 0.681 FAM134A
family with sequence similarity 134, member A
chrX_-_85189194 0.678 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr12_-_54409107 0.676 NM_001040034
NM_001780
CD63

CD63 molecule

chr1_-_152797760 0.676 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr1_-_32054164 0.676 NM_144569
SPOCD1
SPOC domain containing 1
chr17_-_73636386 0.673 NM_001127198
TMC6
transmembrane channel-like 6
chr4_+_128773529 0.672 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr18_-_19271814 0.670 NM_032933
C18orf45
chromosome 18 open reading frame 45
chr20_+_43028533 0.665 NM_006282
STK4
serine/threonine kinase 4
chr3_-_4483955 0.659 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr4_-_47160476 0.657 COMMD8
COMM domain containing 8
chr8_-_74822206 0.656 STAU2
staufen, RNA binding protein, homolog 2 (Drosophila)
chr6_-_7258351 0.653 NM_003144
SSR1
signal sequence receptor, alpha
chr12_-_63439415 0.651 GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_+_109963982 0.639 AMPD2
adenosine monophosphate deaminase 2
chr4_-_90197140 0.636 NM_014883
FAM13A
family with sequence similarity 13, member A
chr8_+_26296439 0.632 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr18_+_75967902 0.626 NM_014913
ADNP2
ADNP homeobox 2
chr1_+_109963950 0.625 NM_139156
AMPD2
adenosine monophosphate deaminase 2
chrX_-_100549444 0.622 GLA
galactosidase, alpha
chr3_-_4483939 0.619 SUMF1
sulfatase modifying factor 1
chr6_-_44333002 0.618 NM_178148
SLC35B2
solute carrier family 35, member B2
chr2_+_208284484 0.617 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr1_-_165112157 0.617 NM_053053
TADA1
transcriptional adaptor 1
chr14_+_73621408 0.616 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr17_-_39556483 0.612 HDAC5
histone deacetylase 5
chr1_-_152867070 0.608 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr20_-_39199936 0.606


chr19_+_10626106 0.605 ILF3
interleukin enhancer binding factor 3, 90kDa
chr4_+_56414565 0.605 NM_001024924
NM_018261
NM_178237
EXOC1


exocyst complex component 1


chr1_+_198263352 0.603 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr22_-_37966852 0.602 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr5_+_150807380 0.601 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr1_-_152867007 0.598 ADAR
adenosine deaminase, RNA-specific
chr17_-_35510431 0.597 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr22_-_35233032 0.596 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr12_-_121316907 0.595 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr5_+_150807397 0.595 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr5_+_34692239 0.591 RAI14
retinoic acid induced 14
chr2_-_176575171 0.589 NM_030650
KIAA1715
KIAA1715
chr2_+_219751192 0.586 FAM134A
family with sequence similarity 134, member A
chr2_-_172572993 0.586


chr5_+_133734768 0.585 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr16_-_28410580 0.581 NM_000086
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_+_15725894 0.581 DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr19_+_45546171 0.581 NM_001031696
NM_012268
PLD3

phospholipase D family, member 3

chr14_-_67353046 0.575 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr5_+_34692352 0.573 NM_001145520
RAI14
retinoic acid induced 14
chr15_-_99609648 0.570 NM_014918
CHSY1
chondroitin sulfate synthase 1
chr9_+_130749812 0.558 NUP188
nucleoporin 188kDa
chr10_-_3817418 0.557 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr12_+_56271181 0.556 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr11_-_6597154 0.555 TPP1
tripeptidyl peptidase I
chr11_-_18300246 0.554 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr6_+_151815298 0.554 C6orf211
chromosome 6 open reading frame 211
chr1_-_27099515 0.552 GPATCH3
G patch domain containing 3
chr2_+_169021001 0.550 LASS6
LAG1 homolog, ceramide synthase 6
chr10_-_112054497 0.549 SMNDC1
survival motor neuron domain containing 1
chr11_-_6597220 0.546 TPP1
tripeptidyl peptidase I
chr17_-_33043514 0.544 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr4_+_76658677 0.541 NM_144721
THAP6
THAP domain containing 6
chr2_+_208284610 0.535 CCNYL1
cyclin Y-like 1
chr21_-_35343065 0.535 RUNX1
runt-related transcription factor 1
chr17_+_17816851 0.531 NM_001130090
NM_001130091
NM_001130092
NM_031294
LRRC48



leucine rich repeat containing 48



chr16_-_1464927 0.530 CLCN7
chloride channel 7
chr6_-_163754903 0.530 LOC100526820
hypothetical LOC100526820
chr6_+_42126228 0.530 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr1_+_20081510 0.527


chr1_-_52936573 0.525 C1orf163
chromosome 1 open reading frame 163
chr12_+_102883687 0.524 NM_003211
TDG
thymine-DNA glycosylase
chr8_-_81246215 0.523 NM_001025253
NM_005079
TPD52

tumor protein D52

chr21_-_37561463 0.520 DSCR3
Down syndrome critical region gene 3
chr5_+_150807331 0.519 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr4_+_53975597 0.514 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr1_-_77920914 0.512 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr7_+_92699588 0.505 NM_017667
NM_024553
CCDC132

coiled-coil domain containing 132

chr12_+_67426225 0.505 SLC35E3
solute carrier family 35, member E3
chr3_-_188945921 0.504 BCL6
B-cell CLL/lymphoma 6
chr19_-_9908014 0.500 NM_058164
OLFM2
olfactomedin 2
chr1_-_27099524 0.499 NM_022078
GPATCH3
G patch domain containing 3
chr21_+_29593098 0.498 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr5_+_139924595 0.498 NM_080670
SLC35A4
solute carrier family 35, member A4
chr1_-_40335451 0.496 PPT1
palmitoyl-protein thioesterase 1
chr17_-_35510074 0.493 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr16_+_5023672 0.492 LOC100507589
hypothetical LOC100507589
chr12_-_63439322 0.492 GNS
glucosamine (N-acetyl)-6-sulfatase
chr12_-_54409710 0.491 CD63
CD63 molecule
chr16_-_69876262 0.489 FTSJD1
FtsJ methyltransferase domain containing 1
chr20_+_43028590 0.484 STK4
serine/threonine kinase 4
chr7_+_101860958 0.484 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr17_-_44037332 0.483 NM_018952
HOXB6
homeobox B6
chr20_+_33823318 0.481 NM_016436
PHF20
PHD finger protein 20
chr11_+_18300370 0.478 NM_001142307
NM_005316
GTF2H1

general transcription factor IIH, polypeptide 1, 62kDa

chr19_+_7493436 0.478 NM_020533
MCOLN1
mucolipin 1
chr12_-_54409059 0.477 CD63
CD63 molecule
chr8_+_104102477 0.477 ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr14_+_92869317 0.476 NM_020818
KIAA1409
KIAA1409
chr10_+_12211586 0.475 NM_001142627
NM_001142628
NM_018144
SEC61A2


Sec61 alpha 2 subunit (S. cerevisiae)


chr11_-_36267510 0.474 COMMD9
COMM domain containing 9
chr14_-_19999324 0.474 TMEM55B
transmembrane protein 55B
chr5_+_149320630 0.472 SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr11_-_85457469 0.472 PICALM
phosphatidylinositol binding clathrin assembly protein
chr12_-_61614930 0.472 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr10_+_70553862 0.470 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr5_-_122786902 0.466 NM_001166226
NM_153223
CEP120

centrosomal protein 120kDa

chr12_+_70435176 0.465 RAB21
RAB21, member RAS oncogene family
chr1_-_224253678 0.462 NM_152608
C1orf55
chromosome 1 open reading frame 55
chr1_-_239587007 0.462 RGS7
regulator of G-protein signaling 7
chr1_+_26609819 0.462 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr6_+_42126242 0.461 TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr12_-_54409015 0.460 CD63
CD63 molecule
chr7_-_38915306 0.459 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr2_+_176689737 0.456 NM_002148
HOXD10
homeobox D10
chr11_+_107385195 0.452 CUL5
cullin 5
chr14_-_23981493 0.452 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr2_+_172573049 0.451 NM_199227
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr22_+_23153529 0.451 NM_000675
ADORA2A
adenosine A2a receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.35e-04 GO:0044237 cellular metabolic process
5.56 3.44e-04 GO:0015682 ferric iron transport
5.56 3.44e-04 GO:0033572 transferrin transport
1.52 1.12e-03 GO:0051641 cellular localization
1.18 3.85e-03 GO:0044238 primary metabolic process
1.16 4.53e-03 GO:0008152 metabolic process
1.10 5.81e-03 GO:0009987 cellular process
1.30 9.45e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 1.62e-02 GO:0006807 nitrogen compound metabolic process
1.27 1.91e-02 GO:0034641 cellular nitrogen compound metabolic process
1.45 2.06e-02 GO:0033036 macromolecule localization
2.80 2.30e-02 GO:0000041 transition metal ion transport
1.48 2.64e-02 GO:0044248 cellular catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 1.60e-20 GO:0005622 intracellular
1.19 3.88e-20 GO:0044424 intracellular part
1.25 1.78e-17 GO:0043227 membrane-bounded organelle
1.25 2.09e-17 GO:0043231 intracellular membrane-bounded organelle
1.21 5.30e-15 GO:0043229 intracellular organelle
1.21 5.88e-15 GO:0043226 organelle
1.24 1.37e-14 GO:0005737 cytoplasm
1.31 3.30e-13 GO:0044444 cytoplasmic part
2.87 3.78e-13 GO:0005773 vacuole
1.33 6.42e-13 GO:0044446 intracellular organelle part
1.32 1.90e-12 GO:0044422 organelle part
2.74 1.34e-09 GO:0000323 lytic vacuole
2.74 1.34e-09 GO:0005764 lysosome
1.48 1.43e-08 GO:0031974 membrane-enclosed lumen
3.19 2.46e-08 GO:0044437 vacuolar part
1.48 3.54e-08 GO:0043233 organelle lumen
3.17 9.46e-08 GO:0005774 vacuolar membrane
1.46 1.71e-07 GO:0070013 intracellular organelle lumen
1.60 9.26e-07 GO:0005654 nucleoplasm
1.44 1.97e-06 GO:0044428 nuclear part
1.06 6.62e-06 GO:0044464 cell part
1.06 6.85e-06 GO:0005623 cell
1.23 7.86e-06 GO:0005634 nucleus
1.46 1.71e-05 GO:0031981 nuclear lumen
3.12 1.96e-05 GO:0005765 lysosomal membrane
1.28 1.31e-04 GO:0032991 macromolecular complex
1.39 1.46e-04 GO:0005829 cytosol
1.88 3.95e-04 GO:0005768 endosome
1.34 2.21e-03 GO:0031090 organelle membrane
1.62 2.92e-03 GO:0044451 nucleoplasm part
5.77 3.50e-03 GO:0033176 proton-transporting V-type ATPase complex
2.63 4.48e-03 GO:0005770 late endosome
1.60 5.47e-03 GO:0031967 organelle envelope
1.26 7.49e-03 GO:0043234 protein complex
1.57 1.05e-02 GO:0031975 envelope
1.40 1.13e-02 GO:0005739 mitochondrion
2.74 2.05e-02 GO:0042470 melanosome
2.74 2.05e-02 GO:0048770 pigment granule
3.58 3.37e-02 GO:0016469 proton-transporting two-sector ATPase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.22 1.13e-08 GO:0005515 protein binding
1.10 3.99e-05 GO:0005488 binding