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Motif ID: SREBF1,2.p2

Z-value: 1.153

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_73638430	2.715	NM_152468	TMC8	transmembrane channel-like 8
chr13_+_48582389	2.212	NM_014923	FNDC3A	fibronectin type III domain containing 3A
chr12_-_56432385	2.033	NM_000075	CDK4	cyclin-dependent kinase 4
chr6_-_84994032	1.823	NM_014895	KIAA1009	KIAA1009
chr12_-_56432375	1.728		CDK4	cyclin-dependent kinase 4
chr12_-_56432377	1.709		CDK4	cyclin-dependent kinase 4
chr10_+_69314347	1.662	NM_012238	SIRT1	sirtuin 1
chr12_+_102982365	1.532	NM_013320	HCFC2	host cell factor C2
chr8_-_54918099	1.496	NM_213620	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chrX_+_101862297	1.486	NM_001142524 NM_001142525 NM_001142526 NM_001142527 NM_001142528 NM_030639	BHLHB9	basic helix-loop-helix domain containing, class B, 9
chr19_+_45546369	1.465		PLD3	phospholipase D family, member 3
chr6_+_160310118	1.347	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr5_+_133735004	1.321		UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr10_-_45410197	1.315	NM_001002265 NM_145021	MARCH8	membrane-associated ring finger (C3HC4) 8
chr11_+_125586828	1.276	NM_024556	FAM118B	family with sequence similarity 118, member B
chr8_-_54918389	1.239	NM_015941 NM_213619	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr17_+_69781980	1.221	NM_001172810 NM_023036	DNAI2	dynein, axonemal, intermediate chain 2
chr11_-_125586733	1.218	NM_001144827 NM_032795	RPUSD4	RNA pseudouridylate synthase domain containing 4
chr2_-_172675873	1.202		DLX2	distal-less homeobox 2
chr19_+_37528340	1.124	NM_001136156 NM_014910	ZNF507	zinc finger protein 507
chr16_-_28411123	1.109	NM_001042432	CLN3	ceroid-lipofuscinosis, neuronal 3
chr1_-_26266571	1.105	NM_032588	TRIM63	tripartite motif containing 63
chr20_+_43953606	1.079		CTSA	cathepsin A
chr12_-_56432292	1.077		CDK4	cyclin-dependent kinase 4
chr17_-_27210330	1.069	NM_018405	C17orf79	chromosome 17 open reading frame 79
chr8_-_54918369	1.069		ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr20_-_4743768	1.058	NM_170774	RASSF2	Ras association (RalGDS/AF-6) domain family member 2
chr8_-_54918325	1.043		ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr11_+_62295412	1.029	NM_006473	TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr1_-_39097904	0.995	NM_022157	RRAGC	Ras-related GTP binding C
chr11_-_85457753	0.983	NM_001008660 NM_007166	PICALM	phosphatidylinositol binding clathrin assembly protein
chr1_+_20385164	0.973	NM_152376	UBXN10	UBX domain protein 10
chr16_+_1341937	0.970		GNPTG	N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr7_-_42918013	0.954	NM_001099858 NM_024054	C7orf25	chromosome 7 open reading frame 25
chr1_-_152797820	0.946		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr17_-_17816425	0.932	NM_001033551 NM_001082968	TOM1L2	target of myb1-like 2 (chicken)
chr2_+_219751230	0.932		FAM134A	family with sequence similarity 134, member A
chr3_-_20202622	0.931	NM_001012409 NM_001012410 NM_001012411 NM_001012412 NM_001012413 NM_138484	SGOL1	shugoshin-like 1 (S. pombe)
chr10_-_50066386	0.930	NM_001010863	C10orf128	chromosome 10 open reading frame 128
chr12_+_67426184	0.927	NM_018656	SLC35E3	solute carrier family 35, member E3
chr6_+_87921980	0.921	NM_015021	ZNF292	zinc finger protein 292
chr2_-_20115269	0.910	NM_014713	LAPTM4A	lysosomal protein transmembrane 4 alpha
chr3_-_123995216	0.899	NM_024610	HSPBAP1	HSPB (heat shock 27kDa) associated protein 1
chr19_-_17236522	0.898	NM_031941	USHBP1	Usher syndrome 1C binding protein 1
chr10_+_112317401	0.877	NM_005445	SMC3	structural maintenance of chromosomes 3
chr7_-_44496703	0.860	NM_015332	NUDCD3	NudC domain containing 3
chr5_+_41940216	0.857	NM_175921	C5orf51	chromosome 5 open reading frame 51
chr20_+_37024383	0.857	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr13_-_49057707	0.855	NM_018191	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr10_+_25345513	0.827	NM_024838	THNSL1	threonine synthase-like 1 (S. cerevisiae)
chr16_+_22124870	0.822	NM_013302	EEF2K	eukaryotic elongation factor-2 kinase
chr10_+_69314714	0.819		SIRT1	sirtuin 1
chr13_-_49057629	0.818		RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr3_-_121550767	0.816	NM_001099678	LRRC58	leucine rich repeat containing 58
chr17_+_63252704	0.803		BPTF	bromodomain PHD finger transcription factor
chr2_+_227898163	0.802		MFF	mitochondrial fission factor
chr8_+_17824631	0.777	NM_006197	PCM1	pericentriolar material 1
chr5_+_34692124	0.773	NM_001145522 NM_015577	RAI14	retinoic acid induced 14
chr12_+_88627601	0.767		LOC338758	hypothetical LOC338758
chr15_+_73415426	0.762	NM_017828	COMMD4	COMM domain containing 4
chr15_+_41871809	0.762		SERF2-C15ORF63 SERF2	SERF2-C15orf63 read-through transcript small EDRK-rich factor 2
chr18_-_45241014	0.754	NM_017653	DYM	dymeclin
chr11_+_18300689	0.754		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr17_-_39556535	0.752	NM_001015053 NM_005474	HDAC5	histone deacetylase 5
chr4_-_47160403	0.746	NM_017845	COMMD8	COMM domain containing 8
chr12_-_63439456	0.743	NM_002076	GNS	glucosamine (N-acetyl)-6-sulfatase
chr12_-_63439449	0.743		GNS	glucosamine (N-acetyl)-6-sulfatase
chr13_-_32757835	0.742	NM_178006	STARD13	StAR-related lipid transfer (START) domain containing 13
chr8_+_98725505	0.738	NM_178812	MTDH	metadherin
chr1_-_152797707	0.731	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr19_-_15436333	0.722	NM_022904	RASAL3	RAS protein activator like 3
chr19_-_45546250	0.721		C19orf47	chromosome 19 open reading frame 47
chr19_-_45546123	0.718	NM_178830	C19orf47	chromosome 19 open reading frame 47
chr1_+_109221271	0.711		GPSM2	G-protein signaling modulator 2
chr9_-_37894098	0.707		MCART1	mitochondrial carrier triple repeat 1
chr1_-_159459999	0.704	NM_001643	APOA2	apolipoprotein A-II
chr3_-_4483952	0.701		SUMF1	sulfatase modifying factor 1
chr16_-_87570716	0.697	NM_005187	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr15_+_41871768	0.695	NM_001018108	SERF2	small EDRK-rich factor 2
chr1_+_181871830	0.695	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr11_-_85457736	0.690		PICALM	phosphatidylinositol binding clathrin assembly protein
chr1_-_152797767	0.687		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_123996655	0.686		DIRC2	disrupted in renal carcinoma 2
chr2_+_219751207	0.681		FAM134A	family with sequence similarity 134, member A
chrX_-_85189194	0.678	NM_000390 NM_001145414	CHM	choroideremia (Rab escort protein 1)
chr12_-_54409107	0.676	NM_001040034 NM_001780	CD63	CD63 molecule
chr1_-_152797760	0.676		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr1_-_32054164	0.676	NM_144569	SPOCD1	SPOC domain containing 1
chr17_-_73636386	0.673	NM_001127198	TMC6	transmembrane channel-like 6
chr4_+_128773529	0.672	NM_015693	INTU	inturned planar cell polarity effector homolog (Drosophila)
chr18_-_19271814	0.670	NM_032933	C18orf45	chromosome 18 open reading frame 45
chr20_+_43028533	0.665	NM_006282	STK4	serine/threonine kinase 4
chr3_-_4483955	0.659	NM_001164674 NM_001164675 NM_182760	SUMF1	sulfatase modifying factor 1
chr4_-_47160476	0.657		COMMD8	COMM domain containing 8
chr8_-_74822206	0.656		STAU2	staufen, RNA binding protein, homolog 2 (Drosophila)
chr6_-_7258351	0.653	NM_003144	SSR1	signal sequence receptor, alpha
chr12_-_63439415	0.651		GNS	glucosamine (N-acetyl)-6-sulfatase
chr1_+_109963982	0.639		AMPD2	adenosine monophosphate deaminase 2
chr4_-_90197140	0.636	NM_014883	FAM13A	family with sequence similarity 13, member A
chr8_+_26296439	0.632	NM_004331	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr18_+_75967902	0.626	NM_014913	ADNP2	ADNP homeobox 2
chr1_+_109963950	0.625	NM_139156	AMPD2	adenosine monophosphate deaminase 2
chrX_-_100549444	0.622		GLA	galactosidase, alpha
chr3_-_4483939	0.619		SUMF1	sulfatase modifying factor 1
chr6_-_44333002	0.618	NM_178148	SLC35B2	solute carrier family 35, member B2
chr2_+_208284484	0.617	NM_001142300 NM_152523	CCNYL1	cyclin Y-like 1
chr1_-_165112157	0.617	NM_053053	TADA1	transcriptional adaptor 1
chr14_+_73621408	0.616	NM_001024674	LIN52	lin-52 homolog (C. elegans)
chr17_-_39556483	0.612		HDAC5	histone deacetylase 5
chr1_-_152867070	0.608	NM_001025107	ADAR	adenosine deaminase, RNA-specific
chr20_-_39199936	0.606
chr19_+_10626106	0.605		ILF3	interleukin enhancer binding factor 3, 90kDa
chr4_+_56414565	0.605	NM_001024924 NM_018261 NM_178237	EXOC1	exocyst complex component 1
chr1_+_198263352	0.603	NM_003822 NM_205860	NR5A2	nuclear receptor subfamily 5, group A, member 2
chr22_-_37966852	0.602	NM_033016	PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr5_+_150807380	0.601		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr1_-_152867007	0.598		ADAR	adenosine deaminase, RNA-specific
chr17_-_35510431	0.597	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr22_-_35233032	0.596	NM_024955 NM_001102371	FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr12_-_121316907	0.595		VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr5_+_150807397	0.595		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr5_+_34692239	0.591		RAI14	retinoic acid induced 14
chr2_-_176575171	0.589	NM_030650	KIAA1715	KIAA1715
chr2_+_219751192	0.586		FAM134A	family with sequence similarity 134, member A
chr2_-_172572993	0.586
chr5_+_133734768	0.585	NM_003337	UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr16_-_28410580	0.581	NM_000086	CLN3	ceroid-lipofuscinosis, neuronal 3
chr1_+_15725894	0.581		DNAJC16	DnaJ (Hsp40) homolog, subfamily C, member 16
chr19_+_45546171	0.581	NM_001031696 NM_012268	PLD3	phospholipase D family, member 3
chr14_-_67353046	0.575	NM_015346	ZFYVE26	zinc finger, FYVE domain containing 26
chr5_+_34692352	0.573	NM_001145520	RAI14	retinoic acid induced 14
chr15_-_99609648	0.570	NM_014918	CHSY1	chondroitin sulfate synthase 1
chr9_+_130749812	0.558		NUP188	nucleoporin 188kDa
chr10_-_3817418	0.557	NM_001160124 NM_001160125 NM_001300	KLF6	Kruppel-like factor 6
chr12_+_56271181	0.556	NM_001146258 NM_001146259 NM_001146260 NM_024779	PIP4K2C	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr11_-_6597154	0.555		TPP1	tripeptidyl peptidase I
chr11_-_18300246	0.554	NM_007216 NM_181507 NM_181508	HPS5	Hermansky-Pudlak syndrome 5
chr6_+_151815298	0.554		C6orf211	chromosome 6 open reading frame 211
chr1_-_27099515	0.552		GPATCH3	G patch domain containing 3
chr2_+_169021001	0.550		LASS6	LAG1 homolog, ceramide synthase 6
chr10_-_112054497	0.549		SMNDC1	survival motor neuron domain containing 1
chr11_-_6597220	0.546		TPP1	tripeptidyl peptidase I
chr17_-_33043514	0.544	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chr4_+_76658677	0.541	NM_144721	THAP6	THAP domain containing 6
chr2_+_208284610	0.535		CCNYL1	cyclin Y-like 1
chr21_-_35343065	0.535		RUNX1	runt-related transcription factor 1
chr17_+_17816851	0.531	NM_001130090 NM_001130091 NM_001130092 NM_031294	LRRC48	leucine rich repeat containing 48
chr16_-_1464927	0.530		CLCN7	chloride channel 7
chr6_-_163754903	0.530		LOC100526820	hypothetical LOC100526820
chr6_+_42126228	0.530	NM_138572	TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr1_+_20081510	0.527
chr1_-_52936573	0.525		C1orf163	chromosome 1 open reading frame 163
chr12_+_102883687	0.524	NM_003211	TDG	thymine-DNA glycosylase
chr8_-_81246215	0.523	NM_001025253 NM_005079	TPD52	tumor protein D52
chr21_-_37561463	0.520		DSCR3	Down syndrome critical region gene 3
chr5_+_150807331	0.519	NM_078483	SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr4_+_53975597	0.514		FIP1L1	FIP1 like 1 (S. cerevisiae)
chr1_-_77920914	0.512	NM_015534	ZZZ3	zinc finger, ZZ-type containing 3
chr7_+_92699588	0.505	NM_017667 NM_024553	CCDC132	coiled-coil domain containing 132
chr12_+_67426225	0.505		SLC35E3	solute carrier family 35, member E3
chr3_-_188945921	0.504		BCL6	B-cell CLL/lymphoma 6
chr19_-_9908014	0.500	NM_058164	OLFM2	olfactomedin 2
chr1_-_27099524	0.499	NM_022078	GPATCH3	G patch domain containing 3
chr21_+_29593098	0.498		BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr5_+_139924595	0.498	NM_080670	SLC35A4	solute carrier family 35, member A4
chr1_-_40335451	0.496		PPT1	palmitoyl-protein thioesterase 1
chr17_-_35510074	0.493		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr16_+_5023672	0.492		LOC100507589	hypothetical LOC100507589
chr12_-_63439322	0.492		GNS	glucosamine (N-acetyl)-6-sulfatase
chr12_-_54409710	0.491		CD63	CD63 molecule
chr16_-_69876262	0.489		FTSJD1	FtsJ methyltransferase domain containing 1
chr20_+_43028590	0.484		STK4	serine/threonine kinase 4
chr7_+_101860958	0.484	NM_001126340 NM_032831	ORAI2	ORAI calcium release-activated calcium modulator 2
chr17_-_44037332	0.483	NM_018952	HOXB6	homeobox B6
chr20_+_33823318	0.481	NM_016436	PHF20	PHD finger protein 20
chr11_+_18300370	0.478	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr19_+_7493436	0.478	NM_020533	MCOLN1	mucolipin 1
chr12_-_54409059	0.477		CD63	CD63 molecule
chr8_+_104102477	0.477		ATP6V1C1	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
chr14_+_92869317	0.476	NM_020818	KIAA1409	KIAA1409
chr10_+_12211586	0.475	NM_001142627 NM_001142628 NM_018144	SEC61A2	Sec61 alpha 2 subunit (S. cerevisiae)
chr11_-_36267510	0.474		COMMD9	COMM domain containing 9
chr14_-_19999324	0.474		TMEM55B	transmembrane protein 55B
chr5_+_149320630	0.472		SLC26A2	solute carrier family 26 (sulfate transporter), member 2
chr11_-_85457469	0.472		PICALM	phosphatidylinositol binding clathrin assembly protein
chr12_-_61614930	0.472	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr10_+_70553862	0.470	NM_001035260 NM_004896	VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)
chr5_-_122786902	0.466	NM_001166226 NM_153223	CEP120	centrosomal protein 120kDa
chr12_+_70435176	0.465		RAB21	RAB21, member RAS oncogene family
chr1_-_224253678	0.462	NM_152608	C1orf55	chromosome 1 open reading frame 55
chr1_-_239587007	0.462		RGS7	regulator of G-protein signaling 7
chr1_+_26609819	0.462	NM_024674	LIN28A	lin-28 homolog A (C. elegans)
chr6_+_42126242	0.461		TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr12_-_54409015	0.460		CD63	CD63 molecule
chr7_-_38915306	0.459	NM_014396 NM_080631	VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)
chr2_+_176689737	0.456	NM_002148	HOXD10	homeobox D10
chr11_+_107385195	0.452		CUL5	cullin 5
chr14_-_23981493	0.452	NM_020195	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1
chr2_+_172573049	0.451	NM_199227	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)
chr22_+_23153529	0.451	NM_000675	ADORA2A	adenosine A2a receptor

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.21	1.35e-04	GO:0044237	cellular metabolic process
5.56	3.44e-04	GO:0015682	ferric iron transport
5.56	3.44e-04	GO:0033572	transferrin transport
1.52	1.12e-03	GO:0051641	cellular localization
1.18	3.85e-03	GO:0044238	primary metabolic process
1.16	4.53e-03	GO:0008152	metabolic process
1.10	5.81e-03	GO:0009987	cellular process
1.30	9.45e-03	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27	1.62e-02	GO:0006807	nitrogen compound metabolic process
1.27	1.91e-02	GO:0034641	cellular nitrogen compound metabolic process
1.45	2.06e-02	GO:0033036	macromolecule localization
2.80	2.30e-02	GO:0000041	transition metal ion transport
1.48	2.64e-02	GO:0044248	cellular catabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.19	1.60e-20	GO:0005622	intracellular
1.19	3.88e-20	GO:0044424	intracellular part
1.25	1.78e-17	GO:0043227	membrane-bounded organelle
1.25	2.09e-17	GO:0043231	intracellular membrane-bounded organelle
1.21	5.30e-15	GO:0043229	intracellular organelle
1.21	5.88e-15	GO:0043226	organelle
1.24	1.37e-14	GO:0005737	cytoplasm
1.31	3.30e-13	GO:0044444	cytoplasmic part
2.87	3.78e-13	GO:0005773	vacuole
1.33	6.42e-13	GO:0044446	intracellular organelle part
1.32	1.90e-12	GO:0044422	organelle part
2.74	1.34e-09	GO:0000323	lytic vacuole
2.74	1.34e-09	GO:0005764	lysosome
1.48	1.43e-08	GO:0031974	membrane-enclosed lumen
3.19	2.46e-08	GO:0044437	vacuolar part
1.48	3.54e-08	GO:0043233	organelle lumen
3.17	9.46e-08	GO:0005774	vacuolar membrane
1.46	1.71e-07	GO:0070013	intracellular organelle lumen
1.60	9.26e-07	GO:0005654	nucleoplasm
1.44	1.97e-06	GO:0044428	nuclear part
1.06	6.62e-06	GO:0044464	cell part
1.06	6.85e-06	GO:0005623	cell
1.23	7.86e-06	GO:0005634	nucleus
1.46	1.71e-05	GO:0031981	nuclear lumen
3.12	1.96e-05	GO:0005765	lysosomal membrane
1.28	1.31e-04	GO:0032991	macromolecular complex
1.39	1.46e-04	GO:0005829	cytosol
1.88	3.95e-04	GO:0005768	endosome
1.34	2.21e-03	GO:0031090	organelle membrane
1.62	2.92e-03	GO:0044451	nucleoplasm part
5.77	3.50e-03	GO:0033176	proton-transporting V-type ATPase complex
2.63	4.48e-03	GO:0005770	late endosome
1.60	5.47e-03	GO:0031967	organelle envelope
1.26	7.49e-03	GO:0043234	protein complex
1.57	1.05e-02	GO:0031975	envelope
1.40	1.13e-02	GO:0005739	mitochondrion
2.74	2.05e-02	GO:0042470	melanosome
2.74	2.05e-02	GO:0048770	pigment granule
3.58	3.37e-02	GO:0016469	proton-transporting two-sector ATPase complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.22	1.13e-08	GO:0005515	protein binding
1.10	3.99e-05	GO:0005488	binding