Motif ID: HOXA9_MEIS1.p2

Z-value: 1.309


Transcription factors associated with HOXA9_MEIS1.p2:

Gene SymbolEntrez IDGene Name
HOXA9 3205 homeobox A9
MEIS1 4211 Meis homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEIS1chr2_+_66519949-0.601.8e-02Click!
HOXA9chr7_-_27171673-0.582.4e-02Click!


Activity profile for motif HOXA9_MEIS1.p2.

activity profile for motif HOXA9_MEIS1.p2


Sorted Z-values histogram for motif HOXA9_MEIS1.p2

Sorted Z-values for motif HOXA9_MEIS1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA9_MEIS1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_611896 4.034 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr18_+_9875722 4.008 NM_001098529
NM_032243
TXNDC2

thioredoxin domain containing 2 (spermatozoa)

chr4_-_40211324 3.672 RBM47
RNA binding motif protein 47
chr12_-_49708279 3.207 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr10_-_76488277 3.194 NM_001003892
DUPD1
dual specificity phosphatase and pro isomerase domain containing 1
chr20_-_60435983 2.933 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr1_+_357502 2.344 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr15_-_56093477 2.162 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_-_93172119 2.021


chr13_+_77007809 2.004 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr11_-_104515670 1.877 NM_021571
CARD18
caspase recruitment domain family, member 18
chr8_-_107023 1.870 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr19_+_61624 1.868 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr2_+_169631777 1.840 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_+_27019084 1.712 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_+_58899 1.705 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr12_+_7348194 1.199 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr3_-_139960874 1.164 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr15_+_42815851 1.162 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr15_-_100280784 1.038 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr18_+_18989786 1.009 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr20_-_44575599 0.949 NM_018102
NM_199441
ZNF334

zinc finger protein 334

chrX_-_102870207 0.936 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chr9_-_99740243 0.933 NM_197978
HEMGN
hemogen
chr7_+_115650240 0.908 NM_152829
TES
testis derived transcript (3 LIM domains)
chr1_-_148854503 0.884


chr19_+_10689813 0.882 DNM2
dynamin 2
chr1_-_157313179 0.881 NM_004833
AIM2
absent in melanoma 2
chr15_-_41346346 0.858 NM_004245
NM_201631
TGM5

transglutaminase 5

chr21_-_46849413 0.804 NM_006272
S100B
S100 calcium binding protein B
chr1_+_144152864 0.790 TXNIP
thioredoxin interacting protein
chr11_-_5946299 0.788 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr9_+_129951552 0.761 NM_005564
LCN2
lipocalin 2
chr6_+_29382381 0.756 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr11_+_56224436 0.731 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr11_-_111287657 0.727 NM_001885
CRYAB
crystallin, alpha B
chr6_+_31782618 0.718 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr6_+_125346208 0.707 NM_152553
RNF217
ring finger protein 217
chr17_+_38247493 0.707 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr5_+_180726874 0.706 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr11_-_16387001 0.685 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chrX_+_37750778 0.671 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr19_+_10689725 0.667 NM_001005360
NM_001005361
NM_001005362
NM_001190716
NM_004945
DNM2




dynamin 2




chr19_-_3723208 0.660 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr19_+_10689750 0.636 DNM2
dynamin 2
chr19_+_10689763 0.623 DNM2
dynamin 2
chr17_-_35464414 0.603 NM_001079518
NM_014815
MED24

mediator complex subunit 24

chr15_-_23204887 0.592 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr12_-_107551783 0.571 NM_003006
SELPLG
selectin P ligand
chr1_+_196874839 0.557 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_24522116 0.553 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr18_+_19826734 0.547 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr7_+_72883128 0.543 NM_001305
CLDN4
claudin 4
chr12_+_8866416 0.541 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr12_-_51332214 0.521 NM_000423
KRT2
keratin 2
chr16_+_29597965 0.521 QPRT
quinolinate phosphoribosyltransferase
chr6_+_28032997 0.510 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr6_-_27988152 0.502 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr15_+_64481270 0.492 MAP2K1
mitogen-activated protein kinase kinase 1
chr3_+_58459131 0.491 NM_153331
KCTD6
potassium channel tetramerisation domain containing 6
chr1_+_13903936 0.489 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr1_+_224079597 0.484 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr19_-_43926953 0.459 NM_144691
CAPN12
calpain 12
chr3_+_112743729 0.452 CD96
CD96 molecule
chr2_+_61243132 0.444 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chrX_+_117410693 0.443 WDR44
WD repeat domain 44
chr11_-_62145952 0.439 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr15_-_74091817 0.436 NM_138573
NRG4
neuregulin 4
chr4_+_39084936 0.433 KLB
klotho beta
chr4_-_87247829 0.429 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr6_-_29451042 0.424 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr9_+_95886625 0.393 PTPDC1
protein tyrosine phosphatase domain containing 1
chr7_-_143560850 0.393 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr2_-_160764819 0.388 NM_000888
ITGB6
integrin, beta 6
chr10_-_75071498 0.386 NM_021245
MYOZ1
myozenin 1
chr14_-_93926679 0.386 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr21_+_39745649 0.383 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr1_+_245818284 0.379 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr5_-_134290789 0.365


chr5_+_67558217 0.352 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_84099261 0.347


chr1_-_200397300 0.346 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr3_+_112743615 0.341 NM_005816
NM_198196
CD96

CD96 molecule

chr19_+_10689772 0.339 DNM2
dynamin 2
chr10_-_23673777 0.332 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr1_-_153477511 0.332 GBA
glucosidase, beta, acid
chr9_+_95886558 0.327 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr13_-_97916768 0.325 STK24
serine/threonine kinase 24
chr11_+_71524403 0.322 NM_000804
FOLR3
folate receptor 3 (gamma)
chr11_-_73397929 0.319 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr6_-_49712483 0.312 NM_000324
RHAG
Rh-associated glycoprotein
chrX_-_77469635 0.306 NM_006639
CYSLTR1
cysteinyl leukotriene receptor 1
chr9_+_124463665 0.305 NM_001005236
OR1L1
olfactory receptor, family 1, subfamily L, member 1
chr4_+_39084867 0.305 NM_175737
KLB
klotho beta
chr12_-_107551694 0.304 SELPLG
selectin P ligand
chr17_-_60439764 0.303 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr2_-_135498716 0.299 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr22_+_21393107 0.298 IGLJ3
immunoglobulin lambda joining 3
chr11_+_56862395 0.296 NM_002559
P2RX3
purinergic receptor P2X, ligand-gated ion channel, 3
chr3_+_153014550 0.296 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr1_+_67404756 0.293 NM_144701
IL23R
interleukin 23 receptor
chr19_+_9222605 0.293 NM_001079935
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr21_-_44836811 0.284 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr19_-_54258935 0.274 NM_006179
NTF4
neurotrophin 4
chr16_+_29597829 0.272 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr4_+_123311207 0.272 NM_015312
KIAA1109
KIAA1109
chr12_-_107551744 0.266 SELPLG
selectin P ligand
chr3_+_14691609 0.261 NM_001184957
NM_001184958
NM_032137
C3orf20


chromosome 3 open reading frame 20


chr3_-_173723754 0.260 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr19_-_15451203 0.255 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr15_+_97990705 0.255 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr5_-_22889192 0.253 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_+_28678274 0.253 PLB1
phospholipase B1
chr1_-_245237977 0.252 NM_020394
ZNF695
zinc finger protein 695
chr1_-_153477673 0.250 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr7_+_143646150 0.248 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr14_+_19735334 0.246 NM_001005503
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr9_-_124280025 0.245 NM_001004451
OR1J1
olfactory receptor, family 1, subfamily J, member 1
chr1_-_150463292 0.245 NM_001009931
HRNR
hornerin
chr7_-_112515068 0.241 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr4_-_100575313 0.240 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr11_-_5964790 0.240 NM_001005173
OR52L1
olfactory receptor, family 52, subfamily L, member 1
chr12_+_63084317 0.239 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr2_-_74634569 0.239 NM_032603
LOXL3
lysyl oxidase-like 3
chr5_+_127012611 0.236 NM_001048252
CTXN3
cortexin 3
chr3_-_191650291 0.235 NM_207316
TMEM207
transmembrane protein 207
chr12_-_119826433 0.232 NM_139015
SPPL3
signal peptide peptidase 3
chr4_+_68995761 0.232 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr1_-_57204208 0.229 NM_000066
C8B
complement component 8, beta polypeptide
chr1_+_196874759 0.227 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_-_245237925 0.221 ZNF695
zinc finger protein 695
chr18_+_41558089 0.220 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr18_+_70317548 0.213 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_+_35471971 0.211 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr4_-_68511738 0.210 NM_001114387
NM_182606
TMPRSS11A

transmembrane protease, serine 11A

chr1_-_109651140 0.206 NM_001010985
MYBPHL
myosin binding protein H-like
chr1_+_151117421 0.204 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr2_+_28892366 0.203 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr2_-_37269193 0.201 NM_001032377
SULT6B1
sulfotransferase family, cytosolic, 6B, member 1
chr3_-_186454509 0.198 NM_001166415
NM_001966
EHHADH

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

chr3_+_99699137 0.197 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr1_+_227506751 0.196 NM_006542
SPHAR
S-phase response (cyclin related)
chr22_-_25205376 0.194 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr2_+_68445821 0.193 NM_002664
PLEK
pleckstrin
chr7_-_143213296 0.193 FAM115A
family with sequence similarity 115, member A
chr7_+_104468614 0.192 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr8_-_27997306 0.191 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr21_-_31175722 0.190 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr14_+_19473606 0.189 NM_001004063
OR4K1
olfactory receptor, family 4, subfamily K, member 1
chr2_+_114916368 0.186 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr18_+_53967544 0.185 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr17_+_53587492 0.185 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr6_+_64414389 0.173 NM_015153
PHF3
PHD finger protein 3
chr8_-_13018123 0.171 NM_001164271
DLC1
deleted in liver cancer 1
chrX_+_79562601 0.166 NM_152630
FAM46D
family with sequence similarity 46, member D
chr2_-_160765008 0.165 ITGB6
integrin, beta 6
chr15_+_70193652 0.163 NM_001166340
SENP8
SUMO/sentrin specific peptidase family member 8
chr5_+_161208475 0.163 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_-_137582197 0.161 IFNGR1
interferon gamma receptor 1
chr12_-_119961143 0.159 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr11_+_111288669 0.156 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr7_+_26644014 0.155 NM_001145531
C7orf71
chromosome 7 open reading frame 71
chr5_-_22889487 0.155 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chrX_+_64625339 0.155 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr6_+_25760352 0.153 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr16_-_70306198 0.153 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr6_-_137582128 0.152 IFNGR1
interferon gamma receptor 1
chr5_-_179040580 0.152 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chr22_-_39587944 0.148 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr17_+_37425612 0.148 NM_001144927
NM_001144928
NM_001144929
NM_017595
NKIRAS2



NFKB inhibitor interacting Ras-like 2



chr1_+_196874867 0.148 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_150564302 0.146 NM_002016
FLG
filaggrin
chr4_-_120445047 0.146 NM_001170330
C4orf3
chromosome 4 open reading frame 3
chr10_-_46039941 0.146 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr19_+_44681374 0.144 NM_016941
NM_203486
DLL3

delta-like 3 (Drosophila)

chr10_+_80942362 0.142 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr1_+_195213289 0.142 NM_030787
CFHR5
complement factor H-related 5
chr19_+_44681443 0.141 DLL3
delta-like 3 (Drosophila)
chr6_-_159386007 0.141 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr6_-_32227695 0.140 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr6_-_29163027 0.140 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr9_+_92629525 0.139 NM_001174167
SYK
spleen tyrosine kinase
chr12_+_61645361 0.139 RPL14
ribosomal protein L14
chr1_+_109043550 0.138 PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr2_-_2313894 0.135 NM_015025
MYT1L
myelin transcription factor 1-like
chr11_-_4675524 0.134 NM_030774
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr10_+_18589589 0.133 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr14_+_19285426 0.133 NM_172194
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3
chr12_+_11694172 0.133 ETV6
ets variant 6
chr12_-_119249938 0.133 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr6_-_52217185 0.132 NM_052872
IL17F
interleukin 17F
chrX_-_30505804 0.132 NM_025159
CXorf21
chromosome X open reading frame 21
chr2_-_6924092 0.132 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr3_-_52544061 0.125 NM_022908
NT5DC2
5'-nucleotidase domain containing 2
chr7_-_50596238 0.124 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr18_-_27594696 0.124 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr1_-_9052207 0.123 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_+_27736027 0.122 NM_182506
MAGEB10
melanoma antigen family B, 10
chr8_-_124477846 0.120 ATAD2
ATPase family, AAA domain containing 2
chr12_-_21439637 0.115 NM_134431
SLCO1A2
solute carrier organic anion transporter family, member 1A2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.53 1.29e-13 GO:0007608 sensory perception of smell
5.09 6.36e-13 GO:0007606 sensory perception of chemical stimulus
3.58 1.05e-10 GO:0007600 sensory perception
2.55 9.02e-10 GO:0003008 system process
2.79 1.03e-09 GO:0050877 neurological system process
1.41 1.02e-03 GO:0050896 response to stimulus
3.87 1.97e-03 GO:0050778 positive regulation of immune response
27.42 8.06e-03 GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production
4.06 9.54e-03 GO:0002253 activation of immune response
1.42 9.57e-03 GO:0032501 multicellular organismal process
2.09 1.11e-02 GO:0002376 immune system process
2.84 4.23e-02 GO:0050776 regulation of immune response
18.98 4.35e-02 GO:0006957 complement activation, alternative pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.59 3.38e-05 GO:0005886 plasma membrane
1.56 6.93e-05 GO:0071944 cell periphery
1.37 6.22e-03 GO:0016021 integral to membrane
1.35 1.51e-02 GO:0031224 intrinsic to membrane
1.30 2.64e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.96 8.85e-16 GO:0004984 olfactory receptor activity
3.14 2.07e-08 GO:0004930 G-protein coupled receptor activity
2.54 2.03e-07 GO:0004888 transmembrane receptor activity
2.22 1.00e-06 GO:0004872 receptor activity
1.94 3.54e-05 GO:0004871 signal transducer activity
1.94 3.54e-05 GO:0060089 molecular transducer activity