Motif ID: KLF4.p3

Z-value: 3.391


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_109290107-0.553.6e-02Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_99906944 4.618 NM_006281
 STK3
serine/threonine kinase 3
chr7_-_150305933 3.825 NM_000238
NM_172056
 KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr1_+_103840900 3.584 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr22_-_17489718 3.501 DGCR2
DiGeorge syndrome critical region gene 2
chr12_+_56435042 3.458 NM_138396
 MARCH9
membrane-associated ring finger (C3HC4) 9
chr7_+_64136078 3.198 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr11_+_65049102 3.064 NM_001048218
NM_020680
 SCYL1

SCY1-like 1 (S. cerevisiae)

chr22_-_17489912 2.910 NM_001173533
NM_001173534
NM_001184781
NM_005137
 DGCR2



DiGeorge syndrome critical region gene 2



chr19_+_3045528 2.769 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr1_+_158603480 2.719 NM_005598
 NHLH1
nescient helix loop helix 1
chr22_+_18081968 2.713 NM_002688
 SEPT5
septin 5
chr18_-_26935883 2.679 NM_004949
NM_024422
 DSC2

desmocollin 2

chr20_+_34523231 2.621 NM_001042486
 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr4_-_71924409 2.524 GRSF1
G-rich RNA sequence binding factor 1
chr19_-_15421761 2.521 NM_021241
 WIZ
widely interspaced zinc finger motifs
chr11_+_65049152 2.514 SCYL1
SCY1-like 1 (S. cerevisiae)
chr8_-_145609737 2.476 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr4_-_71924477 2.473 NM_002092
 GRSF1
G-rich RNA sequence binding factor 1
chr15_-_100082134 2.452 NM_152334
 TARSL2
threonyl-tRNA synthetase-like 2
chr1_+_26728846 2.402 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 151 entries
enrichment   p-value GO term description
2.31 4.69e-02 GO:0051457 maintenance of protein location in nucleus
1.68 2.19e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.56 3.10e-04 GO:0022604 regulation of cell morphogenesis
1.56 5.50e-03 GO:0010720 positive regulation of cell development
1.55 4.87e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.40 1.31e-02 GO:0051051 negative regulation of transport
1.38 3.84e-02 GO:0010562 positive regulation of phosphorus metabolic process
1.38 3.84e-02 GO:0045937 positive regulation of phosphate metabolic process
1.36 1.31e-03 GO:0032446 protein modification by small protein conjugation
1.35 4.68e-04 GO:0070647 protein modification by small protein conjugation or removal
1.35 2.65e-02 GO:0007507 heart development
1.34 6.39e-03 GO:0010608 posttranscriptional regulation of gene expression
1.34 1.53e-02 GO:0016567 protein ubiquitination
1.33 8.86e-03 GO:0051270 regulation of cellular component movement
1.33 1.19e-02 GO:0040012 regulation of locomotion
1.31 8.92e-06 GO:0070727 cellular macromolecule localization
1.31 2.08e-05 GO:0034613 cellular protein localization
1.31 6.78e-04 GO:0006886 intracellular protein transport
1.31 1.60e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.31 2.83e-02 GO:0051130 positive regulation of cellular component organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 46 entries
enrichment   p-value GO term description
1.35 5.04e-04 GO:0000323 lytic vacuole
1.35 5.04e-04 GO:0005764 lysosome
1.32 3.13e-03 GO:0012506 vesicle membrane
1.31 7.40e-03 GO:0030659 cytoplasmic vesicle membrane
1.29 3.90e-03 GO:0005773 vacuole
1.28 6.25e-04 GO:0045202 synapse
1.28 3.47e-03 GO:0048471 perinuclear region of cytoplasm
1.28 2.02e-02 GO:0044456 synapse part
1.27 2.30e-02 GO:0044433 cytoplasmic vesicle part
1.26 6.41e-06 GO:0015630 microtubule cytoskeleton
1.25 1.88e-20 GO:0005829 cytosol
1.24 8.95e-11 GO:0005654 nucleoplasm
1.24 2.38e-06 GO:0031982 vesicle
1.24 6.95e-06 GO:0031410 cytoplasmic vesicle
1.24 1.36e-05 GO:0031988 membrane-bounded vesicle
1.24 2.91e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.23 5.68e-05 GO:0044451 nucleoplasm part
1.23 7.84e-04 GO:0030054 cell junction
1.21 5.33e-15 GO:0044428 nuclear part
1.21 6.98e-13 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
1.70 9.60e-05 GO:0031625 ubiquitin protein ligase binding
1.40 1.52e-04 GO:0019900 kinase binding
1.39 2.45e-03 GO:0019901 protein kinase binding
1.37 2.93e-03 GO:0003713 transcription coactivator activity
1.35 5.96e-03 GO:0019787 small conjugating protein ligase activity
1.34 1.45e-02 GO:0004842 ubiquitin-protein ligase activity
1.32 4.03e-11 GO:0019899 enzyme binding
1.32 1.52e-04 GO:0000988 protein binding transcription factor activity
1.32 1.52e-04 GO:0000989 transcription factor binding transcription factor activity
1.32 6.39e-03 GO:0016881 acid-amino acid ligase activity
1.31 2.03e-04 GO:0003712 transcription cofactor activity
1.29 2.43e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.28 3.98e-04 GO:0019904 protein domain specific binding
1.27 1.45e-03 GO:0004674 protein serine/threonine kinase activity
1.26 3.26e-07 GO:0016301 kinase activity
1.26 3.06e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 5.61e-07 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.24 1.55e-03 GO:0008092 cytoskeletal protein binding
1.23 2.29e-03 GO:0004672 protein kinase activity
1.22 4.02e-02 GO:0060589 nucleoside-triphosphatase regulator activity