Motif ID: GFI1B.p2

Z-value: 1.883


Transcription factors associated with GFI1B.p2:

Gene SymbolEntrez IDGene Name
GFI1B 8328 growth factor independent 1B transcription repressor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GFI1Bchr9_+_134843918-0.524.6e-02Click!


Activity profile for motif GFI1B.p2.

activity profile for motif GFI1B.p2


Sorted Z-values histogram for motif GFI1B.p2

Sorted Z-values for motif GFI1B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102100833 7.201 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr9_+_676640 5.334


chr14_+_95792299 5.036 NM_000710
BDKRB1
bradykinin receptor B1
chr4_+_15080586 4.509 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr4_-_23500706 4.223 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr8_-_19584373 3.777 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr2_+_219180821 3.141 PLCD4
phospholipase C, delta 4
chr2_+_219180862 2.914 PLCD4
phospholipase C, delta 4
chr2_+_219180875 2.796 NM_032726
PLCD4
phospholipase C, delta 4
chr1_+_66570683 2.772 PDE4B
phosphodiesterase 4B, cAMP-specific
chr12_-_28016182 2.736 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr11_-_35503720 2.697 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr2_+_62754489 2.685 NM_001142615
EHBP1
EH domain binding protein 1
chr20_-_51633042 2.494 NM_006526
ZNF217
zinc finger protein 217
chr2_-_133895795 2.479 NCKAP5
NCK-associated protein 5
chr15_-_81744469 2.403 NM_001717
BNC1
basonuclin 1
chr8_-_93099040 2.388 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_43717864 2.361 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_+_66570363 2.303 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr14_+_20580224 2.281 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr11_-_85074848 2.224 NM_152723
CCDC89
coiled-coil domain containing 89
chr4_+_41234944 2.140 LIMCH1
LIM and calponin homology domains 1
chr17_-_26672757 2.074 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr4_-_87247829 2.059 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr12_-_111114908 2.056 C12orf51
chromosome 12 open reading frame 51
chr11_-_117305277 2.056 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr11_-_102219450 1.970 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr3_-_64186151 1.961 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr15_+_38082041 1.930 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr6_-_138862271 1.907 NM_001144060
NHSL1
NHS-like 1
chr2_-_142605010 1.872 LRP1B
low density lipoprotein receptor-related protein 1B
chr3_+_190372456 1.844 NM_198485
TPRG1
tumor protein p63 regulated 1
chr6_+_152168500 1.823 NM_001122741
ESR1
estrogen receptor 1
chr4_+_113958652 1.795 NM_001127493
ANK2
ankyrin 2, neuronal
chr11_+_18244383 1.773 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr5_+_66160359 1.742 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_116184846 1.708 NM_001111061
NHLH2
nescient helix loop helix 2
chr1_-_197173159 1.698 LOC100131234
familial acute myelogenous leukemia related factor
chr4_-_151990061 1.687 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr6_-_138862273 1.659


chr16_+_70117523 1.634 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr1_+_154520693 1.615 NM_032323
TMEM79
transmembrane protein 79
chr3_-_135231518 1.607 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr12_-_113328271 1.572 NM_181486
TBX5
T-box 5
chr16_-_73859451 1.520 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr19_-_15252261 1.515 NM_014299
NM_058243
BRD4

bromodomain containing 4

chrX_-_33056464 1.497 NM_004010
NM_004009
DMD

dystrophin

chr15_+_60146467 1.481 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr17_-_67628523 1.456 FLJ37644
hypothetical LOC400618
chr5_-_59100091 1.449 PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_116185215 1.404 NM_005599
NHLH2
nescient helix loop helix 2
chr2_-_189752575 1.342 NM_000393
COL5A2
collagen, type V, alpha 2
chrX_+_17303270 1.331 NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr7_-_81910956 1.322 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr11_-_128279670 1.301 C11orf45
chromosome 11 open reading frame 45
chr7_+_47801413 1.301 NM_025031
PKD1L1
C7orf69
polycystic kidney disease 1 like 1
chromosome 7 open reading frame 69
chr9_+_95273241 1.290 FAM120A
family with sequence similarity 120A
chr14_-_36121536 1.289 NM_014360
NKX2-8
NK2 homeobox 8
chr3_-_124822113 1.281 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_-_188936941 1.275 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr4_-_88669267 1.266 SPARCL1
SPARC-like 1 (hevin)
chr1_-_214963279 1.245 NM_001438
ESRRG
estrogen-related receptor gamma
chr1_-_17180659 1.239 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr12_-_22378833 1.211 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr9_-_90983501 1.207 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr7_+_18515440 1.199 HDAC9
histone deacetylase 9
chr2_+_61225710 1.168 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr8_+_67946290 1.158 NM_001136160
C8orf45
chromosome 8 open reading frame 45
chr1_+_116455898 1.155 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr4_-_77147625 1.142 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr6_-_26125939 1.135 NM_005325
HIST1H1A
histone cluster 1, H1a
chr22_+_38903825 1.132 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_-_124821868 1.112 MYLK
myosin light chain kinase
chr1_-_7998265 1.109 ERRFI1
ERBB receptor feedback inhibitor 1
chr22_-_48604455 1.092 NM_014577
BRD1
bromodomain containing 1
chr17_-_36451189 1.077 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr3_+_51550635 1.073 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr4_+_120167264 1.071 SYNPO2
synaptopodin 2
chr4_+_41235077 1.053 LIMCH1
LIM and calponin homology domains 1
chr10_-_90702490 1.045 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_20024050 1.039 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr1_+_161305558 1.037 NM_001113381
RGS4
regulator of G-protein signaling 4
chr3_+_187840842 1.033 NM_014375
FETUB
fetuin B
chrX_+_69559605 1.026 NM_001171191
NM_001171192
NM_001171193
NM_017711
GDPD2



glycerophosphodiester phosphodiesterase domain containing 2



chrX_-_57953578 1.024 NM_007156
ZXDA
zinc finger, X-linked, duplicated A
chr7_+_18515488 1.015 HDAC9
histone deacetylase 9
chr4_+_42094612 1.014 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr13_-_85271329 1.000 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr13_-_35327798 0.991 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr19_+_51492136 0.978 NM_152795
HIF3A
hypoxia inducible factor 3, alpha subunit
chr8_+_32698892 0.976 NM_001159996
NRG1
neuregulin 1
chr10_+_89257569 0.975 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr3_-_191522886 0.956 NM_021101
CLDN1
claudin 1
chr9_+_1040367 0.955 DMRT2
doublesex and mab-3 related transcription factor 2
chr15_+_100163424 0.946 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chr15_+_64481270 0.943 MAP2K1
mitogen-activated protein kinase kinase 1
chr12_-_14929991 0.937 NM_000900
NM_001190839
MGP

matrix Gla protein

chr11_+_27019084 0.919 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr6_-_134540666 0.912 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_12398514 0.908 NM_001168319
NM_001955
EDN1

endothelin 1

chr5_-_137099602 0.896 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr17_+_71232370 0.893 NM_001005619
ITGB4
integrin, beta 4
chr11_+_111294810 0.889 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr4_-_140280031 0.882 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr18_-_33399997 0.870 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr10_+_104525877 0.866 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr11_-_84312085 0.864 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr8_-_114518194 0.846 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr14_-_94677807 0.838 NM_030621
DICER1
dicer 1, ribonuclease type III
chr11_-_84311867 0.837 DLG2
discs, large homolog 2 (Drosophila)
chr6_-_116973465 0.836 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr22_-_41366550 0.823 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr12_-_8706746 0.823 MFAP5
microfibrillar associated protein 5
chr19_+_51493486 0.812 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr8_+_62363078 0.809 NM_173519
CLVS1
clavesin 1
chr5_-_111340421 0.809 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr17_+_56884560 0.808 TBX4
T-box 4
chr4_+_86968069 0.804 ARHGAP24
Rho GTPase activating protein 24
chr10_-_91393610 0.795 NM_138316
NM_148978
PANK1

pantothenate kinase 1

chr3_-_192063158 0.795 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr8_-_68821131 0.794 NM_020361
CPA6
carboxypeptidase A6
chr2_-_53940571 0.787 NM_001164165
NM_006794
GPR75-ASB3
GPR75
GPR75-ASB3 read-through transcript
G protein-coupled receptor 75
chr9_+_1040333 0.784 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr5_-_35266305 0.784 PRLR
prolactin receptor
chr21_+_29439768 0.780 C21orf7
chromosome 21 open reading frame 7
chr14_+_69021149 0.777 NM_001161498
UPF0639
UPF0639 protein
chr13_+_96726415 0.775 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_108032645 0.769 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr11_-_8849485 0.768 ST5
suppression of tumorigenicity 5
chr17_+_37122138 0.763 NM_000805
GAST
gastrin
chr2_-_201930311 0.759 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr3_+_113200696 0.740 NM_001008273
TAGLN3
transgelin 3
chr5_-_88215034 0.739 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr22_-_40194602 0.738 NM_032758
PHF5A
PHD finger protein 5A
chr2_-_113259441 0.734 NM_000575
IL1A
interleukin 1, alpha
chr8_-_42353719 0.726 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr5_-_22889192 0.725 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_+_28887203 0.707 NM_001142634
NM_182756
SPDYA

speedy homolog A (Xenopus laevis)

chr12_+_83954229 0.702 NM_001079910
NM_032165
LRRIQ1

leucine-rich repeats and IQ motif containing 1

chr5_-_22889487 0.700 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_-_155630197 0.696 NM_001038705
GPR149
G protein-coupled receptor 149
chr6_-_41362370 0.691 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chr1_-_176205672 0.687 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr8_-_68136700 0.680 COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
chrX_+_17303458 0.675 NM_198270
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr18_+_30327341 0.675 DTNA
dystrobrevin, alpha
chrX_+_113724806 0.674 NM_000868
HTR2C
5-hydroxytryptamine (serotonin) receptor 2C
chr9_+_91123204 0.672 NM_024077
SECISBP2
SECIS binding protein 2
chr11_+_111551417 0.665 NM_031938
BCO2
beta-carotene oxygenase 2
chr13_-_77391525 0.665


chr7_+_28415495 0.659 LOC401317
hypothetical LOC401317
chr6_+_31538934 0.655 NM_006674
HCP5
HLA complex P5
chr3_-_113842350 0.651 CCDC80
coiled-coil domain containing 80
chr3_-_69064364 0.650 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr1_+_161305188 0.648 NM_005613
RGS4
regulator of G-protein signaling 4
chr10_+_118177371 0.634 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr8_+_1980564 0.629 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr18_+_53863865 0.627 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_-_40631397 0.621 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr12_-_83954185 0.616 NM_001100917
TSPAN19
tetraspanin 19
chr7_-_81910740 0.613 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr17_+_7199178 0.605 NM_198154
TMEM95
transmembrane protein 95
chr22_-_40012115 0.601 RANGAP1
Ran GTPase activating protein 1
chr2_+_183290912 0.600 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr18_+_30327243 0.591 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr12_-_121753795 0.588 NM_177551
GPR109A
G protein-coupled receptor 109A
chr2_-_113310796 0.579 NM_000576
IL1B
interleukin 1, beta
chr10_-_91001531 0.579 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr10_-_91001542 0.577 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr12_-_8706533 0.565 MFAP5
microfibrillar associated protein 5
chr11_-_68537243 0.562 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr3_-_159932899 0.560 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_+_161040343 0.547 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr3_-_159872960 0.545 NM_020169
LXN
latexin
chr10_-_91001496 0.544 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr3_-_159932965 0.543 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr4_+_183482130 0.541 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr21_-_30510113 0.541 NM_199328
CLDN8
claudin 8
chr14_-_72430545 0.535 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr10_+_69539255 0.534 NM_032578
MYPN
myopalladin
chr12_-_11230809 0.533 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr5_-_35266550 0.529 NM_000949
PRLR
prolactin receptor
chr5_+_102229425 0.528 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr15_+_97990705 0.528 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr12_-_55637648 0.527 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr2_-_51113040 0.526 NM_001135659
NM_004801
NRXN1

neurexin 1

chr22_+_36533845 0.520 NM_001171690
NM_014291
GCAT

glycine C-acetyltransferase

chr1_+_46151845 0.520 MAST2
microtubule associated serine/threonine kinase 2
chr18_+_3402071 0.517 NM_174886
TGIF1
TGFB-induced factor homeobox 1
chr2_+_162908828 0.500 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr19_+_19164007 0.500 NM_003721
NM_134440
RFXANK

regulatory factor X-associated ankyrin-containing protein

chr1_+_1207351 0.498 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chrX_-_21586337 0.496 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr3_+_173951163 0.496 ECT2
epithelial cell transforming sequence 2 oncogene
chr11_-_101292462 0.495 NM_178127
ANGPTL5
angiopoietin-like 5
chr17_+_67628772 0.489 SOX9
SRY (sex determining region Y)-box 9
chrX_+_16051344 0.486 NM_005314
GRPR
gastrin-releasing peptide receptor
chr3_-_159932924 0.484 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr6_-_52060327 0.483 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr5_-_137099361 0.463 KLHL3
kelch-like 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.07 2.22e-02 GO:0051403 stress-activated MAPK cascade

Nothing significant found in compartment category.

Nothing significant found in function category.