Motif ID: NKX2-2,8.p2

Z-value: 1.935


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-2chr20_-_21442663-0.572.6e-02Click!
NKX2-8chr14_-_36121536-0.553.4e-02Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_101115677 4.333 NM_002674
PMCH
pro-melanin-concentrating hormone
chr3_-_122862391 2.989 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862447 2.796 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr7_+_37689903 2.459


chr11_-_128217550 2.056 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr9_+_115303527 2.051 NM_130795
RGS3
regulator of G-protein signaling 3
chr11_+_117680504 1.918 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr17_-_35327318 1.796 NM_018530
GSDMB
gasdermin B
chr10_+_97505398 1.696 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr1_+_61642287 1.639 NFIA
nuclear factor I/A
chr7_+_139175420 1.579 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_+_111818111 1.550 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr21_-_14840506 1.522 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr3_+_188197029 1.506


chr3_-_153541468 1.506 NM_001123228
TMEM14E
transmembrane protein 14E
chr2_+_102320148 1.497 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr12_+_9033403 1.474 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr16_+_24475129 1.464 RBBP6
retinoblastoma binding protein 6
chr7_-_107667728 1.462 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_-_15814678 1.462 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr4_-_24590867 1.430 NM_173463
CCDC149
coiled-coil domain containing 149
chr21_-_35343065 1.317 RUNX1
runt-related transcription factor 1
chr2_+_183290912 1.301 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_+_201862845 1.273 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr18_-_65766068 1.264 CD226
CD226 molecule
chr19_+_46503524 1.255 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr6_-_27988152 1.242 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr22_+_38652555 1.240 GRAP2
GRB2-related adaptor protein 2
chr17_-_1195096 1.214 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr11_-_47467094 1.201 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr6_+_88021644 1.164 ZNF292
zinc finger protein 292
chr4_+_53975597 1.150 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr2_+_102401580 1.131 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_-_20374273 1.124 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr10_+_74323344 1.123 NM_152635
OIT3
oncoprotein induced transcript 3
chr1_+_165564904 1.110 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_+_100714995 1.109 MTTP
microsomal triglyceride transfer protein
chr15_-_53440069 1.106 CCPG1
cell cycle progression 1
chr19_+_54530458 1.102 CD37
CD37 molecule
chr10_-_93992982 1.093 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr4_-_110942783 1.087 NM_000204
CFI
complement factor I
chr1_+_242281175 1.085 NM_205768
ZNF238
zinc finger protein 238
chr2_+_228064531 1.082 AGFG1
ArfGAP with FG repeats 1
chr20_+_56919233 1.082 GNAS
GNAS complex locus
chr1_+_12728749 1.039 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr1_+_160868822 1.039 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr14_-_24148658 1.032 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr14_+_22633728 1.031 C14orf119
chromosome 14 open reading frame 119
chr3_+_153499883 1.026 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr7_+_113853790 1.023 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr1_+_242281199 1.018 ZNF238
zinc finger protein 238
chr3_+_120982020 1.011 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr14_+_20319049 0.995 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr10_+_91488704 0.995 KIF20B
kinesin family member 20B
chr12_+_119617060 0.990


chr1_+_165565006 0.966 POU2F1
POU class 2 homeobox 1
chrX_-_49008115 0.958 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr17_-_35975227 0.956 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr19_+_54530485 0.931 NM_001040031
NM_001774
CD37

CD37 molecule

chr5_+_140772691 0.911 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr14_-_31026901 0.904 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr2_+_173394560 0.887 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_180622083 0.886 GLUL
glutamate-ammonia ligase
chr18_+_54039730 0.885 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_195436258 0.880 NM_194314
ZBTB41
zinc finger and BTB domain containing 41
chr3_-_113701073 0.872 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr19_+_54530497 0.859 CD37
CD37 molecule
chr5_-_88155360 0.857 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr22_-_22426551 0.846 NM_013378
VPREB3
pre-B lymphocyte 3
chr12_+_10054492 0.843 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr10_+_5478521 0.840 NM_005863
NET1
neuroepithelial cell transforming 1
chr19_+_54530512 0.839 CD37
CD37 molecule
chr21_+_37714470 0.838 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr5_-_39306465 0.832 FYB
FYN binding protein
chr14_-_81069951 0.832 NM_005065
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr11_+_65027721 0.827


chr14_+_66901237 0.818 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_-_151549790 0.815 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr15_-_53350383 0.814 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr6_+_31604717 0.795 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr1_-_207891264 0.791 NM_001017402
LAMB3
laminin, beta 3
chr1_-_41398126 0.789 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_+_103840900 0.788 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr10_-_98326435 0.784 TM9SF3
transmembrane 9 superfamily member 3
chr4_-_77176163 0.777 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr1_-_205161821 0.775 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr14_-_56346849 0.769 NM_021728
OTX2
orthodenticle homeobox 2
chr16_-_45339605 0.768 NM_182493
MYLK3
myosin light chain kinase 3
chr18_+_54039818 0.758 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_81069865 0.757 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr6_-_99957253 0.756 SFRS18
splicing factor, arginine/serine-rich 18
chr13_+_110653407 0.753 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr12_-_54850231 0.748 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr1_+_116727514 0.743 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr18_+_54039779 0.738 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_11490487 0.735 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr16_+_28413421 0.729 NM_018690
APOBR
apolipoprotein B receptor
chr13_-_102517196 0.727 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chrX_-_154216929 0.725 NM_001289
CLIC2
chloride intracellular channel 2
chr12_-_91346054 0.722 NM_001025232
CLLU1OS
chronic lymphocytic leukemia up-regulated 1 opposite strand
chr5_-_147996769 0.705 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr4_-_153493133 0.705 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_+_22646229 0.703 NM_177553
GAS2
growth arrest-specific 2
chr1_-_159543847 0.702 MPZ
myelin protein zero
chrX_+_108665665 0.697 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr1_+_100099353 0.691 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr2_-_151052391 0.689 NM_005168
RND3
Rho family GTPase 3
chr14_-_19871267 0.689 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr9_-_113561613 0.684 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr1_+_169747788 0.683 PRRC2C
proline-rich coiled-coil 2C
chr5_+_147754467 0.681 FBXO38
F-box protein 38
chr6_+_4835224 0.679 NM_001143971
CDYL
chromodomain protein, Y-like
chr5_+_148711419 0.674 GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr17_+_25292748 0.673 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr1_-_173979292 0.672 NM_003285
TNR
tenascin R (restrictin, janusin)
chr12_-_9913199 0.670 CLEC2B
C-type lectin domain family 2, member B
chr12_-_69837831 0.663 TSPAN8
tetraspanin 8
chrX_-_70391771 0.659 NM_001171162
ZMYM3
zinc finger, MYM-type 3
chr2_-_183095308 0.658 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr15_-_58477407 0.657 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr9_-_124981125 0.654 STRBP
spermatid perinuclear RNA binding protein
chr14_-_88948486 0.654 FOXN3
forkhead box N3
chr3_+_153074118 0.648 NM_033050
SUCNR1
succinate receptor 1
chr5_+_169713458 0.647 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr3_-_57209319 0.644 NM_003865
HESX1
HESX homeobox 1
chr6_+_143971009 0.627 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr19_+_46121963 0.618 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr20_+_56369012 0.615


chr19_-_6643953 0.615 C3
complement component 3
chr8_+_118216517 0.609 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr5_-_37220702 0.608 C5orf42
chromosome 5 open reading frame 42
chr6_-_150109324 0.599 NM_198887
NUP43
nucleoporin 43kDa
chr3_+_133798770 0.596 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr4_-_170314382 0.593 SH3RF1
SH3 domain containing ring finger 1
chr19_+_54530546 0.590 CD37
CD37 molecule
chr5_+_76470829 0.588


chr17_+_23824784 0.588 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr6_-_33393696 0.587 NM_001145338
ZBTB22
zinc finger and BTB domain containing 22
chr10_+_13668964 0.586 PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr15_-_75135496 0.582 TSPAN3
tetraspanin 3
chr4_-_170770111 0.575 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr21_+_29322100 0.574 USP16
ubiquitin specific peptidase 16
chr16_-_4794749 0.574 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_54132447 0.572 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr14_+_38719462 0.568 PNN
pinin, desmosome associated protein
chr12_-_69317441 0.568 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_+_23994914 0.568


chr22_-_48865907 0.567 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr20_+_56397568 0.565 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr9_+_129066576 0.564 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr4_+_86918870 0.563 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr10_+_13668944 0.562 NM_003675
PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr9_-_21472311 0.559 NM_176891
IFNE
interferon, epsilon
chr7_-_115458064 0.557 TFEC
transcription factor EC
chr2_+_170363573 0.555 NM_003142
SSB
Sjogren syndrome antigen B (autoantigen La)
chr10_-_64698831 0.555 NM_004241
JMJD1C
jumonji domain containing 1C
chr7_+_149696263 0.550 REPIN1
replication initiator 1
chr11_-_82460518 0.550 RAB30
RAB30, member RAS oncogene family
chr10_+_5976354 0.547 NM_032807
FBXO18
F-box protein, helicase, 18
chr22_+_38627031 0.543 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr6_-_152744022 0.541 SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_+_161981046 0.537 TBR1
T-box, brain, 1
chr2_+_161981138 0.536 TBR1
T-box, brain, 1
chr19_-_44920451 0.534 NM_001828
CLC
Charcot-Leyden crystal protein
chr7_-_36991189 0.534 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_+_95595419 0.533 PDLIM5
PDZ and LIM domain 5
chr9_+_19280748 0.533 NM_017925
DENND4C
DENN/MADD domain containing 4C
chr17_-_69869552 0.531 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr1_-_41399632 0.530 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr8_+_92330691 0.529 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr8_-_82536312 0.528 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr7_+_69869099 0.528 AUTS2
autism susceptibility candidate 2
chr3_-_33675484 0.528 CLASP2
cytoplasmic linker associated protein 2
chr18_-_65775139 0.525 NM_006566
CD226
CD226 molecule
chr11_+_93916653 0.522 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr12_+_4700012 0.521 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chrX_+_47999740 0.519 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr15_-_91078307 0.517 FAM174B
family with sequence similarity 174, member B
chr1_+_84402962 0.517 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_117345894 0.512 NM_004258
CD101
CD101 molecule
chr2_+_170074457 0.508 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr22_-_25344037 0.506 CRYBB1
crystallin, beta B1
chr1_-_158759606 0.506 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr5_-_39238818 0.505 FYB
FYN binding protein
chr9_+_99303282 0.499 NM_001166116
TMOD1
tropomodulin 1
chr9_+_122923864 0.496 CEP110
centrosomal protein 110kDa
chr9_+_263025 0.496 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr22_+_22435207 0.494 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr22_-_16070778 0.492 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr5_+_176955595 0.491


chr1_-_197173159 0.488 LOC100131234
familial acute myelogenous leukemia related factor
chr17_-_36113502 0.487 NM_019016
KRT24
keratin 24
chr9_+_124173143 0.484 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_110942576 0.482 CFI
complement factor I
chr18_+_70352779 0.476 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr5_-_139917861 0.471 NM_001035235
SRA1
steroid receptor RNA activator 1
chr9_+_78246401 0.468 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr7_-_111216180 0.468 DOCK4
dedicator of cytokinesis 4
chr18_+_70352649 0.468 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr8_-_145613058 0.466 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.33e-02 GO:0050896 response to stimulus
1.31 2.45e-02 GO:0007165 signal transduction
1.28 3.35e-02 GO:0023052 signaling
1.26 3.90e-02 GO:0051716 cellular response to stimulus

Nothing significant found in compartment category.

Nothing significant found in function category.