Motif ID: NFE2L2.p2

Z-value: 2.756


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_1778367730.411.3e-01Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21340757 8.386


chr22_+_21359175 7.514 IGLV3-25
immunoglobulin lambda variable 3-25
chr22_+_21094094 7.039


chr10_-_76538859 6.947 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr19_-_54350457 6.717 NM_002152
HRC
histidine rich calcium binding protein
chr22_+_21484240 6.371


chr22_+_21053972 5.676


chr22_+_21393107 5.624 IGLJ3
immunoglobulin lambda joining 3
chr22_+_21079355 5.583


chr22_+_21370394 5.485 IGL@
immunoglobulin lambda locus
chr6_-_31853027 5.092 NM_025258
C6orf27
chromosome 6 open reading frame 27
chrX_-_70243362 5.087 NM_001025265
CXorf65
chromosome X open reading frame 65
chr22_+_21495273 5.084


chrX_-_100527799 4.930 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr15_+_36776090 4.823 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr17_+_77910411 4.810 NM_207459
TEX19
testis expressed 19
chr4_-_977163 4.784 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr16_+_28413421 4.747 NM_018690
APOBR
apolipoprotein B receptor
chr17_+_72883759 4.740 NM_001113494
SEPT9
septin 9
chr22_+_20316968 4.690 NM_152612
CCDC116
coiled-coil domain containing 116
chr5_+_61750467 4.618 NM_001134779
IPO11
importin 11
chr19_-_6621598 4.594 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr1_+_153232685 4.490 NM_018655
LENEP
lens epithelial protein
chr3_+_122794859 4.409 NM_016298
FBXO40
F-box protein 40
chr18_+_148480 4.338 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr22_+_21042091 4.335 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_-_150352484 4.140 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr22_-_25344037 4.031 CRYBB1
crystallin, beta B1
chr22_+_21116283 3.995


chr16_+_31274030 3.854 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr8_-_42742729 3.853 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr16_+_31274020 3.718 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr22_+_21407066 3.687


chr22_-_25343959 3.654 NM_001887
CRYBB1
crystallin, beta B1
chr7_-_75280962 3.644 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr17_-_35975227 3.596 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_+_72660894 3.512 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr22_+_21065134 3.427 LOC100290481
immunoglobulin lambda light chain-like
chr19_-_6621078 3.413 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr7_+_139175420 3.410 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_7923464 3.404 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr19_-_43926953 3.394 NM_144691
CAPN12
calpain 12
chr22_+_21065202 3.384


chr22_+_21065207 3.322 IGLJ3
immunoglobulin lambda joining 3
chr16_+_31273969 3.274 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr19_-_53914768 3.159 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr7_+_37926943 3.151 EPDR1
ependymin related protein 1 (zebrafish)
chr20_-_29524476 3.112 NM_001037500
DEFB124
defensin, beta 124
chr16_-_66075216 3.083 NM_001138
AGRP
agouti related protein homolog (mouse)
chr20_+_41621119 3.032 SGK2
serum/glucocorticoid regulated kinase 2
chr20_+_41621079 3.004 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_156923111 2.999 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr19_+_56319948 2.995 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr22_+_20899155 2.973


chr1_-_45045543 2.969 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr1_+_17507276 2.915 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chrX_+_69314060 2.841 NM_198512
DGAT2L6
diacylglycerol O-acyltransferase 2-like 6
chr12_+_54361685 2.831 METTL7B
methyltransferase like 7B
chr16_-_28528149 2.823 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr6_+_1556543 2.821 FOXC1
forkhead box C1
chr12_+_10256682 2.804 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr1_-_199259133 2.790 KIF21B
kinesin family member 21B
chr4_-_80548378 2.782 NM_033214
GK2
glycerol kinase 2
chr18_+_148586 2.768 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr12_+_54361596 2.766 NM_152637
METTL7B
methyltransferase like 7B
chr16_-_28528780 2.765 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr7_+_116099648 2.756 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr22_+_20880159 2.750 IGLV6-57
immunoglobulin lambda variable 6-57
chr3_-_39209075 2.740 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr14_-_22658078 2.736 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr6_+_31782618 2.734 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr1_-_199259447 2.733 NM_017596
KIF21B
kinesin family member 21B
chr11_+_123600553 2.643 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr1_-_158815850 2.592 CD84
CD84 molecule
chr20_+_24877904 2.572 CST7
cystatin F (leukocystatin)
chr6_-_29563657 2.569 NM_052967
MAS1L
MAS1 oncogene-like
chr10_+_85889164 2.565 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr16_+_30876115 2.564 NM_014712
SETD1A
SET domain containing 1A
chr22_-_39189369 2.530 MKL1
megakaryoblastic leukemia (translocation) 1
chr5_-_39306465 2.510 FYB
FYN binding protein
chr1_+_158063130 2.436 SLAMF8
SLAM family member 8
chr1_+_158063102 2.433 NM_020125
SLAMF8
SLAM family member 8
chr22_+_25347927 2.431 NM_001886
CRYBA4
crystallin, beta A4
chr1_+_158063278 2.424 SLAMF8
SLAM family member 8
chr9_-_139042526 2.401 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr11_+_5916033 2.365


chr17_+_71109734 2.362 MYO15B
myosin XVB pseudogene
chr5_-_75954807 2.344 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr16_-_4778317 2.284 NM_001154458
NM_144605
SEPT12

septin 12

chr12_-_112326037 2.274 NM_006843
SDS
serine dehydratase
chr9_-_139042416 2.274 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr16_-_28515195 2.267 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr5_+_150206277 2.252 NM_001145805
IRGM
immunity-related GTPase family, M
chrX_-_152863251 2.209 NM_002910
RENBP
renin binding protein
chr16_+_30326864 2.192 ZNF771
zinc finger protein 771
chr21_-_35181956 2.156 RUNX1
runt-related transcription factor 1
chr5_+_179180447 2.142 NM_003900
SQSTM1
sequestosome 1
chr2_-_85948287 2.140 NM_001042437
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr20_+_24877862 2.129 NM_003650
CST7
cystatin F (leukocystatin)
chr5_-_149515613 2.118 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chrX_-_109570113 2.094 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_19706979 2.084 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr19_-_56279278 2.063 NM_022046
KLK14
kallikrein-related peptidase 14
chr15_+_57691382 2.060 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr7_+_150319076 2.055 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr10_+_134751398 2.046 NM_001083909
GPR123
G protein-coupled receptor 123
chr9_-_99974994 2.036 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr11_+_67107641 2.024 NM_000852
GSTP1
glutathione S-transferase pi 1
chr10_-_73281056 2.021 NM_001042465
NM_001042466
NM_002778
PSAP


prosaposin


chr1_+_67404756 2.012 NM_144701
IL23R
interleukin 23 receptor
chr2_-_70901186 1.985 NM_173535
CLEC4F
C-type lectin domain family 4, member F
chr5_-_149515502 1.981 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_46151845 1.953 MAST2
microtubule associated serine/threonine kinase 2
chr5_+_179180517 1.936 SQSTM1
sequestosome 1
chr1_-_6585268 1.913 KLHL21
kelch-like 21 (Drosophila)
chrX_-_154216929 1.897 NM_001289
CLIC2
chloride intracellular channel 2
chr19_+_45564549 1.896 PLD3
phospholipase D family, member 3
chr19_+_10820105 1.879 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr5_+_179057968 1.870 CANX
calnexin
chr5_+_179180509 1.868 SQSTM1
sequestosome 1
chr1_+_117345894 1.857 NM_004258
CD101
CD101 molecule
chr1_-_43168247 1.848 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr6_+_150112537 1.842 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr19_+_56337368 1.838 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr15_+_57691272 1.837 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_+_67107852 1.830 GSTP1
glutathione S-transferase pi 1
chr1_+_36327039 1.811 NM_017825
ADPRHL2
ADP-ribosylhydrolase like 2
chr12_+_100512877 1.795 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr9_+_129962292 1.793 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr4_-_40212670 1.791 NM_019027
RBM47
RNA binding motif protein 47
chr20_+_61337679 1.789 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr6_-_154719560 1.765 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chrX_+_9391314 1.758 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr3_-_180460372 1.756 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr17_+_27795632 1.740 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_21631992 1.734


chr22_+_21006814 1.730


chr9_-_126309510 1.729 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr22_+_43451351 1.698 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr14_-_105804211 1.694 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_32121784 1.687 NM_032470
TNXB
tenascin XB
chr17_+_27795633 1.686 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_3102690 1.680 NM_001069
TUBB2A
tubulin, beta 2A
chr20_+_34937928 1.674 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr3_-_180467483 1.671 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr1_+_114295289 1.670 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr6_+_32003380 1.665 C2
complement component 2
chr17_+_27795607 1.640 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_-_176869440 1.634 DOK3
docking protein 3
chr9_-_115880372 1.629 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_+_102672745 1.616 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr19_+_41051186 1.600 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr10_-_99521701 1.599 NM_003015
SFRP5
secreted frizzled-related protein 5
chr14_-_24148658 1.597 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr22_+_21011653 1.596


chr9_+_138760432 1.587 LOC100128593
hypothetical LOC100128593
chr1_+_152644471 1.581 IL6R
interleukin 6 receptor
chr17_+_27795598 1.579 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_70662364 1.578 NM_001002032
NM_001002033
NM_016185
HN1


hematological and neurological expressed 1


chr19_-_61039939 1.562 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chr12_+_63084317 1.559 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr16_-_70763524 1.554 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr5_+_176955595 1.550


chr8_-_144887876 1.550 NM_198488
FAM83H
family with sequence similarity 83, member H
chr19_+_55398680 1.542 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr22_+_20880112 1.515


chr10_-_73281047 1.511 PSAP
prosaposin
chr2_-_42844705 1.511 NM_148962
OXER1
oxoeicosanoid (OXE) receptor 1
chr9_-_122728173 1.509 TRAF1
TNF receptor-associated factor 1
chr6_-_28429950 1.504 NM_145909
ZNF323
zinc finger protein 323
chr16_+_73810383 1.502 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr6_+_150112511 1.490 NM_005389
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr20_-_43889339 1.486 NM_003279
TNNC2
troponin C type 2 (fast)
chr19_-_1989937 1.482 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr20_+_42273013 1.465 LOC100505783
hypothetical LOC100505783
chr4_-_191143017 1.460 NM_020040
TUBB4Q
tubulin, beta polypeptide 4, member Q
chr10_+_88418243 1.459 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr17_+_27795645 1.457 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_199390183 1.456 TMEM9
transmembrane protein 9
chrX_+_41078787 1.449 DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr5_+_132237253 1.441 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr17_-_62793129 1.425 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr14_+_19681734 1.423 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr6_+_150112549 1.418 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr4_+_155707089 1.415 FGB
fibrinogen beta chain
chr11_+_10433241 1.410 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr22_+_43451600 1.403 PRR5
proline rich 5 (renal)
chr1_+_152644292 1.391 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr17_+_1578083 1.390 WDR81
WD repeat domain 81
chr12_+_54910767 1.383 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr14_-_21108714 1.379 NM_001005465
OR10G3
olfactory receptor, family 10, subfamily G, member 3
chr4_-_26100986 1.366 NM_000730
CCKAR
cholecystokinin A receptor
chr17_+_27795635 1.364 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr14_-_95011790 1.353 NM_152592
C14orf49
chromosome 14 open reading frame 49
chr9_+_139041736 1.346 NM_207511
C9orf139
chromosome 9 open reading frame 139
chr3_+_142525744 1.331 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr21_+_31953803 1.321 NM_000454
SOD1
superoxide dismutase 1, soluble
chr2_-_169596078 1.313 NM_003742
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr11_+_74548472 1.311 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr22_+_18388656 1.310 C22orf25
chromosome 22 open reading frame 25

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.28 1.08e-04 GO:0050896 response to stimulus
6.02 2.46e-04 GO:0032313 regulation of Rab GTPase activity
6.02 2.46e-04 GO:0032483 regulation of Rab protein signal transduction
5.32 4.41e-04 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
5.32 4.41e-04 GO:0072395 signal transduction involved in cell cycle checkpoint
5.32 4.41e-04 GO:0072401 signal transduction involved in DNA integrity checkpoint
5.32 4.41e-04 GO:0072404 signal transduction involved in G1/S transition checkpoint
5.32 4.41e-04 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
5.32 4.41e-04 GO:0072422 signal transduction involved in DNA damage checkpoint
5.32 4.41e-04 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
5.32 4.41e-04 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
5.68 5.18e-04 GO:0006521 regulation of cellular amino acid metabolic process
4.90 5.25e-04 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.52 6.72e-04 GO:0051351 positive regulation of ligase activity
5.07 8.31e-04 GO:0071158 positive regulation of cell cycle arrest
3.93 1.12e-03 GO:0000077 DNA damage checkpoint
4.51 1.59e-03 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.77 1.82e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.46 1.89e-03 GO:0051443 positive regulation of ubiquitin-protein ligase activity
4.34 2.65e-03 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.69 2.96e-03 GO:0031570 DNA integrity checkpoint
2.46 3.47e-03 GO:0009894 regulation of catabolic process
3.49 3.58e-03 GO:0032318 regulation of Ras GTPase activity
4.24 3.68e-03 GO:2000045 regulation of G1/S transition of mitotic cell cycle
3.94 4.56e-03 GO:0051340 regulation of ligase activity
4.71 5.21e-03 GO:0033238 regulation of cellular amine metabolic process
3.16 5.56e-03 GO:0010498 proteasomal protein catabolic process
3.16 5.56e-03 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.45 8.27e-03 GO:0006950 response to stress
3.17 8.87e-03 GO:0043087 regulation of GTPase activity
3.15 9.86e-03 GO:0033124 regulation of GTP catabolic process
1.68 1.00e-02 GO:0050790 regulation of catalytic activity
4.16 1.02e-02 GO:0000216 M/G1 transition of mitotic cell cycle
4.16 1.02e-02 GO:0031575 mitotic cell cycle G1/S transition checkpoint
4.16 1.02e-02 GO:0071779 G1/S transition checkpoint
3.86 1.23e-02 GO:0051438 regulation of ubiquitin-protein ligase activity
2.97 1.52e-02 GO:0030811 regulation of nucleotide catabolic process
2.97 1.52e-02 GO:0033121 regulation of purine nucleotide catabolic process
3.77 3.27e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.39 3.63e-02 GO:0031329 regulation of cellular catabolic process
4.15 4.83e-02 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.25 2.50e-07 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.91 7.46e-05 GO:0005097 Rab GTPase activator activity
5.79 2.43e-03 GO:0003823 antigen binding
3.31 3.43e-02 GO:0005099 Ras GTPase activator activity