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• Mean activities

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• Activity deltas table
• Regulatory interactions
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Motif ID: NFE2L2.p2

Z-value: 2.756

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr22_+_21340757	8.386
chr22_+_21359175	7.514		IGLV3-25	immunoglobulin lambda variable 3-25
chr22_+_21094094	7.039
chr10_-_76538859	6.947	NM_001007271 NM_001007272 NM_001007273	DUSP13	dual specificity phosphatase 13
chr19_-_54350457	6.717	NM_002152	HRC	histidine rich calcium binding protein
chr22_+_21484240	6.371
chr22_+_21053972	5.676
chr22_+_21393107	5.624		IGLJ3	immunoglobulin lambda joining 3
chr22_+_21079355	5.583
chr22_+_21370394	5.485		IGL@	immunoglobulin lambda locus
chr6_-_31853027	5.092	NM_025258	C6orf27	chromosome 6 open reading frame 27
chrX_-_70243362	5.087	NM_001025265	CXorf65	chromosome X open reading frame 65
chr22_+_21495273	5.084
chrX_-_100527799	4.930	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr15_+_36776090	4.823	NM_207444	C15orf53	chromosome 15 open reading frame 53
chr17_+_77910411	4.810	NM_207459	TEX19	testis expressed 19
chr4_-_977163	4.784	NM_022042 NM_134425 NM_213613	SLC26A1	solute carrier family 26 (sulfate transporter), member 1
chr16_+_28413421	4.747	NM_018690	APOBR	apolipoprotein B receptor
chr17_+_72883759	4.740	NM_001113494	SEPT9	septin 9
chr22_+_20316968	4.690	NM_152612	CCDC116	coiled-coil domain containing 116
chr5_+_61750467	4.618	NM_001134779	IPO11	importin 11
chr19_-_6621598	4.594	NM_003807 NM_172014	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr1_+_153232685	4.490	NM_018655	LENEP	lens epithelial protein
chr3_+_122794859	4.409	NM_016298	FBXO40	F-box protein 40
chr18_+_148480	4.338	NM_001037334 NM_005151	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr22_+_21042091	4.335		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr7_-_150352484	4.140	NM_173681	ATG9B	ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr22_-_25344037	4.031		CRYBB1	crystallin, beta B1
chr22_+_21116283	3.995
chr16_+_31274030	3.854		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr8_-_42742729	3.853	NM_004198	CHRNA6	cholinergic receptor, nicotinic, alpha 6
chr16_+_31274020	3.718		ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr22_+_21407066	3.687
chr22_-_25343959	3.654	NM_001887	CRYBB1	crystallin, beta B1
chr7_-_75280962	3.644	NM_002991	CCL24	chemokine (C-C motif) ligand 24
chr17_-_35975227	3.596	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr11_+_72660894	3.512	NM_004154	P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6
chr22_+_21065134	3.427		LOC100290481	immunoglobulin lambda light chain-like
chr19_-_6621078	3.413		TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr7_+_139175420	3.410	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr1_-_7923464	3.404	NM_001561	TNFRSF9	tumor necrosis factor receptor superfamily, member 9
chr19_-_43926953	3.394	NM_144691	CAPN12	calpain 12
chr22_+_21065202	3.384
chr22_+_21065207	3.322		IGLJ3	immunoglobulin lambda joining 3
chr16_+_31273969	3.274	NM_000887	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr19_-_53914768	3.159	NM_001130915	MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator
chr7_+_37926943	3.151		EPDR1	ependymin related protein 1 (zebrafish)
chr20_-_29524476	3.112	NM_001037500	DEFB124	defensin, beta 124
chr16_-_66075216	3.083	NM_001138	AGRP	agouti related protein homolog (mouse)
chr20_+_41621119	3.032		SGK2	serum/glucocorticoid regulated kinase 2
chr20_+_41621079	3.004	NM_170693	SGK2	serum/glucocorticoid regulated kinase 2
chr1_-_156923111	2.999	NM_003126	SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr19_+_56319948	2.995	NM_001198558 NM_014441	SIGLEC9	sialic acid binding Ig-like lectin 9
chr22_+_20899155	2.973
chr1_-_45045543	2.969	NM_001013632	TCTEX1D4	Tctex1 domain containing 4
chr1_+_17507276	2.915	NM_012387	PADI4	peptidyl arginine deiminase, type IV
chrX_+_69314060	2.841	NM_198512	DGAT2L6	diacylglycerol O-acyltransferase 2-like 6
chr12_+_54361685	2.831		METTL7B	methyltransferase like 7B
chr16_-_28528149	2.823	NM_177530 NM_177534	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr6_+_1556543	2.821		FOXC1	forkhead box C1
chr12_+_10256682	2.804	NM_031412	GABARAPL1	GABA(A) receptor-associated protein like 1
chr1_-_199259133	2.790		KIF21B	kinesin family member 21B
chr4_-_80548378	2.782	NM_033214	GK2	glycerol kinase 2
chr18_+_148586	2.768		USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr12_+_54361596	2.766	NM_152637	METTL7B	methyltransferase like 7B
chr16_-_28528780	2.765	NM_001055 NM_177529	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr7_+_116099648	2.756	NM_000245 NM_001127500	MET	met proto-oncogene (hepatocyte growth factor receptor)
chr22_+_20880159	2.750		IGLV6-57	immunoglobulin lambda variable 6-57
chr3_-_39209075	2.740	NM_194293 NM_001198621	XIRP1	xin actin-binding repeat containing 1
chr14_-_22658078	2.736	NM_001805	CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon
chr6_+_31782618	2.734	NM_001003693	LY6G6F	lymphocyte antigen 6 complex, locus G6F
chr1_-_199259447	2.733	NM_017596	KIF21B	kinesin family member 21B
chr11_+_123600553	2.643	NM_001007249	OR8G2	olfactory receptor, family 8, subfamily G, member 2
chr1_-_158815850	2.592		CD84	CD84 molecule
chr20_+_24877904	2.572		CST7	cystatin F (leukocystatin)
chr6_-_29563657	2.569	NM_052967	MAS1L	MAS1 oncogene-like
chr10_+_85889164	2.565	NM_014394	GHITM	growth hormone inducible transmembrane protein
chr16_+_30876115	2.564	NM_014712	SETD1A	SET domain containing 1A
chr22_-_39189369	2.530		MKL1	megakaryoblastic leukemia (translocation) 1
chr5_-_39306465	2.510		FYB	FYN binding protein
chr1_+_158063130	2.436		SLAMF8	SLAM family member 8
chr1_+_158063102	2.433	NM_020125	SLAMF8	SLAM family member 8
chr22_+_25347927	2.431	NM_001886	CRYBA4	crystallin, beta A4
chr1_+_158063278	2.424		SLAMF8	SLAM family member 8
chr9_-_139042526	2.401	NM_001606	ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2
chr11_+_5916033	2.365
chr17_+_71109734	2.362		MYO15B	myosin XVB pseudogene
chr5_-_75954807	2.344	NM_004101	F2RL2	coagulation factor II (thrombin) receptor-like 2
chr16_-_4778317	2.284	NM_001154458 NM_144605	SEPT12	septin 12
chr12_-_112326037	2.274	NM_006843	SDS	serine dehydratase
chr9_-_139042416	2.274		ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2
chr16_-_28515195	2.267	NM_177528	SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr5_+_150206277	2.252	NM_001145805	IRGM	immunity-related GTPase family, M
chrX_-_152863251	2.209	NM_002910	RENBP	renin binding protein
chr16_+_30326864	2.192		ZNF771	zinc finger protein 771
chr21_-_35181956	2.156		RUNX1	runt-related transcription factor 1
chr5_+_179180447	2.142	NM_003900	SQSTM1	sequestosome 1
chr2_-_85948287	2.140	NM_001042437	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr20_+_24877862	2.129	NM_003650	CST7	cystatin F (leukocystatin)
chr5_-_149515613	2.118	NM_002609	PDGFRB	platelet-derived growth factor receptor, beta polypeptide
chrX_-_109570113	2.094	NM_001171689	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_19706979	2.084	NM_000227 NM_001127718	LAMA3	laminin, alpha 3
chr19_-_56279278	2.063	NM_022046	KLK14	kallikrein-related peptidase 14
chr15_+_57691382	2.060		GCNT3	glucosaminyl (N-acetyl) transferase 3, mucin type
chr7_+_150319076	2.055	NM_000603	NOS3	nitric oxide synthase 3 (endothelial cell)
chr10_+_134751398	2.046	NM_001083909	GPR123	G protein-coupled receptor 123
chr9_-_99974994	2.036	NM_003389	CORO2A	coronin, actin binding protein, 2A
chr11_+_67107641	2.024	NM_000852	GSTP1	glutathione S-transferase pi 1
chr10_-_73281056	2.021	NM_001042465 NM_001042466 NM_002778	PSAP	prosaposin
chr1_+_67404756	2.012	NM_144701	IL23R	interleukin 23 receptor
chr2_-_70901186	1.985	NM_173535	CLEC4F	C-type lectin domain family 4, member F
chr5_-_149515502	1.981		PDGFRB	platelet-derived growth factor receptor, beta polypeptide
chr1_+_46151845	1.953		MAST2	microtubule associated serine/threonine kinase 2
chr5_+_179180517	1.936		SQSTM1	sequestosome 1
chr1_-_6585268	1.913		KLHL21	kelch-like 21 (Drosophila)
chrX_-_154216929	1.897	NM_001289	CLIC2	chloride intracellular channel 2
chr19_+_45564549	1.896		PLD3	phospholipase D family, member 3
chr19_+_10820105	1.879	NM_001136482	C19orf38	chromosome 19 open reading frame 38
chr5_+_179057968	1.870		CANX	calnexin
chr5_+_179180509	1.868		SQSTM1	sequestosome 1
chr1_+_117345894	1.857	NM_004258	CD101	CD101 molecule
chr1_-_43168247	1.848		SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1
chr6_+_150112537	1.842		PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr19_+_56337368	1.838	NM_014385 NM_016543	SIGLEC7	sialic acid binding Ig-like lectin 7
chr15_+_57691272	1.837	NM_004751	GCNT3	glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_+_67107852	1.830		GSTP1	glutathione S-transferase pi 1
chr1_+_36327039	1.811	NM_017825	ADPRHL2	ADP-ribosylhydrolase like 2
chr12_+_100512877	1.795	NM_002465 NM_206819 NM_206820 NM_206821	MYBPC1	myosin binding protein C, slow type
chr9_+_129962292	1.793	NM_024112	C9orf16	chromosome 9 open reading frame 16
chr4_-_40212670	1.791	NM_019027	RBM47	RNA binding motif protein 47
chr20_+_61337679	1.789	NM_022161 NM_139317	BIRC7	baculoviral IAP repeat containing 7
chr6_-_154719560	1.765	NM_001130700 NM_015553	IPCEF1	interaction protein for cytohesin exchange factors 1
chrX_+_9391314	1.758	NM_001139466 NM_001139467 NM_001139468	TBL1X	transducin (beta)-like 1X-linked
chr3_-_180460372	1.756	NM_171829	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3
chr17_+_27795632	1.740		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_21631992	1.734
chr22_+_21006814	1.730
chr9_-_126309510	1.729	NM_004959	NR5A1	nuclear receptor subfamily 5, group A, member 1
chr22_+_43451351	1.698	NM_001017530 NM_001198721 NM_015366	PRR5	proline rich 5 (renal)
chr14_-_105804211	1.694		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_32121784	1.687	NM_032470	TNXB	tenascin XB
chr17_+_27795633	1.686		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_3102690	1.680	NM_001069	TUBB2A	tubulin, beta 2A
chr20_+_34937928	1.674	NM_080628	C20orf118	chromosome 20 open reading frame 118
chr3_-_180467483	1.671	NM_001163677 NM_171828	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3
chr1_+_114295289	1.670	NM_198269	HIPK1	homeodomain interacting protein kinase 1
chr6_+_32003380	1.665		C2	complement component 2
chr17_+_27795607	1.640	NM_002815	PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_-_176869440	1.634		DOK3	docking protein 3
chr9_-_115880372	1.629		AMBP	alpha-1-microglobulin/bikunin precursor
chr14_+_102672745	1.616		TNFAIP2	tumor necrosis factor, alpha-induced protein 2
chr19_+_41051186	1.600	NM_001024807 NM_005166	APLP1	amyloid beta (A4) precursor-like protein 1
chr10_-_99521701	1.599	NM_003015	SFRP5	secreted frizzled-related protein 5
chr14_-_24148658	1.597	NM_033423	GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)
chr22_+_21011653	1.596
chr9_+_138760432	1.587		LOC100128593	hypothetical LOC100128593
chr1_+_152644471	1.581		IL6R	interleukin 6 receptor
chr17_+_27795598	1.579		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_70662364	1.578	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chr19_-_61039939	1.562	NM_145007	NLRP11	NLR family, pyrin domain containing 11
chr12_+_63084317	1.559	NM_007235	XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chr16_-_70763524	1.554	NM_031293	PMFBP1	polyamine modulated factor 1 binding protein 1
chr5_+_176955595	1.550
chr8_-_144887876	1.550	NM_198488	FAM83H	family with sequence similarity 83, member H
chr19_+_55398680	1.542	NM_001077186 NM_001145809 NM_024729	MYH14	myosin, heavy chain 14, non-muscle
chr22_+_20880112	1.515
chr10_-_73281047	1.511		PSAP	prosaposin
chr2_-_42844705	1.511	NM_148962	OXER1	oxoeicosanoid (OXE) receptor 1
chr9_-_122728173	1.509		TRAF1	TNF receptor-associated factor 1
chr6_-_28429950	1.504	NM_145909	ZNF323	zinc finger protein 323
chr16_+_73810383	1.502	NM_001906	CTRB1 CTRB2	chymotrypsinogen B1 chymotrypsinogen B2
chr6_+_150112511	1.490	NM_005389	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr20_-_43889339	1.486	NM_003279	TNNC2	troponin C type 2 (fast)
chr19_-_1989937	1.482		MKNK2	MAP kinase interacting serine/threonine kinase 2
chr20_+_42273013	1.465		LOC100505783	hypothetical LOC100505783
chr4_-_191143017	1.460	NM_020040	TUBB4Q	tubulin, beta polypeptide 4, member Q
chr10_+_88418243	1.459	NM_001080116 NM_001080114 NM_001080115 NM_001171611 NM_007078	LDB3	LIM domain binding 3
chr17_+_27795645	1.457		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_199390183	1.456		TMEM9	transmembrane protein 9
chrX_+_41078787	1.449		DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr5_+_132237253	1.441	NM_052971	LEAP2	liver expressed antimicrobial peptide 2
chr17_-_62793129	1.425	NM_002816 NM_174871	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr14_+_19681734	1.423	NM_001004724	OR4N5	olfactory receptor, family 4, subfamily N, member 5
chr6_+_150112549	1.418		PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr4_+_155707089	1.415		FGB	fibrinogen beta chain
chr11_+_10433241	1.410	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr22_+_43451600	1.403		PRR5	proline rich 5 (renal)
chr1_+_152644292	1.391	NM_000565 NM_181359	IL6R	interleukin 6 receptor
chr17_+_1578083	1.390		WDR81	WD repeat domain 81
chr12_+_54910767	1.383	NM_001135195	SLC39A5	solute carrier family 39 (metal ion transporter), member 5
chr14_-_21108714	1.379	NM_001005465	OR10G3	olfactory receptor, family 10, subfamily G, member 3
chr4_-_26100986	1.366	NM_000730	CCKAR	cholecystokinin A receptor
chr17_+_27795635	1.364		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr14_-_95011790	1.353	NM_152592	C14orf49	chromosome 14 open reading frame 49
chr9_+_139041736	1.346	NM_207511	C9orf139	chromosome 9 open reading frame 139
chr3_+_142525744	1.331	NM_001080412	ZBTB38	zinc finger and BTB domain containing 38
chr21_+_31953803	1.321	NM_000454	SOD1	superoxide dismutase 1, soluble
chr2_-_169596078	1.313	NM_003742	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr11_+_74548472	1.311	NM_001145211	SLCO2B1	solute carrier organic anion transporter family, member 2B1
chr22_+_18388656	1.310		C22orf25	chromosome 22 open reading frame 25

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.28	1.08e-04	GO:0050896	response to stimulus
6.02	2.46e-04	GO:0032313	regulation of Rab GTPase activity
6.02	2.46e-04	GO:0032483	regulation of Rab protein signal transduction
5.32	4.41e-04	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
5.32	4.41e-04	GO:0072395	signal transduction involved in cell cycle checkpoint
5.32	4.41e-04	GO:0072401	signal transduction involved in DNA integrity checkpoint
5.32	4.41e-04	GO:0072404	signal transduction involved in G1/S transition checkpoint
5.32	4.41e-04	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
5.32	4.41e-04	GO:0072422	signal transduction involved in DNA damage checkpoint
5.32	4.41e-04	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
5.32	4.41e-04	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
5.68	5.18e-04	GO:0006521	regulation of cellular amino acid metabolic process
4.90	5.25e-04	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.52	6.72e-04	GO:0051351	positive regulation of ligase activity
5.07	8.31e-04	GO:0071158	positive regulation of cell cycle arrest
3.93	1.12e-03	GO:0000077	DNA damage checkpoint
4.51	1.59e-03	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.77	1.82e-03	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
4.46	1.89e-03	GO:0051443	positive regulation of ubiquitin-protein ligase activity
4.34	2.65e-03	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.69	2.96e-03	GO:0031570	DNA integrity checkpoint
2.46	3.47e-03	GO:0009894	regulation of catabolic process
3.49	3.58e-03	GO:0032318	regulation of Ras GTPase activity
4.24	3.68e-03	GO:2000045	regulation of G1/S transition of mitotic cell cycle
3.94	4.56e-03	GO:0051340	regulation of ligase activity
4.71	5.21e-03	GO:0033238	regulation of cellular amine metabolic process
3.16	5.56e-03	GO:0010498	proteasomal protein catabolic process
3.16	5.56e-03	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
1.45	8.27e-03	GO:0006950	response to stress
3.17	8.87e-03	GO:0043087	regulation of GTPase activity
3.15	9.86e-03	GO:0033124	regulation of GTP catabolic process
1.68	1.00e-02	GO:0050790	regulation of catalytic activity
4.16	1.02e-02	GO:0000216	M/G1 transition of mitotic cell cycle
4.16	1.02e-02	GO:0031575	mitotic cell cycle G1/S transition checkpoint
4.16	1.02e-02	GO:0071779	G1/S transition checkpoint
3.86	1.23e-02	GO:0051438	regulation of ubiquitin-protein ligase activity
2.97	1.52e-02	GO:0030811	regulation of nucleotide catabolic process
2.97	1.52e-02	GO:0033121	regulation of purine nucleotide catabolic process
3.77	3.27e-02	GO:0030330	DNA damage response, signal transduction by p53 class mediator
2.39	3.63e-02	GO:0031329	regulation of cellular catabolic process
4.15	4.83e-02	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
6.25	2.50e-07	GO:0000502	proteasome complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
5.91	7.46e-05	GO:0005097	Rab GTPase activator activity
5.79	2.43e-03	GO:0003823	antigen binding
3.31	3.43e-02	GO:0005099	Ras GTPase activator activity