Motif ID: MSX1,2.p2

Z-value: 1.693


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX2chr5_+_1740841370.185.1e-01Click!
MSX1chr4_+_4912272-0.126.7e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_108032645 5.892 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr14_-_64479198 4.111 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr11_+_7574992 3.594 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_-_52060327 3.463 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr3_-_139315011 3.204 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr19_-_40696393 2.486 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr5_-_148738980 2.196 NM_014443
IL17B
interleukin 17B
chr4_+_155703581 2.181 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chrX_+_128966844 2.179 NM_021946
BCORL1
BCL6 corepressor-like 1
chr2_+_113542017 2.179 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr11_+_101693403 2.126 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr17_-_25685175 2.078 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chrX_-_15530112 2.043 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr17_-_19592178 1.950 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr21_-_36774257 1.929 NM_001146079
NM_144492
CLDN14

claudin 14

chr1_-_150328153 1.920 NM_001008536
TCHHL1
trichohyalin-like 1
chr3_+_25445071 1.883 RARB
retinoic acid receptor, beta
chr6_-_48186868 1.865 C6orf138
chromosome 6 open reading frame 138
chr4_+_71096830 1.846 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr2_-_180135559 1.810 NM_001113398
ZNF385B
zinc finger protein 385B
chr11_-_85074848 1.668 NM_152723
CCDC89
coiled-coil domain containing 89
chr17_-_36113502 1.603 NM_019016
KRT24
keratin 24
chr5_+_59819761 1.596 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr6_-_39801088 1.555 NM_145027
KIF6
kinesin family member 6
chr1_+_31654998 1.525 NM_001199038
SERINC2
serine incorporator 2
chr3_-_101316038 1.516 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr14_-_93324518 1.511 NM_178013
PRIMA1
proline rich membrane anchor 1
chr4_+_89115862 1.450 SPP1
secreted phosphoprotein 1
chr1_+_31655607 1.407 NM_001199037
SERINC2
serine incorporator 2
chr16_-_29817841 1.379 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr4_-_159311959 1.377 FAM198B
family with sequence similarity 198, member B
chr3_+_25444753 1.338 NM_016152
RARB
retinoic acid receptor, beta
chr7_-_96471544 1.333 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr12_+_32546243 1.297 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_-_150422474 1.291 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_+_89115825 1.282 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr17_+_72380323 1.273 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr12_-_6354818 1.229 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_-_50871953 1.206 NM_001081492
NM_182507
KRT80

keratin 80

chr2_+_84597087 1.200 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr1_+_151456683 1.196 NM_001195571
PRR9
proline rich 9
chr14_-_49543987 1.191 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr4_+_89115892 1.169 SPP1
secreted phosphoprotein 1
chr2_-_192420168 1.159 NM_004657
SDPR
serum deprivation response
chr10_-_74384485 1.117 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr8_-_110689396 1.083 SYBU
syntabulin (syntaxin-interacting)
chr20_-_48686832 1.058 NM_080829
FAM65C
family with sequence similarity 65, member C
chr2_-_165133239 1.038 GRB14
growth factor receptor-bound protein 14
chr10_+_124310170 1.037 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr14_+_20595820 1.036 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr3_+_187866464 1.026 NM_000412
HRG
histidine-rich glycoprotein
chr8_-_15140162 1.021 NM_139167
SGCZ
sarcoglycan, zeta
chr4_+_77575276 1.019 NM_020859
SHROOM3
shroom family member 3
chr20_+_31613800 1.005 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr13_+_51496679 0.983 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr2_-_104834344 0.973 LOC100506421
hypothetical LOC100506421
chr5_-_90645974 0.970 LOC100505994
hypothetical LOC100505994
chr2_-_134042500 0.962 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr12_+_99712504 0.957 NM_178826
ANO4
anoctamin 4
chr10_-_62002672 0.952 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_162808123 0.925 NM_004460
FAP
fibroblast activation protein, alpha
chr7_+_111850367 0.922 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr5_+_34723420 0.917 NM_001145523
RAI14
retinoic acid induced 14
chr3_+_25444837 0.915 NM_000965
RARB
retinoic acid receptor, beta
chr3_-_150578207 0.903 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr7_-_13992351 0.888 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr17_+_65582981 0.886 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_+_7039453 0.885


chr10_-_74384569 0.881 PLA2G12B
phospholipase A2, group XIIB
chr3_-_150578148 0.881 TM4SF1
transmembrane 4 L six family member 1
chr4_-_66218777 0.880 EPHA5
EPH receptor A5
chr11_+_130745580 0.863 NM_001048209
NTM
neurotrimin
chr9_-_115880372 0.851 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_+_7785331 0.844 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_90252990 0.842 NM_145715
TIGD2
tigger transposable element derived 2
chr2_-_192419896 0.826 SDPR
serum deprivation response
chrX_-_19598912 0.810 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr10_+_7785360 0.806 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_-_56615544 0.802 NM_001723
NM_015548
DST

dystonin

chr6_+_71192862 0.797 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr9_-_126309510 0.788 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr9_+_18464138 0.777 ADAMTSL1
ADAMTS-like 1
chr20_+_71230 0.772 NM_030931
DEFB126
defensin, beta 126
chr4_+_89115923 0.771 SPP1
secreted phosphoprotein 1
chrX_+_115481774 0.767 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_+_70119785 0.767 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr11_-_128567302 0.761 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr9_-_115880425 0.759 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_-_70760381 0.752 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr15_-_64644758 0.738 NM_207338
LCTL
lactase-like
chr7_+_80145461 0.736 CD36
CD36 molecule (thrombospondin receptor)
chr4_+_74566325 0.720 NM_001133
AFM
afamin
chr12_-_69837831 0.704 TSPAN8
tetraspanin 8
chr5_-_56814310 0.698 NM_001017992
ACTBL2
actin, beta-like 2
chr6_-_31215089 0.686 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr1_+_31823097 0.685 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr18_+_19826734 0.661 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr3_-_167037946 0.654 NM_000055
BCHE
butyrylcholinesterase
chr12_-_6354650 0.651 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_+_46591048 0.650 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr5_+_73145098 0.647 RGNEF
190 kDa guanine nucleotide exchange factor
chr6_+_50894397 0.644 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr9_-_115880281 0.635 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_+_101316463 0.601 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr3_+_101720753 0.601 TMEM45A
transmembrane protein 45A
chr4_+_71330797 0.600 NM_001145006
MUC7
mucin 7, secreted
chr6_+_16237300 0.592 MYLIP
myosin regulatory light chain interacting protein
chr9_+_110664366 0.583 NM_006687
ACTL7A
actin-like 7A
chr6_-_31789824 0.574


chr8_-_8276598 0.568 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr1_+_110361634 0.554 AHCYL1
adenosylhomocysteinase-like 1
chr11_-_8789457 0.550 NM_139157
ST5
suppression of tumorigenicity 5
chr7_-_16471817 0.549 NM_015464
SOSTDC1
sclerostin domain containing 1
chr5_+_68703036 0.542 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr2_-_237987554 0.534 COL6A3
collagen, type VI, alpha 3
chr2_+_102169864 0.533 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr17_-_15109315 0.531 NM_000304
PMP22
peripheral myelin protein 22
chr10_+_115501202 0.525 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr2_-_237987579 0.517 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr3_-_127810087 0.511 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr2_+_220033777 0.509 NM_001173476
SPEG
SPEG complex locus
chr5_+_139856688 0.508 ANKHD1
ankyrin repeat and KH domain containing 1
chr21_-_30460841 0.505 NM_012131
CLDN17
claudin 17
chr2_-_237987545 0.505 COL6A3
collagen, type VI, alpha 3
chr2_-_237987553 0.499 COL6A3
collagen, type VI, alpha 3
chrX_+_115481848 0.498 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_+_7785290 0.492 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785347 0.483 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_-_55042614 0.481 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr2_-_237987509 0.480 COL6A3
collagen, type VI, alpha 3
chr16_-_21197072 0.478 CRYM
crystallin, mu
chr2_+_234209838 0.477 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr1_+_151596953 0.472 NM_002965
S100A9
S100 calcium binding protein A9
chr16_+_55042924 0.460 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr16_+_55042936 0.440 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr5_-_13997588 0.437 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr9_-_115880366 0.434 AMBP
alpha-1-microglobulin/bikunin precursor
chr5_-_59819642 0.432 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_51112743 0.431 NRXN1
neurexin 1
chr16_+_80626402 0.422 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_+_116238309 0.419 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr14_+_51025604 0.417 NM_001042481
FRMD6
FERM domain containing 6
chr1_+_162795328 0.417 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr1_-_149245503 0.415 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr13_+_100902942 0.409 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_+_12622286 0.405


chr8_-_22145795 0.396 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr3_-_121884091 0.395 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr16_+_80626459 0.394 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr10_-_51678318 0.391 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr16_+_80626456 0.386 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_21087435 0.385 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_67943157 0.377 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr1_+_200246370 0.376 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr16_-_11918019 0.374 NM_001130007
GSPT1
G1 to S phase transition 1
chr2_-_215957927 0.372 FN1
fibronectin 1
chr8_-_145613058 0.369 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr5_+_60969392 0.369 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr4_-_155753332 0.368 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr19_+_53016910 0.366 NM_000554
CRX
cone-rod homeobox
chr9_+_134843918 0.364 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr11_-_64484184 0.362 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr9_-_110658030 0.361 NM_006686
ACTL7B
actin-like 7B
chr17_+_38306339 0.360 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr8_+_67096344 0.359 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr2_+_138438277 0.358 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr14_+_22375632 0.357 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr10_+_685887 0.353 C10orf108
chromosome 10 open reading frame 108
chr19_-_14030970 0.352 NM_001145028
PALM3
paralemmin 3
chr13_-_45577144 0.349 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr2_-_56266408 0.349 LOC100129434
hypothetical LOC100129434
chr3_+_125586241 0.347 KALRN
kalirin, RhoGEF kinase
chr11_-_102100833 0.347 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr12_+_52105131 0.341 AMHR2
anti-Mullerian hormone receptor, type II
chr6_-_26038817 0.339 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr3_-_167037861 0.337 BCHE
butyrylcholinesterase
chr1_+_78243181 0.333 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr8_-_145613034 0.332 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr1_+_195055483 0.329 NM_002113
CFHR1
complement factor H-related 1
chr8_+_75899326 0.326 NM_015886
PI15
peptidase inhibitor 15
chr5_+_36644187 0.324 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_150578103 0.318 TM4SF1
transmembrane 4 L six family member 1
chr13_-_85271329 0.318 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr2_-_21081694 0.314 APOB
apolipoprotein B (including Ag(x) antigen)
chr12_+_108038774 0.313 ACACB
acetyl-CoA carboxylase beta
chr5_+_126887056 0.309 PRRC1
proline-rich coiled-coil 1
chr2_-_219614481 0.308 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr14_-_104330982 0.308 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr12_-_9252227 0.302 NM_002864
PZP
pregnancy-zone protein
chr12_+_79362256 0.300 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr1_+_100089118 0.299 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr3_+_161877640 0.292 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr10_+_7785235 0.291 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_15038726 0.284 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_+_132901119 0.281 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr7_+_94377145 0.279 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr3_-_150578023 0.275 TM4SF1
transmembrane 4 L six family member 1
chr3_+_185300660 0.268 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chrX_-_43717864 0.266 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_+_40977092 0.263 NFYC
nuclear transcription factor Y, gamma

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.79 5.47e-04 GO:0005576 extracellular region
2.16 1.11e-03 GO:0044421 extracellular region part
2.23 6.23e-03 GO:0005615 extracellular space
23.17 4.41e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.37 4.28e-02 GO:0043498 cell surface binding