Motif ID: PAX6.p2

Z-value: 0.648


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX6chr11_-_31796061-0.283.2e-01Click!


Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_165564904 1.716 NM_001198783
POU2F1
POU class 2 homeobox 1
chr1_+_165565006 1.681 POU2F1
POU class 2 homeobox 1
chr6_-_131333173 1.671 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr10_+_35934343 1.087 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr5_-_135259403 1.069 NM_000590
IL9
interleukin 9
chr6_-_42270671 0.872 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr16_+_70646008 0.763 NM_001126102
NM_005143
HP

haptoglobin

chr9_+_102380156 0.669 NM_001018116
MURC
muscle-related coiled-coil protein
chr15_-_48192804 0.610 ATP8B4
ATPase, class I, type 8B, member 4
chr16_+_70654625 0.596 NM_020995
HPR
haptoglobin-related protein
chr2_+_39000007 0.593 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr15_+_49760841 0.526 NM_001165257
NM_013243
SCG3

secretogranin III

chr1_-_31117948 0.506 SDC3
syndecan 3
chr5_-_142057692 0.472 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr8_+_39911630 0.448 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr3_-_15538164 0.438 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr8_-_21827057 0.415 NM_003974
DOK2
docking protein 2, 56kDa
chr2_+_170074457 0.395 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chrX_-_15242589 0.348 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr4_-_174557191 0.343 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr15_+_27001131 0.339 NM_001130414
NM_005503
APBA2

amyloid beta (A4) precursor protein-binding, family A, member 2

chr8_+_21972804 0.329 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr4_-_26100986 0.321 NM_000730
CCKAR
cholecystokinin A receptor
chr19_-_56825400 0.321 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr11_+_4859624 0.310 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr2_+_178893216 0.290 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr3_-_120861959 0.287 NM_022135
POPDC2
popeye domain containing 2
chr4_+_114190233 0.264 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr19_+_56990222 0.261 NM_002030
FPR3
formyl peptide receptor 3
chr1_+_113038202 0.260 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_+_123600553 0.257 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chrX_-_123925343 0.256 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr16_-_11282595 0.255 NM_002761
PRM1
protamine 1
chr6_-_10520264 0.253 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr8_-_27524744 0.253 NM_203339
CLU
clusterin
chr2_-_157890400 0.243 NM_020711
ERMN
ermin, ERM-like protein
chr22_+_24468168 0.238 MYO18B
myosin XVIIIB
chr17_-_1195096 0.228 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr12_+_108035424 0.225


chrX_-_130251068 0.223 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr9_-_94206648 0.220 NM_014057
NM_033014
OGN

osteoglycin

chr1_+_145841569 0.219 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr12_-_68379331 0.216 NM_032735
BEST3
bestrophin 3
chr5_+_40945315 0.205 NM_000587
C7
complement component 7
chr22_+_38652555 0.200 GRAP2
GRB2-related adaptor protein 2
chr1_+_108794426 0.199 NM_001143987
NM_001143988
NBPF4
NBPF6

neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6

chr1_+_51855133 0.197 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chrX_-_65176564 0.195 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr11_-_5178505 0.187 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr11_-_117253354 0.185 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr2_-_171631728 0.184 NM_001136555
TLK1
tousled-like kinase 1
chr1_-_209732881 0.183 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr5_+_180399871 0.182 BTNL9
butyrophilin-like 9
chr6_+_25760352 0.180 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr3_-_196792059 0.179 APOD
apolipoprotein D
chr12_-_131725848 0.179 POLE
polymerase (DNA directed), epsilon
chr11_+_19328846 0.179 NM_001111018
NAV2
neuron navigator 2
chr5_+_42792676 0.176 NM_001134848
CCDC152
coiled-coil domain containing 152
chr1_+_61697209 0.173 NFIA
nuclear factor I/A
chr20_+_31713750 0.172 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr19_+_15920817 0.170 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr1_+_51855343 0.162 OSBPL9
oxysterol binding protein-like 9
chr5_+_180399830 0.162 NM_152547
BTNL9
butyrophilin-like 9
chr20_-_45360903 0.156 ZMYND8
zinc finger, MYND-type containing 8
chrX_-_130250880 0.152 IGSF1
immunoglobulin superfamily, member 1
chr19_+_59941785 0.148 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr7_-_26198673 0.146 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr5_+_40945244 0.146 C7
complement component 7
chr17_-_36276987 0.144 NM_000223
KRT12
keratin 12
chr8_-_27525084 0.144 NM_001171138
CLU
clusterin
chr14_+_28311740 0.144 C14orf23
chromosome 14 open reading frame 23
chr8_-_62764839 0.143 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr11_+_76561471 0.141 MYO7A
myosin VIIA
chrX_-_106336199 0.141 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr16_-_46823682 0.139 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chrX_-_135783496 0.138


chr15_+_63124760 0.135 NM_178859
OSTBETA
organic solute transporter beta
chr6_-_10520592 0.130 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_48127911 0.130 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr14_-_20694023 0.129 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr3_-_129668780 0.129 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr1_-_12830728 0.127 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr17_-_36294962 0.124 NM_019010
KRT20
keratin 20
chr3_+_134978615 0.122 TF
transferrin
chr12_+_55201854 0.118 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr11_+_119862014 0.118 ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr22_-_48865907 0.117 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_169657312 0.114 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_28591542 0.112 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr3_+_16949585 0.112 NM_015184
PLCL2
phospholipase C-like 2
chr1_+_207944807 0.111 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_-_8602601 0.110 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr10_-_7699192 0.108 ITIH5
inter-alpha (globulin) inhibitor H5
chr1_-_246804680 0.104 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr11_-_95715976 0.101 NM_032427
MAML2
mastermind-like 2 (Drosophila)
chr1_+_87153025 0.096 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr5_-_79982584 0.095 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr6_+_155579788 0.095 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_-_76823813 0.094


chr4_+_187385618 0.094 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr16_+_68705029 0.093 NM_017990
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr5_-_94250357 0.092 MCTP1
multiple C2 domains, transmembrane 1
chr9_-_139262009 0.092 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr7_-_107930170 0.091 PNPLA8
patatin-like phospholipase domain containing 8
chr10_+_18280773 0.091 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chrX_-_13745134 0.088 GPM6B
glycoprotein M6B
chr2_+_62787534 0.086 NM_001142614
EHBP1
EH domain binding protein 1
chr2_-_133256097 0.086 NCKAP5
NCK-associated protein 5
chrX_-_52700674 0.084 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr10_+_114033403 0.081 NM_058222
TECTB
tectorin beta
chr10_-_45350804 0.078 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr11_+_117680504 0.075 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr5_+_121493113 0.074 NM_207317
ZNF474
zinc finger protein 474
chr1_+_97033103 0.072


chr13_+_52500830 0.069 NM_006418
OLFM4
olfactomedin 4
chrX_+_49718954 0.064 NM_000084
CLCN5
chloride channel 5
chr3_-_148605996 0.063 NM_001168379
ZIC4
Zic family member 4
chr17_-_31831093 0.061 NM_001123392
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
TBC1 domain family, member 3F
chr8_+_7340777 0.060 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr1_-_108588186 0.059 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chrX_+_52797004 0.058 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr6_-_134415311 0.057 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr8_-_7710547 0.054 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr15_+_43331719 0.047 NM_004212
SLC28A2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chrX_-_13744933 0.044 GPM6B
glycoprotein M6B
chr12_+_9925354 0.044 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr1_+_202033273 0.043 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr20_-_32877029 0.042 NM_014071
NCOA6
nuclear receptor coactivator 6
chr15_-_23204887 0.042 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr17_-_31616071 0.039 NM_001001418
NM_032258
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr3_-_109730858 0.038 NM_014981
MYH15
myosin, heavy chain 15
chr19_+_54299686 0.038 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr3_-_14558591 0.038 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr10_+_102212787 0.037 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr2_-_215951161 0.037 FN1
fibronectin 1
chr5_+_140742585 0.035 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr4_+_100714995 0.033 MTTP
microsomal triglyceride transfer protein
chr5_-_58918031 0.033 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_119224506 0.033 NM_012240
SIRT4
sirtuin 4
chr3_+_122769467 0.032 NM_001012659
ARGFX
arginine-fifty homeobox
chrX_-_13745108 0.032 GPM6B
glycoprotein M6B
chr21_-_30855478 0.031 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr20_+_18070867 0.030 NM_020536
CSRP2BP
CSRP2 binding protein
chr17_-_34209671 0.030 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr1_+_148747208 0.030 ECM1
extracellular matrix protein 1
chr6_+_101953581 0.029 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr6_+_101953389 0.029 GRIK2
glutamate receptor, ionotropic, kainate 2
chr3_+_153499883 0.027 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr12_+_103206625 0.026 TXNRD1
thioredoxin reductase 1
chr3_+_134601479 0.025 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr16_-_71650034 0.025 NM_001164766
ZFHX3
zinc finger homeobox 3
chr7_+_22733290 0.024 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr6_+_167624792 0.024 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chrX_+_144716619 0.023 NM_004709
CXorf1
chromosome X open reading frame 1
chr1_+_148747110 0.023 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr16_-_29514140 0.022


chr2_-_199922047 0.022 SATB2
SATB homeobox 2
chr8_-_93181091 0.021 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_13745234 0.021 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr4_+_71261066 0.020 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr2_+_38746742 0.020 GALM
galactose mutarotase (aldose 1-epimerase)
chr7_+_80105907 0.019 CD36
CD36 molecule (thrombospondin receptor)
chrX_-_48156287 0.018 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr3_+_115495522 0.016 NM_173799
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr7_+_72913424 0.013 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr2_-_200033445 0.012 SATB2
SATB homeobox 2
chrX_+_36163971 0.012 NM_001098843
CXorf30
chromosome X open reading frame 30
chr19_-_59019240 0.012 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr11_-_4827013 0.011 NM_001004758
OR51S1
olfactory receptor, family 51, subfamily S, member 1
chr17_-_33552166 0.010 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr13_+_23742846 0.010 SPATA13
spermatogenesis associated 13
chr6_-_50097606 0.010 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr17_+_55854636 0.010 NM_181707
C17orf64
chromosome 17 open reading frame 64
chr3_-_121117647 0.008 GSK3B
glycogen synthase kinase 3 beta
chr9_+_122923864 0.008 CEP110
centrosomal protein 110kDa
chr8_-_59575249 0.006 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr12_-_69317441 0.005 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_+_55617328 0.004 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr7_+_80105718 0.003 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr4_-_170314382 0.003 SH3RF1
SH3 domain containing ring finger 1
chr16_-_18845223 0.003 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr17_-_33602374 0.002 NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr2_-_138762909 0.001



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.65 8.54e-04 GO:0046578 regulation of Ras protein signal transduction
13.10 3.72e-03 GO:0032313 regulation of Rab GTPase activity
13.10 3.72e-03 GO:0032483 regulation of Rab protein signal transduction
6.94 1.24e-02 GO:0032318 regulation of Ras GTPase activity
5.99 3.56e-02 GO:0043087 regulation of GTPase activity
5.95 3.74e-02 GO:0033124 regulation of GTP catabolic process
3.82 4.36e-02 GO:0051056 regulation of small GTPase mediated signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.85 9.38e-04 GO:0005097 Rab GTPase activator activity