Motif ID: RXRG_dimer.p3

Z-value: 1.415


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_332761410.741.5e-03Click!
RXRAchr9_+_136358134-0.553.3e-02Click!
PPARAchr22_+_44925162-0.515.0e-02Click!
PPARGchr3_+_12304332-0.421.2e-01Click!
NR1H2chr19_+_555714930.136.3e-01Click!
RXRGchr1_-_1636809410.107.2e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_48792574 1.637 NM_001145347
ZNF576
zinc finger protein 576
chr18_-_44730706 1.618 SMAD7
SMAD family member 7
chr2_-_175754366 1.548 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr17_+_35532994 1.537 MSL1
male-specific lethal 1 homolog (Drosophila)
chr19_+_44308224 1.404 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr3_+_142587973 1.346


chr3_+_46514488 1.271 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr2_+_177965617 1.211 NM_003659
AGPS
alkylglycerone phosphate synthase
chr2_-_177965626 1.190 LOC100130691
hypothetical LOC100130691
chr18_-_50004458 1.122 MBD2
methyl-CpG binding domain protein 2
chr2_+_108604111 1.089 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_177965734 1.087 AGPS
alkylglycerone phosphate synthase
chr9_-_138277467 1.065 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr11_+_118374071 1.027 CCDC84
coiled-coil domain containing 84
chr18_-_50004770 1.023 MBD2
methyl-CpG binding domain protein 2
chr1_+_61320213 1.022 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr11_+_118374051 1.002 NM_198489
CCDC84
coiled-coil domain containing 84
chr1_+_101263989 0.995


chr12_-_117294933 0.992 TAOK3
TAO kinase 3
chr18_-_44731078 0.981 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr20_+_55569542 0.966 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr5_-_176914143 0.956 NM_001190946
FAM193B
family with sequence similarity 193, member B
chr13_+_99539269 0.938 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr18_+_52469559 0.931 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr2_-_219141199 0.913 NM_020935
USP37
ubiquitin specific peptidase 37
chr11_-_123261549 0.900 NM_001013743
TMEM225
transmembrane protein 225
chr9_+_114182216 0.867 HSDL2
hydroxysteroid dehydrogenase like 2
chr1_+_43628186 0.844 C1orf84
chromosome 1 open reading frame 84
chr6_-_146327238 0.823 SHPRH
SNF2 histone linker PHD RING helicase
chr3_+_37259684 0.823 NM_001172713
NM_002078
GOLGA4

golgin A4

chr1_-_101263867 0.821 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr4_-_4594620 0.783 STX18
syntaxin 18
chr4_-_4594591 0.782 STX18
syntaxin 18
chr2_+_108432008 0.772 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr12_-_117295095 0.771 NM_016281
TAOK3
TAO kinase 3
chr6_-_146326918 0.768 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr6_+_144040751 0.762 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr14_-_94693359 0.757 DICER1
dicer 1, ribonuclease type III
chr2_+_161725172 0.727 TANK
TRAF family member-associated NFKB activator
chr12_+_65949631 0.669 CAND1
cullin-associated and neddylation-dissociated 1
chr20_+_37024383 0.669 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr6_-_32034607 0.667 NM_002904
RDBP
RD RNA binding protein
chr12_+_14429499 0.656 ATF7IP
activating transcription factor 7 interacting protein
chr1_-_32632601 0.638 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr5_+_1854493 0.636 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr12_-_52407470 0.635 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr19_+_50086482 0.632 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr12_-_6995988 0.631 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr12_+_67489063 0.614 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr17_+_38403991 0.613 RPL27
ribosomal protein L27
chr11_+_86426518 0.609 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr22_+_28493351 0.603 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr20_+_43943254 0.594 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr7_-_139409989 0.580 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr1_-_149404954 0.575 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr2_+_206732859 0.559 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr1_+_78126787 0.556 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr19_-_50271527 0.548 NM_145288
ZNF296
zinc finger protein 296
chr1_+_44870256 0.539 RNF220
ring finger protein 220
chr19_+_16169664 0.530 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr17_+_38403935 0.528 NM_000988
RPL27
ribosomal protein L27
chr6_-_146326863 0.525 SHPRH
SNF2 histone linker PHD RING helicase
chr2_+_73294852 0.524 NM_006062
SMYD5
SMYD family member 5
chr20_-_7869068 0.523 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_+_109761170 0.514 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr1_+_43628136 0.507 NM_001012961
C1orf84
chromosome 1 open reading frame 84
chr12_-_49708279 0.490 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr6_+_143813472 0.490 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr6_+_142510094 0.486 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr19_+_10223912 0.483 MRPL4
mitochondrial ribosomal protein L4
chr2_+_108432097 0.483 GCC2
GRIP and coiled-coil domain containing 2
chr7_-_106991941 0.481 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr12_-_93991235 0.474 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr1_-_43628035 0.471 MED8
mediator complex subunit 8
chr6_+_142510108 0.452 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_-_142816019 0.447 NM_005232
EPHA1
EPH receptor A1
chr3_+_185538998 0.445 FAM131A
family with sequence similarity 131, member A
chr7_+_128136347 0.445 FAM71F1
family with sequence similarity 71, member F1
chr8_+_96106362 0.443 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr12_+_94776901 0.441 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr7_-_100630912 0.437 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr12_+_94776836 0.436 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr16_-_45565068 0.435 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr16_-_86527608 0.421 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr4_+_4594619 0.419 LOC100507266
hypothetical LOC100507266
chr20_+_30409649 0.417 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr2_+_159021653 0.415 PKP4
plakophilin 4
chr12_+_65949414 0.412 CAND1
cullin-associated and neddylation-dissociated 1
chr14_-_20642214 0.404


chr1_-_43628060 0.395 NM_052877
NM_201542
MED8

mediator complex subunit 8

chr4_+_91035025 0.393 NM_007351
MMRN1
multimerin 1
chr5_+_92944680 0.392 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_14717803 0.375 FAM105B
family with sequence similarity 105, member B
chr6_-_33879734 0.370 NM_001040109
NM_001184698
NM_002418
MLN


motilin


chr4_+_140806536 0.364 MGST2
microsomal glutathione S-transferase 2
chr6_+_31731647 0.362 NM_019101
APOM
apolipoprotein M
chr22_+_49368320 0.353 LOC100144603
hypothetical transcript
chr3_-_48911231 0.347 NM_000387
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr2_+_119841611 0.346 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr3_-_12856948 0.344 NM_001007074
RPL32
ribosomal protein L32
chr6_-_146327155 0.332 SHPRH
SNF2 histone linker PHD RING helicase
chr11_+_85690900 0.331 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr18_-_45594206 0.328 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr1_-_224441024 0.328 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr1_-_154147687 0.326 RIT1
Ras-like without CAAX 1
chr20_+_19981157 0.325 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr7_+_142789476 0.323 ZYX
zyxin
chr1_-_224441023 0.320 ACBD3
acyl-CoA binding domain containing 3
chr12_+_65949327 0.312 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr9_+_114182009 0.308 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr1_-_39815048 0.306 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr10_-_103805858 0.305 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr19_+_44082410 0.303 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr18_+_27852785 0.301 RNF125
ring finger protein 125
chr19_+_44082458 0.299 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr2_+_27966985 0.292 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr16_+_3102556 0.292 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr19_-_46504831 0.289


chr1_-_6684426 0.282 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr4_-_7120656 0.273 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr6_+_142510075 0.272 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr19_+_6323443 0.263 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr6_+_32034559 0.262 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr1_-_6684465 0.262 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr15_+_41672543 0.261 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr10_-_119795663 0.261 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr5_+_172416959 0.258 C5orf41
chromosome 5 open reading frame 41
chr17_-_7064092 0.258 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr7_+_142790047 0.255 ZYX
zyxin
chr14_+_94693744 0.253 FLJ45244
hypothetical locus FLJ45244
chr4_-_4594648 0.251 NM_016930
STX18
syntaxin 18
chr1_-_95311031 0.251 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr3_+_46423682 0.249 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr17_-_1342700 0.248 NM_001080779
MYO1C
myosin IC
chr17_+_7063970 0.242 ACADVL
acyl-CoA dehydrogenase, very long chain
chr1_-_172153087 0.239 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr14_-_94693418 0.236 NM_177438
DICER1
dicer 1, ribonuclease type III
chr9_+_88086932 0.228


chr19_+_10223886 0.228 MRPL4
mitochondrial ribosomal protein L4
chr2_-_27966715 0.228 NM_022128
RBKS
ribokinase
chr2_+_138438277 0.226 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr22_+_40195058 0.226 NM_001098
ACO2
aconitase 2, mitochondrial
chr2_-_206732348 0.225 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr1_-_172153024 0.221 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr19_-_10540328 0.215 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr10_+_119796324 0.212 CASC2
cancer susceptibility candidate 2
chr20_-_19981005 0.211 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr6_+_31731667 0.209 APOM
apolipoprotein M
chr5_-_32480174 0.205


chr12_+_105692466 0.204 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr15_-_80342045 0.202 EFTUD1
elongation factor Tu GTP binding domain containing 1
chr2_+_218992053 0.202 NM_007127
VIL1
villin 1
chr19_+_60691733 0.201 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr16_-_45564984 0.195 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr21_+_44256630 0.193 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr17_+_7474128 0.190 SHBG
sex hormone-binding globulin
chr6_-_2696152 0.189 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr6_+_32034767 0.189 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr2_+_74610751 0.188 HTRA2
HtrA serine peptidase 2
chr4_+_140806371 0.187 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr1_+_44870223 0.185 RNF220
ring finger protein 220
chr19_-_10540620 0.185 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr4_-_84150885 0.184 LIN54
lin-54 homolog (C. elegans)
chr15_+_94674849 0.183 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr12_+_67290951 0.179 RAP1B
RAP1BL
RAP1B, member of RAS oncogene family
RAP1B, member of RAS oncogene family pseudogene
chr12_+_67290881 0.178 NM_001010942
NM_015646
RAP1B

RAP1B, member of RAS oncogene family

chr17_+_71508581 0.176 NM_001258
CDK3
cyclin-dependent kinase 3
chr7_+_134567270 0.172 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr11_-_61415429 0.171 NM_021727
FADS3
fatty acid desaturase 3
chr1_+_113018989 0.169 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr19_-_60272708 0.169 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr11_+_116554597 0.166 SIDT2
SID1 transmembrane family, member 2
chrX_+_152423277 0.165 BGN
biglycan
chr18_-_45593852 0.163 ACAA2
acetyl-CoA acyltransferase 2
chr16_+_4415805 0.162 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr16_+_30617962 0.161 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr1_+_44451698 0.156 NM_001034023
NM_001034024
NM_019100
DMAP1


DNA methyltransferase 1 associated protein 1


chr12_+_48422220 0.155 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr20_+_41621079 0.154 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr8_-_81104938 0.151 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr16_-_30504309 0.151 NM_152458
ZNF785
zinc finger protein 785
chr2_-_64099935 0.150 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr1_-_43691932 0.149 HYI
hydroxypyruvate isomerase (putative)
chr2_+_206732562 0.148 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr2_-_159021201 0.143 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr8_-_103735194 0.142 NM_001032282
KLF10
Kruppel-like factor 10
chr1_-_39815002 0.142 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr15_-_80342131 0.142 NM_001040610
NM_024580
EFTUD1

elongation factor Tu GTP binding domain containing 1

chr14_-_20636337 0.141 ZNF219
zinc finger protein 219
chr18_+_45594326 0.139


chr17_+_7474177 0.139 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chrX_-_122694562 0.137 THOC2
THO complex 2
chr6_+_142510034 0.137 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr20_+_42593849 0.136 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr2_-_24160683 0.135 TP53I3
tumor protein p53 inducible protein 3
chr13_+_20612709 0.134 SAP18
Sin3A-associated protein, 18kDa
chr10_-_17211795 0.132 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr7_+_120415958 0.132 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr22_-_49368203 0.128 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
choline kinase-like, carnitine palmitoyltransferase 1B (muscle) transcription unit
chr14_+_23937766 0.128 NM_025081
NYNRIN
NYN domain and retroviral integrase containing

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.05 4.87e-03 GO:0005739 mitochondrion
2.44 1.76e-02 GO:0044429 mitochondrial part
1.23 3.86e-02 GO:0043231 intracellular membrane-bounded organelle
1.23 4.10e-02 GO:0043227 membrane-bounded organelle

Nothing significant found in function category.