Motif ID: VSX1,2.p2

Z-value: 1.176


Transcription factors associated with VSX1,2.p2:

Gene SymbolEntrez IDGene Name
VSX1 30813 visual system homeobox 1
VSX2 338917 visual system homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VSX2chr14_+_737759270.352.0e-01Click!
VSX1chr20_-_250107560.116.9e-01Click!


Activity profile for motif VSX1,2.p2.

activity profile for motif VSX1,2.p2


Sorted Z-values histogram for motif VSX1,2.p2

Sorted Z-values for motif VSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of VSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_127012611 6.516 NM_001048252
CTXN3
cortexin 3
chr2_+_17861266 6.396 NM_001105569
MSGN1
mesogenin 1
chr3_+_2528272 2.501 CNTN4
contactin 4
chr7_+_37689903 2.319


chr8_-_42742729 2.156 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr8_+_22266256 1.831 PIWIL2
piwi-like 2 (Drosophila)
chr12_+_28301399 1.794 NM_018318
CCDC91
coiled-coil domain containing 91
chr20_+_58004811 1.633 NM_021810
CDH26
cadherin 26
chr6_+_64289585 1.504 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_99238001 1.435 NM_175735
LYG2
lysozyme G-like 2
chr11_-_128399218 1.399 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_+_123256902 1.350 NM_175862
CD86
CD86 molecule
chr2_+_143351536 1.326 NM_001032998
NM_003937
KYNU

kynureninase

chr3_-_109730858 1.278 NM_014981
MYH15
myosin, heavy chain 15
chr21_-_34820916 1.128 NM_203418
RCAN1
regulator of calcineurin 1
chr12_+_15590552 1.126 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr4_-_138673014 1.112 PCDH18
protocadherin 18
chr4_-_138673078 1.043 NM_019035
PCDH18
protocadherin 18
chr1_-_108032645 1.020 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr14_-_94306104 0.915 NM_173849
GSC
goosecoid homeobox
chr11_-_128567302 0.896 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chrX_+_7147471 0.861 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr1_-_42549347 0.844


chr1_-_156013487 0.753 NM_030764
FCRL2
Fc receptor-like 2
chr4_-_90197140 0.712 NM_014883
FAM13A
family with sequence similarity 13, member A
chr15_+_97990705 0.693 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr11_-_118405288 0.688 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr10_+_24795446 0.664 KIAA1217
KIAA1217
chr6_-_166960496 0.661 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_57242492 0.652 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr1_-_156635879 0.644 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr3_+_182900081 0.640 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr11_+_59979857 0.635 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr2_-_218739891 0.601 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr8_-_10550026 0.595 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr1_+_111571803 0.585 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr18_-_28606839 0.585 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr14_-_106249999 0.579 IGHA1
immunoglobulin heavy constant alpha 1
chr11_+_59920062 0.571 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr12_+_15590811 0.569 PTPRO
protein tyrosine phosphatase, receptor type, O
chr18_+_44319365 0.551 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr7_+_2524022 0.540 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_35180656 0.538 NM_002399
MEIS2
Meis homeobox 2
chr18_+_59705918 0.502 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr10_-_56230953 0.478 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr13_+_47948586 0.477 RB1
retinoblastoma 1
chr1_+_117345894 0.473 NM_004258
CD101
CD101 molecule
chr12_-_25041639 0.469 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr7_+_50318801 0.462 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_-_171441234 0.459 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_+_29534109 0.456 NM_030883
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr3_+_110024234 0.434 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_+_100776280 0.425 NM_022049
GPR88
G protein-coupled receptor 88
chr14_-_59264044 0.423 NM_206857
RTN1
reticulon 1
chr3_+_113200696 0.413 NM_001008273
TAGLN3
transgelin 3
chr1_-_27825633 0.407 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chrX_-_21586337 0.404 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr11_-_20138445 0.393 NM_001029865
DBX1
developing brain homeobox 1
chr10_+_96433240 0.375 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr11_+_59804634 0.355 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr3_+_196933422 0.353 NM_152673
MUC20
mucin 20, cell surface associated
chr13_+_110637173 0.348 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_158098962 0.340 NM_001013661
VSIG8
V-set and immunoglobulin domain containing 8
chr5_-_56814310 0.326 NM_001017992
ACTBL2
actin, beta-like 2
chr19_-_51829778 0.321 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chrX_-_138617994 0.317 NM_001099855
NM_001171876
MCF2

MCF.2 cell line derived transforming sequence

chr6_+_132901119 0.301 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr13_-_33148899 0.298 STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_+_91620749 0.296 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr5_-_24535386 0.284 NM_001190450
CDH10
cadherin 10, type 2 (T2-cadherin)
chr12_+_18305740 0.283 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr4_-_74704964 0.281 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr21_-_36836767 0.279 NM_001146078
CLDN14
claudin 14
chr14_+_66901237 0.264 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_-_65013070 0.261 LOC400958
hypothetical LOC400958
chr6_-_166960690 0.257 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_169476391 0.250 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr16_+_31178812 0.235 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr6_+_155626838 0.234 NM_001001346
CLDN20
claudin 20
chr15_-_40236061 0.232 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr1_+_205293217 0.229 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chr6_-_116973465 0.228 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr5_+_71438796 0.227 NM_005909
MAP1B
microtubule-associated protein 1B
chrX_-_107221405 0.227 NM_002814
NM_170750
PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr8_+_9450800 0.210 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_+_66197108 0.206


chr22_+_39789945 0.205


chr8_-_134156437 0.200 SLA
Src-like-adaptor
chr9_-_21067804 0.198 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr9_-_205892 0.197 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_+_242582559 0.191 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr12_-_4358968 0.188 NM_020638
FGF23
fibroblast growth factor 23
chr1_-_45862225 0.188 NM_001114938
NM_001190182
CCDC17

coiled-coil domain containing 17

chr4_+_70831387 0.186 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr1_+_175406685 0.183 FAM5B
family with sequence similarity 5, member B
chr6_-_166960649 0.178 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_+_112337199 0.178 NM_000615
NM_001076682
NM_181351
NCAM1


neural cell adhesion molecule 1


chr12_-_55614311 0.177 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr12_+_103677388 0.175 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_-_47361921 0.171 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chrX_+_55951280 0.170


chrX_-_64112993 0.168 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr15_-_70350609 0.166 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr4_-_39655554 0.164 PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr12_-_51233001 0.161 NM_033448
KRT71
keratin 71
chr1_-_150653351 0.161 NM_016190
CRNN
cornulin
chr1_+_196874839 0.160 PTPRC
protein tyrosine phosphatase, receptor type, C
chr8_+_54926920 0.160 NM_170587
RGS20
regulator of G-protein signaling 20
chr3_-_166278969 0.160 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr1_+_173111306 0.151 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_33870411 0.151 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_28458546 0.147 NM_031459
SESN2
sestrin 2
chr16_+_47965308 0.144 NM_144602
C16orf78
chromosome 16 open reading frame 78
chr2_-_20390601 0.142 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr12_-_55960501 0.141 R3HDM2
R3H domain containing 2
chr8_+_9450832 0.137 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chrX_+_107174855 0.135 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr4_-_66218777 0.135 EPHA5
EPH receptor A5
chr1_+_28134090 0.132 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr12_-_119733062 0.123 SPPL3
signal peptide peptidase 3
chr7_+_1239078 0.111 NM_001080461
UNCX
UNC homeobox
chr7_+_141457977 0.110 LOC93432
maltase-glucoamylase-like pseudogene
chr2_+_201755865 0.107 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr18_+_3437607 0.106 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr3_+_2117246 0.106 NM_175607
CNTN4
contactin 4
chr11_-_16454493 0.097 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr6_+_127940011 0.091 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr1_-_153916221 0.089 NM_001198899
YY1AP1
YY1 associated protein 1
chr9_+_115396020 0.083 NM_144489
RGS3
regulator of G-protein signaling 3
chr11_+_26972244 0.083 FIBIN
fin bud initiation factor homolog (zebrafish)
chr19_+_54708302 0.080 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_-_45611110 0.076 NM_020956
NM_181882
PRX

periaxin

chr19_-_40711034 0.072 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr11_-_117640407 0.069 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr5_+_175041069 0.068 NM_022304
HRH2
histamine receptor H2
chr4_-_164614335 0.066 NM_032136
TKTL2
transketolase-like 2
chr2_-_101291483 0.066 NM_173647
RNF149
ring finger protein 149
chr19_-_41514390 0.065


chrX_+_108665665 0.064 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr11_-_117640078 0.064


chrX_-_23835868 0.063 NM_024122
APOO
apolipoprotein O
chr5_-_111119846 0.062 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr6_+_37511383 0.062


chr17_+_12510030 0.060 MYOCD
myocardin
chr17_+_18027816 0.059 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr12_-_52939636 0.055 NM_001127321
CBX5
chromobox homolog 5
chr7_+_128136347 0.053 FAM71F1
family with sequence similarity 71, member F1
chr11_+_17697685 0.053 NM_002478
MYOD1
myogenic differentiation 1
chr14_+_101345878 0.052 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr1_-_149681265 0.048 NM_207171
POGZ
pogo transposable element with ZNF domain
chr11_-_117640166 0.040 MPZL2
myelin protein zero-like 2
chr3_-_173911467 0.039 NM_001146276
NM_001146277
NM_001146278
NM_020792
NCEH1



neutral cholesterol ester hydrolase 1



chr4_-_39655944 0.038 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr13_-_34948758 0.038 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr3_+_113200275 0.036 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr20_-_19981005 0.034 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr11_+_26972203 0.033 NM_203371
FIBIN
fin bud initiation factor homolog (zebrafish)
chr11_-_36576352 0.032 NM_000536
RAG2
recombination activating gene 2
chr15_-_64644758 0.032 NM_207338
LCTL
lactase-like
chr1_-_230717850 0.031 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr4_+_88790477 0.029 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr7_-_25234582 0.028 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_220977180 0.028 NM_207468
FAM177B
family with sequence similarity 177, member B
chr8_-_87824996 0.025 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr18_-_65775139 0.024 NM_006566
CD226
CD226 molecule
chr17_-_26648375 0.021 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chrX_-_19727828 0.020 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr8_+_39911630 0.012 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr17_-_36165050 0.012 NM_181534
KRT25
keratin 25
chr1_-_23998515 0.012 NM_001127621
GALE
UDP-galactose-4-epimerase
chr3_+_99350859 0.010 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr7_+_113853790 0.006 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr17_+_7732759 0.004 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr3_+_110338250 0.003 FLJ22763
hypothetical LOC401081
chr1_-_149698272 0.001 POGZ
pogo transposable element with ZNF domain

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.31 2.02e-03 GO:0016337 cell-cell adhesion
2.20 1.94e-02 GO:0048583 regulation of response to stimulus
2.29 2.78e-02 GO:0023051 regulation of signaling
1.45 4.12e-02 GO:0050794 regulation of cellular process
123.38 4.60e-02 GO:0043415 positive regulation of skeletal muscle tissue regeneration
123.38 4.60e-02 GO:0043416 regulation of skeletal muscle tissue regeneration

Nothing significant found in compartment category.

Nothing significant found in function category.