Motif ID: IRF1,2,7.p3

Z-value: 3.088


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF1chr5_-_131854325-0.685.2e-03Click!
IRF2chr4_-_185632610-0.496.1e-02Click!
IRF7chr11_-_605649-0.146.2e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_88358946 8.483 FANCA
Fanconi anemia, complementation group A
chr1_+_78858675 5.973 NM_006820
 IFI44L
interferon-induced protein 44-like
chr9_-_21375258 5.656 NM_000605
 IFNA2
interferon, alpha 2
chr22_-_16080265 5.409 CECR1
cat eye syndrome chromosome region, candidate 1
chr9_+_5500544 5.018 NM_025239
 PDCD1LG2
programmed cell death 1 ligand 2
chr8_+_39890484 4.567 NM_002164
 IDO1
indoleamine 2,3-dioxygenase 1
chr11_-_63087430 4.390 NM_017878
 HRASLS2
HRAS-like suppressor 2
chr20_-_55628852 4.382 NM_001160417
NM_001160418
NM_001160419
NM_030776
 ZBP1



Z-DNA binding protein 1



chr22_-_34886727 4.124 NM_145640
 APOL3
apolipoprotein L, 3
chr7_+_150013716 4.076 NM_015660
 GIMAP2
GTPase, IMAP family member 2
chr4_-_169476391 4.036 NM_017631
 DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr11_-_104274606 3.999 NM_001191016
 CASP12
caspase 12 (gene/pseudogene)
chr19_-_7672978 3.948 NM_002002
 FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr19_+_59866217 3.714 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr1_+_245646080 3.619 NM_001079821
NM_001127461
 NLRP3

NLR family, pyrin domain containing 3

chr12_+_8499788 3.528 NM_001007033
 CLEC6A
C-type lectin domain family 6, member A
chr9_+_139758336 3.482 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr1_-_25164061 3.462 NM_001031680
 RUNX3
runt-related transcription factor 3
chr19_-_47724365 3.459 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
 CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr7_+_73826244 3.410 NM_000265
 NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
13.83 1.08e-02 GO:0060907 positive regulation of macrophage cytokine production
11.85 3.59e-02 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
9.96 9.92e-12 GO:0060338 regulation of type I interferon-mediated signaling pathway
8.43 2.08e-19 GO:0034340 response to type I interferon
8.30 1.81e-18 GO:0060337 type I interferon-mediated signaling pathway
8.30 1.81e-18 GO:0071357 cellular response to type I interferon
5.35 6.52e-07 GO:0001959 regulation of cytokine-mediated signaling pathway
5.27 9.02e-07 GO:0060759 regulation of response to cytokine stimulus
4.63 1.62e-14 GO:0009615 response to virus
3.76 4.11e-03 GO:0002699 positive regulation of immune effector process
3.70 4.42e-10 GO:0019221 cytokine-mediated signaling pathway
3.50 8.73e-10 GO:0071345 cellular response to cytokine stimulus
3.49 1.01e-03 GO:0050670 regulation of lymphocyte proliferation
3.45 2.98e-05 GO:0001819 positive regulation of cytokine production
3.45 1.20e-03 GO:0032944 regulation of mononuclear cell proliferation
3.35 2.00e-03 GO:0070663 regulation of leukocyte proliferation
3.34 9.64e-07 GO:0045088 regulation of innate immune response
3.32 4.52e-02 GO:0034341 response to interferon-gamma
3.25 1.91e-02 GO:0051222 positive regulation of protein transport
3.07 1.26e-12 GO:0045087 innate immune response

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
2.53 2.65e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
16.59 9.21e-08 GO:0005132 interferon-alpha/beta receptor binding
3.59 5.56e-10 GO:0005126 cytokine receptor binding
3.25 2.60e-08 GO:0005125 cytokine activity