Motif ID: NR3C1.p2

Z-value: 1.826


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR3C1chr5_-_142764295-0.722.3e-03Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_112796855 5.252 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr9_-_70780574 4.638


chr1_-_144426918 4.545 NM_007053
CD160
CD160 molecule
chr20_-_44612619 4.518 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr5_+_143171918 4.273 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr2_-_31293882 4.103 NM_001145122
CAPN14
calpain 14
chr17_+_42641426 3.834 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr16_-_66075216 3.708 NM_001138
AGRP
agouti related protein homolog (mouse)
chr14_-_91403609 3.449 NM_001128596
TC2N
tandem C2 domains, nuclear
chr1_-_181889070 3.189 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr1_-_202726068 3.092 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr17_+_42641712 2.640 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr11_+_59804634 2.630 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr14_-_105804211 2.572 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_72423633 2.525 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr10_+_24795465 2.414 KIAA1217
KIAA1217
chr10_+_24795446 2.347 KIAA1217
KIAA1217
chr17_-_9870292 2.345 NM_001130831
GAS7
growth arrest-specific 7
chr8_+_103633023 2.340 NM_024410
ODF1
outer dense fiber of sperm tails 1
chrX_-_70243362 2.218 NM_001025265
CXorf65
chromosome X open reading frame 65
chr15_-_72288362 2.217 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chr1_+_67404756 2.144 NM_144701
IL23R
interleukin 23 receptor
chr17_-_31441390 2.104 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr6_+_64289585 2.057 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_85749374 2.056 NM_000542
NM_198843
SFTPB

surfactant protein B

chr22_+_21053972 2.034


chr17_-_60439764 1.951 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr6_-_36412562 1.950 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr13_+_45174446 1.769 NM_152719
SPERT
spermatid associated
chr4_+_35962038 1.762 NM_001170700
DTHD1
death domain containing 1
chr19_+_15644885 1.753 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr16_+_8722068 1.644 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr5_+_169749068 1.625


chr11_+_117680504 1.616 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr22_-_40666168 1.580 NM_001110215
CENPM
centromere protein M
chr1_-_205161821 1.564 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr16_+_4614820 1.543 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr6_-_130585650 1.537 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr19_-_56841819 1.494 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr19_-_1989937 1.438 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr22_+_33792125 1.429 NM_001008494
ISX
intestine-specific homeobox
chr20_-_10360569 1.426 NM_018848
MKKS
McKusick-Kaufman syndrome
chr19_-_2233174 1.369 NM_198532
C19orf35
chromosome 19 open reading frame 35
chr10_-_75352540 1.369 NM_001001791
C10orf55
chromosome 10 open reading frame 55
chr6_-_6265874 1.355 F13A1
coagulation factor XIII, A1 polypeptide
chr22_+_21042091 1.344 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr16_+_4614830 1.323 MGRN1
mahogunin, ring finger 1
chr1_+_117345894 1.313 NM_004258
CD101
CD101 molecule
chr11_+_10439253 1.298 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr14_-_105845570 1.255 IGHA1
immunoglobulin heavy constant alpha 1
chr17_-_8756524 1.239 NM_014308
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr5_+_140690387 1.233 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr1_+_111571803 1.208 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr2_+_143603368 1.204 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr5_-_169749215 1.194 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr6_+_158653679 1.185 NM_001007466
NM_020245
TULP4

tubby like protein 4

chrX_+_118598325 1.182 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr3_+_16949585 1.156 NM_015184
PLCL2
phospholipase C-like 2
chr3_-_188945921 1.140 BCL6
B-cell CLL/lymphoma 6
chrX_+_65299157 1.137 NM_138737
HEPH
hephaestin
chr11_+_72658586 1.135 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_+_32417909 1.126 NM_175852
TXLNA
taxilin alpha
chr15_-_43280664 1.113 NM_138356
SHF
Src homology 2 domain containing F
chr10_-_69125932 1.091 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr12_+_6925997 1.086 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr4_-_95482994 1.086 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr10_-_116241572 1.076


chr6_-_108252200 1.063 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr6_-_6265896 1.055 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chrX_-_135577102 1.054 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_+_87541220 1.053 NM_003608
GPR65
G protein-coupled receptor 65
chr20_+_61838389 1.029 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr12_+_53241365 1.013 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr11_+_110631916 1.000 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr7_-_20223467 0.998 NM_182762
MACC1
metastasis associated in colon cancer 1
chr3_+_42107711 0.989 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr1_-_219977424 0.965 NM_144728
DUSP10
dual specificity phosphatase 10
chr19_+_59865935 0.964 NM_001081438
NM_006847
LILRB4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4

chr12_+_6926014 0.961 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_158759606 0.942 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr4_+_91035025 0.934 NM_007351
MMRN1
multimerin 1
chr1_-_159099090 0.932 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr20_-_24987615 0.927 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr1_-_54861656 0.925 NM_176782
FAM151A
family with sequence similarity 151, member A
chr21_+_37713076 0.925 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr14_+_99309688 0.919 EML1
echinoderm microtubule associated protein like 1
chr8_-_95289945 0.892 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_+_32417846 0.879 TXLNA
taxilin alpha
chr11_-_117589283 0.871 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_+_160868932 0.860 DDR2
discoidin domain receptor tyrosine kinase 2
chr8_-_101384633 0.843 NM_015435
RNF19A
ring finger protein 19A
chr1_+_173111306 0.843 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_52126131 0.836 PRR13
proline rich 13
chr1_+_12325632 0.829 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chrX_+_128741578 0.829 SASH3
SAM and SH3 domain containing 3
chr4_-_10295412 0.825 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr4_-_146315341 0.814 NM_017493
OTUD4
OTU domain containing 4
chrX_+_65300803 0.807 NM_001130860
NM_014799
HEPH

hephaestin

chr2_-_121964373 0.805 CLASP1
cytoplasmic linker associated protein 1
chr9_+_101628829 0.788 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr6_+_37511383 0.788


chr14_-_106270497 0.784 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chrX_+_128741562 0.781 NM_018990
SASH3
SAM and SH3 domain containing 3
chr3_+_188197029 0.773


chr3_-_19950675 0.773 NM_144715
EFHB
EF-hand domain family, member B
chr1_+_190394214 0.772 NM_130782
RGS18
regulator of G-protein signaling 18
chr17_-_53849929 0.763 NM_017763
RNF43
ring finger protein 43
chr11_+_66927976 0.743 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr19_+_40511909 0.742 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr11_-_36576352 0.739 NM_000536
RAG2
recombination activating gene 2
chr17_-_74231266 0.723 CYTH1
cytohesin 1
chr14_-_106184988 0.721 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_-_67039874 0.719 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr16_-_46823682 0.715 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr7_+_20621769 0.713 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr10_-_90601655 0.710 NM_144590
ANKRD22
ankyrin repeat domain 22
chr17_-_43470134 0.706 NM_016429
COPZ2
coatomer protein complex, subunit zeta 2
chr19_+_59705824 0.700 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr19_-_59568222 0.699 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr3_-_69212192 0.698 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chrX_-_83644054 0.689 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr19_-_40317829 0.689 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr1_-_35692668 0.685 KIAA0319L
KIAA0319-like
chr19_-_47724365 0.679 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr20_+_61838479 0.674 LIME1
Lck interacting transmembrane adaptor 1
chr3_+_45902999 0.673 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr7_-_107930170 0.652 PNPLA8
patatin-like phospholipase domain containing 8
chr3_+_179759181 0.645 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr17_-_35327318 0.642 NM_018530
GSDMB
gasdermin B
chrX_+_65299352 0.628 HEPH
hephaestin
chr3_+_122794859 0.627 NM_016298
FBXO40
F-box protein 40
chr11_-_3759886 0.624 NUP98
nucleoporin 98kDa
chr17_-_34014390 0.621 SRCIN1
SRC kinase signaling inhibitor 1
chr21_+_42792810 0.621 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr15_+_40481879 0.618 NM_173088
CAPN3
calpain 3, (p94)
chr6_-_32299757 0.596 NM_004557
NOTCH4
notch 4
chr8_-_53484753 0.594 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr6_+_4835224 0.593 NM_001143971
CDYL
chromodomain protein, Y-like
chr17_-_59363352 0.592 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr9_-_124981125 0.588 STRBP
spermatid perinuclear RNA binding protein
chr16_-_70591377 0.588 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr22_+_42726423 0.587 NM_001003828
PARVB
parvin, beta
chr11_+_19328846 0.584 NM_001111018
NAV2
neuron navigator 2
chr13_-_102517196 0.580 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chrX_+_78087484 0.579 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr17_-_53849888 0.578 RNF43
ring finger protein 43
chr8_-_110724594 0.572 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr10_+_5478521 0.572 NM_005863
NET1
neuroepithelial cell transforming 1
chr1_+_89602023 0.571 NM_198460
GBP6
guanylate binding protein family, member 6
chr19_-_53868075 0.569 NM_145807
NTN5
netrin 5
chr6_+_31746706 0.563 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr21_+_44597911 0.560 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr20_+_30831298 0.556 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr1_-_111544784 0.550 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr1_+_159032551 0.549 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr1_-_199657468 0.545 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr2_-_29150630 0.544 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr12_+_5023345 0.542 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr17_-_68100537 0.541 LOC100499467
hypothetical LOC100499467
chr1_+_111544469 0.534


chrX_-_100434700 0.531 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr4_+_86918870 0.526 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr17_+_19917420 0.526 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr12_+_15017222 0.523 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr6_-_133008834 0.519 NM_138327
TAAR1
trace amine associated receptor 1
chr9_+_124355211 0.518 NM_001004457
OR1N2
olfactory receptor, family 1, subfamily N, member 2
chr1_-_224195495 0.516 NM_001172425
NM_003240
LEFTY2

left-right determination factor 2

chr14_+_22136968 0.507 NM_022060
ABHD4
abhydrolase domain containing 4
chr19_-_59568340 0.503 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr1_-_239865724 0.502 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr17_-_23927973 0.502 ALDOC
aldolase C, fructose-bisphosphate
chr15_+_57696016 0.501 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr14_-_20098929 0.499 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr11_-_47467094 0.495 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr22_+_44083485 0.494 NM_001104595
FAM118A
family with sequence similarity 118, member A
chr17_-_23928048 0.491 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr3_+_52788976 0.489 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr10_+_35466715 0.489 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr2_-_47235929 0.486 NM_001163561
NM_173649
C2orf61

chromosome 2 open reading frame 61

chr3_-_152478843 0.485 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr7_-_122627235 0.485 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr17_-_29714293 0.485 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr7_+_102775309 0.474 NM_002803
PSMC2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
chr16_+_56134037 0.473 GPR114
G protein-coupled receptor 114
chr1_+_32512298 0.470 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr4_+_114190233 0.469 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr2_+_102401580 0.466 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_-_156800017 0.466 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr14_+_34831294 0.465 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr1_-_111544603 0.464


chr17_-_23928041 0.462 ALDOC
aldolase C, fructose-bisphosphate
chr16_-_31007630 0.462 NM_001039503
PRSS53
protease, serine, 53
chr7_+_127020924 0.459 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr6_+_26264531 0.455 HIST1H1E
histone cluster 1, H1e
chr6_+_36752244 0.450 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr11_+_67532592 0.444 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr19_-_4131778 0.436 SIRT6
sirtuin 6
chr12_+_102859354 0.435 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr14_-_105542441 0.433 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr3_-_58175437 0.432 NM_004944
DNASE1L3
deoxyribonuclease I-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.84 2.85e-04 GO:0002376 immune system process
2.02 2.69e-03 GO:0006955 immune response
2.28 4.00e-03 GO:0001775 cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 2.24e-04 GO:0005886 plasma membrane
1.36 2.55e-04 GO:0071944 cell periphery
2.97 4.68e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.64 9.29e-03 GO:0001608 nucleotide receptor activity, G-protein coupled
7.64 9.29e-03 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
10.50 2.62e-02 GO:0004522 pancreatic ribonuclease activity
5.46 3.39e-02 GO:0003823 antigen binding