Motif ID: EOMES.p2

Z-value: 1.612


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EOMESchr3_-_27738788-0.097.5e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_74606819 4.116 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr1_+_150958621 3.282 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr17_-_20311411 2.792 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr17_+_22823151 2.758 NM_014238
KSR1
kinase suppressor of ras 1
chr12_-_51173238 2.631 NM_005554
KRT6A
keratin 6A
chr1_+_17719405 2.547 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_18320822 2.474 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr8_-_11742668 2.336


chr11_+_93394025 2.248 NM_001098672
HEPHL1
hephaestin-like 1
chr17_-_40858775 2.141 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr1_+_89602023 2.085 NM_198460
GBP6
guanylate binding protein family, member 6
chr8_-_72431274 1.997 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr3_+_137224266 1.939 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr11_-_65070625 1.937 LTBP3
latent transforming growth factor beta binding protein 3
chr17_-_36475652 1.917 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr3_-_48446405 1.898 NM_001130082
PLXNB1
plexin B1
chr1_+_24522116 1.890 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr3_-_49434874 1.874 AMT
aminomethyltransferase
chr14_+_20537253 1.786 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr9_-_33455191 1.767 NOL6
nucleolar protein family 6 (RNA-associated)
chr10_-_123346148 1.751 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr17_-_36469869 1.744 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr3_-_110155237 1.700 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr15_-_70288071 1.593 PKM2
pyruvate kinase, muscle
chr8_+_22075112 1.542 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr6_-_130224108 1.521 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr3_+_10832867 1.492 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr5_-_56814310 1.464 NM_001017992
ACTBL2
actin, beta-like 2
chr7_-_16471817 1.423 NM_015464
SOSTDC1
sclerostin domain containing 1
chr6_+_152168500 1.422 NM_001122741
ESR1
estrogen receptor 1
chr2_+_17861266 1.372 NM_001105569
MSGN1
mesogenin 1
chr1_+_35019376 1.352 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr20_+_35406497 1.349 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chrX_+_69559605 1.308 NM_001171191
NM_001171192
NM_001171193
NM_017711
GDPD2



glycerophosphodiester phosphodiesterase domain containing 2



chr21_+_39745649 1.285 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr10_+_4995685 1.268 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr14_+_94148466 1.263 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr15_+_64481270 1.247 MAP2K1
mitogen-activated protein kinase kinase 1
chr10_+_4995597 1.240 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_-_95230143 1.196 NM_001001850
STX19
syntaxin 19
chr16_+_11966464 1.150 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr15_+_73803351 1.148 NM_175881
ODF3L1
outer dense fiber of sperm tails 3-like 1
chr12_-_8706637 1.137 NM_003480
MFAP5
microfibrillar associated protein 5
chrX_+_122145776 1.102 NM_000828
NM_007325
GRIA3

glutamate receptor, ionotrophic, AMPA 3

chr5_+_132037271 1.079 NM_000589
NM_172348
IL4

interleukin 4

chrX_-_62564934 1.078 LOC92249
hypothetical LOC92249
chr18_-_54447168 1.061 NM_052947
ALPK2
alpha-kinase 2
chr20_+_773283 1.060 NM_031424
FAM110A
family with sequence similarity 110, member A
chr5_+_67558217 1.053 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_-_101316038 1.007 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr8_-_42353719 1.004 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr8_+_1980564 1.003 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chrX_-_135783496 1.001


chr2_-_31491057 0.994 XDH
xanthine dehydrogenase
chr20_-_43177137 0.993 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr16_+_70117523 0.985 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr1_-_150328153 0.958 NM_001008536
TCHHL1
trichohyalin-like 1
chr4_+_100957003 0.954 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr1_-_155053124 0.941 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr8_-_8276598 0.941 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr9_-_78710698 0.940 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr17_+_22982319 0.937 LGALS9
lectin, galactoside-binding, soluble, 9
chr10_+_24538094 0.931 KIAA1217
KIAA1217
chr17_+_22982278 0.925 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr4_-_186969202 0.907 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr14_-_23106372 0.895 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr17_+_22982344 0.893 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_+_159943385 0.890 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr5_-_141973875 0.884 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr11_+_73036241 0.883 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr17_+_22982372 0.880 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_22982383 0.876 LGALS9
lectin, galactoside-binding, soluble, 9
chr12_+_56435042 0.864 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr11_+_60858611 0.851 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_-_45862225 0.840 NM_001114938
NM_001190182
CCDC17

coiled-coil domain containing 17

chr15_-_31147376 0.836 NM_001103184
FMN1
formin 1
chr5_-_49772973 0.835 NM_198449
EMB
embigin
chr17_-_36346240 0.834 KRT23
keratin 23 (histone deacetylase inducible)
chr20_-_60435983 0.826 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr12_+_53229625 0.826 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr21_-_44795769 0.825 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr20_-_54013418 0.818 NM_080617
CBLN4
cerebellin 4 precursor
chr11_-_110755112 0.807 POU2AF1
POU class 2 associating factor 1
chr20_-_43601542 0.801 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr14_+_20580224 0.799 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr2_-_31491102 0.793 NM_000379
XDH
xanthine dehydrogenase
chr7_-_93027057 0.777 NM_001164738
CALCR
calcitonin receptor
chr1_+_46151845 0.777 MAST2
microtubule associated serine/threonine kinase 2
chr9_+_126460511 0.753


chr5_-_134810696 0.752 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr1_-_43523825 0.751 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr5_-_35974493 0.750 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr3_-_197549588 0.749 TM4SF19
transmembrane 4 L six family member 19
chr17_-_71535076 0.748 NM_001988
EVPL
envoplakin
chr19_+_60279032 0.747 NM_133180
EPS8L1
EPS8-like 1
chr1_-_114215768 0.743 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr5_+_125828685 0.742 NM_001146322
GRAMD3
GRAM domain containing 3
chr4_-_57242492 0.739 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr21_-_30774502 0.737 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr4_-_186969041 0.724 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr16_+_2757655 0.708 SRRM2
serine/arginine repetitive matrix 2
chr19_+_9132367 0.697


chr7_-_36730525 0.691 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr8_+_62363078 0.688 NM_173519
CLVS1
clavesin 1
chr6_-_31246159 0.684 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
chr2_-_215711313 0.677 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr10_-_105228986 0.671 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr4_+_75393053 0.655 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr12_+_53229443 0.655 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr6_+_64339869 0.654 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_159306037 0.654 ARHGAP30
Rho GTPase activating protein 30
chr11_-_62445587 0.651 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr11_-_46364681 0.648 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr12_-_51200347 0.642 NM_000424
KRT5
keratin 5
chr16_+_21623784 0.633 NM_170664
OTOA
otoancorin
chr12_-_60872814 0.633 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr2_-_29997935 0.629 NM_004304
ALK
anaplastic lymphoma receptor tyrosine kinase
chr3_-_62836052 0.628 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr12_-_50971516 0.625 NM_002281
KRT81
keratin 81
chr6_+_47774247 0.620 NM_153838
GPR115
G protein-coupled receptor 115
chr20_+_43531806 0.610 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr9_-_34652629 0.604 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr5_-_147266257 0.600 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr4_-_54152480 0.599 NM_001126328
LNX1
ligand of numb-protein X 1
chr2_+_69055208 0.599 NM_019617
GKN1
gastrokine 1
chr11_+_122214415 0.597 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr5_-_49772940 0.596 EMB
embigin
chr14_-_23106779 0.595 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr17_-_76919068 0.594 NM_178520
TMEM105
transmembrane protein 105
chr1_-_85703198 0.590 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr20_+_58064360 0.589 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr18_-_22696532 0.575 NM_004028
AQP4
aquaporin 4
chr1_+_17404206 0.574 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr20_-_1922701 0.571 NM_001190899
NM_001190898
NM_024411
PDYN


prodynorphin


chr15_-_88095363 0.566 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr3_-_197549640 0.564 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr1_-_1131795 0.550 NM_004195
NM_148901
NM_148902
TNFRSF18


tumor necrosis factor receptor superfamily, member 18


chr5_-_39306465 0.549 FYB
FYN binding protein
chr5_-_1935764 0.548 NM_016358
IRX4
iroquois homeobox 4
chrX_+_123307812 0.547 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr3_+_52786642 0.547 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr1_-_153098811 0.544 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr15_-_81271859 0.543 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr2_-_218739891 0.540 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr6_+_31651319 0.540 NM_000594
TNF
tumor necrosis factor
chr14_+_51804180 0.538 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr3_-_156876798 0.538 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr1_-_159306369 0.537 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr4_-_140280031 0.536 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chrX_-_15783015 0.534 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_233112680 0.534 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr1_+_154478574 0.532 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr3_-_186752952 0.523 NM_139248
LIPH
lipase, member H
chr12_-_8706746 0.521 MFAP5
microfibrillar associated protein 5
chr1_+_154389945 0.521 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr12_-_8706533 0.517 MFAP5
microfibrillar associated protein 5
chr6_-_159386007 0.516 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr16_-_28457728 0.512 NUPR1
nuclear protein, transcriptional regulator, 1
chr10_+_24537725 0.511 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr17_+_18221803 0.510 NM_001145127
EVPLL
envoplakin-like
chr1_-_159306327 0.509 ARHGAP30
Rho GTPase activating protein 30
chr1_+_213245507 0.503 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr14_+_54104383 0.502 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr14_+_66725862 0.497 NM_173526
FAM71D
family with sequence similarity 71, member D
chr5_+_67622242 0.495 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_150819586 0.492 NM_032563
LCE3D
late cornified envelope 3D
chr1_+_149851112 0.492


chr16_-_80602546 0.490 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr11_-_128279670 0.483 C11orf45
chromosome 11 open reading frame 45
chr1_-_28392966 0.483 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr4_+_2596956 0.473 NM_003704
FAM193A
family with sequence similarity 193, member A
chr6_-_130578110 0.473 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr14_-_65550379 0.470


chrX_+_37750778 0.466 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr6_+_31059463 0.466 NM_001010909
MUC21
mucin 21, cell surface associated
chr1_+_201711505 0.460 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr12_+_10222823 0.450 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr2_+_27652892 0.446 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr2_+_241213334 0.446 NM_005301
GPR35
G protein-coupled receptor 35
chr17_-_36559579 0.432 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr1_+_148496792 0.430 NM_012113
CA14
carbonic anhydrase XIV
chr14_-_23107106 0.429 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr5_-_132228375 0.427 NM_005260
GDF9
growth differentiation factor 9
chr5_+_156752739 0.424 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_218954995 0.423 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr12_+_55896844 0.422 NM_007224
NXPH4
neurexophilin 4
chr1_+_180836050 0.419


chr2_+_131203112 0.419 NM_207364
GPR148
G protein-coupled receptor 148
chr11_+_34599163 0.418 NM_012153
EHF
ets homologous factor
chr20_+_32926452 0.418 ACSS2
acyl-CoA synthetase short-chain family member 2
chr11_-_65120042 0.413 NM_005714
NM_033347
NM_033348
NM_033455
KCNK7



potassium channel, subfamily K, member 7



chr8_-_22145462 0.410 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr7_+_129634935 0.409 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr1_-_54392030 0.408 NM_201546
CDCP2
CUB domain containing protein 2
chr6_+_88024152 0.407 ZNF292
zinc finger protein 292
chr1_-_159306210 0.406 ARHGAP30
Rho GTPase activating protein 30
chr2_+_165858586 0.405 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chrX_-_15782826 0.404


chr8_+_75899326 0.399 NM_015886
PI15
peptidase inhibitor 15
chr6_+_167456230 0.398 NM_031409
CCR6
chemokine (C-C motif) receptor 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 3.76e-04 GO:0023052 signaling
1.29 5.61e-03 GO:0007165 signal transduction
1.57 1.65e-02 GO:0007154 cell communication
1.24 2.39e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 4.27e-06 GO:0044459 plasma membrane part
1.30 9.28e-06 GO:0071944 cell periphery
1.30 1.28e-05 GO:0005886 plasma membrane
1.48 4.98e-03 GO:0005887 integral to plasma membrane
1.71 4.98e-03 GO:0030054 cell junction
1.46 7.24e-03 GO:0031226 intrinsic to plasma membrane
1.14 1.28e-02 GO:0016020 membrane
1.83 1.41e-02 GO:0045202 synapse
1.86 1.46e-02 GO:0009986 cell surface
4.75 2.36e-02 GO:0032153 cell division site
4.75 2.36e-02 GO:0032155 cell division site part
1.32 2.41e-02 GO:0005576 extracellular region
2.95 2.98e-02 GO:0045095 keratin filament
1.15 3.29e-02 GO:0044425 membrane part
1.90 4.81e-02 GO:0044456 synapse part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.12 4.19e-02 GO:0005200 structural constituent of cytoskeleton
1.48 4.68e-02 GO:0005102 receptor binding