Motif ID: PITX1..3.p2

Z-value: 9.434


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PITX2chr4_-_111777956-0.741.7e-03Click!
PITX1chr5_-_1343977400.631.3e-02Click!
PITX3chr10_-_103991219-0.572.6e-02Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_73654028 22.469 NM_001163075
C17orf99
chromosome 17 open reading frame 99
chr19_+_52532210 16.942 NM_018485
GPR77
G protein-coupled receptor 77
chr3_+_188222337 16.157 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_40631603 15.357 NM_001198979
SMAP2
small ArfGAP2
chr19_+_40465249 14.294 NM_021175
HAMP
hepcidin antimicrobial peptide
chr2_+_218992053 14.242 NM_007127
VIL1
villin 1
chr11_-_117718532 13.880 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr19_-_56585603 13.431 NM_001193623
LOC147646
hypothetical protein LOC147646
chr16_-_30301634 13.318 NM_052838
SEPT1
septin 1
chr1_-_24112345 13.102 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chrX_-_70243362 12.912 NM_001025265
CXorf65
chromosome X open reading frame 65
chr12_-_7793335 12.340 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr3_-_197726587 11.604 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr8_-_27997306 11.515 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr12_-_55042793 11.202 NM_001638
APOF
apolipoprotein F
chr19_-_54093749 11.077 NM_003323
TULP2
tubby like protein 2
chr22_-_22426551 10.483 NM_013378
VPREB3
pre-B lymphocyte 3
chr16_+_11966464 10.063 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_+_4104593 9.908 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr22_-_36305883 9.852 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr19_-_43926953 9.738 NM_144691
CAPN12
calpain 12
chr11_-_63087430 9.672 NM_017878
HRASLS2
HRAS-like suppressor 2
chr3_-_197422653 9.474 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr22_-_20314274 9.459 NM_001017964
YDJC
YdjC homolog (bacterial)
chr1_+_16203317 9.270 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr15_-_48192804 9.268 ATP8B4
ATPase, class I, type 8B, member 4
chr2_-_74395657 9.066 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr17_-_35328368 9.044 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr11_+_118561375 8.705 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr20_-_4938913 8.689 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr1_+_159032551 8.674 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr22_-_20314366 8.399 YDJC
YdjC homolog (bacterial)
chr4_-_40212670 8.236 NM_019027
RBM47
RNA binding motif protein 47
chr3_-_9896933 7.903 CIDEC
cell death-inducing DFFA-like effector c
chr19_+_10820105 7.854 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr16_-_88604029 7.661 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr9_-_116196505 7.643 NM_030767
AKNA
AT-hook transcription factor
chr17_+_37247568 7.571 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr10_-_7701619 7.566 NM_032817
ITIH5
inter-alpha (globulin) inhibitor H5
chr1_-_148854503 7.549


chr22_-_16080265 7.539 CECR1
cat eye syndrome chromosome region, candidate 1
chr17_+_37957509 7.502 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chrX_+_48505097 7.444 NM_001080489
GLOD5
glyoxalase domain containing 5
chr16_+_56286212 7.395 NM_032269
CCDC135
coiled-coil domain containing 135
chr9_+_263025 7.330 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_+_10083196 7.317 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr19_-_8473473 7.304 NM_032152
PRAM1
PML-RARA regulated adaptor molecule 1
chr19_+_59705824 7.266 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr22_+_20715340 7.249


chr19_-_6621598 7.226 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr19_-_17236522 7.201 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr16_-_29664765 7.158 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr3_-_9895633 7.091 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr9_+_6710862 6.979 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr19_-_5790702 6.974 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr6_-_31668476 6.916 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr17_-_59818033 6.828 PECAM1
platelet/endothelial cell adhesion molecule
chr16_-_66590856 6.747 NM_022355
DPEP2
dipeptidase 2
chr19_+_4134350 6.728 NM_133475
ANKRD24
ankyrin repeat domain 24
chr19_-_60241424 6.663 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr16_-_31013626 6.469 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr19_+_50137334 6.430 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 read-through transcript
apolipoprotein C-IV
chr19_+_16115454 6.417 HSH2D
hematopoietic SH2 domain containing
chr12_-_116021473 6.399 NM_001168325
NM_017899
TESC

tescalcin

chr1_-_28375722 6.391 NM_001164723
PTAFR
platelet-activating factor receptor
chr12_-_112326037 6.331 NM_006843
SDS
serine dehydratase
chr16_+_30391609 6.268


chr19_-_53515143 6.241 NM_144577
CCDC114
coiled-coil domain containing 114
chr16_+_29597829 6.237 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr16_+_19375272 6.230 NM_024780
TMC5
transmembrane channel-like 5
chr22_+_20350272 6.156 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr20_-_43972061 6.148 PLTP
phospholipid transfer protein
chr19_-_55560686 6.110 NM_004851
NAPSA
napsin A aspartic peptidase
chr6_-_137536412 6.066 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr16_-_30301357 5.976 SEPT1
septin 1
chr1_+_15655809 5.971 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr16_+_65552600 5.962 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr11_+_76423082 5.857 NM_138706
B3GNT6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr19_+_17723285 5.846 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr11_-_73397929 5.798 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr16_+_30391550 5.721 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr1_-_211087570 5.698 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr19_-_56564068 5.686 NM_152353
CLDND2
claudin domain containing 2
chr16_+_30391460 5.678 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr20_+_51235228 5.604 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr19_+_49894260 5.541 NM_001039213
CEACAM16
carcinoembryonic antigen-related cell adhesion molecule 16
chr19_-_44386731 5.539 NM_001080468
SYCN
syncollin
chr15_+_40484249 5.516 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr3_+_32968069 5.513 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr12_-_120270035 5.486 ANAPC5
anaphase promoting complex subunit 5
chr9_-_115178161 5.485 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr12_+_45896318 5.483 NM_138371
FAM113B
family with sequence similarity 113, member B
chr20_+_35445350 5.466 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr6_-_3390197 5.419 NM_021945
SLC22A23
solute carrier family 22, member 23
chr3_-_180452338 5.367 NM_171830
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr11_-_65070625 5.331 LTBP3
latent transforming growth factor beta binding protein 3
chr19_+_16860807 5.321 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr1_+_10457579 5.308 NM_004565
PEX14
peroxisomal biogenesis factor 14
chr19_+_17495109 5.297 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr20_-_61907299 5.292 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr3_-_180452096 5.283 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr19_-_12807221 5.281 NM_031429
RTBDN
retbindin
chr16_+_3499894 5.278 NM_024793
CLUAP1
clusterin associated protein 1
chr7_-_99604171 5.250 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr19_+_3679373 5.224 NM_014428
TJP3
tight junction protein 3 (zona occludens 3)
chr11_+_67871999 5.221 LRP5
low density lipoprotein receptor-related protein 5
chr19_+_14554895 5.174 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr19_+_54583286 5.166 NM_144688
CCDC155
coiled-coil domain containing 155
chr7_-_99518294 5.162 ZNF3
zinc finger protein 3
chr14_-_31026901 5.140 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr5_+_176744037 5.119 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr3_-_126136261 5.114 NM_033049
MUC13
mucin 13, cell surface associated
chr16_-_21762256 5.089 LOC100132247
NPIPL3
LOC613037
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
nuclear pore complex interacting protein pseudogene
chr19_+_7651706 5.066 NM_001042462
TRAPPC5
trafficking protein particle complex 5
chr12_+_122510338 5.038 NM_180699
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr16_-_68349445 5.014


chr1_+_109450116 4.993


chr8_+_49083522 4.981 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr19_+_17440577 4.980 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr11_+_63030099 4.971 NM_001142535
NM_001142536
NM_033101
LGALS12


lectin, galactoside-binding, soluble, 12


chr12_-_107551744 4.956 SELPLG
selectin P ligand
chr19_-_12858956 4.952 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr12_+_53178834 4.950 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr1_-_54861656 4.883 NM_176782
FAM151A
family with sequence similarity 151, member A
chr6_+_31782618 4.864 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr12_+_54910086 4.859 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr2_+_68815416 4.792 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr12_+_121218218 4.780 NM_152759
LRRC43
leucine rich repeat containing 43
chr11_-_905057 4.775 NM_001142675
CHID1
chitinase domain containing 1
chr19_+_495026 4.771 NM_005317
GZMM
granzyme M (lymphocyte met-ase 1)
chr4_+_74499651 4.768 ALB
albumin
chrX_+_153101278 4.759 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr19_-_55539769 4.750 NAPSB
napsin B aspartic peptidase pseudogene
chr6_-_52217185 4.715 NM_052872
IL17F
interleukin 17F
chr12_-_108989882 4.709 NM_207435
C12orf76
chromosome 12 open reading frame 76
chr5_-_10361167 4.680 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr20_+_61963009 4.669 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr11_+_63030131 4.648 LGALS12
lectin, galactoside-binding, soluble, 12
chr5_+_61750467 4.647 NM_001134779
IPO11
importin 11
chr2_+_74913289 4.636 NM_000189
HK2
hexokinase 2
chr7_+_99562255 4.631 NM_203397
MBLAC1
metallo-beta-lactamase domain containing 1
chr16_+_28850760 4.621 NM_001178098
NM_001770
CD19

CD19 molecule

chr12_-_107551694 4.616 SELPLG
selectin P ligand
chr7_+_100169184 4.596 NM_003386
NM_173059
ZAN

zonadhesin

chr17_-_39500512 4.588 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr15_-_87565813 4.579 NM_000326
RLBP1
retinaldehyde binding protein 1
chr2_+_10103735 4.572


chr11_+_66927955 4.572 TBC1D10C
TBC1 domain family, member 10C
chr1_+_22251706 4.571 NM_001039802
NM_001791
NM_044472
CDC42


cell division cycle 42 (GTP binding protein, 25kDa)


chr6_-_88095714 4.566 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr12_-_56159895 4.493 NM_032496
ARHGAP9
Rho GTPase activating protein 9
chr16_-_18705578 4.490


chr19_-_56825400 4.482 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr14_+_104267270 4.469 NM_199165
ADSSL1
adenylosuccinate synthase like 1
chr13_+_109936080 4.466 COL4A2
collagen, type IV, alpha 2
chr16_+_32660135 4.454 LOC100289574
hect domain and RLD 2 pseudogene
chr16_+_70654625 4.430 NM_020995
HPR
haptoglobin-related protein
chr5_+_76181581 4.403 NM_130772
S100Z
S100 calcium binding protein Z
chr1_+_40486159 4.385 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr7_+_138675644 4.384 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr1_+_159899528 4.362 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr6_-_44341296 4.361 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_31871530 4.353 NM_006295
VARS
valyl-tRNA synthetase
chr19_-_44518465 4.346 GMFG
glia maturation factor, gamma
chr1_-_226679648 4.334 NM_003493
HIST3H3
histone cluster 3, H3
chr21_+_29322100 4.298 USP16
ubiquitin specific peptidase 16
chr12_-_6611075 4.289 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr16_+_25135783 4.277 NM_001169
AQP8
aquaporin 8
chr1_-_32157845 4.270 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr15_-_39310152 4.262 NM_152596
EXD1
exonuclease 3'-5' domain containing 1
chr2_+_151974630 4.253 NM_001177663
NM_018151
NM_001177664
RIF1


RAP1 interacting factor homolog (yeast)


chr19_+_12064077 4.253 ZNF788
zinc finger family member 788
chr17_-_30909219 4.241 NM_001129820
SLFN14
schlafen family member 14
chr7_-_72360722 4.223 NM_001168347
NM_001168348
NM_018044
NM_148956
NSUN5



NOP2/Sun domain family, member 5



chr19_+_59865935 4.211 NM_001081438
NM_006847
LILRB4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4

chr22_-_29231597 4.204 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr22_-_40673025 4.182 NM_001002876
NM_024053
CENPM

centromere protein M

chr17_+_7325444 4.167 NM_001102614
AMAC1L3
acyl-malonyl condensing enzyme 1-like 3
chr1_-_159099090 4.162 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr8_-_38127489 4.154 NM_000349
STAR
steroidogenic acute regulatory protein
chr6_-_150099352 4.125 NUP43
nucleoporin 43kDa
chr22_-_22714230 4.123 NM_000853
GSTT1
glutathione S-transferase theta 1
chr12_-_31836441 4.107 NM_001013699
H3F3C
H3 histone, family 3C
chr11_+_10439253 4.063 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr11_-_118405288 4.014 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr5_+_67622242 4.014 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_100657321 4.011 NM_001177948
NM_001177949
NM_153694
SYCP3


synaptonemal complex protein 3


chr19_-_60528480 4.001 NM_001085488
TMEM150B
transmembrane protein 150B
chr19_-_2207415 3.998 NM_144616
JSRP1
junctional sarcoplasmic reticulum protein 1
chr9_+_139047441 3.989 C9orf139
chromosome 9 open reading frame 139
chrX_+_9391314 3.983 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr19_+_16105837 3.981 NM_032855
HSH2D
hematopoietic SH2 domain containing
chr3_+_48239865 3.974 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr11_-_33870411 3.957 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_+_5558682 3.925 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr1_-_226357663 3.919 C1orf35
chromosome 1 open reading frame 35
chr1_+_245647973 3.904 NM_001127462
NM_004895
NM_183395
NLRP3


NLR family, pyrin domain containing 3


chr1_+_3658821 3.890 NM_152492
CCDC27
coiled-coil domain containing 27
chr16_+_65918220 3.885 NM_018296
LRRC36
leucine rich repeat containing 36
chr19_+_50141068 3.877 NM_000483
APOC2
apolipoprotein C-II

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.