Motif ID: FOXD3.p2

Z-value: 1.198


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD3chr1_+_63561317-0.332.3e-01Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_30238961 4.091 NM_033229
TRIM15
tripartite motif containing 15
chr10_+_5976354 3.357 NM_032807
FBXO18
F-box protein, helicase, 18
chr19_+_13999959 3.004 NM_080864
RLN3
relaxin 3
chr22_+_21384862 2.610 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr20_+_56919233 2.323 GNAS
GNAS complex locus
chr3_-_171070314 2.291 NM_024727
LRRC31
leucine rich repeat containing 31
chrX_+_154880439 2.099 NM_002186
IL9R
interleukin 9 receptor
chr3_-_184756101 2.060 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr21_+_42697058 2.035 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr12_+_9925354 2.034 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr1_+_15655809 1.953 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr1_+_357502 1.932 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr16_+_20328355 1.917 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr1_-_158759606 1.891 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr2_-_157890400 1.844 NM_020711
ERMN
ermin, ERM-like protein
chr1_-_611896 1.739 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr9_-_99974994 1.724 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr5_-_39238818 1.699 FYB
FYN binding protein
chr3_-_57209319 1.669 NM_003865
HESX1
HESX homeobox 1
chr6_+_26609427 1.642 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr11_-_77730573 1.623 NM_012296
GAB2
GRB2-associated binding protein 2
chr2_-_127817143 1.590 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr19_-_14646626 1.569 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr1_-_24112345 1.542 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr1_+_40635058 1.539 NM_001198980
SMAP2
small ArfGAP2
chr6_+_64414389 1.538 NM_015153
PHF3
PHD finger protein 3
chr12_+_53178834 1.525 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr1_+_61697209 1.497 NFIA
nuclear factor I/A
chr6_-_49712483 1.496 NM_000324
RHAG
Rh-associated glycoprotein
chr17_-_30909219 1.483 NM_001129820
SLFN14
schlafen family member 14
chrX_+_11221453 1.469 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr17_-_39500512 1.460 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr9_-_139047112 1.442 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr7_-_25234582 1.429 NM_022150
NPVF
neuropeptide VF precursor
chr1_-_158948176 1.402 NM_001778
CD48
CD48 molecule
chr11_-_59369501 1.399 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr2_-_32344192 1.374 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr19_+_12995782 1.337 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_+_106292932 1.334 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_+_38238080 1.294 OXSR1
oxidative-stress responsive 1
chr9_+_139047441 1.269 C9orf139
chromosome 9 open reading frame 139
chr19_-_11550765 1.265 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr3_-_15357878 1.224 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr19_-_55539769 1.212 NAPSB
napsin B aspartic peptidase pseudogene
chr19_-_55560686 1.199 NM_004851
NAPSA
napsin A aspartic peptidase
chr7_+_99263571 1.198 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr6_-_31668476 1.179 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr8_-_30704984 1.158 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr11_-_56914668 1.155 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr6_+_131936057 1.154 NM_000045
ARG1
arginase, liver
chr11_-_5110383 1.145 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr11_-_59707074 1.137 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr19_+_6415259 1.127 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr1_+_43063817 1.113 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr15_+_40484249 1.109 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr3_+_171022403 1.066 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr18_-_46068689 1.055 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr11_+_61943082 1.045 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr22_-_20667165 1.041 TOP3B
topoisomerase (DNA) III beta
chr4_+_186587537 1.034 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr1_-_7895873 1.025 UTS2
urotensin 2
chr18_-_65766068 1.023 CD226
CD226 molecule
chr13_-_98708549 1.022 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr13_+_51496679 1.004 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr16_-_11282595 1.004 NM_002761
PRM1
protamine 1
chr3_+_32968069 0.997 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr6_-_137536412 0.987 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr22_-_20667211 0.976 TOP3B
topoisomerase (DNA) III beta
chr10_-_921694 0.972 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr7_-_86433139 0.970 NM_152748
KIAA1324L
KIAA1324-like
chr20_-_33658823 0.967 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr14_+_31868229 0.964 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr7_+_139175420 0.961 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr11_+_63060848 0.959 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr8_+_86287161 0.956 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr15_-_56093477 0.954 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr5_+_141326620 0.926 NM_183399
RNF14
ring finger protein 14
chr1_-_229627412 0.912 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr1_+_15637521 0.912 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr12_+_45896318 0.912 NM_138371
FAM113B
family with sequence similarity 113, member B
chr16_+_29971955 0.912 ALDOA
aldolase A, fructose-bisphosphate
chr12_-_94914133 0.911 NM_002108
HAL
histidine ammonia-lyase
chr4_-_145159889 0.910 NM_002100
GYPB
glycophorin B (MNS blood group)
chr14_+_20319049 0.888 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr16_-_3567354 0.881 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr6_-_123999640 0.881 NM_006073
TRDN
triadin
chr3_-_10309600 0.880 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr19_-_16111695 0.879


chr7_+_77307382 0.878 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr17_-_16038607 0.874 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr19_-_9087438 0.871 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr11_+_123625632 0.866 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr1_+_160733587 0.865 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr19_+_56990222 0.863 NM_002030
FPR3
formyl peptide receptor 3
chr9_+_92629525 0.862 NM_001174167
SYK
spleen tyrosine kinase
chr22_-_20667131 0.860 NM_003935
TOP3B
topoisomerase (DNA) III beta
chr6_+_10629550 0.858 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_+_102401580 0.857 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_32512298 0.855 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr9_-_129740583 0.853 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr12_+_27066768 0.850 MED21
mediator complex subunit 21
chr9_+_126460511 0.844


chr1_-_25164061 0.840 NM_001031680
RUNX3
runt-related transcription factor 3
chr16_+_29971971 0.822 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr11_-_5212168 0.820 NM_000519
HBD
hemoglobin, delta
chr6_-_28294642 0.819 LOC222699
transducer of ERBB2, 2 pseudogene
chr1_-_41399632 0.818 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr9_-_70780574 0.817


chr20_-_23014828 0.812 NM_012072
CD93
CD93 molecule
chr19_-_60528480 0.812 NM_001085488
TMEM150B
transmembrane protein 150B
chr3_-_42818221 0.809


chr19_+_61379200 0.807 NM_001145546
NM_033106
GALP

galanin-like peptide

chr12_+_56462794 0.803 NM_001172695
NM_001172696
NM_001172697
NM_005726
TSFM



Ts translation elongation factor, mitochondrial



chr6_-_150099352 0.803 NUP43
nucleoporin 43kDa
chr7_+_106897737 0.800 NM_005295
GPR22
G protein-coupled receptor 22
chr11_-_63087430 0.797 NM_017878
HRASLS2
HRAS-like suppressor 2
chr21_-_32879617 0.796 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr6_+_52159143 0.792 NM_002190
IL17A
interleukin 17A
chr1_-_151352587 0.784 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr3_-_3127057 0.783 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr8_-_110724594 0.781 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr12_+_94200306 0.779 VEZT
vezatin, adherens junctions transmembrane protein
chr20_+_1132097 0.777 NM_001009612
C20orf202
chromosome 20 open reading frame 202
chr19_-_16111594 0.771


chr4_+_71713324 0.763 NM_031889
ENAM
enamelin
chr8_-_116749382 0.753 TRPS1
trichorhinophalangeal syndrome I
chr12_-_53664722 0.751 NM_001136030
KIAA0748
KIAA0748
chr19_-_44518516 0.751 NM_004877
GMFG
glia maturation factor, gamma
chr13_+_109932934 0.751 COL4A2
collagen, type IV, alpha 2
chr10_+_74323344 0.745 NM_152635
OIT3
oncoprotein induced transcript 3
chr12_+_27066749 0.742 NM_004264
MED21
mediator complex subunit 21
chr9_-_205892 0.739 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_-_160613203 0.736 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr3_+_123256902 0.735 NM_175862
CD86
CD86 molecule
chr4_-_47709717 0.734 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr6_+_132000134 0.730 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr20_+_47986342 0.726 RNF114
ring finger protein 114
chr15_+_94677572 0.724 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr4_+_71806538 0.724 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr15_+_20287609 0.721 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr1_+_159817752 0.721 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_+_100957003 0.719 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr6_+_28032997 0.718 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr20_+_47986335 0.717 RNF114
ring finger protein 114
chr16_-_29797172 0.716 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr4_-_56153135 0.715 NM_152401
PDCL2
phosducin-like 2
chr19_+_40895669 0.713 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr1_+_559129 0.711


chr6_-_31938530 0.711 NEU1
sialidase 1 (lysosomal sialidase)
chr20_+_54533191 0.702 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chr1_+_246087230 0.702 TRIM58
tripartite motif containing 58
chr1_+_246087104 0.701 NM_015431
TRIM58
tripartite motif containing 58
chr1_+_159899528 0.701 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr7_-_92693716 0.701 NM_001039372
HEPACAM2
HEPACAM family member 2
chr19_+_59866217 0.699 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr11_-_16380967 0.697 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chrX_-_23955223 0.694 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr2_+_169631777 0.694 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr13_-_102517196 0.691 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr7_+_134567270 0.690 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr1_+_556968 0.687


chr11_-_64335341 0.685 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr8_-_81155564 0.685 NM_001025252
TPD52
tumor protein D52
chr22_+_20350272 0.683 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr20_+_55569542 0.682 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr14_+_66901237 0.681 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr18_+_59726183 0.679 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr14_+_87560646 0.674 LOC283587
hypothetical protein LOC283587
chrX_-_76823813 0.674


chr6_+_25862905 0.673 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr19_+_56671649 0.671 NM_001080405
CEACAM18
carcinoembryonic antigen-related cell adhesion molecule 18
chr22_-_20314366 0.671 YDJC
YdjC homolog (bacterial)
chr15_+_56217686 0.661 NM_020980
AQP9
aquaporin 9
chr4_-_164754106 0.659 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr12_+_91620749 0.658 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr16_-_88604029 0.656 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr8_-_27997306 0.654 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr20_+_47986309 0.653 NM_018683
RNF114
ring finger protein 114
chr4_-_977163 0.651 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr1_-_150044365 0.649 NM_001004432
LINGO4
leucine rich repeat and Ig domain containing 4
chr19_+_55488632 0.648 MYH14
myosin, heavy chain 14, non-muscle
chr5_-_10361167 0.644 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chrX_-_70248022 0.643 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr6_+_34590624 0.642 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chrX_+_135558001 0.640 NM_000074
CD40LG
CD40 ligand
chr19_-_4782711 0.640 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr19_-_12028126 0.639 NM_001080404
ZNF878
zinc finger protein 878
chr2_+_38009405 0.635 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr18_-_21184824 0.633


chr11_-_16387001 0.633 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr6_+_32114060 0.633 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr8_-_42742729 0.630 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr4_-_123596921 0.627 NM_000586
IL2
interleukin 2
chr4_+_71096830 0.627 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr22_+_27779877 0.627 ZNRF3
zinc and ring finger 3
chr19_+_10258642 0.625 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr7_+_26298136 0.621 SNX10
sorting nexin 10
chr2_-_95514205 0.621 NM_001164464
TRIM43
TRIM43B
tripartite motif containing 43
tripartite motif containing 43B
chr20_-_43972061 0.617 PLTP
phospholipid transfer protein
chr6_-_159160387 0.617 EZR
ezrin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.81 3.97e-07 GO:0007608 sensory perception of smell
1.72 2.64e-06 GO:0007606 sensory perception of chemical stimulus
1.44 9.86e-04 GO:0006952 defense response
1.33 3.48e-03 GO:0002376 immune system process
1.42 2.60e-02 GO:0002682 regulation of immune system process
1.53 2.66e-02 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.14 2.71e-03 GO:0071944 cell periphery
1.14 3.38e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.85 5.17e-08 GO:0004984 olfactory receptor activity
1.33 4.57e-06 GO:0004872 receptor activity
3.41 4.40e-05 GO:0003823 antigen binding
1.27 8.87e-05 GO:0004871 signal transducer activity
1.27 8.87e-05 GO:0060089 molecular transducer activity
1.44 1.56e-04 GO:0004930 G-protein coupled receptor activity
1.30 3.31e-03 GO:0004888 transmembrane receptor activity