Motif ID: E2F1..5.p2

Z-value: 2.087


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F5chr8_+_86287161-0.713.2e-03Click!
E2F2chr1_-_23730298-0.582.4e-02Click!
E2F1chr20_-_31737815-0.459.2e-02Click!
E2F3chr6_+_205100190.342.1e-01Click!
E2F4chr16_+_65783571-0.039.2e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_17124974 3.746 NM_001114395
NM_017738
 CNTLN

centlein, centrosomal protein

chr6_+_72949092 2.173 RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_52257500 1.845 NM_002388
 MCM3
minichromosome maintenance complex component 3
chr6_-_52257475 1.834 MCM3
minichromosome maintenance complex component 3
chr5_-_146869613 1.737 DPYSL3
dihydropyrimidinase-like 3
chr6_-_52257431 1.698 MCM3
minichromosome maintenance complex component 3
chr15_+_45263517 1.616 NM_001198999
 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr10_+_96295511 1.606 NM_018063
 HELLS
helicase, lymphoid-specific
chr7_-_27153892 1.573 NM_024014
 HOXA6
homeobox A6
chr6_+_27941012 1.509 NM_003511
 HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr5_-_146869811 1.464 NM_001197294
 DPYSL3
dihydropyrimidinase-like 3
chr14_+_85069217 1.464


chr6_+_27208763 1.370 NM_021064
 HIST1H2AG
histone cluster 1, H2ag
chr8_+_31616809 1.344 NM_013962
 NRG1
neuregulin 1
chr10_-_131652007 1.313 NM_001005463
 EBF3
early B-cell factor 3
chr20_-_5048443 1.280 NM_182649
 PCNA
proliferating cell nuclear antigen
chr6_-_132314004 1.263 NM_001901
 CTGF
connective tissue growth factor
chr8_-_24869945 1.240 NM_006158
 NEFL
neurofilament, light polypeptide
chrX_-_131451675 1.232 NM_001170704
 MBNL3
muscleblind-like 3 (Drosophila)
chr7_+_113513726 1.232 FOXP2
forkhead box P2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 84 entries
enrichment   p-value GO term description
6.83 4.67e-02 GO:0071897 DNA biosynthetic process
5.85 1.47e-02 GO:0007062 sister chromatid cohesion
5.57 7.65e-03 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
5.57 7.65e-03 GO:0016444 somatic cell DNA recombination
4.42 3.27e-12 GO:0031497 chromatin assembly
4.16 1.40e-11 GO:0065004 protein-DNA complex assembly
4.15 8.96e-10 GO:0006334 nucleosome assembly
4.14 3.06e-12 GO:0071824 protein-DNA complex subunit organization
4.09 1.29e-10 GO:0034728 nucleosome organization
3.93 2.33e-12 GO:0006323 DNA packaging
3.77 3.31e-13 GO:0071103 DNA conformation change
3.68 1.02e-04 GO:0006261 DNA-dependent DNA replication
3.50 9.03e-10 GO:0006333 chromatin assembly or disassembly
3.24 1.29e-10 GO:0006260 DNA replication
2.93 1.05e-03 GO:0007059 chromosome segregation
2.86 5.35e-05 GO:0006310 DNA recombination
2.66 1.14e-02 GO:0051320 S phase
2.61 1.30e-03 GO:0000082 G1/S transition of mitotic cell cycle
2.60 2.66e-02 GO:0000084 S phase of mitotic cell cycle
2.55 3.70e-02 GO:0051321 meiotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
8.78 4.10e-03 GO:0042555 MCM complex
4.34 2.06e-07 GO:0000786 nucleosome
3.98 5.82e-10 GO:0032993 protein-DNA complex
3.80 1.52e-02 GO:0005657 replication fork
2.76 8.14e-10 GO:0000785 chromatin
2.69 3.25e-06 GO:0044454 nuclear chromosome part
2.68 6.96e-08 GO:0000228 nuclear chromosome
2.66 1.20e-21 GO:0005694 chromosome
2.59 1.77e-16 GO:0044427 chromosomal part
2.51 8.04e-04 GO:0000793 condensed chromosome
2.29 1.06e-02 GO:0000775 chromosome, centromeric region
1.91 5.40e-18 GO:0005654 nucleoplasm
1.82 2.41e-21 GO:0031981 nuclear lumen
1.79 2.46e-24 GO:0044428 nuclear part
1.78 1.12e-06 GO:0044451 nucleoplasm part
1.74 6.56e-04 GO:0030529 ribonucleoprotein complex
1.71 6.40e-21 GO:0070013 intracellular organelle lumen
1.68 6.74e-20 GO:0031974 membrane-enclosed lumen
1.68 8.14e-20 GO:0043233 organelle lumen
1.51 3.68e-38 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
11.70 2.52e-04 GO:0032135 DNA insertion or deletion binding
11.70 3.53e-02 GO:0032138 single base insertion or deletion binding
6.69 3.39e-03 GO:0030983 mismatched DNA binding
3.70 3.99e-04 GO:0003697 single-stranded DNA binding
3.41 1.96e-02 GO:0003684 damaged DNA binding
2.60 5.30e-04 GO:0003690 double-stranded DNA binding
2.34 4.75e-04 GO:0043566 structure-specific DNA binding
1.61 4.13e-16 GO:0003677 DNA binding
1.54 3.09e-04 GO:0030528 transcription regulator activity
1.54 2.24e-02 GO:0043565 sequence-specific DNA binding
1.53 4.75e-19 GO:0003676 nucleic acid binding
1.53 5.62e-04 GO:0001071 nucleic acid binding transcription factor activity
1.53 5.62e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.32 7.89e-04 GO:0000166 nucleotide binding
1.22 5.36e-11 GO:0005515 protein binding
1.12 2.46e-12 GO:0005488 binding