Motif ID: ATF4.p2

Z-value: 1.309


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_382465090.234.2e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_121946635 2.471 NM_024667
 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr12_-_121946581 1.990 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr20_+_19863716 1.823 RIN2
Ras and Rab interactor 2
chr19_+_10388448 1.592 PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_-_216009015 1.424 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr12_-_121946561 1.267


chr6_+_139497933 1.200 NM_016217
 HECA
headcase homolog (Drosophila)
chr9_-_139473606 1.117 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
 NELF




nasal embryonic LHRH factor




chr2_+_219453487 1.033 NM_025216
 WNT10A
wingless-type MMTV integration site family, member 10A
chr7_-_158314945 0.999 ESYT2
extended synaptotagmin-like protein 2
chr6_-_3102690 0.987 NM_001069
 TUBB2A
tubulin, beta 2A
chr7_-_129379947 0.983 NM_003344
NM_182697
 UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr20_+_33667160 0.942 NM_003116
 SPAG4
sperm associated antigen 4
chr16_-_78192111 0.941 NM_001031804
NM_005360
 MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr7_-_158314963 0.915 NM_020728
 ESYT2
extended synaptotagmin-like protein 2
chr9_-_109291866 0.907 NM_004235
 KLF4
Kruppel-like factor 4 (gut)
chr7_+_30140868 0.885 NM_152793
 C7orf41
chromosome 7 open reading frame 41
chr9_-_139473569 0.838 NELF
nasal embryonic LHRH factor
chr18_+_586997 0.809 NM_014410
 CLUL1
clusterin-like 1 (retinal)
chr5_-_1547872 0.802 LPCAT1
lysophosphatidylcholine acyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.78 4.53e-02 GO:0044265 cellular macromolecule catabolic process
1.65 1.35e-02 GO:0033554 cellular response to stress
1.48 1.75e-05 GO:0090304 nucleic acid metabolic process
1.44 6.21e-06 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 2.99e-05 GO:0044267 cellular protein metabolic process
1.43 1.18e-11 GO:0044260 cellular macromolecule metabolic process
1.43 1.30e-02 GO:0016070 RNA metabolic process
1.41 2.00e-02 GO:0010467 gene expression
1.38 3.49e-05 GO:0034641 cellular nitrogen compound metabolic process
1.37 6.05e-10 GO:0043170 macromolecule metabolic process
1.36 6.25e-05 GO:0006807 nitrogen compound metabolic process
1.35 1.04e-03 GO:0019538 protein metabolic process
1.30 7.39e-03 GO:0016043 cellular component organization
1.29 5.62e-03 GO:0071840 cellular component organization or biogenesis
1.27 1.72e-07 GO:0044237 cellular metabolic process
1.26 7.50e-07 GO:0044238 primary metabolic process
1.20 3.04e-04 GO:0008152 metabolic process
1.10 4.54e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.58 6.41e-05 GO:0005654 nucleoplasm
1.52 5.87e-06 GO:0031981 nuclear lumen
1.49 1.43e-06 GO:0044428 nuclear part
1.45 1.11e-05 GO:0043233 organelle lumen
1.44 1.60e-05 GO:0070013 intracellular organelle lumen
1.43 2.45e-05 GO:0031974 membrane-enclosed lumen
1.32 6.03e-10 GO:0005634 nucleus
1.28 1.28e-07 GO:0044446 intracellular organelle part
1.28 2.11e-07 GO:0044422 organelle part
1.25 4.30e-14 GO:0043231 intracellular membrane-bounded organelle
1.25 5.82e-14 GO:0043227 membrane-bounded organelle
1.23 3.83e-02 GO:0032991 macromolecular complex
1.22 8.30e-15 GO:0043229 intracellular organelle
1.22 1.44e-14 GO:0043226 organelle
1.18 3.46e-15 GO:0044424 intracellular part
1.17 2.89e-14 GO:0005622 intracellular
1.17 1.48e-05 GO:0005737 cytoplasm
1.17 2.33e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
2.44 4.97e-02 GO:0004386 helicase activity
1.46 1.62e-03 GO:0030554 adenyl nucleotide binding
1.46 1.93e-03 GO:0032559 adenyl ribonucleotide binding
1.46 2.21e-03 GO:0005524 ATP binding
1.40 3.40e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.39 4.42e-04 GO:0000166 nucleotide binding
1.39 5.09e-03 GO:0017076 purine nucleotide binding
1.39 5.63e-03 GO:0032553 ribonucleotide binding
1.39 5.63e-03 GO:0032555 purine ribonucleotide binding
1.32 2.09e-04 GO:0003676 nucleic acid binding
1.24 1.79e-08 GO:0005515 protein binding
1.13 2.43e-08 GO:0005488 binding