Motif ID: HNF1A.p2

Z-value: 6.024


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199006770.942.7e-07Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74566325 32.045 NM_001133
AFM
afamin
chr10_+_44726635 18.923 NM_001123376
TMEM72
transmembrane protein 72
chr6_-_24491498 18.251 NM_001195610
DCDC2
doublecortin domain containing 2
chr14_+_94097513 18.027 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr14_+_20226762 17.841 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr10_+_114144512 17.547 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_205344200 17.108 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr19_+_11211282 16.907 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr17_+_38306339 16.074 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr17_+_71065478 15.923 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr4_-_155731288 15.408 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr1_+_48460943 15.011 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr1_-_20014180 14.790 NM_019062
RNF186
ring finger protein 186
chr15_-_88150823 14.539 ANPEP
alanyl (membrane) aminopeptidase
chr7_-_50600536 14.048 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr16_-_67943157 14.028 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr20_+_41621119 13.917 SGK2
serum/glucocorticoid regulated kinase 2
chr3_+_142525744 13.866 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr20_+_41621079 13.101 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr21_-_46399900 12.848 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
40.67 3.10e-02 GO:0015712 hexose phosphate transport
40.67 3.10e-02 GO:0015760 glucose-6-phosphate transport
24.65 1.10e-03 GO:0046415 urate metabolic process
24.10 1.68e-02 GO:0051918 negative regulation of fibrinolysis
22.59 1.85e-03 GO:0051917 regulation of fibrinolysis
21.69 2.76e-02 GO:0019934 cGMP-mediated signaling
14.27 2.45e-02 GO:0034381 plasma lipoprotein particle clearance
13.56 7.22e-04 GO:0030195 negative regulation of blood coagulation
13.09 9.36e-04 GO:0050819 negative regulation of coagulation
9.73 7.88e-03 GO:0030193 regulation of blood coagulation
9.49 9.40e-03 GO:0030301 cholesterol transport
9.30 4.87e-02 GO:0097006 regulation of plasma lipoprotein particle levels
9.26 1.12e-02 GO:0015918 sterol transport
9.04 3.04e-03 GO:0061041 regulation of wound healing
9.04 1.32e-02 GO:0050818 regulation of coagulation
8.89 1.92e-04 GO:0010951 negative regulation of endopeptidase activity
7.91 3.27e-02 GO:0033993 response to lipid
7.34 5.35e-08 GO:0006805 xenobiotic metabolic process
7.34 5.35e-08 GO:0071466 cellular response to xenobiotic stimulus
7.29 6.07e-08 GO:0009410 response to xenobiotic stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
23.24 3.72e-02 GO:0005577 fibrinogen complex
8.34 8.12e-04 GO:0031983 vesicle lumen
8.08 4.06e-03 GO:0031093 platelet alpha granule lumen
7.91 4.67e-03 GO:0034774 secretory granule lumen
7.59 6.14e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
7.48 1.88e-03 GO:0031091 platelet alpha granule
7.23 2.99e-02 GO:0005903 brush border
6.14 5.18e-08 GO:0016324 apical plasma membrane
5.40 6.49e-08 GO:0045177 apical part of cell
3.45 6.00e-03 GO:0005792 microsome
3.34 8.80e-03 GO:0042598 vesicular fraction
2.90 1.45e-07 GO:0005624 membrane fraction
2.81 3.73e-07 GO:0005626 insoluble fraction
2.60 2.88e-05 GO:0005615 extracellular space
2.56 2.00e-07 GO:0000267 cell fraction
2.45 1.54e-03 GO:0005789 endoplasmic reticulum membrane
2.39 2.38e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
2.33 1.98e-03 GO:0044432 endoplasmic reticulum part
2.23 3.03e-04 GO:0044421 extracellular region part
2.01 5.83e-03 GO:0005783 endoplasmic reticulum

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
17.43 3.50e-07 GO:0015020 glucuronosyltransferase activity
14.46 4.19e-02 GO:0008514 organic anion transmembrane transporter activity
9.86 3.83e-04 GO:0043498 cell surface binding
6.55 2.88e-02 GO:0033293 monocarboxylic acid binding
6.16 1.57e-03 GO:0004867 serine-type endopeptidase inhibitor activity
4.60 2.08e-02 GO:0008194 UDP-glycosyltransferase activity
4.43 5.71e-03 GO:0004866 endopeptidase inhibitor activity
4.26 8.52e-03 GO:0061135 endopeptidase regulator activity
4.20 9.69e-03 GO:0030414 peptidase inhibitor activity
4.08 6.24e-03 GO:0016758 transferase activity, transferring hexosyl groups
3.95 3.59e-02 GO:0031406 carboxylic acid binding
3.55 2.67e-02 GO:0015291 secondary active transmembrane transporter activity
3.37 4.35e-03 GO:0004857 enzyme inhibitor activity
2.00 3.62e-02 GO:0030234 enzyme regulator activity