Motif ID: HNF1A.p2

Z-value: 6.024


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1199006770.942.7e-07Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74566325 32.045 NM_001133
AFM
afamin
chr10_+_44726635 18.923 NM_001123376
TMEM72
transmembrane protein 72
chr6_-_24491498 18.251 NM_001195610
DCDC2
doublecortin domain containing 2
chr14_+_94097513 18.027 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr14_+_20226762 17.841 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr10_+_114144512 17.547 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_205344200 17.108 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr19_+_11211282 16.907 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr17_+_38306339 16.074 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr17_+_71065478 15.923 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr4_-_155731288 15.408 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr1_+_48460943 15.011 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr1_-_20014180 14.790 NM_019062
RNF186
ring finger protein 186
chr15_-_88150823 14.539 ANPEP
alanyl (membrane) aminopeptidase
chr7_-_50600536 14.048 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr16_-_67943157 14.028 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr20_+_41621119 13.917 SGK2
serum/glucocorticoid regulated kinase 2
chr3_+_142525744 13.866 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr20_+_41621079 13.101 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr21_-_46399900 12.848 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chrX_-_105169370 12.823 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr7_-_44547382 12.652 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr4_+_155703581 12.616 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr16_+_21152516 12.364 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr14_-_93924873 12.231 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_-_64582568 11.988 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr16_-_46826588 11.893 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr8_-_17797127 11.582 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr6_+_167624792 11.526 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr20_+_42417752 11.160 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_+_31731667 11.067 APOM
apolipoprotein M
chr16_-_65510230 11.011 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr1_-_195302973 10.967 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr4_+_74520796 10.774 NM_001134
AFP
alpha-fetoprotein
chr6_+_31731647 10.664 NM_019101
APOM
apolipoprotein M
chr20_+_42417502 10.640 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_62539857 10.617 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr14_-_93924663 10.587 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_+_99334411 10.526 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr19_-_63556632 10.490 NM_130786
A1BG
alpha-1-B glycoprotein
chr6_-_26038817 10.402 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr14_-_93829347 10.401 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_42463279 10.373 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr4_-_186970366 10.226 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr14_-_93829309 10.163 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_+_71154240 9.991 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr6_+_167456230 9.766 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr20_+_42463350 9.733 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_+_17779528 9.721 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr5_+_175908948 9.718 NM_017675
CDHR2
cadherin-related family member 2
chr8_+_21967008 9.709 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_+_64289585 9.571 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_18680010 9.485 NM_152375
KLHDC7A
kelch domain containing 7A
chr14_-_93829113 9.474 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_88208650 9.457 NM_001443
FABP1
fatty acid binding protein 1, liver
chr6_-_52060327 9.441 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr20_+_42463419 9.400 HNF4A
hepatocyte nuclear factor 4, alpha
chr4_-_69852090 9.297 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr14_+_38772870 9.231 NM_054024
MIA2
melanoma inhibitory activity 2
chr20_+_42463387 9.161 HNF4A
hepatocyte nuclear factor 4, alpha
chr17_-_61655915 9.044 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr9_-_122852356 8.869 NM_001735
C5
complement component 5
chr14_+_54238581 8.783 SAMD4A
sterile alpha motif domain containing 4A
chr16_+_88224276 8.457 DPEP1
dipeptidase 1 (renal)
chr14_-_57030227 8.310 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr2_+_27573206 8.228 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr6_-_52736231 8.186 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr4_+_3413489 8.082 NM_001528
HGFAC
HGF activator
chr12_-_15757114 8.011 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_100359353 7.686 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr4_+_3413457 7.662 HGFAC
HGF activator
chr20_-_7869068 7.623 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr16_+_88224175 7.575 DPEP1
dipeptidase 1 (renal)
chr3_+_187866464 7.477 NM_000412
HRG
histidine-rich glycoprotein
chr14_-_93859394 7.456 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr12_+_54910767 7.380 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr8_-_124818754 7.291 NM_001003954
NM_004306
ANXA13

annexin A13

chr17_+_1592879 7.225 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr16_-_86527608 7.192 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr10_-_69736600 7.125 PBLD
phenazine biosynthesis-like protein domain containing
chr1_-_42402973 7.056 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr1_-_204455269 7.000 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr19_-_53081383 6.802 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr19_-_44135166 6.769 NM_148169
FBXO17
F-box protein 17
chr6_+_161043214 6.703 NM_000301
NM_001168338
PLG

plasminogen

chr4_+_74488835 6.500 NM_000477
ALB
albumin
chr19_-_53081326 6.474 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr11_+_64079665 6.292 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr13_-_99983945 6.089 NM_033110
A2LD1
AIG2-like domain 1
chr4_+_74488910 5.975 ALB
albumin
chr7_-_47545717 5.961 NM_022748
TNS3
tensin 3
chr4_-_110942783 5.950 NM_000204
CFI
complement factor I
chr3_-_171070314 5.925 NM_024727
LRRC31
leucine rich repeat containing 31
chr18_+_27425727 5.831 NM_000371
TTR
transthyretin
chr17_+_1592893 5.642 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr2_+_234333653 5.638 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr6_+_25862905 5.523 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr17_+_1586034 5.406 WDR81
WD repeat domain 81
chr4_+_74497998 5.383 ALB
albumin
chr4_+_74488947 5.382 ALB
albumin
chr4_-_977163 5.371 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr6_+_31815703 5.218 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6ORF26
MSH5



MSH5-C6orf26 read-through transcript
mutS homolog 5 (E. coli)



chr22_-_36836478 5.081 BAIAP2L2
BAI1-associated protein 2-like 2
chr15_-_96875133 5.080 NM_182562
FAM169B
family with sequence similarity 169, member B
chr6_-_25982418 5.010 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr4_+_187424111 4.985 NM_000128
F11
coagulation factor XI
chr6_+_54281161 4.890 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr6_-_31789824 4.878


chr4_+_74498042 4.857 ALB
albumin
chr15_+_56511466 4.838 NM_000236
LIPC
lipase, hepatic
chr12_-_54965996 4.837 CS
citrate synthase
chr19_+_46201665 4.702 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr22_-_36836620 4.692 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr10_+_115302767 4.540 NM_004132
HABP2
hyaluronan binding protein 2
chr4_-_110942576 4.279 CFI
complement factor I
chr7_-_104354325 4.253 LOC723809
hypothetical LOC723809
chr20_-_43972061 4.218 PLTP
phospholipid transfer protein
chr10_-_52315390 4.171 A1CF
APOBEC1 complementation factor
chr19_-_40995606 4.056 PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_69996780 4.048 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_+_99334069 3.956 NM_001134670
NM_138413
HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

chrX_+_70351773 3.938 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr16_-_20271530 3.890 NM_001008389
NM_003361
UMOD

uromodulin

chr2_+_87828718 3.855 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr3_+_150675117 3.850 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr5_+_140509803 3.815 NM_018939
PCDHB6
protocadherin beta 6
chr20_-_17589122 3.780 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr10_-_52315436 3.766 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_+_101981888 3.731 NM_173343
IL1R2
interleukin 1 receptor, type II
chr19_-_38052481 3.704 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chrX_+_70351812 3.618 GJB1
gap junction protein, beta 1, 32kDa
chr2_+_234302511 3.583 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr11_+_46697345 3.517 F2
coagulation factor II (thrombin)
chr11_+_64114857 3.433 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

chr16_+_56286212 3.378 NM_032269
CCDC135
coiled-coil domain containing 135
chr5_+_141326620 3.360 NM_183399
RNF14
ring finger protein 14
chr11_+_46697335 3.359 F2
coagulation factor II (thrombin)
chr11_+_46697312 3.320 NM_000506
F2
coagulation factor II (thrombin)
chr11_+_118561375 3.219 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr12_+_119900677 3.186 HNF1A
HNF1 homeobox A
chr3_+_150675169 3.150 TM4SF4
transmembrane 4 L six family member 4
chr7_+_94953148 3.058 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr1_+_42391678 3.057 NM_007102
GUCA2B
guanylate cyclase activator 2B (uroguanylin)
chr14_+_87560646 3.033 LOC283587
hypothetical protein LOC283587
chr5_-_138746840 2.999 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr19_-_40996040 2.901 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr9_+_81376666 2.856 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr20_+_35406497 2.810 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr17_+_1593040 2.804 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr2_+_97696462 2.791 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr16_+_20682812 2.727 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr14_+_38805251 2.690 NM_203356
CTAGE5
CTAGE family, member 5
chr1_+_205328834 2.661 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr9_+_80134302 2.628 PSAT1
phosphoserine aminotransferase 1
chr2_+_10103735 2.627


chr5_+_73145098 2.610 RGNEF
190 kDa guanine nucleotide exchange factor
chr1_+_198263352 2.590 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr2_-_87102453 2.551 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr5_-_138746917 2.525 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr9_-_33385265 2.425 AQP7
aquaporin 7
chr6_+_31604717 2.424 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr17_+_4638966 2.333 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr10_+_85923473 2.313 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr17_+_77910411 2.299 NM_207459
TEX19
testis expressed 19
chr4_-_70115037 2.275 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr4_-_40211324 2.143 RBM47
RNA binding motif protein 47
chr7_-_36992221 2.105 NM_130442
ELMO1
engulfment and cell motility 1
chr20_+_55569542 2.075 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_+_20854904 2.041 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr19_-_40995564 2.021 PRODH2
proline dehydrogenase (oxidase) 2
chr6_+_131936057 2.004 NM_000045
ARG1
arginase, liver
chr7_+_139175420 2.003 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_+_99263571 2.001 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chrX_-_131375217 2.001 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr12_+_25096755 1.999 LRMP
lymphoid-restricted membrane protein
chr13_-_40491405 1.995 ELF1
E74-like factor 1 (ets domain transcription factor)
chr16_-_56393871 1.970 KIFC3
kinesin family member C3
chr1_-_151852128 1.963 NM_080388
S100A16
S100 calcium binding protein A16
chrX_+_107174855 1.952 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr3_-_10309600 1.902 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr6_-_29120930 1.866 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr9_-_115901157 1.853 NM_138424
KIF12
kinesin family member 12
chr11_-_118405288 1.843 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr13_+_52500830 1.832 NM_006418
OLFM4
olfactomedin 4
chr6_-_116488458 1.830 NM_002031
FRK
fyn-related kinase
chr20_-_4938913 1.827 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr6_-_108252200 1.800 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr8_-_6407882 1.767 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr4_-_100492854 1.749 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr17_-_202557 1.735 RPH3AL
rabphilin 3A-like (without C2 domains)
chr4_-_69116839 1.733 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr12_+_91620749 1.711 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr2_+_108271526 1.670 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr20_+_31713750 1.645 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr16_-_56389176 1.628 NM_001130099
KIFC3
kinesin family member C3
chr12_-_69838045 1.603 NM_004616
TSPAN8
tetraspanin 8
chrX_-_15593074 1.594 NM_020665
TMEM27
transmembrane protein 27
chr5_+_67622242 1.588 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr13_-_40491491 1.582 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_-_6924092 1.572 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.34 5.35e-08 GO:0006805 xenobiotic metabolic process
7.34 5.35e-08 GO:0071466 cellular response to xenobiotic stimulus
7.29 6.07e-08 GO:0009410 response to xenobiotic stimulus
5.18 9.84e-07 GO:0008202 steroid metabolic process
3.72 6.02e-06 GO:0071702 organic substance transport
2.93 1.58e-05 GO:0006082 organic acid metabolic process
8.89 1.92e-04 GO:0010951 negative regulation of endopeptidase activity
1.84 3.82e-04 GO:0042221 response to chemical stimulus
1.96 3.92e-04 GO:0044281 small molecule metabolic process
5.02 4.07e-04 GO:0015849 organic acid transport
13.56 7.22e-04 GO:0030195 negative regulation of blood coagulation
13.09 9.36e-04 GO:0050819 negative regulation of coagulation
2.36 9.62e-04 GO:0006629 lipid metabolic process
24.65 1.10e-03 GO:0046415 urate metabolic process
2.60 1.53e-03 GO:0042180 cellular ketone metabolic process
22.59 1.85e-03 GO:0051917 regulation of fibrinolysis
1.38 2.01e-03 GO:0050896 response to stimulus
2.57 2.88e-03 GO:0019752 carboxylic acid metabolic process
2.57 2.88e-03 GO:0043436 oxoacid metabolic process
9.04 3.04e-03 GO:0061041 regulation of wound healing
5.13 5.04e-03 GO:0051346 negative regulation of hydrolase activity
9.73 7.88e-03 GO:0030193 regulation of blood coagulation
5.90 9.31e-03 GO:0010466 negative regulation of peptidase activity
9.49 9.40e-03 GO:0030301 cholesterol transport
4.41 1.07e-02 GO:0046942 carboxylic acid transport
9.26 1.12e-02 GO:0015918 sterol transport
1.74 1.17e-02 GO:0065008 regulation of biological quality
9.04 1.32e-02 GO:0050818 regulation of coagulation
3.28 1.39e-02 GO:0032787 monocarboxylic acid metabolic process
24.10 1.68e-02 GO:0051918 negative regulation of fibrinolysis
7.23 1.70e-02 GO:0033500 carbohydrate homeostasis
7.23 1.70e-02 GO:0042593 glucose homeostasis
4.46 2.12e-02 GO:0006869 lipid transport
4.81 2.33e-02 GO:0030162 regulation of proteolysis
14.27 2.45e-02 GO:0034381 plasma lipoprotein particle clearance
21.69 2.76e-02 GO:0019934 cGMP-mediated signaling
40.67 3.10e-02 GO:0015712 hexose phosphate transport
40.67 3.10e-02 GO:0015760 glucose-6-phosphate transport
7.91 3.27e-02 GO:0033993 response to lipid
6.58 3.47e-02 GO:0055088 lipid homeostasis
6.48 3.88e-02 GO:0015711 organic anion transport
4.45 4.81e-02 GO:0006820 anion transport
9.30 4.87e-02 GO:0097006 regulation of plasma lipoprotein particle levels
4.10 4.95e-02 GO:0010876 lipid localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.14 5.18e-08 GO:0016324 apical plasma membrane
5.40 6.49e-08 GO:0045177 apical part of cell
2.90 1.45e-07 GO:0005624 membrane fraction
2.56 2.00e-07 GO:0000267 cell fraction
2.81 3.73e-07 GO:0005626 insoluble fraction
1.97 2.86e-06 GO:0005576 extracellular region
2.60 2.88e-05 GO:0005615 extracellular space
2.23 3.03e-04 GO:0044421 extracellular region part
8.34 8.12e-04 GO:0031983 vesicle lumen
2.45 1.54e-03 GO:0005789 endoplasmic reticulum membrane
7.48 1.88e-03 GO:0031091 platelet alpha granule
2.33 1.98e-03 GO:0044432 endoplasmic reticulum part
2.39 2.38e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
8.08 4.06e-03 GO:0031093 platelet alpha granule lumen
7.91 4.67e-03 GO:0034774 secretory granule lumen
2.01 5.83e-03 GO:0005783 endoplasmic reticulum
3.45 6.00e-03 GO:0005792 microsome
7.59 6.14e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.34 8.80e-03 GO:0042598 vesicular fraction
7.23 2.99e-02 GO:0005903 brush border
23.24 3.72e-02 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
17.43 3.50e-07 GO:0015020 glucuronosyltransferase activity
9.86 3.83e-04 GO:0043498 cell surface binding
6.16 1.57e-03 GO:0004867 serine-type endopeptidase inhibitor activity
3.37 4.35e-03 GO:0004857 enzyme inhibitor activity
4.43 5.71e-03 GO:0004866 endopeptidase inhibitor activity
4.08 6.24e-03 GO:0016758 transferase activity, transferring hexosyl groups
4.26 8.52e-03 GO:0061135 endopeptidase regulator activity
4.20 9.69e-03 GO:0030414 peptidase inhibitor activity
4.60 2.08e-02 GO:0008194 UDP-glycosyltransferase activity
3.55 2.67e-02 GO:0015291 secondary active transmembrane transporter activity
6.55 2.88e-02 GO:0033293 monocarboxylic acid binding
3.95 3.59e-02 GO:0031406 carboxylic acid binding
2.00 3.62e-02 GO:0030234 enzyme regulator activity
14.46 4.19e-02 GO:0008514 organic anion transmembrane transporter activity