Motif ID: EN1,2.p2

Z-value: 3.647


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.496.2e-02Click!
EN1chr2_-_119322228-0.165.7e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_40211324 11.354 RBM47
RNA binding motif protein 47
chr7_+_50318801 9.426 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_102401580 9.204 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr1_+_173111306 8.500 NM_001035230
 RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_188197029 8.422


chr6_-_30188845 8.130 NM_007028
 TRIM31
tripartite motif containing 31
chr6_+_28601767 5.449 NM_001509
NM_003996
 GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr11_+_123600553 4.890 NM_001007249
 OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr16_+_56567839 4.864 NM_199046
NM_199456
 TEPP

testis, prostate and placenta expressed

chr1_+_246635918 4.683 NM_030904
 OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_-_180822686 4.660 NM_021133
 RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr19_+_45973139 4.539 NM_006533
 MIA
melanoma inhibitory activity
chr22_+_38627031 4.349 NM_004810
 GRAP2
GRB2-related adaptor protein 2
chr10_-_48036698 4.319 NM_016204
 GDF2
growth differentiation factor 2
chr14_+_59782222 4.259 NM_177952
 PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr10_-_98021144 4.059 NM_001114094
NM_013314
 BLNK

B-cell linker

chr1_+_160618143 4.017 NM_001085375
 C1orf226
chromosome 1 open reading frame 226
chr1_+_159032551 4.007 NM_001033667
NM_002348
 LY9

lymphocyte antigen 9

chr14_-_22658078 3.991 NM_001805
 CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr12_+_55018925 3.980 NM_016584
 IL23A
interleukin 23, alpha subunit p19

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
3.57 2.38e-26 GO:0007608 sensory perception of smell
3.39 4.27e-26 GO:0007606 sensory perception of chemical stimulus
3.21 1.93e-02 GO:0006959 humoral immune response
2.42 2.61e-18 GO:0007600 sensory perception
2.09 1.73e-09 GO:0006955 immune response
2.06 1.93e-03 GO:0045087 innate immune response
1.82 1.02e-10 GO:0050877 neurological system process
1.77 1.27e-04 GO:0006952 defense response
1.72 5.97e-11 GO:0003008 system process
1.66 8.67e-06 GO:0002376 immune system process
1.33 4.18e-13 GO:0050896 response to stimulus
1.24 3.25e-04 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.48 1.74e-03 GO:0005882 intermediate filament
2.29 4.32e-03 GO:0045111 intermediate filament cytoskeleton
1.65 8.65e-04 GO:0005615 extracellular space
1.51 5.89e-03 GO:0044421 extracellular region part
1.43 1.60e-13 GO:0071944 cell periphery
1.43 2.18e-13 GO:0005886 plasma membrane
1.40 2.64e-04 GO:0005576 extracellular region
1.27 6.83e-08 GO:0031224 intrinsic to membrane
1.26 4.38e-07 GO:0016021 integral to membrane
1.22 4.44e-06 GO:0044425 membrane part
1.15 6.46e-04 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
4.03 6.02e-03 GO:0008009 chemokine activity
3.71 4.64e-28 GO:0004984 olfactory receptor activity
3.64 2.03e-02 GO:0042379 chemokine receptor binding
2.50 9.35e-22 GO:0004930 G-protein coupled receptor activity
2.44 6.29e-04 GO:0005125 cytokine activity
2.09 3.44e-19 GO:0004888 transmembrane receptor activity
1.84 3.19e-16 GO:0004872 receptor activity
1.74 8.10e-16 GO:0004871 signal transducer activity
1.74 8.10e-16 GO:0060089 molecular transducer activity