Motif ID: EN1,2.p2

Z-value: 3.647


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.496.2e-02Click!
EN1chr2_-_119322228-0.165.7e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_40211324 11.354 RBM47
RNA binding motif protein 47
chr7_+_50318801 9.426 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_102401580 9.204 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_+_173111306 8.500 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr3_+_188197029 8.422


chr6_-_30188845 8.130 NM_007028
TRIM31
tripartite motif containing 31
chr6_+_28601767 5.449 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr11_+_123600553 4.890 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr16_+_56567839 4.864 NM_199046
NM_199456
TEPP

testis, prostate and placenta expressed

chr1_+_246635918 4.683 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_-_180822686 4.660 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr19_+_45973139 4.539 NM_006533
MIA
melanoma inhibitory activity
chr22_+_38627031 4.349 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr10_-_48036698 4.319 NM_016204
GDF2
growth differentiation factor 2
chr14_+_59782222 4.259 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr10_-_98021144 4.059 NM_001114094
NM_013314
BLNK

B-cell linker

chr1_+_160618143 4.017 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr1_+_159032551 4.007 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr14_-_22658078 3.991 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr12_+_55018925 3.980 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr2_+_96355661 3.898 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr17_+_22996461 3.737 LGALS9
lectin, galactoside-binding, soluble, 9
chr6_+_30212488 3.736 NM_138700
TRIM40
tripartite motif containing 40
chr16_-_79811475 3.727 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr16_-_28425632 3.716 NM_145659
IL27
interleukin 27
chr2_+_68855436 3.601 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chrX_+_65152004 3.500


chr17_-_74361620 3.485 TIMP2
TIMP metallopeptidase inhibitor 2
chr8_-_107023 3.468 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr4_+_186587537 3.183 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr16_-_88358946 3.154 FANCA
Fanconi anemia, complementation group A
chr15_-_40089736 3.153 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr6_-_32121784 3.080 NM_032470
TNXB
tenascin XB
chr5_+_132021763 3.035 NM_002188
IL13
interleukin 13
chr3_+_48239865 2.977 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr6_+_41411505 2.931 NM_004828
NCR2
natural cytotoxicity triggering receptor 2
chr11_+_123639909 2.922 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr11_+_59979857 2.900 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr22_+_38627129 2.877 GRAP2
GRB2-related adaptor protein 2
chr9_-_34681135 2.816 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr12_+_6424293 2.803 NM_001242
CD27
CD27 molecule
chrX_+_41433169 2.799 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr12_+_91620749 2.743 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr17_-_74361975 2.739 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_36928604 2.729 NM_002275
KRT15
keratin 15
chr2_+_68726457 2.722 NM_138964
PROKR1
prokineticin receptor 1
chr11_-_47356650 2.694 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_+_123625632 2.689 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr6_+_31782618 2.677 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr22_+_33792125 2.675 NM_001008494
ISX
intestine-specific homeobox
chr6_-_25834733 2.668 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr1_-_26070330 2.667 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr12_-_55917134 2.645 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr21_-_33805490 2.599 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr11_+_62231741 2.594 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr3_+_120375053 2.594 NM_006952
UPK1B
uroplakin 1B
chr22_-_48865907 2.584 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_-_48865797 2.581 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr17_-_60439764 2.581 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr3_+_52788976 2.569 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr19_+_47073029 2.566 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr11_-_47356562 2.541 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr11_-_47356672 2.539 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr4_-_54152480 2.528 NM_001126328
LNX1
ligand of numb-protein X 1
chr12_-_103846186 2.522 NM_032148
SLC41A2
solute carrier family 41, member 2
chr13_+_112349358 2.510 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr11_-_47356642 2.503 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr4_-_80466177 2.494 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr14_-_23623657 2.449 NM_006177
NRL
neural retina leucine zipper
chr3_+_38238080 2.444 OXSR1
oxidative-stress responsive 1
chr21_+_42583259 2.436 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr16_+_49288550 2.425 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr1_+_15675182 2.405 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr5_-_180560535 2.398 NM_203297
TRIM7
tripartite motif containing 7
chr3_+_99733432 2.323 NM_005290
GPR15
G protein-coupled receptor 15
chr11_+_61389756 2.299 FADS2
fatty acid desaturase 2
chr9_+_124072947 2.294 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr22_-_48865864 2.277 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_86739683 2.260 CCNH
cyclin H
chr6_+_47732181 2.254 NM_153839
GPR111
G protein-coupled receptor 111
chr1_+_159943385 2.245 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr3_-_46224791 2.215 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr22_+_20929199 2.214 NM_007128
VPREB1
pre-B lymphocyte 1
chr11_-_58947001 2.209 NM_001001954
OR5A2
olfactory receptor, family 5, subfamily A, member 2
chr10_-_72032447 2.174 PRF1
perforin 1 (pore forming protein)
chr6_-_116488458 2.171 NM_002031
FRK
fyn-related kinase
chr10_-_72032519 2.160 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr19_+_13999959 2.150 NM_080864
RLN3
relaxin 3
chr1_-_148854503 2.148


chr12_-_121767272 2.096 NM_006018
GPR109B
G protein-coupled receptor 109B
chr2_+_171316462 2.091 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr12_+_49922592 2.080 DAZAP2
DAZ associated protein 2
chr19_+_61624 2.055 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_-_17415918 2.049 DCAF16
DDB1 and CUL4 associated factor 16
chr11_-_62231636 2.046 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr14_-_52689782 2.028 NM_001160147
NM_001160148
NM_030637
DDHD1


DDHD domain containing 1


chr8_-_66863841 2.014 NM_002603
PDE7A
phosphodiesterase 7A
chr3_+_171022403 2.012 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr11_-_64403712 2.007 EHD1
EH-domain containing 1
chr11_-_116605761 1.988 PCSK7
proprotein convertase subtilisin/kexin type 7
chr19_-_14030970 1.983 NM_001145028
PALM3
paralemmin 3
chr9_-_70780574 1.976


chr10_+_5976354 1.962 NM_032807
FBXO18
F-box protein, helicase, 18
chr18_+_70352779 1.949 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr22_+_19660361 1.939 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr22_+_49333327 1.933 NM_138433
KLHDC7B
kelch domain containing 7B
chr5_+_67558217 1.929 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr15_-_40173949 1.926 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr15_+_41672543 1.914 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr17_-_36209672 1.908 NM_181535
KRT28
keratin 28
chr17_-_31441390 1.906 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr11_+_62231689 1.875 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr11_+_94398069 1.871 NM_001161630
KDM4DL
lysine (K)-specific demethylase 4D-like
chr19_-_56164628 1.871 NM_002774
KLK6
kallikrein-related peptidase 6
chr12_+_51783554 1.857 SOAT2
sterol O-acyltransferase 2
chr22_+_19248733 1.856 MED15
mediator complex subunit 15
chr7_-_86433139 1.855 NM_152748
KIAA1324L
KIAA1324-like
chr16_-_20271530 1.853 NM_001008389
NM_003361
UMOD

uromodulin

chr1_+_25471470 1.832 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr2_+_191009265 1.829 MFSD6
major facilitator superfamily domain containing 6
chr12_-_101396459 1.828 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_+_118269310 1.792 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr20_+_186376 1.787 NM_207469
DEFB132
defensin, beta 132
chr9_-_124981125 1.785 STRBP
spermatid perinuclear RNA binding protein
chr11_-_47356479 1.769 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr17_-_69869552 1.761 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr7_+_74017015 1.747 NM_001145063
GATSL1
GATSL2
GATS protein-like 1
GATS protein-like 2
chr15_+_56217686 1.725 NM_020980
AQP9
aquaporin 9
chr8_+_128497038 1.724 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr3_+_45902999 1.720 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr4_+_39874921 1.713 NM_004310
RHOH
ras homolog gene family, member H
chr11_-_5212168 1.707 NM_000519
HBD
hemoglobin, delta
chr19_-_40925151 1.707 NM_024660
TMEM149
transmembrane protein 149
chr1_+_154390939 1.705 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr15_-_78050515 1.703 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr12_-_101036407 1.694 NM_024057
NUP37
nucleoporin 37kDa
chr4_-_54152385 1.692 LNX1
ligand of numb-protein X 1
chr14_+_87541220 1.687 NM_003608
GPR65
G protein-coupled receptor 65
chrX_-_135577102 1.681 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr17_-_37181626 1.680


chr11_+_5367182 1.679 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr1_+_32447281 1.670 NM_001099434
DCDC2B
doublecortin domain containing 2B
chr20_+_34019942 1.663 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr3_+_3056307 1.661 NM_175612
CNTN4
contactin 4
chr9_+_95886558 1.660 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr11_-_123918759 1.660 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr7_-_25234582 1.656 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_111217244 1.652 NM_000560
CD53
CD53 molecule
chr19_-_53515143 1.650 NM_144577
CCDC114
coiled-coil domain containing 114
chrX_+_36163971 1.621 NM_001098843
CXorf30
chromosome X open reading frame 30
chr6_+_25834983 1.618 NM_170610
HIST1H2BA
histone cluster 1, H2ba
chr20_+_43470354 1.616 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr12_+_52103905 1.613 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr11_+_20577521 1.599 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr18_-_22699650 1.598 NM_001650
AQP4
aquaporin 4
chr3_-_185578621 1.590 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr17_-_39500512 1.588 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr12_+_1596482 1.581 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr17_-_59349867 1.580 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr12_-_642786 1.579 NM_016533
NINJ2
ninjurin 2
chr7_+_106897737 1.570 NM_005295
GPR22
G protein-coupled receptor 22
chr18_+_70352649 1.569 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr14_-_20340377 1.553 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr3_-_113334657 1.549 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chrX_-_48212683 1.535 SLC38A5
solute carrier family 38, member 5
chr17_+_43165608 1.518 NM_013351
TBX21
T-box 21
chr19_-_56841819 1.518 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr21_+_42697058 1.517 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr9_-_34719463 1.511 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr1_-_202726068 1.502 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr5_+_180514548 1.496 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr11_-_5037432 1.493 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr1_+_86707113 1.487 NM_001285
CLCA1
chloride channel accessory 1
chr12_+_6926014 1.482 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr5_-_22889487 1.481 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr20_-_45410033 1.480 ZMYND8
zinc finger, MYND-type containing 8
chr12_+_46802695 1.478 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr6_+_6533932 1.475 NM_004271
LY86
lymphocyte antigen 86
chrX_-_7855400 1.473 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr6_-_76022565 1.472 TMEM30A
transmembrane protein 30A
chr5_+_125723686 1.467 NM_001146319
GRAMD3
GRAM domain containing 3
chr15_-_48345453 1.458 NM_002112
HDC
histidine decarboxylase
chr16_+_55950195 1.454 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chrX_-_48655978 1.454 PIM2
pim-2 oncogene
chr11_-_18226743 1.451 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr2_-_158008763 1.451 NM_004288
CYTIP
cytohesin 1 interacting protein
chrX_-_47374647 1.434 NM_002621
CFP
complement factor properdin
chr12_-_7172641 1.432 NM_031491
RBP5
retinol binding protein 5, cellular
chr12_+_6925997 1.431 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_119617060 1.428


chr16_+_28850760 1.416 NM_001178098
NM_001770
CD19

CD19 molecule

chr17_+_69781980 1.415 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr12_-_69434330 1.414 PTPRR
protein tyrosine phosphatase, receptor type, R
chr6_+_29732736 1.414 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr15_+_57286313 1.410 NM_033195
LDHAL6B
lactate dehydrogenase A-like 6B
chr8_+_22266256 1.396 PIWIL2
piwi-like 2 (Drosophila)
chr19_-_45141473 1.391 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr7_+_117651947 1.388 NM_019644
ANKRD7
ankyrin repeat domain 7
chr14_-_23107106 1.386 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr6_-_41823056 1.386 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.57 2.38e-26 GO:0007608 sensory perception of smell
3.39 4.27e-26 GO:0007606 sensory perception of chemical stimulus
2.42 2.61e-18 GO:0007600 sensory perception
1.33 4.18e-13 GO:0050896 response to stimulus
1.72 5.97e-11 GO:0003008 system process
1.82 1.02e-10 GO:0050877 neurological system process
2.09 1.73e-09 GO:0006955 immune response
1.66 8.67e-06 GO:0002376 immune system process
1.77 1.27e-04 GO:0006952 defense response
1.24 3.25e-04 GO:0032501 multicellular organismal process
2.06 1.93e-03 GO:0045087 innate immune response
3.21 1.93e-02 GO:0006959 humoral immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 1.60e-13 GO:0071944 cell periphery
1.43 2.18e-13 GO:0005886 plasma membrane
1.27 6.83e-08 GO:0031224 intrinsic to membrane
1.26 4.38e-07 GO:0016021 integral to membrane
1.22 4.44e-06 GO:0044425 membrane part
1.40 2.64e-04 GO:0005576 extracellular region
1.15 6.46e-04 GO:0016020 membrane
1.65 8.65e-04 GO:0005615 extracellular space
2.48 1.74e-03 GO:0005882 intermediate filament
2.29 4.32e-03 GO:0045111 intermediate filament cytoskeleton
1.51 5.89e-03 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.71 4.64e-28 GO:0004984 olfactory receptor activity
2.50 9.35e-22 GO:0004930 G-protein coupled receptor activity
2.09 3.44e-19 GO:0004888 transmembrane receptor activity
1.84 3.19e-16 GO:0004872 receptor activity
1.74 8.10e-16 GO:0004871 signal transducer activity
1.74 8.10e-16 GO:0060089 molecular transducer activity
2.44 6.29e-04 GO:0005125 cytokine activity
4.03 6.02e-03 GO:0008009 chemokine activity
3.64 2.03e-02 GO:0042379 chemokine receptor binding