Motif ID: NKX6-1,2.p2

Z-value: 1.623


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_856384100.243.8e-01Click!
NKX6-2chr10_-_1344494670.194.9e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17861266 4.129 NM_001105569
MSGN1
mesogenin 1
chr20_+_19863716 3.210 RIN2
Ras and Rab interactor 2
chr11_+_7574992 2.662 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_-_152368492 2.517 SH3D19
SH3 domain containing 19
chr12_-_28016182 2.435 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_+_218698980 2.382 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr4_+_75393053 2.348 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr3_-_143230124 2.290 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr6_+_47774247 2.005 NM_153838
GPR115
G protein-coupled receptor 115
chr10_-_90601655 1.912 NM_144590
ANKRD22
ankyrin repeat domain 22
chr4_-_77147625 1.889 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr22_-_25291268 1.832 NM_001008566
TPST2
tyrosylprotein sulfotransferase 2
chr11_-_128399218 1.815 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr1_+_185064654 1.746 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr21_-_35343065 1.633 RUNX1
runt-related transcription factor 1
chr12_-_6103945 1.625 NM_000552
VWF
von Willebrand factor
chr13_-_35327798 1.624 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr12_+_48443232 1.606 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_-_31251315 1.603 PUM1
pumilio homolog 1 (Drosophila)
chr6_-_32447626 1.558 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr4_-_70760381 1.556 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr3_-_79899748 1.548 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_+_147562531 1.548 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr1_+_78858675 1.541 NM_006820
IFI44L
interferon-induced protein 44-like
chr3_-_64186151 1.496 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr19_+_45973139 1.461 NM_006533
MIA
melanoma inhibitory activity
chr6_-_32892705 1.436 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr17_-_39191658 1.423 NM_025237
SOST
sclerostin
chr7_-_41709191 1.419 NM_002192
INHBA
inhibin, beta A
chr9_-_21375258 1.415 NM_000605
IFNA2
interferon, alpha 2
chr11_-_117305277 1.408 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr21_-_30510113 1.390 NM_199328
CLDN8
claudin 8
chr14_+_62740878 1.386 NM_020663
RHOJ
ras homolog gene family, member J
chr4_-_90978469 1.380 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr5_-_111119846 1.377 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr2_+_218698242 1.350 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr12_+_111375382 1.341 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr2_-_160765008 1.320 ITGB6
integrin, beta 6
chr1_+_208568218 1.297 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr11_-_101906640 1.289 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr7_-_93027057 1.281 NM_001164738
CALCR
calcitonin receptor
chr18_+_59705918 1.253 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr6_+_116956868 1.239 NM_153036
FAM26D
family with sequence similarity 26, member D
chr1_+_205068844 1.238 NM_013371
IL19
interleukin 19
chr8_-_122722674 1.236 NM_005328
HAS2
hyaluronan synthase 2
chr11_-_117552355 1.229 SCN2B
sodium channel, voltage-gated, type II, beta
chr7_-_105009160 1.229 EFCAB10
EF-hand calcium binding domain 10
chr18_+_59405513 1.194 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr2_-_202271598 1.177 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_117552545 1.160 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr4_-_23500706 1.159 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr20_+_11846536 1.157 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr7_-_83662152 1.154 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr13_-_83354474 1.153 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr1_+_207668787 1.150 NM_001104548
LOC642587
NPC-A-5
chr2_-_136590210 1.141 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr10_+_101532450 1.112 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_+_74071116 1.112 GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_-_116184846 1.111 NM_001111061
NHLH2
nescient helix loop helix 2
chr4_-_138673078 1.090 NM_019035
PCDH18
protocadherin 18
chr12_+_32546243 1.070 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_150997129 1.065 NM_001025231
KPRP
keratinocyte proline-rich protein
chr10_+_101532544 1.047 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr15_-_40089736 1.036 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr1_-_221920023 1.034 NM_001143962
CAPN8
calpain 8
chrX_-_33139349 1.015 NM_004006
DMD
dystrophin
chr9_-_111253484 1.000 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr13_+_96726415 0.984 MBNL2
muscleblind-like 2 (Drosophila)
chr13_-_83354425 0.955 SLITRK1
SLIT and NTRK-like family, member 1
chr12_+_9871343 0.954 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr21_-_34820916 0.953 NM_203418
RCAN1
regulator of calcineurin 1
chr21_-_35343331 0.946 RUNX1
runt-related transcription factor 1
chr4_-_185963859 0.940 ACSL1
acyl-CoA synthetase long-chain family member 1
chr2_-_160764819 0.937 NM_000888
ITGB6
integrin, beta 6
chr5_-_13997588 0.934 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr6_-_46811388 0.932 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chrX_-_10504852 0.931 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_225519974 0.924 DOCK10
dedicator of cytokinesis 10
chr18_+_27152049 0.897 NM_001942
DSG1
desmoglein 1
chr21_-_35343500 0.894 RUNX1
runt-related transcription factor 1
chr3_+_188397967 0.879 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr3_+_179759181 0.878 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_-_52939584 0.874 NM_001127322
CBX5
chromobox homolog 5
chr21_+_29439768 0.871 C21orf7
chromosome 21 open reading frame 7
chr1_-_149004916 0.868 NM_004079
CTSS
cathepsin S
chr2_+_108571336 0.864 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr21_-_35343448 0.847 RUNX1
runt-related transcription factor 1
chr21_-_35343456 0.844 NM_001754
RUNX1
runt-related transcription factor 1
chr15_+_97990705 0.844 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr18_+_54013575 0.844 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_221919982 0.843 CAPN8
calpain 8
chr4_-_77176163 0.834 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr21_+_42492867 0.831 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr6_-_138862271 0.827 NM_001144060
NHSL1
NHS-like 1
chr12_-_10464308 0.826 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr1_+_78888064 0.825 NM_006417
IFI44
interferon-induced protein 44
chrX_+_85404626 0.822 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr8_+_79591074 0.817 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr17_+_24598000 0.814 NM_005208
CRYBA1
crystallin, beta A1
chr5_+_35892747 0.812 NM_002185
IL7R
interleukin 7 receptor
chr12_-_52939636 0.811 NM_001127321
CBX5
chromobox homolog 5
chr2_+_234265059 0.811 NM_205862
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr3_-_51912376 0.806 NM_152397
IQCF1
IQ motif containing F1
chr5_-_150707281 0.806 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr7_+_28692122 0.803 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr5_+_49997489 0.798 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chrX_-_78509662 0.792 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr18_+_30544193 0.784 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr2_+_68815416 0.783 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr14_-_60185659 0.780 NM_005982
SIX1
SIX homeobox 1
chr17_+_36228869 0.777 NM_001195387
NM_145274
NM_001195386
TMEM99


transmembrane protein 99


chr2_-_217267742 0.775 IGFBP5
insulin-like growth factor binding protein 5
chr12_+_111829121 0.774 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr3_+_133518900 0.772 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr4_-_138673014 0.771 PCDH18
protocadherin 18
chr12_+_28301399 0.767 NM_018318
CCDC91
coiled-coil domain containing 91
chr12_+_106692291 0.764 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr6_+_36206239 0.757 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr4_-_68678181 0.753 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr7_-_20223467 0.742 NM_182762
MACC1
metastasis associated in colon cancer 1
chr6_-_26151863 0.732 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr2_+_113542017 0.726 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr6_+_125346208 0.725 NM_152553
RNF217
ring finger protein 217
chr8_-_38324809 0.711 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr18_-_49944986 0.709 MBD2
methyl-CpG binding domain protein 2
chr13_-_45323757 0.707 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr14_-_74600469 0.706 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr16_+_22432344 0.706 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr3_-_95230143 0.705 NM_001001850
STX19
syntaxin 19
chr13_-_59485299 0.701 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr3_-_122862447 0.698 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr17_+_25292748 0.696 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr13_-_98708549 0.679 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr2_-_207291364 0.675 NM_001093730
DYTN
dystrotelin
chr12_-_10983072 0.673 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr21_-_35343428 0.673 RUNX1
runt-related transcription factor 1
chr6_-_138935359 0.672 NM_020464
NHSL1
NHS-like 1
chr12_-_56422120 0.671 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr4_-_186969041 0.666 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_-_64087806 0.655 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr6_-_138862273 0.655


chr3_+_133518966 0.652 ACPP
acid phosphatase, prostate
chr3_+_190990142 0.648 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr3_-_11585264 0.648 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr6_-_128263868 0.628 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr19_-_46504831 0.628


chrX_-_43717864 0.626 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_-_171286634 0.624 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr2_+_219180821 0.619 PLCD4
phospholipase C, delta 4
chr12_+_55018925 0.618 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr4_+_54790020 0.616 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr1_+_144188375 0.613 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr8_-_23768242 0.612 NM_003155
STC1
stanniocalcin 1
chr6_-_56824672 0.610 DST
dystonin
chr3_-_17757402 0.610 NM_014744
TBC1D5
TBC1 domain family, member 5
chrX_-_23765377 0.607 RPL9
ribosomal protein L9
chrX_+_105823723 0.604 NM_024539
RNF128
ring finger protein 128
chr2_+_11591692 0.602 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr2_-_227952249 0.602 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr10_-_120091795 0.601 NM_001134672
NM_022063
C10orf84

chromosome 10 open reading frame 84

chr12_+_48443588 0.600 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr11_+_59027624 0.599 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr6_-_56824371 0.594 DST
dystonin
chr1_+_111571803 0.592 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr16_-_70685715 0.588 NM_001142318
TXNL4B
thioredoxin-like 4B
chr13_-_37070862 0.588 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chrX_-_119550402 0.585 CUL4B
cullin 4B
chr2_+_201756048 0.584 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr4_+_54790190 0.584 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr20_-_49747397 0.582 ATP9A
ATPase, class II, type 9A
chr1_+_242691295 0.582 NM_001130957
NM_173807
C1orf101

chromosome 1 open reading frame 101

chr3_-_122862391 0.579 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr2_+_108571209 0.575 LIMS1
LIM and senescent cell antigen-like domains 1
chr14_-_63076155 0.575 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr10_-_123343761 0.567 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr4_-_140420789 0.558 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr2_-_113310796 0.557 NM_000576
IL1B
interleukin 1, beta
chr9_+_92629525 0.553 NM_001174167
SYK
spleen tyrosine kinase
chr3_-_194579207 0.550 NM_198505
ATP13A5
ATPase type 13A5
chr12_+_91620749 0.547 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr7_+_5609416 0.539 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr8_-_114518194 0.539 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr20_-_25319435 0.536 NM_001042472
NM_015600
ABHD12

abhydrolase domain containing 12

chr1_-_181826292 0.534 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr8_-_72431274 0.528 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr10_-_123343320 0.527 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr1_-_149115667 0.524 ARNT
aryl hydrocarbon receptor nuclear translocator
chr1_-_149004852 0.522 CTSS
cathepsin S
chr6_+_32713160 0.519 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_37397669 0.517 NM_005813
PRKD3
protein kinase D3
chr5_+_166644420 0.517 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr8_-_42742729 0.512 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr5_+_145296313 0.512 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr11_-_125055884 0.511 NM_001612
NM_020069
NM_020107
NM_020108
NM_020109
NM_020110
NM_020111
NM_020113
NM_020115
ACRV1








acrosomal vesicle protein 1








chr13_-_32658215 0.511 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_+_187227302 0.510 NM_003265
TLR3
toll-like receptor 3
chr6_+_110608284 0.509 NM_015891
CDC40
cell division cycle 40 homolog (S. cerevisiae)
chr20_-_25319338 0.508 ABHD12
abhydrolase domain containing 12
chr4_+_166350620 0.507 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chrX_+_35847771 0.507 NM_152632
CXorf22
chromosome X open reading frame 22

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.39e-02 GO:0050896 response to stimulus
2.06 1.76e-02 GO:0051707 response to other organism
1.44 3.99e-02 GO:0007166 cell surface receptor linked signaling pathway
1.68 4.94e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.55 1.81e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.59 9.34e-03 GO:0005102 receptor binding
2.34 3.45e-02 GO:0005125 cytokine activity