Motif ID: RUNX1..3.p2

Z-value: 4.749


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.913.4e-06Click!
RUNX1chr21_-_351828730.611.5e-02Click!
RUNX2chr6_+_45497796-0.486.9e-02Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_25164061 14.633 NM_001031680
 RUNX3
runt-related transcription factor 3
chr11_+_60495690 8.731 NM_006725
 CD6
CD6 molecule
chr6_-_41276901 8.447 NM_024807
 TREML2
triggering receptor expressed on myeloid cells-like 2
chr16_+_28413421 8.315 NM_018690
 APOBR
apolipoprotein B receptor
chr15_-_75259714 7.847 PEAK1
NKF3 kinase family member
chr9_-_129580732 7.785 NM_170600
 SH2D3C
SH2 domain containing 3C
chr1_+_207995999 7.393 NM_025228
 TRAF3IP3
TRAF3 interacting protein 3
chr4_-_1185144 7.329 LOC100130872
hypothetical LOC100130872
chrX_+_71280758 7.312 NM_207422
 FLJ44635
TPT1-like protein
chr5_+_125723686 6.950 NM_001146319
 GRAMD3
GRAM domain containing 3
chr12_+_45896511 6.932 FAM113B
family with sequence similarity 113, member B
chr14_+_92188329 6.890 RIN3
Ras and Rab interactor 3
chr17_+_23818922 6.830


chr16_-_66590856 6.558 NM_022355
 DPEP2
dipeptidase 2
chr19_-_55560686 6.487 NM_004851
 NAPSA
napsin A aspartic peptidase
chr15_+_36776090 6.436 NM_207444
 C15orf53
chromosome 15 open reading frame 53
chr1_-_205012348 6.424 NM_000572
 IL10
interleukin 10
chr6_+_52159143 6.350 NM_002190
 IL17A
interleukin 17A
chr14_-_93493519 6.277 NM_016150
 ASB2
ankyrin repeat and SOCS box containing 2
chr5_+_140871107 6.133



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.34 1.22e-03 GO:0046649 lymphocyte activation
2.30 2.18e-09 GO:0007608 sensory perception of smell
2.16 2.09e-08 GO:0007606 sensory perception of chemical stimulus
2.09 2.22e-02 GO:0051249 regulation of lymphocyte activation
2.08 9.54e-03 GO:0045321 leukocyte activation
2.05 2.36e-03 GO:0050778 positive regulation of immune response
1.94 3.39e-02 GO:0001817 regulation of cytokine production
1.82 3.08e-03 GO:0002684 positive regulation of immune system process
1.80 1.37e-03 GO:0001775 cell activation
1.79 2.75e-06 GO:0006955 immune response
1.77 9.66e-03 GO:0050776 regulation of immune response
1.76 4.10e-11 GO:0002376 immune system process
1.73 7.08e-06 GO:0007600 sensory perception
1.72 2.07e-04 GO:0002682 regulation of immune system process
1.64 4.80e-04 GO:0048584 positive regulation of response to stimulus
1.49 2.74e-04 GO:0050877 neurological system process
1.48 1.01e-05 GO:0003008 system process
1.34 3.31e-02 GO:0007166 cell surface receptor linked signaling pathway
1.27 1.98e-02 GO:0048518 positive regulation of biological process
1.26 4.13e-10 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.45 7.92e-04 GO:0005887 integral to plasma membrane
1.43 1.47e-03 GO:0031226 intrinsic to plasma membrane
1.37 1.54e-12 GO:0005886 plasma membrane
1.36 1.29e-12 GO:0071944 cell periphery
1.30 2.44e-03 GO:0044459 plasma membrane part
1.18 4.45e-04 GO:0031224 intrinsic to membrane
1.17 2.12e-03 GO:0016021 integral to membrane
1.16 5.19e-04 GO:0044425 membrane part
1.13 2.94e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
4.44 9.43e-05 GO:0003823 antigen binding
2.29 2.29e-09 GO:0004984 olfactory receptor activity
1.71 2.03e-06 GO:0004930 G-protein coupled receptor activity
1.62 1.10e-11 GO:0004872 receptor activity
1.59 2.43e-07 GO:0004888 transmembrane receptor activity
1.51 6.61e-10 GO:0004871 signal transducer activity
1.51 6.61e-10 GO:0060089 molecular transducer activity