Motif ID: RUNX1..3.p2

Z-value: 4.749


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RUNX3chr1_-_251640610.913.4e-06Click!
RUNX1chr21_-_351828730.611.5e-02Click!
RUNX2chr6_+_45497796-0.486.9e-02Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_25164061 14.633 NM_001031680
RUNX3
runt-related transcription factor 3
chr11_+_60495690 8.731 NM_006725
CD6
CD6 molecule
chr6_-_41276901 8.447 NM_024807
TREML2
triggering receptor expressed on myeloid cells-like 2
chr16_+_28413421 8.315 NM_018690
APOBR
apolipoprotein B receptor
chr15_-_75259714 7.847 PEAK1
NKF3 kinase family member
chr9_-_129580732 7.785 NM_170600
SH2D3C
SH2 domain containing 3C
chr1_+_207995999 7.393 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr4_-_1185144 7.329 LOC100130872
hypothetical LOC100130872
chrX_+_71280758 7.312 NM_207422
FLJ44635
TPT1-like protein
chr5_+_125723686 6.950 NM_001146319
GRAMD3
GRAM domain containing 3
chr12_+_45896511 6.932 FAM113B
family with sequence similarity 113, member B
chr14_+_92188329 6.890 RIN3
Ras and Rab interactor 3
chr17_+_23818922 6.830


chr16_-_66590856 6.558 NM_022355
DPEP2
dipeptidase 2
chr19_-_55560686 6.487 NM_004851
NAPSA
napsin A aspartic peptidase
chr15_+_36776090 6.436 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr1_-_205012348 6.424 NM_000572
IL10
interleukin 10
chr6_+_52159143 6.350 NM_002190
IL17A
interleukin 17A
chr14_-_93493519 6.277 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr5_+_140871107 6.133


chr12_-_66839589 6.042 NM_000619
IFNG
interferon, gamma
chr17_-_31441390 5.953 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr1_+_202000906 5.840 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr2_+_102401580 5.803 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr19_-_6671585 5.650 NM_000064
C3
complement component 3
chr8_-_21827057 5.448 NM_003974
DOK2
docking protein 2, 56kDa
chr5_+_140870881 5.326


chr1_+_158063102 5.289 NM_020125
SLAMF8
SLAM family member 8
chr19_-_40925151 5.276 NM_024660
TMEM149
transmembrane protein 149
chr6_+_30212488 5.202 NM_138700
TRIM40
tripartite motif containing 40
chr6_-_36412562 5.171 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr12_-_101396459 5.152 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_-_102872354 5.137 NCALD
neurocalcin delta
chr4_+_76700281 5.004 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr1_-_159099090 4.990 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr8_-_102872372 4.961 NCALD
neurocalcin delta
chr15_-_63290839 4.923 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr14_-_106154332 4.907 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_40631603 4.905 NM_001198979
SMAP2
small ArfGAP2
chr1_-_114215768 4.814 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr22_+_38627031 4.707 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr6_-_31853027 4.622 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr9_-_99740243 4.621 NM_197978
HEMGN
hemogen
chr12_-_4624536 4.603 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr4_+_38740246 4.538 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr8_-_102872614 4.503 NM_032041
NCALD
neurocalcin delta
chr5_+_156628929 4.473 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr20_-_1548589 4.432 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr4_-_10295412 4.410 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_-_205161821 4.373 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_-_158008763 4.365 NM_004288
CYTIP
cytohesin 1 interacting protein
chr14_+_99601498 4.363 NM_016337
EVL
Enah/Vasp-like
chr14_+_99601517 4.333 EVL
Enah/Vasp-like
chr1_+_205068844 4.310 NM_013371
IL19
interleukin 19
chr5_-_39238818 4.233 FYB
FYN binding protein
chr18_+_59726183 4.220 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr19_+_17495109 4.220 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr6_+_31648071 4.162 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr6_+_31647854 4.144 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr5_-_140875591 4.134 DIAPH1
diaphanous homolog 1 (Drosophila)
chr19_+_60109319 4.130 NM_001145457
NM_001145458
NM_004829
NCR1


natural cytotoxicity triggering receptor 1


chr1_+_158063130 4.103 SLAMF8
SLAM family member 8
chr22_+_38627129 4.102 GRAP2
GRB2-related adaptor protein 2
chr19_+_17923110 4.039 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr1_-_155788775 4.035 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr20_+_56919233 4.007 GNAS
GNAS complex locus
chr6_-_116488458 3.992 NM_002031
FRK
fyn-related kinase
chr17_+_77910411 3.974 NM_207459
TEX19
testis expressed 19
chr1_+_234624266 3.918 NM_145861
EDARADD
EDAR-associated death domain
chr22_+_23333610 3.916 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr1_+_190811479 3.905 NM_002922
RGS1
regulator of G-protein signaling 1
chr14_+_92188546 3.880 RIN3
Ras and Rab interactor 3
chr11_+_36379122 3.856 NM_001160169
PRR5L
proline rich 5 like
chr6_+_31651319 3.852 NM_000594
TNF
tumor necrosis factor
chr15_-_100280784 3.834 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr14_-_105900687 3.807 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr6_-_11490487 3.797 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr16_+_28797309 3.795 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr19_-_16111695 3.791


chr19_+_61624 3.773 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_+_207926172 3.734 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr7_+_149761674 3.707 LOC285972
hypothetical LOC285972
chr10_-_6144119 3.697 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr16_+_29582069 3.676 NM_003123
SPN
sialophorin
chrX_+_154880439 3.651 NM_002186
IL9R
interleukin 9 receptor
chr8_+_21956335 3.632 NM_003867
FGF17
fibroblast growth factor 17
chr1_+_158063278 3.627 SLAMF8
SLAM family member 8
chr20_-_61669550 3.600 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr1_-_144426918 3.554 NM_007053
CD160
CD160 molecule
chr17_-_31548167 3.544 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr1_+_32489426 3.515 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr1_-_30969016 3.488 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr16_+_31273969 3.486 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr11_-_56761250 3.455 NM_005161
APLNR
apelin receptor
chr19_-_16111594 3.431


chr7_+_37689903 3.424


chr7_+_75892187 3.354 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chrX_-_77801480 3.351 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr9_+_129893948 3.318 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr22_+_35586950 3.299 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_156590109 3.289 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chrX_-_70755023 3.270 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr16_+_55523248 3.261 NM_001010989
NM_001010990
NM_014685
HERPUD1


homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1


chr19_+_8023887 3.254 NM_005624
CCL25
chemokine (C-C motif) ligand 25
chr19_+_2240996 3.214


chr8_-_134141586 3.196 NM_006748
SLA
Src-like-adaptor
chr12_+_15017222 3.189 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chrX_-_30505804 3.174 NM_025159
CXorf21
chromosome X open reading frame 21
chr19_-_4131778 3.165 SIRT6
sirtuin 6
chr3_-_152403636 3.145 NM_013308
GPR171
G protein-coupled receptor 171
chr2_-_29150630 3.134 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr8_-_38324809 3.105 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr8_+_1436938 3.091 NM_004745
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr11_+_65403859 3.071 NM_001335
CTSW
cathepsin W
chr6_+_37511383 3.066


chrX_+_78087484 3.051 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr9_-_21132143 3.003 NM_002177
IFNW1
interferon, omega 1
chr3_+_99733432 2.999 NM_005290
GPR15
G protein-coupled receptor 15
chr16_+_29582065 2.961 SPN
sialophorin
chr11_-_66961709 2.960 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr2_+_148319033 2.955 NM_001616
ACVR2A
activin A receptor, type IIA
chr14_-_24047261 2.948 NM_001836
CMA1
chymase 1, mast cell
chr6_+_28032997 2.925 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_+_63864263 2.910 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr16_+_27346079 2.896 NM_021798
IL21R
interleukin 21 receptor
chr22_-_36305883 2.891 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr8_-_127032577 2.883 LOC100130231
similar to hCG1814455
chr6_+_158654464 2.879 TULP4
tubby like protein 4
chr6_+_158653679 2.863 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_+_20489998 2.857 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr17_+_69974116 2.844 NM_007261
CD300A
CD300a molecule
chr18_-_72820939 2.843 MBP
myelin basic protein
chr4_-_71751070 2.821 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr9_-_122728173 2.803 TRAF1
TNF receptor-associated factor 1
chr1_+_205038837 2.769 NM_153758
IL19
interleukin 19
chr5_+_132021763 2.757 NM_002188
IL13
interleukin 13
chr22_+_21484240 2.741


chr20_+_36365965 2.738 NM_001725
BPI
bactericidal/permeability-increasing protein
chr8_+_39890484 2.737 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr3_+_142587973 2.736


chr1_+_204797079 2.733 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr16_-_10696285 2.723 NM_144674
TEKT5
tektin 5
chr16_-_66075216 2.719 NM_001138
AGRP
agouti related protein homolog (mouse)
chr3_-_15515382 2.699 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr4_-_71751205 2.694 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chrX_+_9391314 2.632 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_+_61243132 2.614 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr22_-_22426551 2.606 NM_013378
VPREB3
pre-B lymphocyte 3
chr12_+_25096472 2.587 NM_006152
LRMP
lymphoid-restricted membrane protein
chr11_-_31782169 2.576 PAX6
paired box 6
chr11_+_123986661 2.535 NM_052959
PANX3
pannexin 3
chr1_+_196874839 2.533 PTPRC
protein tyrosine phosphatase, receptor type, C
chr22_+_21384862 2.529 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr6_+_158654890 2.528


chr19_-_14646626 2.521 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr1_+_196874759 2.513 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr2_-_10860093 2.512 PDIA6
protein disulfide isomerase family A, member 6
chrX_-_48655978 2.509 PIM2
pim-2 oncogene
chr17_-_53849888 2.476 RNF43
ring finger protein 43
chrX_+_48427137 2.475 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_120036237 2.440 NM_014619
GRIK4
glutamate receptor, ionotropic, kainate 4
chr12_+_9713472 2.440 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr1_-_157313179 2.429 NM_004833
AIM2
absent in melanoma 2
chr21_-_35181956 2.425 RUNX1
runt-related transcription factor 1
chrX_+_48427103 2.424 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_+_1846478 2.415 NM_001013253
LSP1
lymphocyte-specific protein 1
chr19_+_55627971 2.411 NM_004533
MYBPC2
myosin binding protein C, fast type
chr12_-_8584658 2.393 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr6_-_34632061 2.385 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr17_-_53849929 2.352 NM_017763
RNF43
ring finger protein 43
chr16_+_31178828 2.340 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr1_+_52871603 2.332 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr21_-_35343500 2.313 RUNX1
runt-related transcription factor 1
chr1_-_30977931 2.311 LAPTM5
lysosomal protein transmembrane 5
chr5_+_131424245 2.285 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr2_+_204279624 2.258 CD28
CD28 molecule
chr5_-_159478967 2.212 NM_001130864
NM_052927
PWWP2A

PWWP domain containing 2A

chr17_+_1578083 2.209 WDR81
WD repeat domain 81
chr12_+_52697160 2.208 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_-_92686773 2.203 NM_198151
HEPACAM2
HEPACAM family member 2
chr6_+_35856798 2.201 NM_001010886
C6orf127
chromosome 6 open reading frame 127
chr16_+_31178812 2.195 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr4_-_122357104 2.191 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr12_+_47658502 2.186 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr5_-_76970264 2.182 NM_032109
OTP
orthopedia homeobox
chr6_+_135558572 2.179


chr2_-_47235929 2.177 NM_001163561
NM_173649
C2orf61

chromosome 2 open reading frame 61

chr12_+_52696908 2.173 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr19_-_48976852 2.168 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr5_-_76970129 2.165 OTP
orthopedia homeobox
chr11_-_10630408 2.164 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr6_-_149847809 2.155 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_+_58899 2.127 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr1_+_170894780 2.109 NM_000639
FASLG
Fas ligand (TNF superfamily, member 6)
chrX_-_135690699 2.100 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_-_26554413 2.081 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr12_+_48443232 2.069 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr20_-_1586359 2.059 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr1_-_159306273 2.046 ARHGAP30
Rho GTPase activating protein 30
chrX_-_49008115 2.035 NM_001114377
NM_014009
FOXP3

forkhead box P3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.76 4.10e-11 GO:0002376 immune system process
1.26 4.13e-10 GO:0050896 response to stimulus
2.30 2.18e-09 GO:0007608 sensory perception of smell
2.16 2.09e-08 GO:0007606 sensory perception of chemical stimulus
1.79 2.75e-06 GO:0006955 immune response
1.73 7.08e-06 GO:0007600 sensory perception
1.48 1.01e-05 GO:0003008 system process
1.72 2.07e-04 GO:0002682 regulation of immune system process
1.49 2.74e-04 GO:0050877 neurological system process
1.64 4.80e-04 GO:0048584 positive regulation of response to stimulus
1.21 6.30e-04 GO:0032501 multicellular organismal process
2.34 1.22e-03 GO:0046649 lymphocyte activation
1.80 1.37e-03 GO:0001775 cell activation
2.05 2.36e-03 GO:0050778 positive regulation of immune response
1.82 3.08e-03 GO:0002684 positive regulation of immune system process
1.25 5.06e-03 GO:0007165 signal transduction
1.23 6.93e-03 GO:0023052 signaling
2.08 9.54e-03 GO:0045321 leukocyte activation
1.77 9.66e-03 GO:0050776 regulation of immune response
1.27 1.98e-02 GO:0048518 positive regulation of biological process
2.09 2.22e-02 GO:0051249 regulation of lymphocyte activation
1.34 3.31e-02 GO:0007166 cell surface receptor linked signaling pathway
1.94 3.39e-02 GO:0001817 regulation of cytokine production

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 1.29e-12 GO:0071944 cell periphery
1.37 1.54e-12 GO:0005886 plasma membrane
1.18 4.45e-04 GO:0031224 intrinsic to membrane
1.16 5.19e-04 GO:0044425 membrane part
1.45 7.92e-04 GO:0005887 integral to plasma membrane
1.43 1.47e-03 GO:0031226 intrinsic to plasma membrane
1.17 2.12e-03 GO:0016021 integral to membrane
1.30 2.44e-03 GO:0044459 plasma membrane part
1.13 2.94e-03 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 1.10e-11 GO:0004872 receptor activity
1.51 6.61e-10 GO:0004871 signal transducer activity
1.51 6.61e-10 GO:0060089 molecular transducer activity
2.29 2.29e-09 GO:0004984 olfactory receptor activity
1.59 2.43e-07 GO:0004888 transmembrane receptor activity
1.71 2.03e-06 GO:0004930 G-protein coupled receptor activity
4.44 9.43e-05 GO:0003823 antigen binding