Motif ID: NR6A1.p2

Z-value: 1.219


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_126573349-0.224.3e-01Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_100037817 2.890 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr1_-_156923111 2.168 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr16_+_82540172 2.092 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr8_-_145672525 2.090 NM_003923
FOXH1
forkhead box H1
chr16_+_31274020 2.054 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_-_149669622 1.996 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr9_-_14303509 1.932 NFIB
nuclear factor I/B
chr11_+_118259684 1.900 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr6_-_133076873 1.755 NM_004666
VNN1
vanin 1
chr20_-_42457717 1.748


chr14_-_106241445 1.714 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr9_-_14304036 1.592 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr1_+_154386358 1.531 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_-_6671585 1.482 NM_000064
C3
complement component 3
chr6_+_32114060 1.455 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr17_-_45280377 1.347 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr14_-_106038122 1.301 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_10964680 1.283 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr16_+_31274030 1.244 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chrX_+_48505097 1.232 NM_001080489
GLOD5
glyoxalase domain containing 5
chr9_-_14303943 1.094 NFIB
nuclear factor I/B
chr9_-_14303899 1.085 NFIB
nuclear factor I/B
chr17_+_71586857 1.067 NM_180990
ZACN
zinc activated ligand-gated ion channel
chr10_+_91488704 1.044 KIF20B
kinesin family member 20B
chr1_-_158883666 1.002 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr6_+_146906520 0.917 NM_006834
RAB32
RAB32, member RAS oncogene family
chr6_-_2696152 0.914 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr14_+_104462195 0.913 PLD4
phospholipase D family, member 4
chr10_+_80777265 0.864 PPIF
peptidylprolyl isomerase F
chr10_+_106003941 0.841 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr11_+_71387572 0.822 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr11_-_73397929 0.818 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr14_-_105524207 0.818 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_80777248 0.813 PPIF
peptidylprolyl isomerase F
chr12_-_56422120 0.787 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr14_+_92188329 0.785 RIN3
Ras and Rab interactor 3
chr3_-_127719283 0.784 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr11_-_16387001 0.778 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr14_+_104462199 0.757 PLD4
phospholipase D family, member 4
chr7_+_37926943 0.751 EPDR1
ependymin related protein 1 (zebrafish)
chr7_-_126670804 0.730 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr1_-_6684426 0.728 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr14_+_92188546 0.694 RIN3
Ras and Rab interactor 3
chr16_+_24765052 0.682 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr3_+_46594079 0.678 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_210805319 0.676 NM_001030287
ATF3
activating transcription factor 3
chr12_+_107797985 0.582 NM_001917
DAO
D-amino-acid oxidase
chr4_-_160175782 0.580 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr22_+_21393107 0.556 IGLJ3
immunoglobulin lambda joining 3
chr7_-_65084597 0.555 GUSB
glucuronidase, beta
chr7_-_65084622 0.554 GUSB
glucuronidase, beta
chr6_+_84799969 0.552 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr2_-_128792515 0.550 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr22_+_21559959 0.549 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr7_-_65084641 0.536 GUSB
glucuronidase, beta
chr11_-_107969554 0.533 NM_015065
EXPH5
exophilin 5
chr17_-_45619038 0.512 COL1A1
collagen, type I, alpha 1
chr22_-_22252376 0.501 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr1_-_209732881 0.497 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr22_-_22389436 0.497


chr20_-_29464301 0.489 NM_001171832
DEFB121
defensin, beta 121
chr14_-_106240998 0.483 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_+_155453114 0.471 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_+_7039453 0.462


chr6_+_43136159 0.460 NM_201522
KLC4
kinesin light chain 4
chr3_+_46386636 0.458 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr17_-_9870292 0.452 NM_001130831
GAS7
growth arrest-specific 7
chr14_-_106038573 0.445 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr14_+_104462210 0.435 NM_138790
PLD4
phospholipase D family, member 4
chr16_-_65781499 0.430 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chrX_+_54483565 0.421 NM_058163
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr11_-_5980953 0.421 NM_001005179
OR56A4
olfactory receptor, family 56, subfamily A, member 4
chr8_-_145671947 0.409 FOXH1
forkhead box H1
chr12_+_50592379 0.402 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr14_-_105542441 0.399 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr2_+_33555182 0.398 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_-_205290921 0.383 NM_018566
YOD1
YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
chr19_+_10057972 0.380 C19orf66
chromosome 19 open reading frame 66
chr3_+_186529376 0.376 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr6_-_25982418 0.374 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr2_+_190710730 0.370 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr1_+_144152864 0.362 TXNIP
thioredoxin interacting protein
chr21_-_44926485 0.362 NM_181686
KRTAP12-1
keratin associated protein 12-1
chr11_-_64520964 0.361 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr1_+_224064365 0.349 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr19_-_54231884 0.344 NM_033377
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr22_-_22389502 0.326 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr21_-_44506526 0.325 NM_013369
NM_175867
DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

chr12_+_52697160 0.321 HOXC5
HOXC6
homeobox C5
homeobox C6
chr9_-_129719031 0.318 NM_175039
NM_175040
ST6GALNAC4

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

chr3_-_150286812 0.311 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr19_+_10058023 0.304 C19orf66
chromosome 19 open reading frame 66
chr4_-_47709717 0.298 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr3_+_187866464 0.298 NM_000412
HRG
histidine-rich glycoprotein
chr6_+_117910472 0.296 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr9_-_38059207 0.289 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr8_-_37576515 0.286 LOC157860
hypothetical protein LOC157860
chr17_-_24426752 0.283 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr22_-_22389524 0.283 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr21_+_44902276 0.275 NM_198697
KRTAP12-3
keratin associated protein 12-3
chr14_-_105804211 0.275 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_140879463 0.268 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr18_-_648246 0.267 NM_001012716
C18orf56
chromosome 18 open reading frame 56
chr19_-_47261761 0.248 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr21_-_36836767 0.243 NM_001146078
CLDN14
claudin 14
chr22_+_30340152 0.239 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr1_+_46151845 0.227 MAST2
microtubule associated serine/threonine kinase 2
chr16_+_31273969 0.224 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr11_-_2113297 0.214 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_119632213 0.204 NM_001080533
UNC119B
unc-119 homolog B (C. elegans)
chr1_+_174698929 0.197 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr9_-_38059082 0.196 SHB
Src homology 2 domain containing adaptor protein B
chr19_-_44518465 0.196 GMFG
glia maturation factor, gamma
chr4_+_1923629 0.192 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr16_-_70591377 0.192 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr16_-_3246587 0.190 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr1_+_224064427 0.176 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr5_-_41249270 0.170 NM_000065
C6
complement component 6
chr22_+_19649460 0.169 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr6_+_167504070 0.165 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chr19_+_44838373 0.165 NM_001190441
LGALS16
beta-galactoside-binding lectin
chr12_-_16652202 0.163 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_7604569 0.161 NM_174895
PCP2
Purkinje cell protein 2
chr10_-_126097483 0.158 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr15_-_38953628 0.158 NM_133639
RHOV
ras homolog gene family, member V
chr17_-_57023322 0.156 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr20_-_7869068 0.156 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_167717907 0.147 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr2_-_97775300 0.142 TMEM131
transmembrane protein 131
chr3_-_38153467 0.141 ACAA1
acetyl-CoA acyltransferase 1
chr11_+_66070949 0.135 NM_001104
ACTN3
actinin, alpha 3
chr7_+_5904858 0.134 NM_015622
C7orf28B
CCZ1
chromosome 7 open reading frame 28B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chrX_-_152748526 0.134 PDZD4
PDZ domain containing 4
chr14_-_105523735 0.133 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_43592670 0.129 YIPF3
Yip1 domain family, member 3
chr16_+_716936 0.124 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr13_+_22653059 0.123 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr17_+_77289704 0.123 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr9_-_21156609 0.121 NM_002175
IFNA21
interferon, alpha 21
chr16_+_55553262 0.117 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr21_-_42789369 0.115 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr3_+_134947573 0.113 NM_001063
TF
transferrin
chr2_-_208763017 0.111 NM_001099334
C2orf80
chromosome 2 open reading frame 80
chr1_+_36160375 0.108 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr5_+_43639069 0.105 NNT
nicotinamide nucleotide transhydrogenase
chr1_+_150005754 0.103 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr5_+_134237325 0.102 NM_024715
TXNDC15
thioredoxin domain containing 15
chr1_+_19796044 0.099 NM_001032363
C1orf15-NBL1
C1orf151
C1ORF15-NBL1 read-through transcript
chromosome 1 open reading frame 151
chr1_+_143920424 0.099 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr1_+_62835759 0.097 NM_014495
ANGPTL3
angiopoietin-like 3
chr13_+_23723831 0.095 SPATA13
spermatogenesis associated 13
chr3_+_14691609 0.095 NM_001184957
NM_001184958
NM_032137
C3orf20


chromosome 3 open reading frame 20


chr22_+_19649417 0.095 NM_001018060
NM_144704
AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

chr1_-_145712107 0.094 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr8_-_125648576 0.093 MTSS1
metastasis suppressor 1
chr1_+_234372454 0.085 NM_003272
GPR137B
G protein-coupled receptor 137B
chr1_-_120413698 0.085 NOTCH2
notch 2
chr2_-_25418249 0.080 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_-_222100006 0.078 TP53BP2
tumor protein p53 binding protein, 2
chr16_+_55199978 0.077 NM_005953
MT2A
metallothionein 2A
chr2_-_200424140 0.075 LOC348751
hypothetical LOC348751
chr14_-_105712630 0.073 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_102744921 0.070 NM_144632
TMEM182
transmembrane protein 182
chr14_-_105610144 0.068 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr22_+_49388427 0.067 NM_016431
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr8_+_142501188 0.063 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr9_+_37475911 0.061 NM_022490
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr13_-_23369124 0.059 NM_001007537
C1QTNF9B
C1q and tumor necrosis factor related protein 9B
chr1_+_151873134 0.059 NM_015607
C1orf77
chromosome 1 open reading frame 77
chr2_-_224611568 0.058 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr3_+_134947894 0.057 TF
transferrin
chr19_-_5797465 0.056 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr1_+_45046740 0.054 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr12_-_10453409 0.051 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr3_+_134947788 0.049 TF
transferrin
chr14_-_105279582 0.046


chr17_+_72958330 0.043 SEPT9
septin 9
chrX_+_8392870 0.042 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr1_+_75962630 0.041 NM_000016
NM_001127328
ACADM

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

chr12_+_52696908 0.037 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr7_-_97439500 0.036 MGC72080
MGC72080 pseudogene
chr11_+_125163215 0.035 NM_001129883
PATE3
prostate and testis expressed 3
chr19_+_8814268 0.032 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr1_-_151873191 0.032 NM_001024210
S100A13
S100 calcium binding protein A13
chr11_+_65945050 0.031 NM_178864
NPAS4
neuronal PAS domain protein 4
chr1_+_217413746 0.030 NM_138794
LYPLAL1
lysophospholipase-like 1
chr1_-_40009513 0.028 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr6_+_107456457 0.027 C6orf203
chromosome 6 open reading frame 203
chr12_+_103675075 0.026 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr7_+_39956128 0.025 CDK13
cyclin-dependent kinase 13
chr1_-_925332 0.025 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr5_+_175241449 0.025 CPLX2
complexin 2
chr9_-_21197141 0.025 NM_002171
IFNA10
interferon, alpha 10
chr11_-_55815113 0.024 NM_001005199
OR8H1
olfactory receptor, family 8, subfamily H, member 1
chr14_+_88099124 0.024 ZC3H14
zinc finger CCCH-type containing 14
chr19_+_47079089 0.022 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr16_-_360509 0.022 NM_006428
MRPL28
mitochondrial ribosomal protein L28
chr7_+_55999559 0.021 NM_001483
GBAS
glioblastoma amplified sequence
chr9_-_134219950 0.020 SETX
senataxin
chr16_-_2254318 0.019 RNPS1
RNA binding protein S1, serine-rich domain

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
17.74 1.94e-05 GO:0003823 antigen binding