Motif ID: NKX3-1.p2

Z-value: 1.287


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-1chr8_-_23596346-0.136.4e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_156628929 3.190 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr20_+_30160952 2.385 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr22_+_38652555 2.199 GRAP2
GRB2-related adaptor protein 2
chr19_-_56612653 2.128 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr14_+_87541220 2.060 NM_003608
GPR65
G protein-coupled receptor 65
chr6_+_132000134 2.046 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_53847937 1.812 RNF43
ring finger protein 43
chr17_+_71975224 1.637 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr6_-_52060327 1.577 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr20_-_52120710 1.549 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr3_-_42892195 1.496 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr1_-_246869181 1.414 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr3_-_57209319 1.387 NM_003865
HESX1
HESX homeobox 1
chr13_+_51496679 1.380 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr9_-_103237851 1.349 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr6_+_53043729 1.323 NM_012347
FBXO9
F-box protein 9
chr9_+_4829763 1.314 RCL1
RNA terminal phosphate cyclase-like 1
chr6_+_30238961 1.303 NM_033229
TRIM15
tripartite motif containing 15
chr20_+_43764068 1.268 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr2_+_228064531 1.236 AGFG1
ArfGAP with FG repeats 1
chr7_+_99654806 1.234 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr1_+_246682699 1.230 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr4_+_71418886 1.203 NM_212557
AMTN
amelotin
chr19_+_56671649 1.197 NM_001080405
CEACAM18
carcinoembryonic antigen-related cell adhesion molecule 18
chr2_-_207291364 1.196 NM_001093730
DYTN
dystrotelin
chr12_+_130004404 1.187 NM_198827
GPR133
G protein-coupled receptor 133
chr20_-_34707971 1.184 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr20_+_30161173 1.183 TM9SF4
transmembrane 9 superfamily protein member 4
chr16_+_82540172 1.176 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr10_-_11614279 1.174 NM_001080491
USP6NL
USP6 N-terminal like
chr1_+_165565006 1.058 POU2F1
POU class 2 homeobox 1
chr14_-_24148658 1.049 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr2_-_32344192 1.048 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr12_+_91620749 1.047 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr3_-_152403636 1.036 NM_013308
GPR171
G protein-coupled receptor 171
chr12_+_55018925 1.033 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr12_+_8167494 1.013 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr3_-_198784590 1.007 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr18_-_21184824 0.990


chr8_+_23157094 0.990 NM_152272
CHMP7
CHMP family, member 7
chr9_-_124981125 0.982 STRBP
spermatid perinuclear RNA binding protein
chr2_+_69974581 0.977 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr7_+_141457977 0.958 LOC93432
maltase-glucoamylase-like pseudogene
chr1_+_246195157 0.942 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr2_-_127817143 0.931 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr12_+_40117751 0.916 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr6_+_167445284 0.898 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr12_+_61645361 0.884 RPL14
ribosomal protein L14
chr15_+_97990705 0.876 NM_001130928
MEF2A
myocyte enhancer factor 2A
chrX_+_99726445 0.873 NM_022144
TNMD
tenomodulin
chr1_-_151630168 0.870 NM_002964
S100A8
S100 calcium binding protein A8
chr3_+_171183203 0.866 SEC62
SEC62 homolog (S. cerevisiae)
chr21_-_42659671 0.858 NM_003225
TFF1
trefoil factor 1
chr20_+_56919233 0.852 GNAS
GNAS complex locus
chr1_-_156954528 0.822 NM_001005327
OR6K3
olfactory receptor, family 6, subfamily K, member 3
chr1_+_158975662 0.817 NM_021181
SLAMF7
SLAM family member 7
chr12_+_100394787 0.816 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr17_+_23818922 0.810


chrX_+_71280758 0.786 NM_207422
FLJ44635
TPT1-like protein
chr9_-_35860316 0.763 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr10_+_112334066 0.758 SMC3
structural maintenance of chromosomes 3
chr10_+_124660206 0.751 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr8_+_24207524 0.740 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr4_+_17125885 0.739 NM_001079827
CLRN2
clarin 2
chr2_-_165259334 0.735 COBLL1
COBL-like 1
chr4_-_10295412 0.729 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr15_+_57691382 0.711 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_+_49155798 0.698 LARP4
La ribonucleoprotein domain family, member 4
chr1_-_158815850 0.694 CD84
CD84 molecule
chr20_+_12937616 0.693 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr14_+_38772870 0.692 NM_054024
MIA2
melanoma inhibitory activity 2
chr4_+_187385618 0.677 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr2_-_21106291 0.666 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_186587537 0.661 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr3_+_85858321 0.639 NM_153184
CADM2
cell adhesion molecule 2
chr12_-_101835510 0.636 NM_000277
PAH
phenylalanine hydroxylase
chr5_-_179040580 0.634 NM_001164444
CBY3
chibby homolog 3 (Drosophila)
chr12_-_14982708 0.623 NM_152321
ERP27
endoplasmic reticulum protein 27
chr17_-_16816113 0.619 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr20_-_44612619 0.613 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr6_-_138862271 0.611 NM_001144060
NHSL1
NHS-like 1
chr7_+_142723340 0.609 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr18_+_27210737 0.609 NM_001134453
NM_177986
DSG4

desmoglein 4

chr4_+_74520796 0.608 NM_001134
AFP
alpha-fetoprotein
chr4_+_88748704 0.603 NM_014208
DSPP
dentin sialophosphoprotein
chr1_+_57093030 0.603 NM_000562
C8A
complement component 8, alpha polypeptide
chr6_-_76259976 0.598 NM_015687
FILIP1
filamin A interacting protein 1
chr6_+_16251260 0.592 MYLIP
myosin regulatory light chain interacting protein
chr3_-_42892636 0.586 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_-_39500512 0.585 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr6_-_138862273 0.582


chr16_-_88604029 0.577 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr1_+_50348052 0.574 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_+_59804634 0.573 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr2_-_208736533 0.572 NM_014617
CRYGA
crystallin, gamma A
chr3_-_99236520 0.569 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr8_-_17787342 0.567 FGL1
fibrinogen-like 1
chr12_-_86947276 0.567 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr16_+_2195424 0.567 NM_022372
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr20_-_31055892 0.557 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr19_-_47638890 0.554 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr4_+_166350620 0.548 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr7_-_36730525 0.543 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chrX_-_135783496 0.540


chr1_-_229627412 0.539 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr4_+_1872150 0.537 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr14_-_74669864 0.537 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr6_-_25982418 0.527 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr1_+_205329206 0.519 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr1_+_559618 0.516


chr1_-_158815895 0.511 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr5_-_150663519 0.508 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chr1_-_20374273 0.501 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr20_-_51633042 0.501 NM_006526
ZNF217
zinc finger protein 217
chr14_+_66901237 0.500 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr21_-_30460841 0.500 NM_012131
CLDN17
claudin 17
chr12_+_25096472 0.499 NM_006152
LRMP
lymphoid-restricted membrane protein
chr1_-_205012348 0.497 NM_000572
IL10
interleukin 10
chr14_+_38804226 0.497 NM_203354
CTAGE5
CTAGE family, member 5
chr4_+_89115862 0.491 SPP1
secreted phosphoprotein 1
chr9_+_130056513 0.488


chr6_+_158654464 0.486 TULP4
tubby like protein 4
chr5_+_67622242 0.475 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr15_+_57691272 0.471 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr8_-_17797127 0.462 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr4_-_123761615 0.460 NM_021803
IL21
interleukin 21
chr1_-_20318578 0.459 NM_012400
PLA2G2D
phospholipase A2, group IID
chr8_-_59575249 0.455 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr7_+_69869099 0.449 AUTS2
autism susceptibility candidate 2
chr19_-_3922032 0.449 DAPK3
death-associated protein kinase 3
chr14_+_20493467 0.448 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr11_-_30558495 0.448 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr4_+_155703581 0.446 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr5_-_160044844 0.443 ATP10B
ATPase, class V, type 10B
chr17_-_61655915 0.442 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_+_94148466 0.434 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_-_120761092 0.430 NM_005191
CD80
CD80 molecule
chr17_-_64752550 0.430 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr20_+_43691797 0.428 NM_080753
WFDC10A
WAP four-disulfide core domain 10A
chr6_+_152053323 0.428 NM_001122742
ESR1
estrogen receptor 1
chr5_+_147672181 0.426 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr6_+_64344307 0.424 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_28294642 0.422 LOC222699
transducer of ERBB2, 2 pseudogene
chr11_-_55942283 0.418 NM_001004744
OR5R1
olfactory receptor, family 5, subfamily R, member 1
chr13_+_52500830 0.417 NM_006418
OLFM4
olfactomedin 4
chr10_-_69736600 0.416 PBLD
phenazine biosynthesis-like protein domain containing
chr6_-_155818728 0.416 NM_015718
NOX3
NADPH oxidase 3
chr3_+_153074118 0.414 NM_033050
SUCNR1
succinate receptor 1
chr14_+_88130482 0.413 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr4_-_103464491 0.406 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr4_+_89115892 0.406 SPP1
secreted phosphoprotein 1
chr17_+_58440629 0.406 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr22_-_22426551 0.406 NM_013378
VPREB3
pre-B lymphocyte 3
chr1_+_66230977 0.404 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_149681265 0.400 NM_207171
POGZ
pogo transposable element with ZNF domain
chr3_+_187866464 0.399 NM_000412
HRG
histidine-rich glycoprotein
chr2_-_191580567 0.397 STAT1
signal transducer and activator of transcription 1, 91kDa
chr1_-_47179681 0.395 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr11_+_58888460 0.391 NM_001004729
OR5AN1
olfactory receptor, family 5, subfamily AN, member 1
chr1_+_114295289 0.389 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr5_-_39238818 0.389 FYB
FYN binding protein
chr15_-_74941339 0.386 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr3_+_123279439 0.386 NM_006889
CD86
CD86 molecule
chr4_-_186969041 0.385 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chrX_-_131401319 0.384 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr18_-_22696532 0.383 NM_004028
AQP4
aquaporin 4
chr11_+_67133502 0.382 NDUFV1
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
chr1_-_157014048 0.381 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr14_-_101617680 0.381 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr21_-_26175068 0.371 APP
amyloid beta (A4) precursor protein
chr19_-_14771947 0.369 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr20_+_17622319 0.369 NM_001159495
BANF2
barrier to autointegration factor 2
chr1_-_47179729 0.368 NM_000778
CYP4A11
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 22
chr18_-_3209846 0.367 MYOM1
myomesin 1, 185kDa
chr3_-_156904690 0.364 NM_014996
PLCH1
phospholipase C, eta 1
chr2_-_20375497 0.364 PUM2
pumilio homolog 2 (Drosophila)
chr10_-_98021144 0.363 NM_001114094
NM_013314
BLNK

B-cell linker

chrX_+_105823723 0.361 NM_024539
RNF128
ring finger protein 128
chr5_+_180726874 0.358 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr12_+_52126131 0.358 PRR13
proline rich 13
chr1_-_180822686 0.356 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr9_+_126158935 0.355


chr16_+_21603250 0.354 NM_001161683
OTOA
otoancorin
chr17_-_5078773 0.354 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr6_+_158654890 0.352


chr1_+_151051070 0.352 NM_178349
LCE1B
late cornified envelope 1B
chr12_+_111047676 0.351 NM_001143906
NM_006700
TRAFD1

TRAF-type zinc finger domain containing 1

chrX_+_38096679 0.350 NM_000531
OTC
ornithine carbamoyltransferase
chr12_+_45896511 0.349 FAM113B
family with sequence similarity 113, member B
chr11_+_55335418 0.347 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr18_-_22699650 0.347 NM_001650
AQP4
aquaporin 4
chr2_+_24660849 0.346 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr11_+_55362802 0.345 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr8_-_124818754 0.344 NM_001003954
NM_004306
ANXA13

annexin A13

chr2_+_169465995 0.342 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr4_+_75393053 0.341 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr14_+_22859236 0.341 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr14_+_23844269 0.341


chr6_-_137536412 0.340 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr9_-_21218132 0.336 NM_021268
IFNA17
interferon, alpha 17

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.62 1.76e-19 GO:0007608 sensory perception of smell
3.41 5.94e-19 GO:0007606 sensory perception of chemical stimulus
2.41 7.69e-13 GO:0007600 sensory perception
1.80 4.75e-07 GO:0050877 neurological system process
1.69 5.42e-07 GO:0003008 system process
1.33 1.11e-06 GO:0032501 multicellular organismal process
1.25 1.30e-04 GO:0050896 response to stimulus
1.80 2.06e-03 GO:0006952 defense response
2.01 1.75e-02 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 3.34e-06 GO:0005886 plasma membrane
1.34 3.79e-06 GO:0071944 cell periphery
1.52 9.95e-06 GO:0005576 extracellular region
1.19 4.35e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.74 9.39e-21 GO:0004984 olfactory receptor activity
2.42 3.04e-14 GO:0004930 G-protein coupled receptor activity
1.75 3.21e-09 GO:0004872 receptor activity
1.88 4.18e-09 GO:0004888 transmembrane receptor activity
1.60 2.25e-07 GO:0004871 signal transducer activity
1.60 2.25e-07 GO:0060089 molecular transducer activity
14.14 2.64e-04 GO:0005132 interferon-alpha/beta receptor binding
3.86 3.17e-04 GO:0004867 serine-type endopeptidase inhibitor activity
2.56 3.38e-02 GO:0030414 peptidase inhibitor activity
2.57 4.69e-02 GO:0004866 endopeptidase inhibitor activity