Motif ID: KLF12.p2

Z-value: 3.560


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_73605914-0.371.8e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_66535923 4.880 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr16_-_66535457 4.535 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr17_+_1580504 4.482 WDR81
WD repeat domain 81
chr6_+_43565192 2.796 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr17_-_45622064 2.371


chr1_-_33613729 2.336 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr17_-_45620911 2.300 COL1A1
collagen, type I, alpha 1
chr12_+_56135353 2.238 NM_031479
INHBE
inhibin, beta E
chr16_+_27320983 2.058 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr12_+_52665196 1.935 NM_017409
HOXC10
homeobox C10
chr1_+_6767968 1.811 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr16_+_31132842 1.774 NM_001008274
TRIM72
tripartite motif containing 72
chr11_-_70971556 1.758 NM_001005405
KRTAP5-11
keratin associated protein 5-11
chr11_-_65841077 1.728 NM_020404
CD248
CD248 molecule, endosialin
chr15_+_38550451 1.727 NM_130468
CHST14
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
chr19_-_7840806 1.689 FLJ22184
hypothetical protein FLJ22184
chr19_+_40322231 1.687 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr17_-_36451189 1.683 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_-_38285033 1.678 NM_002699
POU3F1
POU class 3 homeobox 1
chr11_+_118259684 1.668 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr1_+_109594163 1.654 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr1_+_1256585 1.633 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr15_+_62578671 1.593 NM_015042
ZNF609
zinc finger protein 609
chr1_-_201411533 1.571 NM_004997
MYBPH
myosin binding protein H
chr7_+_100113664 1.570 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr8_-_145609737 1.545 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr1_+_1157485 1.531 NM_080605
B3GALT6
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
chr15_+_72397934 1.512 NM_182791
CCDC33
coiled-coil domain containing 33
chr1_+_159959072 1.470 NM_001002901
FCRLB
Fc receptor-like B
chr9_-_138387903 1.466 CARD9
caspase recruitment domain family, member 9
chr1_-_201321711 1.432 MYOG
myogenin (myogenic factor 4)
chr11_-_1464386 1.406 NM_001172223
MOB2
Mps one binder kinase activator-like 2
chr11_+_66381451 1.400 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr6_+_30958672 1.378 DDR1
discoidin domain receptor tyrosine kinase 1
chr5_+_155686333 1.372 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr7_+_149657810 1.367 NM_138434
C7orf29
chromosome 7 open reading frame 29
chr1_+_235272324 1.362 NM_001035
RYR2
ryanodine receptor 2 (cardiac)
chr17_-_34607257 1.360 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr12_-_53064565 1.355 ZNF385A
zinc finger protein 385A
chr11_+_120966280 1.352 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_2814410 1.329 NM_031474
NRIP2
nuclear receptor interacting protein 2
chr4_-_185963859 1.325 ACSL1
acyl-CoA synthetase long-chain family member 1
chrX_+_152699616 1.323 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr15_+_49421004 1.318 NM_181789
GLDN
gliomedin
chr19_-_40696393 1.315 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr5_+_133870175 1.314


chr11_-_1731273 1.265


chr9_-_138387926 1.259 NM_052813
NM_052814
CARD9

caspase recruitment domain family, member 9

chr2_+_220015016 1.251 SPEG
SPEG complex locus
chr11_-_1599900 1.251 NM_001012709
KRTAP5-4
keratin associated protein 5-4
chr22_+_35290271 1.249


chr17_-_45617899 1.241 COL1A1
collagen, type I, alpha 1
chr15_-_81146188 1.238 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr19_+_43616167 1.233 NM_000540
NM_001042723
RYR1

ryanodine receptor 1 (skeletal)

chr10_-_105410840 1.232


chr2_+_169367345 1.229 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr15_-_72513311 1.225 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr2_+_220033777 1.218 NM_001173476
SPEG
SPEG complex locus
chr6_-_31853027 1.217 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr21_-_46849413 1.217 NM_006272
S100B
S100 calcium binding protein B
chr9_-_129752687 1.193 NM_203305
FAM102A
family with sequence similarity 102, member A
chr11_-_1728385 1.193 LOC402778
CD225 family protein FLJ76511
chr17_+_71141108 1.183 NM_001162995
LOC643008
hypothetical protein LOC643008
chr6_-_110843432 1.181 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr5_-_176869943 1.174 NM_001144875
NM_001144876
DOK3

docking protein 3

chr2_+_219453487 1.167 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr3_+_42107711 1.164 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr16_+_2503676 1.156 NM_001198569
NM_001694
ATP6V0C

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

chr3_+_42675841 1.153 ZBTB47
zinc finger and BTB domain containing 47
chr2_+_220017617 1.151 SPEG
SPEG complex locus
chr1_+_181028016 1.149 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr12_-_53064723 1.129 NM_015481
ZNF385A
zinc finger protein 385A
chr17_+_35853177 1.127 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr1_-_1840564 1.127 NM_178545
TMEM52
transmembrane protein 52
chr20_+_2744947 1.117 NM_001167670
LOC100288797
hypothetical protein LOC100288797
chr17_-_45620313 1.116


chr1_+_26220895 1.090 EXTL1
exostoses (multiple)-like 1
chr19_-_51081147 1.077 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr17_+_1612092 1.071 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_+_115367122 1.068 NM_134427
RGS3
regulator of G-protein signaling 3
chr15_-_63147350 1.060 NM_016563
RASL12
RAS-like, family 12
chr22_+_39404940 1.058 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr4_+_72321113 1.057 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr20_-_2769120 1.057 FAM113A
family with sequence similarity 113, member A
chr1_+_159943385 1.052 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr1_-_166965034 1.051 NM_001937
DPT
dermatopontin
chr5_+_140871107 1.043


chr16_+_2503915 1.037 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr15_-_63147228 1.037 RASL12
RAS-like, family 12
chr15_-_26017994 1.037 NM_000275
OCA2
oculocutaneous albinism II
chr1_-_201321999 1.026 NM_002479
MYOG
myogenin (myogenic factor 4)
chr16_+_65756179 1.022 HSF4
heat shock transcription factor 4
chr11_-_57173823 1.021 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr15_-_75259714 1.020 PEAK1
NKF3 kinase family member
chr1_-_150862202 1.019 NM_178431
LCE3A
late cornified envelope 3A
chr12_+_115481568 1.018 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr14_+_104238713 1.017 INF2
inverted formin, FH2 and WH2 domain containing
chr22_-_25344037 1.015 CRYBB1
crystallin, beta B1
chr1_+_116744992 1.012 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_-_51971915 1.011 NM_033010
PCBP4
poly(rC) binding protein 4
chr5_+_60663842 1.010 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr19_+_5865192 1.009 NM_004058
NM_080590
CAPS

calcyphosine

chr12_+_46133 1.003 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr8_-_145132582 1.000 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr3_+_50281582 1.000 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr8_-_142446546 0.990 NM_005293
GPR20
G protein-coupled receptor 20
chr1_-_219977424 0.983 NM_144728
DUSP10
dual specificity phosphatase 10
chr2_+_27518736 0.979 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chr22_+_38090120 0.975 NM_145738
SYNGR1
synaptogyrin 1
chr11_-_64269501 0.974 NM_153819
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr11_+_63876924 0.970 CCDC88B
coiled-coil domain containing 88B
chr16_-_30301634 0.962 NM_052838
SEPT1
septin 1
chr9_+_135389698 0.961 NM_014694
ADAMTSL2
ADAMTS-like 2
chr1_+_46151845 0.959 MAST2
microtubule associated serine/threonine kinase 2
chr12_-_55929189 0.953


chr17_-_45621140 0.949


chr1_+_203106600 0.945 NFASC
neurofascin
chr3_+_50281309 0.941 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_-_39238818 0.940 FYB
FYN binding protein
chr19_+_778821 0.939 NM_001700
AZU1
azurocidin 1
chr15_-_81037554 0.938 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr16_+_65756084 0.938 HSF4
heat shock transcription factor 4
chr1_+_1994943 0.930 NM_001033581
PRKCZ
protein kinase C, zeta
chr17_-_45629401 0.914


chr16_-_47873183 0.907 NM_004352
CBLN1
cerebellin 1 precursor
chr17_+_1612031 0.906 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_+_138991835 0.901 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr7_-_106088565 0.900 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr18_+_30810889 0.900 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_+_64737886 0.899 NM_001004326
SLC22A20
solute carrier family 22, member 20
chr12_+_48792015 0.898 NM_032901
C12orf62
chromosome 12 open reading frame 62
chr12_+_79625538 0.897 NM_002469
MYF6
myogenic factor 6 (herculin)
chr12_+_105519049 0.892 NM_002920
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr1_-_221604023 0.886 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr10_-_71753684 0.885 LRRC20
leucine rich repeat containing 20
chr1_+_199108705 0.884 NM_005298
GPR25
G protein-coupled receptor 25
chr9_-_122728993 0.883 NM_005658
TRAF1
TNF receptor-associated factor 1
chr5_+_152850276 0.882 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr7_+_47661366 0.882 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr19_-_3928516 0.882 EEF2
eukaryotic translation elongation factor 2
chr9_+_138991775 0.877 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr10_+_80672842 0.877 ZMIZ1
zinc finger, MIZ-type containing 1
chr17_+_1612056 0.874 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_38250122 0.874 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr16_+_2450081 0.873 NM_025108
C16orf59
chromosome 16 open reading frame 59
chrX_-_135166306 0.865 NM_001173516
MAP7D3
MAP7 domain containing 3
chr19_+_1223475 0.863 CIRBP
cold inducible RNA binding protein
chr6_-_109882116 0.862 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr10_+_50177192 0.856 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr1_-_46789473 0.855 NM_001097611
KNCN
kinocilin
chr17_+_43127628 0.855 NM_014726
TBKBP1
TBK1 binding protein 1
chr10_-_105427898 0.854 SH3PXD2A
SH3 and PX domains 2A
chr12_+_6915698 0.853


chr17_-_36436979 0.853 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr19_-_50975121 0.850


chr3_+_195888701 0.849 FAM43A
family with sequence similarity 43, member A
chr2_+_85834111 0.842 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr22_+_19239221 0.839 MED15
mediator complex subunit 15
chr5_-_149515331 0.839 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr22_-_25343959 0.836 NM_001887
CRYBB1
crystallin, beta B1
chr3_-_46693902 0.829 NM_182775
ALS2CL
ALS2 C-terminal like
chr7_+_129807467 0.828 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr9_-_138378061 0.827 NM_001080849
DNLZ
DNL-type zinc finger
chr9_+_115970599 0.824 COL27A1
collagen, type XXVII, alpha 1
chr20_-_604443 0.823


chr17_-_45621571 0.819 COL1A1
collagen, type I, alpha 1
chr16_+_162845 0.818 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr21_+_45699830 0.816 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chrX_+_69581429 0.815 NM_021120
DLG3
discs, large homolog 3 (Drosophila)
chr19_+_45794895 0.815 NM_001042544
LTBP4
latent transforming growth factor beta binding protein 4
chrX_+_67965517 0.814 NM_004429
EFNB1
ephrin-B1
chr19_-_4406285 0.814 NM_001171091
UBXN6
UBX domain protein 6
chr9_+_130224950 0.813 CERCAM
cerebral endothelial cell adhesion molecule
chr9_+_138367329 0.811 NM_001145639
GPSM1
G-protein signaling modulator 1
chr15_+_87540238 0.806 ABHD2
abhydrolase domain containing 2
chr16_+_28413421 0.805 NM_018690
APOBR
apolipoprotein B receptor
chr16_-_66075216 0.804 NM_001138
AGRP
agouti related protein homolog (mouse)
chr16_+_65756138 0.803 HSF4
heat shock transcription factor 4
chr19_-_60646041 0.803 NM_001145176
SHISA7
shisa homolog 7 (Xenopus laevis)
chr19_-_44386731 0.800 NM_001080468
SYCN
syncollin
chr17_+_35471971 0.799 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr5_+_150008030 0.798 SYNPO
synaptopodin
chr17_+_45617676 0.795


chr1_+_63561317 0.792 NM_012183
FOXD3
forkhead box D3
chrX_+_49013424 0.791 PPP1R3F
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr16_+_28797309 0.791 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr16_-_4794749 0.786 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_-_1171964 0.784 NM_001014980
FAM132A
family with sequence similarity 132, member A
chr20_-_17589122 0.784 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr13_+_23042722 0.782 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_+_207944807 0.782 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_+_54786394 0.779 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr17_-_40839082 0.779 NM_001159330
ARHGAP27
Rho GTPase activating protein 27
chr11_-_132318080 0.776 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr15_+_76343540 0.774 NM_018602
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr7_-_135083906 0.773 NM_205855
FAM180A
family with sequence similarity 180, member A
chr16_+_620932 0.769 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr8_+_11388918 0.768 NM_001715
BLK
B lymphoid tyrosine kinase
chr14_+_57835028 0.768 ARID4A
AT rich interactive domain 4A (RBP1-like)
chr10_+_94439658 0.764 NM_002729
HHEX
hematopoietically expressed homeobox

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 3.13e-12 GO:0007399 nervous system development
1.23 1.07e-11 GO:0007275 multicellular organismal development
1.21 1.85e-11 GO:0032502 developmental process
1.25 3.25e-11 GO:0048731 system development
1.17 5.63e-11 GO:0032501 multicellular organismal process
1.23 3.39e-10 GO:0048856 anatomical structure development
1.30 3.95e-10 GO:0030154 cell differentiation
1.29 1.02e-09 GO:0048869 cellular developmental process
1.45 1.07e-09 GO:0022008 neurogenesis
1.47 1.10e-09 GO:0048699 generation of neurons
1.51 3.98e-09 GO:0030182 neuron differentiation
1.41 7.02e-08 GO:0048468 cell development
1.30 1.14e-06 GO:0009653 anatomical structure morphogenesis
1.27 1.48e-06 GO:0007166 cell surface receptor linked signaling pathway
1.53 1.88e-06 GO:0000904 cell morphogenesis involved in differentiation
1.48 3.49e-06 GO:0048666 neuron development
1.55 4.73e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.31 5.17e-06 GO:0051239 regulation of multicellular organismal process
1.55 7.43e-06 GO:0007409 axonogenesis
1.09 9.41e-06 GO:0065007 biological regulation
1.53 1.01e-05 GO:0048812 neuron projection morphogenesis
1.43 1.11e-05 GO:0010628 positive regulation of gene expression
1.50 1.40e-05 GO:0048858 cell projection morphogenesis
1.34 2.05e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.49 2.53e-05 GO:0019226 transmission of nerve impulse
1.49 2.53e-05 GO:0035637 multicellular organismal signaling
1.16 2.66e-05 GO:0023052 signaling
1.48 2.89e-05 GO:0032990 cell part morphogenesis
1.23 6.04e-05 GO:0048513 organ development
1.42 6.24e-05 GO:0032989 cellular component morphogenesis
1.19 6.84e-05 GO:0048518 positive regulation of biological process
1.40 9.72e-05 GO:0045595 regulation of cell differentiation
1.47 9.92e-05 GO:0031175 neuron projection development
1.43 1.17e-04 GO:0000902 cell morphogenesis
1.34 1.35e-04 GO:0050793 regulation of developmental process
1.40 1.68e-04 GO:0051254 positive regulation of RNA metabolic process
1.37 1.91e-04 GO:0007267 cell-cell signaling
1.20 2.92e-04 GO:0065008 regulation of biological quality
1.31 3.06e-04 GO:0007154 cell communication
1.55 3.79e-04 GO:0007411 axon guidance
1.48 3.81e-04 GO:0032583 regulation of gene-specific transcription
1.09 4.65e-04 GO:0050789 regulation of biological process
1.40 4.77e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.39 5.69e-04 GO:0030030 cell projection organization
1.44 5.89e-04 GO:0007417 central nervous system development
1.09 6.64e-04 GO:0050794 regulation of cellular process
1.18 7.29e-04 GO:0048522 positive regulation of cellular process
1.43 8.92e-04 GO:0006935 chemotaxis
1.43 8.92e-04 GO:0042330 taxis
1.46 1.02e-03 GO:0007268 synaptic transmission
1.32 1.08e-03 GO:0040011 locomotion
1.34 1.25e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.34 1.27e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 1.55e-03 GO:0032879 regulation of localization
2.35 1.64e-03 GO:0045667 regulation of osteoblast differentiation
1.38 2.00e-03 GO:0009887 organ morphogenesis
1.22 2.08e-03 GO:0023051 regulation of signaling
1.40 2.11e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
1.28 2.15e-03 GO:0010646 regulation of cell communication
1.55 2.56e-03 GO:0030029 actin filament-based process
1.40 2.95e-03 GO:0051253 negative regulation of RNA metabolic process
1.42 3.20e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.63 3.41e-03 GO:0043193 positive regulation of gene-specific transcription
1.36 4.31e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.51 4.49e-03 GO:0051093 negative regulation of developmental process
1.47 4.97e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.51 5.00e-03 GO:0060284 regulation of cell development
1.31 5.19e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.48 5.26e-03 GO:0007420 brain development
1.38 8.28e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.06 8.30e-03 GO:0010721 negative regulation of cell development
1.48 8.35e-03 GO:0044057 regulation of system process
1.18 9.13e-03 GO:0048523 negative regulation of cellular process
1.19 9.82e-03 GO:0048583 regulation of response to stimulus
1.17 1.06e-02 GO:0048519 negative regulation of biological process
1.35 1.08e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 1.08e-02 GO:2000026 regulation of multicellular organismal development
1.36 1.21e-02 GO:0050878 regulation of body fluid levels
2.46 1.22e-02 GO:0060349 bone morphogenesis
1.29 1.46e-02 GO:0009891 positive regulation of biosynthetic process
2.24 1.55e-02 GO:0060348 bone development
1.53 1.82e-02 GO:0045596 negative regulation of cell differentiation
1.13 1.94e-02 GO:0007165 signal transduction
1.49 2.00e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.88 2.02e-02 GO:0030278 regulation of ossification
1.63 2.14e-02 GO:0003012 muscle system process
1.53 2.72e-02 GO:0030036 actin cytoskeleton organization
1.19 2.94e-02 GO:0003008 system process
1.26 3.06e-02 GO:0009605 response to external stimulus
1.65 3.31e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.05 3.40e-02 GO:0009987 cellular process
1.49 3.99e-02 GO:0051960 regulation of nervous system development
2.44 4.03e-02 GO:0003014 renal system process
1.33 4.05e-02 GO:0010629 negative regulation of gene expression
1.37 4.07e-02 GO:0007599 hemostasis
1.21 4.08e-02 GO:0009966 regulation of signal transduction
1.33 4.23e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.31 4.29e-02 GO:0009890 negative regulation of biosynthetic process
1.32 4.34e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.29 4.57e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.32 4.87e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.31 4.94e-02 GO:0031327 negative regulation of cellular biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 1.52e-07 GO:0071944 cell periphery
1.15 3.80e-07 GO:0005886 plasma membrane
1.20 4.32e-05 GO:0044459 plasma membrane part
2.14 8.58e-05 GO:0033267 axon part
1.70 2.10e-04 GO:0030424 axon
1.61 9.22e-04 GO:0034702 ion channel complex
2.33 4.25e-03 GO:0044306 neuron projection terminus
2.34 5.73e-03 GO:0043679 axon terminus
1.40 5.75e-03 GO:0043005 neuron projection
1.21 1.30e-02 GO:0031226 intrinsic to plasma membrane
1.38 1.45e-02 GO:0045202 synapse
1.66 1.58e-02 GO:0034703 cation channel complex
1.43 2.16e-02 GO:0044456 synapse part
1.20 2.37e-02 GO:0005887 integral to plasma membrane
1.07 3.13e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.47 2.19e-08 GO:0043565 sequence-specific DNA binding
1.35 6.64e-07 GO:0001071 nucleic acid binding transcription factor activity
1.35 6.64e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.57 7.77e-03 GO:0000975 regulatory region DNA binding
1.57 7.77e-03 GO:0001067 regulatory region nucleic acid binding
1.57 7.77e-03 GO:0044212 transcription regulatory region DNA binding
1.46 8.43e-03 GO:0022836 gated channel activity
1.57 1.10e-02 GO:0010843 promoter binding
1.24 1.82e-02 GO:0030528 transcription regulator activity
1.43 1.89e-02 GO:0003779 actin binding
1.57 1.94e-02 GO:0005244 voltage-gated ion channel activity
1.57 1.94e-02 GO:0022832 voltage-gated channel activity
1.38 2.12e-02 GO:0015267 channel activity
1.37 2.43e-02 GO:0022803 passive transmembrane transporter activity
1.74 2.69e-02 GO:0001653 peptide receptor activity
1.74 2.69e-02 GO:0008528 peptide receptor activity, G-protein coupled
1.38 2.74e-02 GO:0022838 substrate-specific channel activity
1.38 3.11e-02 GO:0005216 ion channel activity
1.45 4.52e-02 GO:0005261 cation channel activity
1.15 4.68e-02 GO:0004871 signal transducer activity
1.15 4.68e-02 GO:0060089 molecular transducer activity