Motif ID: KLF12.p2

Z-value: 3.560


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_73605914-0.371.8e-01Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_66535923 4.880 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr16_-_66535457 4.535 NM_000229
 LCAT
lecithin-cholesterol acyltransferase
chr17_+_1580504 4.482 WDR81
WD repeat domain 81
chr6_+_43565192 2.796 NM_001146017
 TJAP1
tight junction associated protein 1 (peripheral)
chr17_-_45622064 2.371


chr1_-_33613729 2.336 NM_198040
 PHC2
polyhomeotic homolog 2 (Drosophila)
chr17_-_45620911 2.300 COL1A1
collagen, type I, alpha 1
chr12_+_56135353 2.238 NM_031479
 INHBE
inhibin, beta E
chr16_+_27320983 2.058 NM_181078
NM_181079
 IL21R

interleukin 21 receptor

chr12_+_52665196 1.935 NM_017409
 HOXC10
homeobox C10
chr1_+_6767968 1.811 NM_001195563
NM_015215
 CAMTA1

calmodulin binding transcription activator 1

chr16_+_31132842 1.774 NM_001008274
 TRIM72
tripartite motif containing 72
chr11_-_70971556 1.758 NM_001005405
 KRTAP5-11
keratin associated protein 5-11
chr11_-_65841077 1.728 NM_020404
 CD248
CD248 molecule, endosialin
chr15_+_38550451 1.727 NM_130468
 CHST14
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
chr19_-_7840806 1.689 FLJ22184
hypothetical protein FLJ22184
chr19_+_40322231 1.687 NM_005031
 FXYD1
FXYD domain containing ion transport regulator 1
chr17_-_36451189 1.683 NM_030967
 KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_-_38285033 1.678 NM_002699
 POU3F1
POU class 3 homeobox 1
chr11_+_118259684 1.668 NM_001716
 CXCR5
chemokine (C-X-C motif) receptor 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 102 entries
enrichment   p-value GO term description
2.46 1.22e-02 GO:0060349 bone morphogenesis
2.44 4.03e-02 GO:0003014 renal system process
2.35 1.64e-03 GO:0045667 regulation of osteoblast differentiation
2.24 1.55e-02 GO:0060348 bone development
2.06 8.30e-03 GO:0010721 negative regulation of cell development
1.88 2.02e-02 GO:0030278 regulation of ossification
1.65 3.31e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.63 3.41e-03 GO:0043193 positive regulation of gene-specific transcription
1.63 2.14e-02 GO:0003012 muscle system process
1.55 4.73e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.55 7.43e-06 GO:0007409 axonogenesis
1.55 3.79e-04 GO:0007411 axon guidance
1.55 2.56e-03 GO:0030029 actin filament-based process
1.53 1.88e-06 GO:0000904 cell morphogenesis involved in differentiation
1.53 1.01e-05 GO:0048812 neuron projection morphogenesis
1.53 1.82e-02 GO:0045596 negative regulation of cell differentiation
1.53 2.72e-02 GO:0030036 actin cytoskeleton organization
1.51 3.98e-09 GO:0030182 neuron differentiation
1.51 4.49e-03 GO:0051093 negative regulation of developmental process
1.51 5.00e-03 GO:0060284 regulation of cell development

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.34 5.73e-03 GO:0043679 axon terminus
2.33 4.25e-03 GO:0044306 neuron projection terminus
2.14 8.58e-05 GO:0033267 axon part
1.70 2.10e-04 GO:0030424 axon
1.66 1.58e-02 GO:0034703 cation channel complex
1.61 9.22e-04 GO:0034702 ion channel complex
1.43 2.16e-02 GO:0044456 synapse part
1.40 5.75e-03 GO:0043005 neuron projection
1.38 1.45e-02 GO:0045202 synapse
1.21 1.30e-02 GO:0031226 intrinsic to plasma membrane
1.20 4.32e-05 GO:0044459 plasma membrane part
1.20 2.37e-02 GO:0005887 integral to plasma membrane
1.16 1.52e-07 GO:0071944 cell periphery
1.15 3.80e-07 GO:0005886 plasma membrane
1.07 3.13e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
1.74 2.69e-02 GO:0001653 peptide receptor activity
1.74 2.69e-02 GO:0008528 peptide receptor activity, G-protein coupled
1.57 7.77e-03 GO:0000975 regulatory region DNA binding
1.57 7.77e-03 GO:0001067 regulatory region nucleic acid binding
1.57 7.77e-03 GO:0044212 transcription regulatory region DNA binding
1.57 1.10e-02 GO:0010843 promoter binding
1.57 1.94e-02 GO:0005244 voltage-gated ion channel activity
1.57 1.94e-02 GO:0022832 voltage-gated channel activity
1.47 2.19e-08 GO:0043565 sequence-specific DNA binding
1.46 8.43e-03 GO:0022836 gated channel activity
1.45 4.52e-02 GO:0005261 cation channel activity
1.43 1.89e-02 GO:0003779 actin binding
1.38 2.12e-02 GO:0015267 channel activity
1.38 2.74e-02 GO:0022838 substrate-specific channel activity
1.38 3.11e-02 GO:0005216 ion channel activity
1.37 2.43e-02 GO:0022803 passive transmembrane transporter activity
1.35 6.64e-07 GO:0001071 nucleic acid binding transcription factor activity
1.35 6.64e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.24 1.82e-02 GO:0030528 transcription regulator activity
1.15 4.68e-02 GO:0004871 signal transducer activity