Motif ID: POU3F1..4.p2

Z-value: 1.858


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU3F2chr6_+_99389318-0.449.7e-02Click!
POU3F1chr1_-_38285033-0.322.4e-01Click!
POU3F4chrX_+_82649924-0.243.9e-01Click!
POU3F3chr2_+_1048381770.195.0e-01Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_176577228 4.615 NM_004841
RASAL2
RAS protein activator like 2
chr2_+_151922350 3.239 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr6_-_46997579 3.073 NM_001098518
GPR116
G protein-coupled receptor 116
chr2_-_162808123 2.953 NM_004460
FAP
fibroblast activation protein, alpha
chr1_-_202595666 2.824 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_+_66570683 2.743 PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_119768430 2.562


chr15_+_76171981 2.315 NM_001101404
SH2D7
SH2 domain containing 7
chr18_+_59593591 2.134 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_+_169549996 2.075 NM_002022
FMO4
flavin containing monooxygenase 4
chr9_+_674193 2.025


chr15_-_53996597 1.934 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr1_-_171286634 1.923 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr9_+_124835608 1.902 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chr5_-_140875591 1.837 DIAPH1
diaphanous homolog 1 (Drosophila)
chr8_-_13018123 1.777 NM_001164271
DLC1
deleted in liver cancer 1
chr8_-_93099040 1.726 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_80477783 1.701 C14orf145
chromosome 14 open reading frame 145
chr1_-_242073094 1.621 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr18_-_51219880 1.619 TCF4
transcription factor 4
chr8_-_13416554 1.611 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr2_-_206790871 1.552 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr1_-_229071957 1.552 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr8_+_1980564 1.545 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr13_+_23742846 1.542 SPATA13
spermatogenesis associated 13
chr3_-_49372584 1.538 RHOA
ras homolog gene family, member A
chr8_-_93181091 1.490 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_150065732 1.440 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_-_15706340 1.409 EPS8
epidermal growth factor receptor pathway substrate 8
chr2_-_110665188 1.407 NM_033514
LIMS3-LOC440895
LIMS3
LIMS3-LOC440895 read-through
LIM and senescent cell antigen-like domains 3
chr15_+_37330176 1.396 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr12_-_52939636 1.303 NM_001127321
CBX5
chromobox homolog 5
chr6_-_139654807 1.249 NM_153235
TXLNB
taxilin beta
chr13_-_77390907 1.235 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr11_-_85146691 1.228 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr17_-_45629401 1.208


chr12_-_52939584 1.186 NM_001127322
CBX5
chromobox homolog 5
chr12_-_90029328 1.164 LUM
lumican
chr17_-_1211263 1.156 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr5_+_34720368 1.151 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr7_-_32496497 1.146 NM_012322
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr10_-_69095362 1.142 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr4_+_169654742 1.141 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr9_-_21999270 1.128 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr4_-_152368492 1.128 SH3D19
SH3 domain containing 19
chr1_+_157246305 1.120 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr4_+_88076418 1.109


chr13_-_59223074 1.108


chr11_-_71458739 1.106 NUMA1
nuclear mitotic apparatus protein 1
chrX_+_102471769 1.103 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr15_-_50051239 1.093 NM_138792
LEO1
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_-_6407882 1.091 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr8_-_17599438 1.084 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr17_+_29606408 1.074 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr12_-_15757114 1.071 EPS8
epidermal growth factor receptor pathway substrate 8
chr6_+_121798443 1.050 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr21_-_14677310 1.027 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr12_-_90100733 1.024 NM_001920
DCN
decorin
chr1_-_172228673 1.017 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr13_+_100902942 1.006 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr10_+_95838801 1.003 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_-_141981083 1.002 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr3_-_127810087 0.991 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr17_-_36444626 0.981 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr3_+_11242666 0.979 NM_001098211
HRH1
histamine receptor H1
chr1_-_89364273 0.918 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr17_-_58237742 0.913 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr22_+_16423147 0.909 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr7_+_91762227 0.902


chr4_-_54119102 0.901 LNX1
ligand of numb-protein X 1
chr3_+_149930656 0.880 NM_032049
AGTR1
angiotensin II receptor, type 1
chr11_+_33306652 0.879 HIPK3
homeodomain interacting protein kinase 3
chr6_-_131333173 0.868 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr1_-_21249974 0.865 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_+_108571209 0.861 LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_110735158 0.852 NM_004696
SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr8_-_18710575 0.849 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chrX_+_100692071 0.844 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr2_-_162717159 0.839 NM_002054
GCG
glucagon
chr15_-_75135496 0.839 TSPAN3
tetraspanin 3
chr5_+_86712376 0.838


chr1_-_21250039 0.837 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr4_+_120029426 0.833 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr20_+_764710 0.804 NM_207121
FAM110A
family with sequence similarity 110, member A
chr3_-_187744808 0.793 NM_017541
CRYGS
crystallin, gamma S
chr7_+_143263191 0.789 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr4_-_54119123 0.772 LNX1
ligand of numb-protein X 1
chr6_-_46401363 0.772 NM_005822
RCAN2
regulator of calcineurin 2
chr12_-_101115677 0.771 NM_002674
PMCH
pro-melanin-concentrating hormone
chr10_+_64894943 0.753 LOC84989
hypothetical LOC84989
chr9_-_4142182 0.727 NM_152629
GLIS3
GLIS family zinc finger 3
chr7_-_104696678 0.721 NM_182691
SRPK2
SRSF protein kinase 2
chr1_+_78858675 0.707 NM_006820
IFI44L
interferon-induced protein 44-like
chr3_+_123095860 0.699 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr15_-_68781662 0.699 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr13_+_40783340 0.699 NM_001110798
NM_024561
NM_018527
NAA16


N(alpha)-acetyltransferase 16, NatA auxiliary subunit


chr1_+_169326641 0.699 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr4_-_54119159 0.698 NM_032622
LNX1
ligand of numb-protein X 1
chr10_-_75080784 0.697 NM_024875
SYNPO2L
synaptopodin 2-like
chr5_-_75954807 0.690 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr4_-_153523113 0.687 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_-_152445432 0.676 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr4_-_38534802 0.665 NM_006068
TLR6
toll-like receptor 6
chr5_+_159781413 0.663 NM_004219
PTTG1
pituitary tumor-transforming 1
chr16_+_14187965 0.660 MKL2
MKL/myocardin-like 2
chr4_+_2853434 0.651 ADD1
adducin 1 (alpha)
chr6_+_28342766 0.651 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr3_-_158704056 0.629 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr4_-_169476391 0.626 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr18_+_65219114 0.625 NM_152721
DOK6
docking protein 6
chr9_+_83733162 0.621 NM_001145197
FAM75D4
family with sequence similarity 75, member D4
chr9_-_110658030 0.619 NM_006686
ACTL7B
actin-like 7B
chr5_+_149977398 0.618 NM_001166209
SYNPO
synaptopodin
chr1_+_195503956 0.617 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr17_-_74244539 0.617


chr11_-_35235325 0.613 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_-_92151363 0.602


chr2_-_180319013 0.601 NM_001113397
ZNF385B
zinc finger protein 385B
chr22_-_37211467 0.595 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_-_143786993 0.594 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_240228987 0.593 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr2_+_108571177 0.589 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_+_63613383 0.586 NM_001080537
SNTN
sentan, cilia apical structure protein
chr5_-_132300702 0.581


chr18_-_63333487 0.576 DSEL
dermatan sulfate epimerase-like
chr13_+_42253685 0.574 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr13_-_46368968 0.572 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr14_+_23852152 0.571 NM_181657
LTB4R
leukotriene B4 receptor
chr6_-_114490701 0.568 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr11_+_129496792 0.566 APLP2
amyloid beta (A4) precursor-like protein 2
chr17_-_4113777 0.564 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr4_-_153820535 0.559 NM_152680
TMEM154
transmembrane protein 154
chr13_+_110637173 0.557 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr9_+_137107222 0.557 OLFM1
olfactomedin 1
chr1_-_152394215 0.556 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr4_+_124063660 0.554 NM_145207
SPATA5
spermatogenesis associated 5
chr12_-_69317441 0.552 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_+_123339662 0.549 NM_181709
FAM101A
family with sequence similarity 101, member A
chr2_-_198248828 0.542 NM_144629
RFTN2
raftlin family member 2
chr1_+_114273961 0.540 HIPK1
homeodomain interacting protein kinase 1
chr17_-_7434113 0.535 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr13_-_77391525 0.534


chr2_+_108590032 0.534 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chr18_-_45630154 0.534 MYO5B
myosin VB
chr7_-_11838260 0.522 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr7_-_83116414 0.522 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr2_-_202271598 0.515 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_+_114390975 0.515 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr8_+_39890484 0.515 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr17_+_34610117 0.506 RPL19
ribosomal protein L19
chr12_-_13139848 0.505 NM_031289
NM_153823
GSG1

germ cell associated 1

chr3_+_174598937 0.504 NM_014932
NLGN1
neuroligin 1
chr12_-_25041639 0.501 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr16_+_1668291 0.500 HN1L
hematological and neurological expressed 1-like
chr1_+_203106600 0.500 NFASC
neurofascin
chr12_-_119503551 0.495 NM_015918
NM_198202
POP5

processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)

chr12_-_242255 0.493 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr5_+_38439399 0.487 NM_182798
NM_182799
EGFLAM

EGF-like, fibronectin type III and laminin G domains

chr5_+_52892229 0.487 NDUFS4
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr2_+_108604111 0.484 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr5_-_58688428 0.483 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_8215577 0.480 NM_213597
KRBA2
KRAB-A domain containing 2
chrX_-_10495476 0.478 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr3_+_138159396 0.477 NM_144717
IL20RB
interleukin 20 receptor beta
chr3_+_186563529 0.474 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr3_+_100840129 0.474 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr12_-_9913199 0.474 CLEC2B
C-type lectin domain family 2, member B
chr7_-_98983924 0.468 FAM200A
family with sequence similarity 200, member A
chr11_+_71580816 0.463 NM_016729
FOLR1
folate receptor 1 (adult)
chr6_-_46401174 0.456 RCAN2
regulator of calcineurin 2
chr2_-_231697999 0.454 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr8_-_102029997 0.453 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr9_+_116943917 0.449 NM_017418
DEC1
deleted in esophageal cancer 1
chr5_-_146441184 0.448 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr3_+_157343444 0.445 NM_003471
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr8_+_134272463 0.445 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr11_-_19180092 0.444 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr9_+_18464138 0.443 ADAMTSL1
ADAMTS-like 1
chr7_+_28305464 0.440 NM_182899
CREB5
cAMP responsive element binding protein 5
chr9_-_110815542 0.438 NM_003798
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
chr2_+_183290912 0.437 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr11_+_104986009 0.436 NM_000829
NM_001077243
NM_001077244
GRIA4


glutamate receptor, ionotrophic, AMPA 4


chr5_+_52892217 0.436 NM_002495
NDUFS4
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr15_+_87540238 0.430 ABHD2
abhydrolase domain containing 2
chr10_-_116276560 0.429 ABLIM1
actin binding LIM protein 1
chr1_+_111818111 0.424 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr6_-_127705244 0.422 NM_001139510
ECHDC1
enoyl CoA hydratase domain containing 1
chr11_-_17147863 0.419 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr5_-_98290117 0.415 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr12_+_50568010 0.411 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chr14_+_64947592 0.411 NM_178155
NM_178156
FUT8

fucosyltransferase 8 (alpha (1,6) fucosyltransferase)

chr20_-_49747397 0.409 ATP9A
ATPase, class II, type 9A
chr10_-_116276651 0.408 NM_006720
ABLIM1
actin binding LIM protein 1
chr14_+_95792299 0.404 NM_000710
BDKRB1
bradykinin receptor B1
chr2_-_160181206 0.403 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_+_234624084 0.402 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr6_+_17390910 0.400 NM_153020
RBM24
RNA binding motif protein 24
chr7_+_149657810 0.399 NM_138434
C7orf29
chromosome 7 open reading frame 29
chr1_+_185064654 0.397 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr12_-_7136189 0.395 C1R
complement component 1, r subcomponent

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 8.47e-03 GO:0071944 cell periphery
1.29 1.51e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.89 9.21e-04 GO:0004930 G-protein coupled receptor activity