Motif ID: AIRE.p2

Z-value: 0.894


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_44530148-0.468.2e-02Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_64484184 2.113 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr1_-_7895873 1.605 UTS2
urotensin 2
chr18_+_27425727 1.184 NM_000371
TTR
transthyretin
chr11_-_32772731 0.958 NM_001008391
CCDC73
coiled-coil domain containing 73
chr17_-_31231421 0.929 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr1_+_179269183 0.915 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr19_-_14646626 0.860 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_+_13999959 0.836 NM_080864
RLN3
relaxin 3
chr15_+_20287609 0.817 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr7_+_75947762 0.765 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr12_+_45896318 0.755 NM_138371
FAM113B
family with sequence similarity 113, member B
chr19_-_12028126 0.753 NM_001080404
ZNF878
zinc finger protein 878
chr1_-_20318578 0.749 NM_012400
PLA2G2D
phospholipase A2, group IID
chr12_+_108035424 0.727


chr1_-_180624494 0.718 GLUL
glutamate-ammonia ligase
chr2_-_85490997 0.679 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr1_+_151117421 0.677 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr2_+_218698980 0.671 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr16_-_70080678 0.663 NM_006961
ZNF19
zinc finger protein 19
chr15_+_56217686 0.648 NM_020980
AQP9
aquaporin 9
chr6_+_53043729 0.625 NM_012347
FBXO9
F-box protein 9
chr16_+_2749934 0.620


chr7_+_77307382 0.607 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr16_-_727889 0.599 NARFL
nuclear prelamin A recognition factor-like
chr6_+_10629550 0.583 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr20_-_33658823 0.572 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr1_+_158975662 0.567 NM_021181
SLAMF7
SLAM family member 7
chr16_+_20328355 0.564 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr3_+_38238080 0.559 OXSR1
oxidative-stress responsive 1
chr12_-_9976173 0.555 NM_001130711
CLEC2A
C-type lectin domain family 2, member A
chr19_-_6621078 0.554 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_15655809 0.537 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr6_+_4835224 0.533 NM_001143971
CDYL
chromodomain protein, Y-like
chr6_-_32892705 0.530 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr10_-_93992982 0.521 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr19_+_59866237 0.516 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr19_-_23661779 0.511 NM_138330
ZNF675
zinc finger protein 675
chr1_-_155336223 0.506 NM_001004341
ETV3L
ets variant 3-like
chr15_+_43036194 0.504 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr17_-_25685175 0.499 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr11_-_59369501 0.497 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr3_-_152478843 0.478 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr16_+_10430225 0.476 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_-_9052207 0.467 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr4_-_123761615 0.450 NM_021803
IL21
interleukin 21
chr17_+_38259620 0.446 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr15_+_39363442 0.445 LOC729082
hypothetical LOC729082
chr5_-_39238818 0.440 FYB
FYN binding protein
chr22_+_21359175 0.429 IGLV3-25
immunoglobulin lambda variable 3-25
chr12_-_53064723 0.396 NM_015481
ZNF385A
zinc finger protein 385A
chr2_-_231498184 0.390 NM_005683
GPR55
G protein-coupled receptor 55
chr12_-_10173947 0.386 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr6_+_36318922 0.384 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr9_+_6710862 0.380 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr2_-_32344192 0.379 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr1_-_143708467 0.376 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_17499064 0.374 FAM129C
family with sequence similarity 129, member C
chr19_-_16111594 0.374


chr15_-_19007127 0.374 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr17_+_70092651 0.372 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr12_+_132124211 0.369 ZNF84
zinc finger protein 84
chr5_+_176744037 0.368 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr6_-_37575599 0.367 C6orf129
chromosome 6 open reading frame 129
chr3_+_46370228 0.366 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr4_+_17187936 0.366 NM_015907
LAP3
leucine aminopeptidase 3
chr9_-_129740583 0.363 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr3_+_120375053 0.354 NM_006952
UPK1B
uroplakin 1B
chr12_+_28301399 0.354 NM_018318
CCDC91
coiled-coil domain containing 91
chr19_-_8548337 0.349 MYO1F
myosin IF
chr5_-_1050408 0.347 LOC100506688
hypothetical protein LOC100506688
chr15_+_97990705 0.335 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr6_+_32240357 0.335 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr10_+_49279647 0.329 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr2_+_38009405 0.329 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr7_+_2565202 0.328 IQCE
IQ motif containing E
chr3_-_170346760 0.323 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr11_+_65236261 0.323 KAT5
K(lysine) acetyltransferase 5
chrX_-_70045285 0.322 NM_001003811
NM_031276
TEX11

testis expressed 11

chr17_+_28342994 0.317 NM_173847
SPACA3
sperm acrosome associated 3
chr14_+_38804226 0.311 NM_203354
CTAGE5
CTAGE family, member 5
chr22_+_21340757 0.311


chr11_-_47467094 0.309 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr6_-_159386007 0.305 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr1_+_157067729 0.305 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr5_+_138657317 0.303 NM_001194955
NM_001194956
MATR3

matrin 3

chr16_-_56886380 0.300 NM_001080492
PRSS54
protease, serine, 54
chr19_-_16111695 0.298


chr17_-_70220605 0.297 NM_139018
CD300LF
CD300 molecule-like family member f
chr13_-_45640679 0.297 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_4104593 0.297 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr8_-_42742729 0.296 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr5_+_118993152 0.293 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr7_+_2565238 0.293 IQCE
IQ motif containing E
chr1_+_20353284 0.293


chrX_-_100193747 0.292 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr19_+_46489987 0.289 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr7_+_75892187 0.286 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr19_+_56958452 0.285 NM_001462
FPR2
formyl peptide receptor 2
chr11_+_59001421 0.282 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr17_-_47591949 0.281 CA10
carbonic anhydrase X
chr7_-_122627235 0.278 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr18_+_27152049 0.278 NM_001942
DSG1
desmoglein 1
chr16_+_20682812 0.278 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr2_+_12775814 0.277


chr9_-_135923373 0.277 BRD3
bromodomain containing 3
chr8_-_30704984 0.275 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chrX_-_100193698 0.270 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr6_+_6533932 0.269 NM_004271
LY86
lymphocyte antigen 86
chr9_-_21358005 0.269 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr15_-_48198697 0.269 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr15_-_23204887 0.269 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr6_-_159160355 0.265 EZR
ezrin
chr2_+_169637255 0.262 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_32157845 0.261 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr11_-_6418705 0.261 NM_000613
HPX
hemopexin
chr1_+_559129 0.258


chr1_-_9052253 0.258 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr2_-_37397669 0.258 NM_005813
PRKD3
protein kinase D3
chr20_-_10360569 0.257 NM_018848
MKKS
McKusick-Kaufman syndrome
chr11_-_64335341 0.253 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr12_+_53534565 0.252 NM_058173
MUCL1
mucin-like 1
chrX_-_70243362 0.250 NM_001025265
CXorf65
chromosome X open reading frame 65
chr14_-_105796268 0.250 ZCWPW2
IGHV3-23
IGKV3-20
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
chr2_+_218698242 0.248 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr8_-_6783193 0.247 NM_001925
DEFA4
defensin, alpha 4, corticostatin
chr1_+_43055362 0.246 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr1_+_246635918 0.246 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr3_-_152403636 0.245 NM_013308
GPR171
G protein-coupled receptor 171
chr14_-_105785639 0.245


chr12_-_121753795 0.244 NM_177551
GPR109A
G protein-coupled receptor 109A
chr2_+_231829021 0.242


chr11_+_123639909 0.242 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr1_+_153222464 0.242 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr9_+_95886625 0.241 PTPDC1
protein tyrosine phosphatase domain containing 1
chr19_+_44478804 0.239 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr16_-_1434490 0.234 NM_001143980
CCDC154
coiled-coil domain containing 154
chrX_+_21960841 0.234 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr4_-_176970895 0.232 GPM6A
glycoprotein M6A
chr11_-_1586190 0.229 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr4_+_53986759 0.228 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr10_-_101831579 0.227 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr19_+_21056792 0.226 NM_182515
ZNF714
zinc finger protein 714
chr6_-_133120587 0.225 NM_004665
VNN2
vanin 2
chr2_+_73864823 0.222 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr19_-_60528480 0.221 NM_001085488
TMEM150B
transmembrane protein 150B
chr1_-_245334248 0.216 NM_001142572
NM_024804
ZNF669

zinc finger protein 669

chr19_+_52504914 0.216 NM_001736
C5AR1
complement component 5a receptor 1
chr15_+_57696016 0.214 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr19_-_59573869 0.213 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr1_+_246087230 0.213 TRIM58
tripartite motif containing 58
chr19_-_10281220 0.210 NM_001103167
ZGLP1
zinc finger, GATA-like protein 1
chr6_-_31668476 0.210 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr1_+_153222393 0.210 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr4_+_69716298 0.209 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr11_-_4782185 0.209 NM_001005177
OR52R1
olfactory receptor, family 52, subfamily R, member 1
chr18_-_46068689 0.209 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr10_+_135057597 0.208 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr9_-_103187082 0.208 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr6_-_37575666 0.208 NM_138493
C6orf129
chromosome 6 open reading frame 129
chr7_+_2565172 0.207 IQCE
IQ motif containing E
chr5_-_32439067 0.206 ZFR
zinc finger RNA binding protein
chrX_-_102418329 0.206 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr7_-_149960612 0.206 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr1_+_51855343 0.206 OSBPL9
oxysterol binding protein-like 9
chr8_+_30072463 0.206 NM_001128208
NM_015344
LEPROTL1

leptin receptor overlapping transcript-like 1

chr16_-_11588257 0.204 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr10_-_95231933 0.203 NM_013451
NM_133337
MYOF

myoferlin

chr19_-_44518516 0.202 NM_004877
GMFG
glia maturation factor, gamma
chr3_-_152585226 0.196 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_-_27126721 0.196 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr7_+_115926679 0.194 NM_001233
NM_198212
CAV2

caveolin 2

chr2_-_20390601 0.190 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr6_-_33864863 0.190 LEMD2
LEM domain containing 2
chr6_-_149847809 0.190 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_33864876 0.187 LEMD2
LEM domain containing 2
chr3_+_109498082 0.186 HHLA2
HERV-H LTR-associating 2
chr6_-_159160386 0.184 EZR
ezrin
chr10_+_97461525 0.182 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr19_-_17432724 0.181 NM_138454
NXNL1
nucleoredoxin-like 1
chr19_-_10474767 0.176 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr10_+_123738678 0.172 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr9_-_99974994 0.171 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr22_+_34979118 0.168 APOL1
apolipoprotein L, 1
chr19_-_10475083 0.168 KEAP1
kelch-like ECH-associated protein 1
chr19_+_55627971 0.167 NM_004533
MYBPC2
myosin binding protein C, fast type
chr3_-_171070314 0.167 NM_024727
LRRC31
leucine rich repeat containing 31
chrX_+_2934653 0.167 NM_001011719
ARSH
arylsulfatase family, member H
chr17_-_36113502 0.167 NM_019016
KRT24
keratin 24
chr16_-_11282595 0.167 NM_002761
PRM1
protamine 1
chr6_-_159160387 0.166 EZR
ezrin
chrX_+_11221453 0.164 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr19_-_6375801 0.163 KHSRP
KH-type splicing regulatory protein
chr1_+_233597385 0.162 TBCE
tubulin folding cofactor E
chr7_-_38341697 0.162 TRGV7
T cell receptor gamma variable 7 pseudogene
chr8_+_26569709 0.161 DPYSL2
dihydropyrimidinase-like 2
chr2_+_201806410 0.160 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr19_+_7468444 0.157 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr6_+_31791063 0.157 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr4_+_123380569 0.156 KIAA1109
KIAA1109
chr12_+_27511009 0.155 NM_001145010
C12orf70
chromosome 12 open reading frame 70

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.15 3.81e-03 GO:0002682 regulation of immune system process
2.43 7.18e-03 GO:0050776 regulation of immune response
2.38 1.53e-02 GO:0002684 positive regulation of immune system process
2.75 1.73e-02 GO:0050778 positive regulation of immune response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.77 3.15e-02 GO:0001608 nucleotide receptor activity, G-protein coupled
7.77 3.15e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled