Motif ID: IKZF2.p2

Z-value: 1.889


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_2137232980.611.6e-02Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_135079120 2.477 NM_001159704
FHL1
four and a half LIM domains 1
chr1_+_84539876 1.989 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr3_+_69895310 1.836 NM_001184967
MITF
microphthalmia-associated transcription factor
chr9_-_15240113 1.695 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr6_+_42896771 1.539 NM_015349
KIAA0240
KIAA0240
chr8_-_13416554 1.533 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr17_+_36515166 1.514 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr1_+_78888064 1.451 NM_006417
IFI44
interferon-induced protein 44
chr4_-_153523113 1.439 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_-_79244948 1.420 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr1_+_161305558 1.409 NM_001113381
RGS4
regulator of G-protein signaling 4
chr7_+_102340579 1.390 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr3_-_158695832 1.363 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr1_-_167865973 1.348 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr4_-_122357104 1.321 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr6_+_116956868 1.321 NM_153036
FAM26D
family with sequence similarity 26, member D
chr8_+_42671718 1.291 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr8_-_6407882 1.285 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_-_109957195 1.274 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_-_75794919 1.273 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr8_-_133841988 1.236 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr13_-_101852028 1.226 NM_175929
FGF14
fibroblast growth factor 14
chr3_-_150533948 1.221 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr1_+_61642287 1.202 NFIA
nuclear factor I/A
chr17_-_51155073 1.201 NM_018286
TMEM100
transmembrane protein 100
chr1_+_99884018 1.193 NM_017734
PALMD
palmdelphin
chr2_-_40593074 1.186 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_202379442 1.184 NM_139158
CDK15
cyclin-dependent kinase 15
chr4_+_88187215 1.179 AFF1
AF4/FMR2 family, member 1
chr17_-_32730804 1.176 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr2_-_134042500 1.164 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr18_+_30544193 1.142 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr1_+_19807168 1.125


chr2_-_162808123 1.122 NM_004460
FAP
fibroblast activation protein, alpha
chr3_+_69998064 1.122 NM_198177
MITF
microphthalmia-associated transcription factor
chr2_+_33514896 1.120 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr13_-_98757634 1.095 NM_004951
GPR183
G protein-coupled receptor 183
chr8_-_37847095 1.093 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr2_-_175170674 1.088 WIPF1
WAS/WASL interacting protein family, member 1
chr8_+_32698892 1.073 NM_001159996
NRG1
neuregulin 1
chr3_+_129682434 1.062


chrX_-_138742050 1.015 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr8_+_39890484 1.014 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr3_+_46423682 1.002 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr3_+_69895651 0.969 NM_006722
MITF
microphthalmia-associated transcription factor
chr5_-_132300702 0.968


chr10_-_112668679 0.958 NM_001195306
BBIP1
BBSome interacting protein 1
chr17_+_29606408 0.953 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr5_-_142057692 0.944 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr2_-_231697999 0.941 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr1_+_22107137 0.939 RPL21
ribosomal protein L21
chr1_+_100957883 0.937 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr6_+_136214495 0.931 NM_018945
PDE7B
phosphodiesterase 7B
chr2_-_203484445 0.927 WDR12
WD repeat domain 12
chr4_-_89963177 0.917 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr1_-_45868775 0.917 GPBP1L1
GC-rich promoter binding protein 1-like 1
chr2_+_108571336 0.915 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_111995213 0.899 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr11_-_85115105 0.886 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr12_-_90097384 0.881 NM_133503
DCN
decorin
chr13_+_75092570 0.880 NM_005358
LMO7
LIM domain 7
chr3_-_69254226 0.879 NM_198271
LMOD3
leiomodin 3 (fetal)
chr17_+_36493927 0.871 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr1_-_21478571 0.869 NM_001113347
ECE1
endothelin converting enzyme 1
chr1_-_171286634 0.866 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr1_+_161305188 0.845 NM_005613
RGS4
regulator of G-protein signaling 4
chr4_+_146820805 0.839 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr12_+_67366989 0.839 NM_020401
NUP107
nucleoporin 107kDa
chr2_+_36777406 0.834 VIT
vitrin
chr7_-_83662152 0.830 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_+_108571177 0.822 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_-_18585721 0.819 PSD3
pleckstrin and Sec7 domain containing 3
chr11_+_18374388 0.817 NM_001165414
LDHA
lactate dehydrogenase A
chr11_+_33306652 0.816 HIPK3
homeodomain interacting protein kinase 3
chrX_-_74292800 0.815 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr7_-_14847479 0.814 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr13_-_32678142 0.814 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_-_36436979 0.810 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr16_+_83349816 0.807 USP10
ubiquitin specific peptidase 10
chrX_-_19598912 0.805 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr4_+_160408447 0.799 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_-_58538110 0.799 FAM107A
family with sequence similarity 107, member A
chr8_-_17599438 0.785 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr14_+_55148488 0.784 KTN1
kinectin 1 (kinesin receptor)
chrX_+_135079461 0.780 NM_001167819
FHL1
four and a half LIM domains 1
chr4_-_152366970 0.774 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr7_-_41709191 0.773 NM_002192
INHBA
inhibin, beta A
chr5_-_34078991 0.771 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr4_-_24590867 0.761 NM_173463
CCDC149
coiled-coil domain containing 149
chr17_-_23244499 0.758 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr12_+_91654395 0.757 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr6_-_32447626 0.756 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr10_+_69539255 0.756 NM_032578
MYPN
myopalladin
chr4_-_101658094 0.755 NM_001159694
NM_016242
EMCN

endomucin

chr1_+_169326641 0.750 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr5_+_145296313 0.747 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr4_+_95595419 0.747 PDLIM5
PDZ and LIM domain 5
chr6_+_106653429 0.744 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chrX_+_149364377 0.738 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr2_+_108571209 0.732 LIMS1
LIM and senescent cell antigen-like domains 1
chr18_+_54013575 0.729 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_109201228 0.725 NM_152763
AKNAD1
AKNA domain containing 1
chr15_-_40537002 0.725 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr4_+_14985272 0.724 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr20_-_17487480 0.722 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr2_-_202271598 0.719 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr10_+_95838801 0.719 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr11_+_5597749 0.711 NM_001003827
TRIM34
tripartite motif containing 34
chr17_-_64649608 0.708 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr13_+_96592051 0.702 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_157246305 0.697 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr14_-_49932366 0.694 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr1_-_23393808 0.693 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr11_-_58099884 0.690 NM_004811
LPXN
leupaxin
chr12_-_15706340 0.690 EPS8
epidermal growth factor receptor pathway substrate 8
chr6_-_112186977 0.683 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr6_+_129245978 0.677 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr15_+_60838053 0.677 TLN2
talin 2
chr2_-_144994349 0.677 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_+_154120170 0.676 SYT11
synaptotagmin XI
chr1_-_149047329 0.674 NM_000396
CTSK
cathepsin K
chr10_+_63092724 0.673 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr1_-_155281785 0.669 NM_014784
NM_198236
ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11

chr7_-_110989582 0.666 NM_032549
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr17_-_64462976 0.660 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr9_-_90983195 0.660 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr9_+_112470871 0.657 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr7_+_93388951 0.655 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr8_-_125648576 0.654 MTSS1
metastasis suppressor 1
chr11_-_102174032 0.654 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr9_+_129893948 0.652 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr7_-_27133163 0.650 NM_153631
HOXA3
homeobox A3
chr21_-_38210531 0.650 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr9_+_676640 0.649


chr5_+_150008030 0.643 SYNPO
synaptopodin
chr2_-_40510923 0.642 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr9_-_94284455 0.639 ASPN
asporin
chr15_-_70350609 0.639 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr2_+_102320148 0.639 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr3_-_188935363 0.629 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr12_-_52281050 0.620 NM_001130059
ATF7
activating transcription factor 7
chr11_-_114593838 0.617 CADM1
cell adhesion molecule 1
chr22_-_37211467 0.615 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr1_+_17817397 0.611 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_+_161308318 0.611 NM_001113380
RGS4
regulator of G-protein signaling 4
chr10_+_104525877 0.609 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr2_-_99412694 0.607 REV1
REV1 homolog (S. cerevisiae)
chr18_-_51219880 0.605 TCF4
transcription factor 4
chr5_+_147775652 0.605 FBXO38
F-box protein 38
chr5_+_152850276 0.604 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr9_+_35528890 0.603 RUSC2
RUN and SH3 domain containing 2
chr7_+_134226690 0.598 NM_033139
NM_033140
CALD1

caldesmon 1

chr1_-_194844061 0.598 NM_198503
KCNT2
potassium channel, subfamily T, member 2
chr17_-_36451189 0.597 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_+_194887630 0.595 NM_000186
NM_001014975
CFH

complement factor H

chr10_-_35419229 0.585 NM_003591
CUL2
cullin 2
chr12_+_12829807 0.583 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr8_-_103735194 0.583 NM_001032282
KLF10
Kruppel-like factor 10
chr11_-_102174102 0.582 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr12_+_118100977 0.582 NM_014365
HSPB8
heat shock 22kDa protein 8
chr5_+_76470829 0.580


chr15_-_68781662 0.577 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr19_-_47961653 0.577 NM_001130167
NM_001130168
NM_182707
PSG8


pregnancy specific beta-1-glycoprotein 8


chr13_+_51334117 0.577 NM_031290
CCDC70
coiled-coil domain containing 70
chr21_-_38792173 0.575 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr21_-_34749908 0.574 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr2_-_101134146 0.573 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr3_-_188936941 0.569 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr2_-_213723298 0.568 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr6_-_56615544 0.567 NM_001723
NM_015548
DST

dystonin

chr13_-_37070862 0.566 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr3_-_11585264 0.565 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr14_+_38720085 0.563 PNN
pinin, desmosome associated protein
chr5_-_58607673 0.563 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_14929991 0.560 NM_000900
NM_001190839
MGP

matrix Gla protein

chr8_-_82606104 0.560 NM_001105281
FABP12
fatty acid binding protein 12
chr1_+_145841569 0.559 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr14_+_85066265 0.557 FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_-_50871953 0.556 NM_001081492
NM_182507
KRT80

keratin 80

chr13_-_40735619 0.555 NM_004294
MTRF1
mitochondrial translational release factor 1
chr12_-_78853365 0.554 NM_001143885
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chrX_+_56772391 0.553 LOC550643
hypothetical LOC550643
chr20_+_56369012 0.552


chr1_-_151804929 0.552 NM_005978
S100A2
S100 calcium binding protein A2
chr1_+_93317374 0.551 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chrX_-_135166306 0.550 NM_001173516
MAP7D3
MAP7 domain containing 3
chr21_-_35174742 0.547 RUNX1
runt-related transcription factor 1
chr4_+_15080586 0.546 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr1_+_159435728 0.545 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr16_+_31105579 0.545


chr2_-_189363075 0.545 NM_052952
DIRC1
disrupted in renal carcinoma 1
chr10_-_29963906 0.542 NM_021738
SVIL
supervillin
chr12_-_7487989 0.542 NM_174941
CD163L1
CD163 molecule-like 1
chr7_+_90177082 0.538 CDK14
cyclin-dependent kinase 14
chr7_-_137271191 0.536 CREB3L2
cAMP responsive element binding protein 3-like 2
chr5_-_59100194 0.532 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_91762227 0.531


chr10_+_102285690 0.531 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr9_+_35528628 0.530 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr10_-_116434364 0.530 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 6.16e-04 GO:0043228 non-membrane-bounded organelle
1.23 6.16e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.95 4.08e-02 GO:0005681 spliceosomal complex
1.25 4.87e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 1.37e-02 GO:0005515 protein binding