Motif ID: REST.p3

Z-value: 2.307


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57468847-0.468.4e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_9720509 4.510 NM_153635
 CPNE9
copine family member IX
chr10_+_99599984 4.127 NM_001010917
 GOLGA7B
golgin A7 family, member B
chr12_+_46133 3.474 NM_001170738
 IQSEC3
IQ motif and Sec7 domain 3
chr7_-_19778928 3.027 NM_152774
 TMEM196
transmembrane protein 196
chr16_+_66244314 3.013 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr20_+_61798512 2.866 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_23393808 2.812 NM_000864
 HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr9_-_73251639 2.768 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_-_3472245 2.678 LOC100129223
hypothetical LOC100129223
chr17_+_39741306 2.662 NM_001144825
NM_001144826
NM_006695
 RUNDC3A


RUN domain containing 3A


chr20_+_30019465 2.578 NM_001011718
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr20_+_61798446 2.574 NM_003823
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr4_+_158361185 2.541 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr7_+_154943466 2.516 NM_001427
 EN2
engrailed homeobox 2
chr5_+_33972247 2.373 NM_016568
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr14_-_50631407 2.367 TRIM9
tripartite motif containing 9
chr6_+_158877455 2.332 NM_020823
 TMEM181
transmembrane protein 181
chr15_+_65904994 2.252 NM_001031807
 SKOR1
SKI family transcriptional corepressor 1
chr20_+_5839973 2.134 NM_001819
 CHGB
chromogranin B (secretogranin 1)
chr6_+_110406890 2.121 NM_005284
 GPR6
G protein-coupled receptor 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
40.10 2.56e-02 GO:0051954 positive regulation of amine transport
28.96 5.04e-03 GO:0060078 regulation of postsynaptic membrane potential
18.79 2.96e-02 GO:0051952 regulation of amine transport
17.38 4.04e-02 GO:0051899 membrane depolarization
14.02 1.42e-02 GO:0007269 neurotransmitter secretion
13.17 1.93e-02 GO:0007631 feeding behavior
12.78 2.23e-02 GO:0030534 adult behavior
11.48 1.28e-03 GO:0003001 generation of a signal involved in cell-cell signaling
11.48 1.28e-03 GO:0023061 signal release
11.22 7.92e-03 GO:0007626 locomotory behavior
10.15 6.07e-04 GO:0031644 regulation of neurological system process
9.82 3.64e-03 GO:0051969 regulation of transmission of nerve impulse
8.40 5.55e-07 GO:0007610 behavior
8.22 4.59e-02 GO:0042391 regulation of membrane potential
6.99 4.67e-07 GO:0007268 synaptic transmission
6.62 3.07e-07 GO:0019226 transmission of nerve impulse
6.62 3.07e-07 GO:0035637 multicellular organismal signaling
6.55 4.95e-02 GO:0055074 calcium ion homeostasis
6.25 2.25e-07 GO:0007186 G-protein coupled receptor protein signaling pathway
5.98 3.34e-03 GO:0032940 secretion by cell

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
19.31 6.85e-04 GO:0030672 synaptic vesicle membrane
14.15 7.32e-05 GO:0008021 synaptic vesicle
12.27 1.11e-03 GO:0030665 clathrin coated vesicle membrane
9.07 6.23e-03 GO:0030662 coated vesicle membrane
8.70 4.59e-04 GO:0030136 clathrin-coated vesicle
8.28 1.66e-04 GO:0030425 dendrite
8.14 7.50e-04 GO:0043025 neuronal cell body
7.91 9.27e-04 GO:0044297 cell body
7.27 1.08e-05 GO:0044456 synapse part
7.10 2.03e-03 GO:0030135 coated vesicle
7.05 2.50e-02 GO:0045211 postsynaptic membrane
6.80 5.74e-07 GO:0043005 neuron projection
6.29 5.14e-06 GO:0045202 synapse
6.05 2.14e-03 GO:0030659 cytoplasmic vesicle membrane
5.84 2.81e-03 GO:0012506 vesicle membrane
5.02 9.14e-03 GO:0044433 cytoplasmic vesicle part
4.28 5.23e-04 GO:0030054 cell junction
3.81 9.62e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
3.74 1.20e-03 GO:0031988 membrane-bounded vesicle
3.58 1.98e-03 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
86.87 2.15e-02 GO:0016933 extracellular-glycine-gated ion channel activity
86.87 2.15e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
69.50 3.58e-02 GO:0022824 transmitter-gated ion channel activity
69.50 3.58e-02 GO:0022835 transmitter-gated channel activity
40.10 5.57e-03 GO:0016594 glycine binding
24.83 2.51e-02 GO:0005184 neuropeptide hormone activity
22.19 3.01e-05 GO:0005231 excitatory extracellular ligand-gated ion channel activity
14.49 3.90e-04 GO:0005230 extracellular ligand-gated ion channel activity
8.78 2.91e-02 GO:0005179 hormone activity
8.48 8.38e-03 GO:0043176 amine binding
8.35 9.17e-03 GO:0015276 ligand-gated ion channel activity
8.35 9.17e-03 GO:0022834 ligand-gated channel activity
4.63 3.74e-02 GO:0022836 gated channel activity
4.57 7.34e-03 GO:0005216 ion channel activity
4.50 8.35e-03 GO:0022838 substrate-specific channel activity
4.36 1.08e-02 GO:0015267 channel activity
4.35 1.10e-02 GO:0022803 passive transmembrane transporter activity
2.60 2.66e-02 GO:0005215 transporter activity