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• Activity deltas table
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Motif ID: REST.p3

Z-value: 2.307

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr3_+_9720509	4.510	NM_153635	CPNE9	copine family member IX
chr10_+_99599984	4.127	NM_001010917	GOLGA7B	golgin A7 family, member B
chr12_+_46133	3.474	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr7_-_19778928	3.027	NM_152774	TMEM196	transmembrane protein 196
chr16_+_66244314	3.013		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr20_+_61798512	2.866		TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_23393808	2.812	NM_000864	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D
chr9_-_73251639	2.768		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr12_-_3472245	2.678		LOC100129223	hypothetical LOC100129223
chr17_+_39741306	2.662	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr20_+_30019465	2.578	NM_001011718	XKR7	XK, Kell blood group complex subunit-related family, member 7
chr20_+_61798446	2.574	NM_003823	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr4_+_158361185	2.541	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr7_+_154943466	2.516	NM_001427	EN2	engrailed homeobox 2
chr5_+_33972247	2.373	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr14_-_50631407	2.367		TRIM9	tripartite motif containing 9
chr6_+_158877455	2.332	NM_020823	TMEM181	transmembrane protein 181
chr15_+_65904994	2.252	NM_001031807	SKOR1	SKI family transcriptional corepressor 1
chr20_+_5839973	2.134	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr6_+_110406890	2.121	NM_005284	GPR6	G protein-coupled receptor 6
chr8_+_57520915	2.121
chr2_-_27384617	2.106	NM_003353	UCN	urocortin
chr11_+_62136788	2.083	NM_000327	ROM1	retinal outer segment membrane protein 1
chr3_-_133236447	2.072	NM_130808	CPNE4	copine IV
chr10_+_60607232	1.923	NM_001143774	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like
chr8_-_57521065	1.909	NM_006211	PENK	proenkephalin
chr14_+_92459197	1.870	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr16_+_4948318	1.771	NM_014692	SEC14L5	SEC14-like 5 (S. cerevisiae)
chr11_-_74819165	1.765	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr14_+_92459244	1.754		CHGA	chromogranin A (parathyroid secretory protein 1)
chr17_+_27838041	1.716	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr4_+_8633116	1.655	NM_080819	GPR78	G protein-coupled receptor 78
chr12_-_29828958	1.645	NM_175861	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr20_-_60228665	1.645	NM_007232	HRH3	histamine receptor H3
chr2_-_219791902	1.637	NM_005689	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr2_+_207215386	1.635	NM_001102659	LOC200726	hCG1657980
chr11_-_74818858	1.597		KLHL35	kelch-like 35 (Drosophila)
chr9_+_139153409	1.583	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr6_+_158877640	1.567		TMEM181	transmembrane protein 181
chr12_+_50981915	1.552	NM_002284	KRT86	keratin 86
chr17_-_24357014	1.519	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr10_-_102780840	1.437		PDZD7	PDZ domain containing 7
chr3_+_62279707	1.399		C3orf14	chromosome 3 open reading frame 14
chr19_-_60383280	1.386	NM_003180	SYT5	synaptotagmin V
chr14_-_50631794	1.345		TRIM9	tripartite motif containing 9
chr3_-_48675321	1.334	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr20_-_61755145	1.289	NM_015894	STMN3	stathmin-like 3
chr3_+_62280435	1.274	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr10_+_102780974	1.245	NM_030971	SFXN3	sideroflexin 3
chr19_+_38867273	1.241	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr19_-_45416043	1.228		TTC9B	tetratricopeptide repeat domain 9B
chr10_-_102780867	1.223	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr5_-_151284515	1.174	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr1_+_152806874	1.155	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr2_-_219791638	1.144		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr15_+_73074882	1.105	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr17_+_1120607	1.070	NM_001164405	BHLHA9	basic helix-loop-helix family, member a9
chr6_+_154402135	1.026	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145285 NM_001145286 NM_001145284	OPRM1	opioid receptor, mu 1
chr11_-_74818685	0.990		KLHL35	kelch-like 35 (Drosophila)
chr1_+_152806924	0.973		CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr16_+_2959362	0.966		PAQR4	progestin and adipoQ receptor family member IV
chr6_+_35881048	0.962	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr5_+_71050745	0.943	NM_004291	CARTPT	CART prepropeptide
chr11_-_122357545	0.934	NM_001098169	BSX	brain-specific homeobox
chr1_+_208178198	0.926		SYT14	synaptotagmin XIV
chr2_+_131230252	0.903	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr7_-_100595552	0.894	NM_003378	VGF	VGF nerve growth factor inducible
chr11_-_1725662	0.870		LOC402778	CD225 family protein FLJ76511
chr8_-_145723209	0.820	NM_001024678	LRRC24	leucine rich repeat containing 24
chr11_-_123030091	0.815		SCN3B	sodium channel, voltage-gated, type III, beta
chr15_-_70399551	0.794	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr1_+_33124658	0.787	NM_002143	HPCA	hippocalcin
chr15_-_81175542	0.780	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr5_-_175969697	0.769	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chrX_-_47364039	0.765
chr18_-_5187240	0.764	NM_001145194	LOC642597	hypothetical protein LOC642597
chr3_-_188870799	0.761	NM_001048	SST	somatostatin
chr11_-_1725924	0.756	NM_001170820	LOC402778	CD225 family protein FLJ76511
chr15_-_70399523	0.745		CELF6	CUGBP, Elav-like family member 6
chr6_+_25760352	0.727	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr17_-_37022465	0.706	NM_005557	KRT16	keratin 16
chr19_+_4720144	0.702		C19orf30	chromosome 19 open reading frame 30
chr19_-_45416112	0.702	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr16_+_2959342	0.684	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr2_-_51112743	0.678		NRXN1	neurexin 1
chr21_-_34749908	0.663	NM_001127670	KCNE1	potassium voltage-gated channel, Isk-related family, member 1
chr1_+_208178160	0.651	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chrX_-_47364173	0.646	NM_006950 NM_133499	SYN1	synapsin I
chr14_-_73962557	0.642	NM_001105579	TMEM90A	transmembrane protein 90A
chr17_-_77474597	0.627	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr16_+_2450081	0.621	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr15_-_70399181	0.613		CELF6	CUGBP, Elav-like family member 6
chr7_+_145444385	0.576	NM_014141	CNTNAP2	contactin associated protein-like 2
chr11_+_627268	0.572	NM_000797	DRD4	dopamine receptor D4
chr15_-_70399301	0.561	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr10_+_26545599	0.527		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr18_-_39111243	0.521	NM_020783	SYT4	synaptotagmin IV
chr9_-_138236775	0.475	NM_178138	LHX3	LIM homeobox 3
chr14_-_104142125	0.430	NM_207379	TMEM179	transmembrane protein 179
chr1_-_239587090	0.413	NM_002924	RGS7	regulator of G-protein signaling 7
chr15_+_67009892	0.397	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr11_-_27698800	0.394	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr10_-_44200458	0.343	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr6_+_138767007	0.303	NM_014320	HEBP2	heme binding protein 2
chr2_-_51113040	0.300	NM_001135659 NM_004801	NRXN1	neurexin 1
chr6_+_138767151	0.281		HEBP2	heme binding protein 2
chr19_-_50429306	0.275	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr3_+_122109716	0.256	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr2_-_96174502	0.236		DUSP2	dual specificity phosphatase 2
chr17_-_3283884	0.235	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr17_-_3248453	0.217	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr8_-_91164100	0.212	NM_004929	CALB1	calbindin 1, 28kDa
chr12_-_97812633	0.202		ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_152891184	0.180	NM_003492	TMEM187	transmembrane protein 187
chr1_-_151390050	0.176	NM_001014291	SPRR2G	small proline-rich protein 2G
chr17_-_3546236	0.167	NM_002561 NM_175080 NM_175081	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 read-through transcript purinergic receptor P2X, ligand-gated ion channel, 5
chr10_+_69990050	0.166	NM_030625	TET1	tet oncogene 1
chr1_+_100777044	0.163		GPR88	G protein-coupled receptor 88
chr22_-_16636748	0.130	NM_197966	BID	BH3 interacting domain death agonist
chr20_-_10148137	0.123		LOC100131208	similar to hCG2045825
chr12_+_6431437	0.118	NM_018009	TAPBPL	TAP binding protein-like
chr2_-_96174865	0.114	NM_004418	DUSP2	dual specificity phosphatase 2
chr8_+_69027277	0.106		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_77925441	0.101	NM_018949	UTS2R	urotensin 2 receptor
chr5_+_175231098	0.097	NM_001008220	CPLX2	complexin 2
chr5_-_70621688	0.096		SMA4	glucuronidase, beta pseudogene
chr11_-_125278296	0.076	NM_031307	PUS3	pseudouridylate synthase 3
chr8_+_69027143	0.072	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr5_+_175231170	0.068
chr17_-_7159094	0.061	NM_004489	GPS2	G protein pathway suppressor 2
chr11_-_27677755	0.060	NM_170734	BDNF	brain-derived neurotrophic factor
chr5_-_69917721	0.059		SMA4	glucuronidase, beta pseudogene
chr8_+_80685859	0.054		STMN2	stathmin-like 2
chr12_-_29827952	0.049	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr4_-_175986952	0.048	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr5_+_175231144	0.038		CPLX2	complexin 2
chr16_-_2125825	0.035	NM_000296 NM_001009944	PKD1	polycystic kidney disease 1 (autosomal dominant)
chr20_+_56861430	0.026	NM_001077490 NM_080425	GNAS	GNAS complex locus
chr11_-_6633427	0.017	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr1_-_239749683	0.014	NM_000143	FH	fumarate hydratase
chr5_+_175231210	0.009		CPLX2	complexin 2
chr5_+_69732561	0.009		SMA4	glucuronidase, beta pseudogene
chr1_-_20707196	0.008	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr8_+_69026895	0.007		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr5_-_135729062	0.007	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
6.25	2.25e-07	GO:0007186	G-protein coupled receptor protein signaling pathway
6.62	3.07e-07	GO:0019226	transmission of nerve impulse
6.62	3.07e-07	GO:0035637	multicellular organismal signaling
6.99	4.67e-07	GO:0007268	synaptic transmission
8.40	5.55e-07	GO:0007610	behavior
3.65	2.18e-06	GO:0050877	neurological system process
3.26	2.83e-06	GO:0003008	system process
5.96	4.32e-05	GO:0055082	cellular chemical homeostasis
4.30	1.73e-04	GO:0007267	cell-cell signaling
5.73	2.04e-04	GO:0006873	cellular ion homeostasis
5.61	2.56e-04	GO:0046903	secretion
4.67	3.30e-04	GO:0048878	chemical homeostasis
4.91	4.46e-04	GO:0019725	cellular homeostasis
5.29	5.04e-04	GO:0050801	ion homeostasis
10.15	6.07e-04	GO:0031644	regulation of neurological system process
1.81	1.16e-03	GO:0032501	multicellular organismal process
11.48	1.28e-03	GO:0003001	generation of a signal involved in cell-cell signaling
11.48	1.28e-03	GO:0023061	signal release
3.43	1.96e-03	GO:0007154	cell communication
5.98	3.34e-03	GO:0032940	secretion by cell
9.82	3.64e-03	GO:0051969	regulation of transmission of nerve impulse
1.97	4.64e-03	GO:0023052	signaling
28.96	5.04e-03	GO:0060078	regulation of postsynaptic membrane potential
5.61	5.81e-03	GO:0044057	regulation of system process
3.49	5.85e-03	GO:0042592	homeostatic process
11.22	7.92e-03	GO:0007626	locomotory behavior
14.02	1.42e-02	GO:0007269	neurotransmitter secretion
13.17	1.93e-02	GO:0007631	feeding behavior
12.78	2.23e-02	GO:0030534	adult behavior
40.10	2.56e-02	GO:0051954	positive regulation of amine transport
18.79	2.96e-02	GO:0051952	regulation of amine transport
5.12	3.34e-02	GO:0055080	cation homeostasis
2.25	3.64e-02	GO:0065008	regulation of biological quality
17.38	4.04e-02	GO:0051899	membrane depolarization
8.22	4.59e-02	GO:0042391	regulation of membrane potential
6.55	4.95e-02	GO:0055074	calcium ion homeostasis

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
6.80	5.74e-07	GO:0043005	neuron projection
6.29	5.14e-06	GO:0045202	synapse
7.27	1.08e-05	GO:0044456	synapse part
14.15	7.32e-05	GO:0008021	synaptic vesicle
8.28	1.66e-04	GO:0030425	dendrite
8.70	4.59e-04	GO:0030136	clathrin-coated vesicle
4.28	5.23e-04	GO:0030054	cell junction
19.31	6.85e-04	GO:0030672	synaptic vesicle membrane
1.54	7.01e-04	GO:0016020	membrane
8.14	7.50e-04	GO:0043025	neuronal cell body
7.91	9.27e-04	GO:0044297	cell body
3.81	9.62e-04	GO:0016023	cytoplasmic membrane-bounded vesicle
12.27	1.11e-03	GO:0030665	clathrin coated vesicle membrane
1.62	1.20e-03	GO:0044425	membrane part
3.74	1.20e-03	GO:0031988	membrane-bounded vesicle
3.40	1.96e-03	GO:0042995	cell projection
3.58	1.98e-03	GO:0031410	cytoplasmic vesicle
7.10	2.03e-03	GO:0030135	coated vesicle
6.05	2.14e-03	GO:0030659	cytoplasmic vesicle membrane
5.84	2.81e-03	GO:0012506	vesicle membrane
3.47	2.89e-03	GO:0031982	vesicle
1.65	5.83e-03	GO:0031224	intrinsic to membrane
9.07	6.23e-03	GO:0030662	coated vesicle membrane
1.64	7.96e-03	GO:0016021	integral to membrane
5.02	9.14e-03	GO:0044433	cytoplasmic vesicle part
1.76	1.13e-02	GO:0005886	plasma membrane
1.74	1.56e-02	GO:0071944	cell periphery
2.14	1.96e-02	GO:0044459	plasma membrane part
7.05	2.50e-02	GO:0045211	postsynaptic membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
22.19	3.01e-05	GO:0005231	excitatory extracellular ligand-gated ion channel activity
14.49	3.90e-04	GO:0005230	extracellular ligand-gated ion channel activity
40.10	5.57e-03	GO:0016594	glycine binding
4.57	7.34e-03	GO:0005216	ion channel activity
4.50	8.35e-03	GO:0022838	substrate-specific channel activity
8.48	8.38e-03	GO:0043176	amine binding
8.35	9.17e-03	GO:0015276	ligand-gated ion channel activity
8.35	9.17e-03	GO:0022834	ligand-gated channel activity
4.36	1.08e-02	GO:0015267	channel activity
4.35	1.10e-02	GO:0022803	passive transmembrane transporter activity
86.87	2.15e-02	GO:0016933	extracellular-glycine-gated ion channel activity
86.87	2.15e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
24.83	2.51e-02	GO:0005184	neuropeptide hormone activity
2.60	2.66e-02	GO:0005215	transporter activity
8.78	2.91e-02	GO:0005179	hormone activity
69.50	3.58e-02	GO:0022824	transmitter-gated ion channel activity
69.50	3.58e-02	GO:0022835	transmitter-gated channel activity
4.63	3.74e-02	GO:0022836	gated channel activity