Motif ID: GATA6.p2

Z-value: 5.385


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GATA6chr18_+_180034010.391.5e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_31782618 33.420 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr1_+_181028016 28.158 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr10_-_48036698 27.584 NM_016204
GDF2
growth differentiation factor 2
chr7_-_142369534 25.564 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr7_-_142369519 23.769 KEL
Kell blood group, metallo-endopeptidase
chr1_-_27113018 19.636 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_+_200698493 19.328 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr7_-_100077072 16.773 NM_003227
TFR2
transferrin receptor 2
chr19_+_13999959 16.621 NM_080864
RLN3
relaxin 3
chr12_+_52105131 15.581 AMHR2
anti-Mullerian hormone receptor, type II
chr12_-_52975823 13.841 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_+_43063817 13.511 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr16_+_142853 13.239 NM_005332
HBZ
hemoglobin, zeta
chr8_-_86477585 13.151 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr21_+_42697058 13.041 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr9_-_99740243 12.747 NM_197978
HEMGN
hemogen
chr12_-_52975777 12.525 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_+_70745615 12.424 NM_033496
HK1
hexokinase 1
chr10_-_99521701 12.278 NM_003015
SFRP5
secreted frizzled-related protein 5
chr16_-_45339605 12.231 NM_182493
MYLK3
myosin light chain kinase 3
chr16_+_31446703 11.597 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr17_-_39822366 11.500 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr7_+_150321771 11.365 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr12_-_68291208 11.346 NM_201550
LRRC10
leucine rich repeat containing 10
chr1_-_30969016 10.812 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chrX_+_44588192 10.696 NM_022076
DUSP21
dual specificity phosphatase 21
chr11_-_59369501 10.519 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr1_-_156923111 10.302 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr6_-_49712483 10.289 NM_000324
RHAG
Rh-associated glycoprotein
chr9_+_33230165 9.896 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr11_-_123816190 9.857 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr7_-_107667728 9.789 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr22_+_33792125 9.742 NM_001008494
ISX
intestine-specific homeobox
chr19_-_60360768 9.720 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr11_-_56914668 9.663 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr2_-_68952006 9.457 NM_014482
BMP10
bone morphogenetic protein 10
chr19_-_12858956 9.367 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr1_-_26266571 9.039 NM_032588
TRIM63
tripartite motif containing 63
chr15_-_48626193 8.921 NM_203494
USP50
ubiquitin specific peptidase 50
chr1_-_25619863 8.821 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr1_+_152560179 8.805 NM_080429
AQP10
aquaporin 10
chr8_+_124263932 8.392 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr14_+_19681734 8.099 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr6_+_135558572 8.068


chr9_+_96561750 8.019 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chrX_-_55074125 7.885 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chrX_+_65152004 7.851


chr1_+_25471470 7.833 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr6_-_49820030 7.791 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr19_-_60241424 7.705 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr5_-_176868483 7.696 DOK3
docking protein 3
chr1_+_157441133 7.620 NM_002036
DARC
Duffy blood group, chemokine receptor
chr2_+_220145197 7.525 NM_002191
INHA
inhibin, alpha
chr9_-_70780574 7.406


chr19_+_40824486 7.406 NM_014209
ETV2
ets variant 2
chr5_-_34020445 7.231 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr1_-_153537810 7.227 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr2_-_175207521 7.106 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr17_-_59437782 7.053 NM_000873
ICAM2
intercellular adhesion molecule 2
chr2_+_102294393 7.020 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr6_-_30236667 6.848 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr15_-_41300316 6.820 EPB42
erythrocyte membrane protein band 4.2
chr11_+_118463906 6.812 NM_001024382
HMBS
hydroxymethylbilane synthase
chr8_-_38127489 6.759 NM_000349
STAR
steroidogenic acute regulatory protein
chr16_+_557011 6.692 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr16_+_24765052 6.639 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr3_-_10309600 6.609 NM_001134944
NM_001134945
NM_001134946
GHRL


ghrelin/obestatin prepropeptide


chr2_+_27573206 6.568 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_-_206125877 6.501


chr21_+_37714470 6.446 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr11_-_47330797 6.248 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr6_+_135558744 6.244 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr17_+_53761293 6.186 LOC100506779
hypothetical LOC100506779
chr6_-_11887265 6.065 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_-_153537362 6.033 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr11_-_16387001 6.022 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chrX_-_10761729 5.882 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_1254709 5.866 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr8_+_124264054 5.771 FAM83A
family with sequence similarity 83, member A
chr3_-_3127057 5.721 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr19_-_53081326 5.669 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr7_+_129807467 5.660 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr2_+_220087135 5.642 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chrX_+_15435351 5.434 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr9_+_263025 5.349 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr21_+_36458708 5.349 NM_005128
DOPEY2
dopey family member 2
chr1_-_109651140 5.269 NM_001010985
MYBPHL
myosin binding protein H-like
chr17_-_74361620 5.229 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_41399632 5.169 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr3_-_57209319 5.147 NM_003865
HESX1
HESX homeobox 1
chr1_-_166149867 5.069 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr7_-_112515068 5.013 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr1_-_111848265 5.007 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr19_-_53081383 4.893 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr9_+_71009746 4.862 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr1_-_154665807 4.808 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr12_-_55696542 4.770 NM_001178054
NM_013251
TAC3

tachykinin 3

chr8_-_30121741 4.769 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr2_-_144711375 4.733 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr17_-_3766708 4.657 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr11_+_6898780 4.645 NM_001004684
OR2D3
olfactory receptor, family 2, subfamily D, member 3
chr15_-_41879426 4.629 NM_001033517
SERINC4
serine incorporator 4
chr2_-_74424041 4.568 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr2_+_138438277 4.521 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr22_+_21543671 4.512 IGLV4-3
immunoglobulin lambda variable 4-3
chrX_-_76824726 4.485 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr11_+_71605466 4.475 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr7_+_129634935 4.465 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr17_-_3766441 4.444 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr16_-_4778317 4.368 NM_001154458
NM_144605
SEPT12

septin 12

chr7_-_112515035 4.353 GPR85
G protein-coupled receptor 85
chr20_-_29524476 4.352 NM_001037500
DEFB124
defensin, beta 124
chr8_-_145672525 4.291 NM_003923
FOXH1
forkhead box H1
chr19_+_15612706 4.273 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr12_+_25096472 4.229 NM_006152
LRMP
lymphoid-restricted membrane protein
chr17_-_53761119 4.197 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr1_-_180622083 4.176 GLUL
glutamate-ammonia ligase
chr21_+_37377116 4.086 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr15_-_41300488 4.056 EPB42
erythrocyte membrane protein band 4.2
chr1_-_114231691 4.049 NM_001010922
BCL2L15
BCL2-like 15
chrX_+_119379967 4.046 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chr20_+_55569542 4.025 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_+_59612712 4.017 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr12_-_51514328 4.000 NM_175834
KRT79
keratin 79
chr7_-_112514990 4.000 GPR85
G protein-coupled receptor 85
chr2_-_105421661 3.979 NM_201557
FHL2
four and a half LIM domains 2
chr15_-_41300526 3.976 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr1_-_114231519 3.961 BCL2L15
BCL2-like 15
chr1_+_15128882 3.925 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr1_+_158603480 3.916 NM_005598
NHLH1
nescient helix loop helix 1
chr1_-_100416358 3.886 NM_144620
LRRC39
leucine rich repeat containing 39
chr1_+_204484081 3.881 NM_001910
NM_148964
CTSE

cathepsin E

chr9_+_124177421 3.811 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_138810610 3.758 NM_001039374
KIAA1984
KIAA1984
chr12_-_119249938 3.704 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr4_-_75072683 3.698 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr16_-_87570716 3.629 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr11_-_116213511 3.622 NM_000039
APOA1
apolipoprotein A-I
chr7_-_99312591 3.610 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr3_-_180467483 3.449 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr16_-_66535457 3.432 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr7_+_139175420 3.425 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr22_+_20880159 3.397 IGLV6-57
immunoglobulin lambda variable 6-57
chr12_+_48784057 3.354 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr8_-_93176819 3.351 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_169465995 3.259 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr1_-_204179169 3.258 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr15_+_38430517 3.217 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr18_+_41558141 3.216 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr10_+_11246934 3.160 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr12_+_121218218 3.159 NM_152759
LRRC43
leucine rich repeat containing 43
chr20_-_45410033 3.155 ZMYND8
zinc finger, MYND-type containing 8
chr11_+_75106512 3.143 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr4_-_68678181 3.130 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr9_+_138677197 3.108 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr17_-_36594652 3.107 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr11_+_60858611 3.102 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr20_+_42463387 3.086 HNF4A
hepatocyte nuclear factor 4, alpha
chr1_-_46789473 3.072 NM_001097611
KNCN
kinocilin
chr4_-_40212670 3.058 NM_019027
RBM47
RNA binding motif protein 47
chrX_-_24600661 3.010 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr3_-_188492163 3.001 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr1_+_26517032 2.982 CD52
CD52 molecule
chr2_+_43919606 2.970 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr11_-_5523328 2.959 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr1_+_224079597 2.946 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr7_+_149761674 2.882 LOC285972
hypothetical LOC285972
chr20_+_43368904 2.857 NM_014276
RBPJL
recombination signal binding protein for immunoglobulin kappa J region-like
chr6_-_36412562 2.857 NM_001010903
C6orf222
chromosome 6 open reading frame 222
chr11_-_83071084 2.768 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr16_+_80086454 2.767 NM_030629
CMIP
c-Maf-inducing protein
chr20_-_42457717 2.766


chr9_-_74757735 2.764 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr16_-_66535923 2.736 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr11_+_118259684 2.725 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr9_-_126309510 2.717 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr18_+_41558089 2.714 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr19_+_12941431 2.705 NM_152654
DAND5
DAN domain family, member 5
chr3_-_129668780 2.680 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chrX_-_70248022 2.668 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr4_+_39084936 2.659 KLB
klotho beta
chr6_+_31016755 2.654 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr11_+_60727559 2.641 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr3_+_142525744 2.624 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr12_-_14887648 2.616 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr3_-_48015264 2.607 MAP4
microtubule-associated protein 4
chr1_-_26517342 2.582 NM_145345
UBXN11
UBX domain protein 11
chr9_+_33785558 2.581 NM_002771
PRSS3
protease, serine, 3
chr8_-_38324809 2.539 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr6_-_2696152 2.533 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chrX_+_65299157 2.524 NM_138737
HEPH
hephaestin
chr17_-_35975227 2.516 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr7_-_128330615 2.508 KCP
kielin/chordin-like protein
chr19_+_40541327 2.503 NM_005304
FFAR3
free fatty acid receptor 3
chr3_+_186529376 2.471 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr3_-_52839727 2.468 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr2_+_169631777 2.465 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_+_34599227 2.451 EHF
ets homologous factor
chr19_+_10258642 2.449 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr2_-_96924582 2.448 NM_001172667
FAM178B
family with sequence similarity 178, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 1.19e-11 GO:0032501 multicellular organismal process
5.83 8.73e-10 GO:0007586 digestion
1.78 1.48e-07 GO:0003008 system process
2.17 4.26e-07 GO:0007600 sensory perception
2.69 8.69e-07 GO:0007608 sensory perception of smell
2.56 1.49e-06 GO:0007606 sensory perception of chemical stimulus
1.29 2.48e-05 GO:0050896 response to stimulus
1.56 1.22e-04 GO:0065008 regulation of biological quality
1.86 4.00e-04 GO:0006629 lipid metabolic process
3.05 8.08e-04 GO:0003013 circulatory system process
3.05 8.08e-04 GO:0008015 blood circulation
3.46 1.26e-03 GO:0006805 xenobiotic metabolic process
3.46 1.26e-03 GO:0071466 cellular response to xenobiotic stimulus
1.66 1.42e-03 GO:0050877 neurological system process
3.44 1.43e-03 GO:0009410 response to xenobiotic stimulus
2.48 1.55e-03 GO:0044057 regulation of system process
2.04 1.82e-03 GO:0048878 chemical homeostasis
2.79 1.84e-03 GO:0008202 steroid metabolic process
2.27 6.37e-03 GO:0008610 lipid biosynthetic process
1.79 8.42e-03 GO:0042592 homeostatic process
5.80 3.00e-02 GO:0022600 digestive system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.48 2.75e-10 GO:0071944 cell periphery
1.47 9.06e-10 GO:0005886 plasma membrane
1.67 5.72e-08 GO:0005576 extracellular region
1.93 8.73e-07 GO:0044421 extracellular region part
1.29 4.34e-05 GO:0031224 intrinsic to membrane
1.28 1.06e-04 GO:0016021 integral to membrane
1.89 1.75e-04 GO:0005615 extracellular space
1.24 2.02e-04 GO:0044425 membrane part
1.18 2.90e-03 GO:0016020 membrane
1.40 1.44e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.80 1.06e-08 GO:0004872 receptor activity
2.15 9.50e-08 GO:0004930 G-protein coupled receptor activity
2.76 1.37e-07 GO:0004984 olfactory receptor activity
1.86 4.44e-07 GO:0004888 transmembrane receptor activity
1.62 1.54e-06 GO:0004871 signal transducer activity
1.62 1.54e-06 GO:0060089 molecular transducer activity
2.04 7.74e-03 GO:0008289 lipid binding
2.84 4.75e-02 GO:0046906 tetrapyrrole binding