Motif ID: HSF1,2.p2

Z-value: 1.744


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF2chr6_+_1227623840.401.4e-01Click!
HSF1chr8_+_145486052-0.302.8e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_116455898 2.214 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr2_+_241213334 1.809 NM_005301
GPR35
G protein-coupled receptor 35
chr2_+_202379442 1.800 NM_139158
CDK15
cyclin-dependent kinase 15
chr6_+_44234525 1.708 NM_007058
CAPN11
calpain 11
chr19_-_47638890 1.646 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr18_+_27425727 1.575 NM_000371
TTR
transthyretin
chr17_+_9686572 1.573 GLP2R
glucagon-like peptide 2 receptor
chr1_+_179164195 1.528


chr13_+_23042722 1.498 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_-_42892195 1.481 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_+_11591692 1.476 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr12_-_121767272 1.397 NM_006018
GPR109B
G protein-coupled receptor 109B
chr11_-_117589283 1.389 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr2_-_105421661 1.265 NM_201557
FHL2
four and a half LIM domains 2
chr16_-_88358946 1.249 FANCA
Fanconi anemia, complementation group A
chr13_+_75232797 1.209 NM_015842
LMO7
LIM domain 7
chr10_+_95838801 1.189 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr11_-_47467094 1.174 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr3_-_140677990 1.169 NM_004164
RBP2
retinol binding protein 2, cellular
chr3_-_42892636 1.137 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr15_+_73278285 1.133 C15orf39
chromosome 15 open reading frame 39
chr17_+_7199178 1.108 NM_198154
TMEM95
transmembrane protein 95
chr15_+_40438989 1.078 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr6_+_167624792 1.073 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_+_54786394 1.072 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr10_-_75080784 1.064 NM_024875
SYNPO2L
synaptopodin 2-like
chr12_-_121753795 1.057 NM_177551
GPR109A
G protein-coupled receptor 109A
chr1_+_221168388 1.056 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr2_-_224611568 1.046 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr15_-_72981595 1.014 C15orf17
chromosome 15 open reading frame 17
chr3_-_52844274 1.011 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr4_+_76700281 1.004 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr13_+_23742846 0.988 SPATA13
spermatogenesis associated 13
chr19_+_52504914 0.971 NM_001736
C5AR1
complement component 5a receptor 1
chr2_-_121964373 0.962 CLASP1
cytoplasmic linker associated protein 1
chr15_+_87540238 0.960 ABHD2
abhydrolase domain containing 2
chr14_-_21108714 0.955 NM_001005465
OR10G3
olfactory receptor, family 10, subfamily G, member 3
chr3_-_152403636 0.955 NM_013308
GPR171
G protein-coupled receptor 171
chr14_-_64479198 0.942 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_21084911 0.938 APOB
apolipoprotein B (including Ag(x) antigen)
chr9_+_114671635 0.934 SNX30
sorting nexin family member 30
chr15_+_60838053 0.926 TLN2
talin 2
chr11_+_1812115 0.924 NM_138567
SYT8
synaptotagmin VIII
chr1_-_111848265 0.917 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr17_-_25685175 0.912 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr22_+_19458378 0.903 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr2_+_158666627 0.899 NM_173355
UPP2
uridine phosphorylase 2
chr3_-_9895471 0.898 CIDEC
cell death-inducing DFFA-like effector c
chr1_+_190811479 0.887 NM_002922
RGS1
regulator of G-protein signaling 1
chr16_-_46823682 0.882 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr1_+_48460943 0.879 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr1_-_43168247 0.877 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr17_+_38306339 0.874 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr2_+_11600238 0.869 GREB1
growth regulation by estrogen in breast cancer 1
chr9_-_94338072 0.860 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr10_-_28611020 0.860 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr9_-_115877104 0.860 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_-_201411533 0.859 NM_004997
MYBPH
myosin binding protein H
chr2_+_11600287 0.843 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr2_-_219742950 0.843 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr20_+_31334601 0.841 NM_033197
C20orf114
chromosome 20 open reading frame 114
chrX_-_106033202 0.841 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr7_+_129807467 0.838 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr20_+_35406497 0.833 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr8_+_22909305 0.828 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr3_+_150675169 0.826 TM4SF4
transmembrane 4 L six family member 4
chr4_-_77042599 0.808 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr3_-_9265592 0.805 SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr6_-_56615544 0.801 NM_001723
NM_015548
DST

dystonin

chr20_+_9146036 0.799 NM_182797
PLCB4
phospholipase C, beta 4
chr16_+_82540172 0.795 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr3_+_150675117 0.781 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr2_+_102345528 0.780 NM_003855
IL18R1
interleukin 18 receptor 1
chr17_-_36451189 0.762 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr22_+_22907417 0.757 SUSD2
sushi domain containing 2
chr22_+_22907443 0.754 NM_019601
SUSD2
sushi domain containing 2
chr3_-_195553297 0.754 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_+_158317967 0.752 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr4_+_111053488 0.747 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr7_+_113842284 0.744 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr6_-_30188845 0.739 NM_007028
TRIM31
tripartite motif containing 31
chr11_+_62893836 0.735 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr7_-_14847479 0.734 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr11_-_34491878 0.732 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr11_+_7463175 0.732 NM_198474
OLFML1
olfactomedin-like 1
chr2_-_100125402 0.731 NM_002285
AFF3
AF4/FMR2 family, member 3
chr1_-_240679380 0.731 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr7_+_113842470 0.724 FOXP2
forkhead box P2
chr8_-_82769761 0.720 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr11_-_62753574 0.715 NM_199352
SLC22A25
solute carrier family 22, member 25
chr17_-_24426752 0.712 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr16_+_8722068 0.701 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr7_+_101704145 0.700 CUX1
cut-like homeobox 1
chr8_-_37576515 0.695 LOC157860
hypothetical protein LOC157860
chr7_+_113842407 0.692 FOXP2
forkhead box P2
chr14_+_38714111 0.684 NM_002687
PNN
pinin, desmosome associated protein
chr20_+_61337679 0.683 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr10_-_62002672 0.678 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr15_-_97366313 0.671 NM_001102612
PGPEP1L
pyroglutamyl-peptidase I-like
chr22_-_35011703 0.669 MYH9
myosin, heavy chain 9, non-muscle
chr7_-_33047042 0.669 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr7_-_75876830 0.667 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr15_+_72253940 0.666 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr14_-_22354457 0.665 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr7_+_1094248 0.654 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr1_-_20014180 0.653 NM_019062
RNF186
ring finger protein 186
chrX_+_106050261 0.652 NM_020384
CLDN2
claudin 2
chr1_-_199657468 0.650 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr9_+_4829763 0.641 RCL1
RNA terminal phosphate cyclase-like 1
chr1_-_166965034 0.639 NM_001937
DPT
dermatopontin
chr4_+_38740246 0.635 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr17_+_18796202 0.627 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr16_+_68765428 0.626 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr7_+_137411717 0.621 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr14_+_21203136 0.621 NM_001001912
OR4E2
olfactory receptor, family 4, subfamily E, member 2
chr2_-_179623030 0.619 NM_173648
CCDC141
coiled-coil domain containing 141
chr17_+_72883759 0.619 NM_001113494
SEPT9
septin 9
chr2_-_152538694 0.616 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr17_+_71508581 0.616 NM_001258
CDK3
cyclin-dependent kinase 3
chr11_-_47692877 0.614 NM_024783
AGBL2
ATP/GTP binding protein-like 2
chr15_+_70477707 0.614 NM_001080462
TMEM202
transmembrane protein 202
chr7_+_143263191 0.612 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr3_+_101316463 0.611 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr2_+_143603439 0.609 ARHGAP15
Rho GTPase activating protein 15
chr3_-_9895633 0.603 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr3_+_52212969 0.602 ALAS1
aminolevulinate, delta-, synthase 1
chr17_-_53849888 0.595 RNF43
ring finger protein 43
chr1_-_148155986 0.595 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr1_+_144152864 0.592 TXNIP
thioredoxin interacting protein
chr19_-_10074332 0.588 NM_031917
ANGPTL6
angiopoietin-like 6
chr21_+_34367678 0.588 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr6_-_53121540 0.585 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_-_155788775 0.582 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr2_+_143603368 0.569 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr4_-_57242492 0.567 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr17_+_7683958 0.564 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr3_-_48607596 0.564 NM_000094
COL7A1
collagen, type VII, alpha 1
chr7_-_99411573 0.563 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr11_+_64079665 0.562 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr19_-_47723183 0.556 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr11_+_45825244 0.551 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr17_-_53849929 0.550 NM_017763
RNF43
ring finger protein 43
chr17_-_60439764 0.550 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr20_-_34707971 0.550 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr17_-_36347197 0.549 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_1050408 0.548 LOC100506688
hypothetical protein LOC100506688
chr17_-_71648965 0.542 NM_001454
FOXJ1
forkhead box J1
chr14_-_93512818 0.542 ASB2
ankyrin repeat and SOCS box containing 2
chr18_-_54447168 0.541 NM_052947
ALPK2
alpha-kinase 2
chr21_-_42659671 0.540 NM_003225
TFF1
trefoil factor 1
chr2_-_162638174 0.537 DPP4
dipeptidyl-peptidase 4
chr22_+_44059491 0.535 NM_001167574
NM_006953
UPK3A

uroplakin 3A

chr6_+_32021687 0.535 NM_001710
CFB
complement factor B
chr1_-_158190585 0.533 NM_001146172
NM_001146173
NM_033438
SLAMF9


SLAM family member 9


chr1_+_57093030 0.528 NM_000562
C8A
complement component 8, alpha polypeptide
chr14_+_102636233 0.525 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr18_-_28606839 0.525 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr16_-_11274952 0.525 NM_021247
PRM3
protamine 3
chr8_-_52884456 0.519 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr12_-_192990 0.519 NM_001122847
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr1_+_205137410 0.517 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr14_-_21074875 0.516 NM_005407
SALL2
sal-like 2 (Drosophila)
chr12_-_12994584 0.516 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr2_+_228386800 0.512 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr14_-_22354389 0.511 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr13_-_45577144 0.506 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr8_-_110689396 0.503 SYBU
syntabulin (syntaxin-interacting)
chr4_-_15686838 0.503 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr13_-_40735619 0.502 NM_004294
MTRF1
mitochondrial translational release factor 1
chr12_+_56424930 0.501 NM_005981
TSPAN31
tetraspanin 31
chr6_-_110843432 0.499 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr11_+_72660894 0.498 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr17_-_9880729 0.496 NM_201432
GAS7
growth arrest-specific 7
chr14_-_22354851 0.491 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr6_+_158654464 0.491 TULP4
tubby like protein 4
chr1_-_112333192 0.489 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr11_+_36379122 0.488 NM_001160169
PRR5L
proline rich 5 like
chr1_-_54861656 0.481 NM_176782
FAM151A
family with sequence similarity 151, member A
chr6_+_32021742 0.478 CFB
complement factor B
chr1_-_203657803 0.477 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr19_+_40298571 0.477 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr6_-_169392771 0.476


chr1_+_8306976 0.475 NM_001080397
SLC45A1
solute carrier family 45, member 1
chr12_-_52827275 0.475


chr11_+_58146721 0.473 NM_000614
CNTF
ciliary neurotrophic factor
chr1_-_171442937 0.472 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr11_-_905057 0.468 NM_001142675
CHID1
chitinase domain containing 1
chr17_+_38250122 0.467 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr12_+_6424293 0.464 NM_001242
CD27
CD27 molecule
chr9_-_128910132 0.463 ANGPTL2
angiopoietin-like 2
chr12_+_79362256 0.462 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr6_-_127822227 0.461 NM_014702
KIAA0408
KIAA0408
chr3_-_152585226 0.457 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_-_20179495 0.457 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr8_-_124734346 0.455 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr3_-_13032130 0.452


chr10_+_115501202 0.450 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr17_-_35327318 0.449 NM_018530
GSDMB
gasdermin B
chr8_-_68821131 0.448 NM_020361
CPA6
carboxypeptidase A6
chr17_+_38259620 0.447 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 1.28e-03 GO:0002376 immune system process
1.28 2.98e-03 GO:0006950 response to stress
1.29 5.42e-03 GO:0065008 regulation of biological quality
1.48 6.11e-03 GO:0051704 multi-organism process
1.54 8.01e-03 GO:0002682 regulation of immune system process
1.75 1.43e-02 GO:0044419 interspecies interaction between organisms
1.14 2.42e-02 GO:0050896 response to stimulus
2.48 2.75e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.48 3.34e-02 GO:0006955 immune response
1.92 3.54e-02 GO:0002253 activation of immune response
1.63 3.81e-02 GO:0050776 regulation of immune response
2.02 4.33e-02 GO:0002757 immune response-activating signal transduction
2.37 4.60e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 4.08e-07 GO:0005576 extracellular region
1.56 5.09e-07 GO:0044421 extracellular region part
1.52 3.40e-04 GO:0005615 extracellular space
3.24 8.50e-04 GO:0031983 vesicle lumen
3.02 8.92e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.96 2.06e-02 GO:0034774 secretory granule lumen
1.40 2.88e-02 GO:0005626 insoluble fraction
2.14 3.45e-02 GO:0030016 myofibril
1.40 3.84e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 2.27e-02 GO:0005515 protein binding