Motif ID: HSF1,2.p2

Z-value: 1.744


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF2chr6_+_1227623840.401.4e-01Click!
HSF1chr8_+_145486052-0.302.8e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_116455898 2.214 NM_152367
 MAB21L3
mab-21-like 3 (C. elegans)
chr2_+_241213334 1.809 NM_005301
 GPR35
G protein-coupled receptor 35
chr2_+_202379442 1.800 NM_139158
 CDK15
cyclin-dependent kinase 15
chr6_+_44234525 1.708 NM_007058
 CAPN11
calpain 11
chr19_-_47638890 1.646 NM_198477
 CXCL17
chemokine (C-X-C motif) ligand 17
chr18_+_27425727 1.575 NM_000371
 TTR
transthyretin
chr17_+_9686572 1.573 GLP2R
glucagon-like peptide 2 receptor
chr1_+_179164195 1.528


chr13_+_23042722 1.498 NM_148957
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_-_42892195 1.481 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_+_11591692 1.476 NM_014668
 GREB1
growth regulation by estrogen in breast cancer 1
chr12_-_121767272 1.397 NM_006018
 GPR109B
G protein-coupled receptor 109B
chr11_-_117589283 1.389 NM_153206
 AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr2_-_105421661 1.265 NM_201557
 FHL2
four and a half LIM domains 2
chr16_-_88358946 1.249 FANCA
Fanconi anemia, complementation group A
chr13_+_75232797 1.209 NM_015842
 LMO7
LIM domain 7
chr10_+_95838801 1.189 NM_001165979
 PLCE1
phospholipase C, epsilon 1
chr11_-_47467094 1.174 NM_001025596
NM_001172640
 CELF1

CUGBP, Elav-like family member 1

chr3_-_140677990 1.169 NM_004164
 RBP2
retinol binding protein 2, cellular
chr3_-_42892636 1.137 NM_004391
 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.48 2.75e-02 GO:0050851 antigen receptor-mediated signaling pathway
2.37 4.60e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.02 4.33e-02 GO:0002757 immune response-activating signal transduction
1.92 3.54e-02 GO:0002253 activation of immune response
1.75 1.43e-02 GO:0044419 interspecies interaction between organisms
1.63 3.81e-02 GO:0050776 regulation of immune response
1.54 8.01e-03 GO:0002682 regulation of immune system process
1.48 6.11e-03 GO:0051704 multi-organism process
1.48 3.34e-02 GO:0006955 immune response
1.43 1.28e-03 GO:0002376 immune system process
1.29 5.42e-03 GO:0065008 regulation of biological quality
1.28 2.98e-03 GO:0006950 response to stress
1.14 2.42e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.24 8.50e-04 GO:0031983 vesicle lumen
3.02 8.92e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.96 2.06e-02 GO:0034774 secretory granule lumen
2.14 3.45e-02 GO:0030016 myofibril
1.56 5.09e-07 GO:0044421 extracellular region part
1.52 3.40e-04 GO:0005615 extracellular space
1.40 2.88e-02 GO:0005626 insoluble fraction
1.40 3.84e-02 GO:0005624 membrane fraction
1.38 4.08e-07 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.11 2.27e-02 GO:0005515 protein binding