Motif ID: HNF4A_NR2F1,2.p2

Z-value: 5.022


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424632790.929.4e-07Click!
NR2F1chr5_+_92946348-0.487.2e-02Click!
NR2F2chr15_+_946766910.342.1e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_102722275 11.839 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr19_-_63715135 8.037 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr3_-_42892195 7.850 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr17_+_69950782 7.776 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr6_+_32090516 7.674 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr20_-_52120421 7.642 BCAS1
breast carcinoma amplified sequence 1
chr6_+_131190237 7.186 NM_001195597
LOC285733
hypothetical LOC285733
chr20_+_32762976 7.105 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr20_-_52120710 7.053 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr20_-_3097070 6.583 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr16_+_21152516 6.566 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr7_+_134567270 6.387 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr6_+_31731647 6.383 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 6.339 APOM
apolipoprotein M
chr12_+_51783554 6.272 SOAT2
sterol O-acyltransferase 2
chr20_+_55569542 6.204 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_+_51783540 6.193 NM_003578
SOAT2
sterol O-acyltransferase 2
chr14_-_23847000 6.174 CIDEB
cell death-inducing DFFA-like effector b
chr19_+_4104593 6.096 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr21_+_44169706 6.094 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr14_-_23846904 6.043 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_23847024 5.957 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_153537810 5.888 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr16_-_11277806 5.852 NM_002762
PRM2
protamine 2
chr14_-_23846993 5.837 CIDEB
cell death-inducing DFFA-like effector b
chr16_+_82540172 5.636 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr17_-_31353196 5.563 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr9_-_129752687 5.427 NM_203305
FAM102A
family with sequence similarity 102, member A
chr11_-_6418705 5.286 NM_000613
HPX
hemopexin
chr1_+_15941503 5.236 NM_001013641
TMEM82
transmembrane protein 82
chr19_-_15451203 5.226 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr3_-_197422653 4.986 NM_001039617
ZDHHC19
zinc finger, DHHC-type containing 19
chr11_-_116199145 4.939 NM_000482
APOA4
apolipoprotein A-IV
chr22_+_19651446 4.848 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr3_-_42892636 4.793 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_+_241193492 4.765 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr14_-_93924873 4.720 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_172153087 4.686 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr12_+_56802 4.616 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr19_-_55708936 4.582 NM_001114598
ASPDH
aspartate dehydrogenase domain containing
chr2_-_74606819 4.575 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr3_+_52787478 4.539 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr1_-_153537362 4.512 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr19_+_46640902 4.500 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr1_-_172153024 4.498 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_32057779 4.491 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr19_-_19142053 4.489 MEF2B
myocyte enhancer factor 2B
chr15_+_83228895 4.477 NM_004213
NM_201651
SLC28A1

solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

chr7_+_101704145 4.346 CUX1
cut-like homeobox 1
chr17_+_38259620 4.339 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr22_+_20899155 4.244


chr2_+_218992053 4.232 NM_007127
VIL1
villin 1
chr3_+_188043156 4.186 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr20_+_34937928 4.185 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr17_+_7474177 4.184 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr16_-_45339605 4.161 NM_182493
MYLK3
myosin light chain kinase 3
chr9_-_126309510 4.156 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr10_-_101831579 4.051 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr12_-_55637648 4.045 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr8_+_21972631 4.013 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr11_+_74548472 4.000 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr3_+_101316463 3.977 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr3_+_188043172 3.974 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr16_+_3642940 3.963 NM_005223
DNASE1
deoxyribonuclease I
chr17_-_39822366 3.927 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr6_-_31953425 3.923 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr3_-_52454082 3.855 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr17_+_7474128 3.855 SHBG
sex hormone-binding globulin
chr1_-_120112989 3.799 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr16_+_8722068 3.738 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr17_-_35331435 3.732 ORMDL3
ORM1-like 3 (S. cerevisiae)
chr2_+_113648036 3.659 PSD4
pleckstrin and Sec7 domain containing 4
chr20_+_31059038 3.649 NM_025227
BPIL1
bactericidal/permeability-increasing protein-like 1
chr3_-_140677990 3.555 NM_004164
RBP2
retinol binding protein 2, cellular
chr22_+_20316968 3.540 NM_152612
CCDC116
coiled-coil domain containing 116
chr17_+_35075124 3.438 NM_003673
TCAP
titin-cap (telethonin)
chr19_-_63556632 3.412 NM_130786
A1BG
alpha-1-B glycoprotein
chr19_+_5774817 3.403 NM_004558
NRTN
neurturin
chr8_+_22909305 3.380 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr10_+_114123828 3.354 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_176205672 3.353 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_-_26553168 3.351 NM_001039775
AIM1L
absent in melanoma 1-like
chr19_-_19142090 3.320 NM_001145785
MEF2B
myocyte enhancer factor 2B
chr2_-_241480058 3.312 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr10_+_114123765 3.296 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_464844 3.266 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr6_-_29635456 3.250 UBD
ubiquitin D
chr2_-_70901186 3.243 NM_173535
CLEC4F
C-type lectin domain family 4, member F
chr11_+_45899747 3.203 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr17_+_38306339 3.190 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr11_-_46674233 3.142 ARHGAP1
Rho GTPase activating protein 1
chr15_+_41672543 3.136 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr20_+_35406497 3.134 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr3_-_9896933 3.111 CIDEC
cell death-inducing DFFA-like effector c
chr6_+_30238961 3.060 NM_033229
TRIM15
tripartite motif containing 15
chr11_-_62753574 3.041 NM_199352
SLC22A25
solute carrier family 22, member 25
chr3_-_198784590 3.035 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr17_+_73638430 3.018 NM_152468
TMC8
transmembrane channel-like 8
chr7_+_100037817 2.959 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr7_-_150352484 2.943 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr20_+_32763440 2.901 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr2_+_11597530 2.895 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr6_-_30188845 2.876 NM_007028
TRIM31
tripartite motif containing 31
chr6_-_168222645 2.868 NM_024919
FRMD1
FERM domain containing 1
chr19_-_15906669 2.868 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr16_-_30032330 2.858 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr7_-_50600536 2.857 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr17_-_68769613 2.776 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr6_+_32003380 2.771 C2
complement component 2
chr16_-_1419345 2.765 NM_001010878
C16orf91
chromosome 16 open reading frame 91
chrX_+_106030049 2.761 NM_001171092
CLDN2
claudin 2
chr12_-_53065758 2.759 ZNF385A
zinc finger protein 385A
chr1_-_11029882 2.756 MASP2
mannan-binding lectin serine peptidase 2
chr22_-_35835548 2.701 TMPRSS6
transmembrane protease, serine 6
chr22_-_29231597 2.689 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr2_+_231569082 2.684 NM_139073
SPATA3
spermatogenesis associated 3
chr22_-_40856821 2.684 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chr6_-_31853027 2.643 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr8_-_82769761 2.641 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr3_-_101316038 2.618 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr2_-_88208650 2.617 NM_001443
FABP1
fatty acid binding protein 1, liver
chr19_-_17432724 2.602 NM_138454
NXNL1
nucleoredoxin-like 1
chr19_+_50137334 2.600 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 read-through transcript
apolipoprotein C-IV
chr6_+_46869052 2.589 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr6_+_31604717 2.585 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr1_-_43523825 2.574 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr1_-_20122638 2.551 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr8_-_110773195 2.543 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr22_-_40856736 2.538 CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr6_+_43373986 2.536 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr2_+_158666627 2.522 NM_173355
UPP2
uridine phosphorylase 2
chr11_-_73397929 2.515 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chrX_+_106057984 2.511 CLDN2
claudin 2
chr16_+_24765052 2.507 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr13_-_112392051 2.506 LOC440149
hypothetical LOC440149
chr1_-_176205970 2.501 SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_-_33982580 2.499 SRCIN1
SRC kinase signaling inhibitor 1
chr3_-_9895633 2.483 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr1_+_1351370 2.481 NM_001146685
TMEM88B
transmembrane protein 88B
chr12_+_119900677 2.476 HNF1A
HNF1 homeobox A
chr8_+_21972804 2.475 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr14_+_100365390 2.443 MEG3
maternally expressed 3 (non-protein coding)
chr11_-_64582568 2.427 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr8_-_145672525 2.414 NM_003923
FOXH1
forkhead box H1
chr3_-_9895471 2.393 CIDEC
cell death-inducing DFFA-like effector c
chr11_-_102001259 2.386 NM_004771
MMP20
matrix metallopeptidase 20
chr14_+_20226762 2.356 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_52235218 2.356 NM_017442
TLR9
toll-like receptor 9
chr2_-_238164452 2.339 NM_022449
RAB17
RAB17, member RAS oncogene family
chr10_-_76529253 2.317 NM_016364
DUSP13
dual specificity phosphatase 13
chr6_-_2696152 2.310 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr2_-_27457088 2.303 NM_144631
ZNF513
zinc finger protein 513
chr2_+_218929822 2.301 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr12_+_56114724 2.300 NM_005538
INHBC
inhibin, beta C
chr3_-_195553297 2.291 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr17_-_31352720 2.287 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr16_-_46826588 2.287 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr16_-_86527608 2.279 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr6_+_43565192 2.272 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr12_-_52975823 2.262 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr13_+_112825113 2.251 NM_000504
F10
coagulation factor X
chr12_+_107797985 2.250 NM_001917
DAO
D-amino-acid oxidase
chr1_-_228916958 2.248 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_238164042 2.242 RAB17
RAB17, member RAS oncogene family
chr4_-_120445047 2.241 NM_001170330
C4orf3
chromosome 4 open reading frame 3
chr11_-_16380967 2.231 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr21_+_41616590 2.220 FAM3B
family with sequence similarity 3, member B
chr7_-_99115454 2.210 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr17_-_31352643 2.207 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr7_+_137411717 2.204 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr1_+_178867744 2.196 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr22_+_43451600 2.191 PRR5
proline rich 5 (renal)
chr14_+_22911857 2.170 NM_172314
NM_022789
IL25

interleukin 25

chr2_+_242398954 2.169 NEU4
sialidase 4
chr1_-_159459814 2.151 APOA2
apolipoprotein A-II
chr11_-_116213511 2.139 NM_000039
APOA1
apolipoprotein A-I
chr12_-_55042793 2.137 NM_001638
APOF
apolipoprotein F
chr4_+_100714995 2.134 MTTP
microsomal triglyceride transfer protein
chr3_+_46514488 2.130 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr6_+_32003180 2.129 NM_000063
NM_001145903
C2

complement component 2

chr6_-_41811916 2.127 NM_001167827
TFEB
transcription factor EB
chr19_-_56537189 2.109 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr21_+_43462209 2.108 NM_000394
CRYAA
crystallin, alpha A
chr19_-_1125263 2.106 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr22_+_23333610 2.099 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr2_+_42249896 2.093 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr19_-_56567602 2.080 NM_005601
NKG7
natural killer cell group 7 sequence
chr14_+_38805251 2.078 NM_203356
CTAGE5
CTAGE family, member 5
chr17_-_31332568 2.078 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr16_+_68542126 2.073 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr14_-_22658078 2.072 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr17_+_71586857 2.070 NM_180990
ZACN
zinc activated ligand-gated ion channel
chr17_-_8588829 2.058 NM_001158261
NM_144681
CCDC42

coiled-coil domain containing 42

chr1_-_11029737 2.043 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr19_+_1156773 2.040 NM_000455
STK11
serine/threonine kinase 11
chr12_+_119900931 2.037 NM_000545
HNF1A
HNF1 homeobox A
chr12_-_192752 2.032 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr11_+_66070949 2.028 NM_001104
ACTN3
actinin, alpha 3
chr14_-_23752875 2.023 NM_014169
CHMP4A
chromatin modifying protein 4A
chr2_-_208702760 2.010 NM_020989
CRYGC
crystallin, gamma C

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 5.00e-06 GO:0042221 response to chemical stimulus
1.31 2.70e-04 GO:0044281 small molecule metabolic process
1.86 2.18e-03 GO:0008202 steroid metabolic process
1.25 3.49e-03 GO:0065008 regulation of biological quality
1.45 8.32e-03 GO:0006082 organic acid metabolic process
1.12 1.04e-02 GO:0050896 response to stimulus
1.81 1.67e-02 GO:0016053 organic acid biosynthetic process
1.81 1.67e-02 GO:0046394 carboxylic acid biosynthetic process
2.38 2.42e-02 GO:0002576 platelet degranulation
1.43 2.54e-02 GO:0019752 carboxylic acid metabolic process
1.43 2.54e-02 GO:0043436 oxoacid metabolic process
1.42 3.19e-02 GO:0042180 cellular ketone metabolic process
1.35 3.91e-02 GO:0006629 lipid metabolic process
1.53 4.61e-02 GO:0046903 secretion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 4.24e-07 GO:0005626 insoluble fraction
1.53 9.34e-07 GO:0005624 membrane fraction
1.44 1.87e-06 GO:0000267 cell fraction
1.10 4.83e-04 GO:0005737 cytoplasm
1.12 1.52e-03 GO:0044444 cytoplasmic part
1.09 6.97e-03 GO:0016020 membrane
1.22 1.02e-02 GO:0005829 cytosol
1.62 1.23e-02 GO:0015629 actin cytoskeleton
3.69 1.84e-02 GO:0034361 very-low-density lipoprotein particle
3.69 1.84e-02 GO:0034385 triglyceride-rich lipoprotein particle
1.23 4.45e-02 GO:0012505 endomembrane system

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.68 3.54e-02 GO:0019825 oxygen binding