Motif ID: HES1.p2

Z-value: 1.328


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_195336631-0.048.8e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_72949092 1.259 RIMS1
regulating synaptic membrane exocytosis 1
chr3_+_127743868 1.258 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr19_-_61680510 1.234 NM_022103
 ZNF667
zinc finger protein 667
chr14_+_73073570 1.062 NM_001037161
 ACOT1
acyl-CoA thioesterase 1
chr12_-_105057940 0.983 NM_014840
 NUAK1
NUAK family, SNF1-like kinase, 1
chr8_+_145393450 0.983 NM_001008271
NM_001080514
 SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr13_-_77390907 0.967 NM_001122659
NM_003991
 EDNRB

endothelin receptor type B

chr11_-_86061003 0.928 NM_006680
 ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr15_+_82113813 0.924 NM_207517
 ADAMTSL3
ADAMTS-like 3
chr8_+_145461356 0.919 NM_001008271
NM_001080514
 SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr20_-_36322587 0.902 NM_001029864
 KIAA1755
KIAA1755
chr7_-_15692551 0.871 MEOX2
mesenchyme homeobox 2
chr12_+_120840829 0.868 NM_001178003
NM_144668
 WDR66

WD repeat domain 66

chr13_+_30378311 0.867 NM_032849
 C13orf33
chromosome 13 open reading frame 33
chr8_+_69405510 0.820 NM_001195639
NM_052958
 C8orf34

chromosome 8 open reading frame 34

chr21_-_38954433 0.801 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr2_-_45090025 0.793 NM_016932
 SIX2
SIX homeobox 2
chr2_-_225615556 0.777 NM_014689
 DOCK10
dedicator of cytokinesis 10
chr11_-_86060812 0.775 NM_001014811
 ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr7_+_44110527 0.761 AEBP1
AE binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 90 entries
enrichment   p-value GO term description
2.41 4.10e-02 GO:0035282 segmentation
2.20 4.65e-04 GO:0048705 skeletal system morphogenesis
1.90 7.37e-04 GO:0048514 blood vessel morphogenesis
1.87 3.33e-02 GO:0001525 angiogenesis
1.76 3.35e-03 GO:0001568 blood vessel development
1.75 1.68e-03 GO:0001944 vasculature development
1.74 6.79e-04 GO:0001501 skeletal system development
1.72 3.63e-02 GO:0003002 regionalization
1.68 4.23e-02 GO:0030334 regulation of cell migration
1.67 1.67e-02 GO:0051270 regulation of cellular component movement
1.67 4.88e-02 GO:0016567 protein ubiquitination
1.65 4.12e-02 GO:0032446 protein modification by small protein conjugation
1.63 4.27e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.62 1.31e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.60 1.48e-05 GO:0009887 organ morphogenesis
1.58 1.51e-03 GO:0072358 cardiovascular system development
1.58 1.51e-03 GO:0072359 circulatory system development
1.58 2.77e-02 GO:0048598 embryonic morphogenesis
1.58 4.90e-02 GO:0007389 pattern specification process
1.57 3.08e-03 GO:0048646 anatomical structure formation involved in morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.81 3.04e-02 GO:0005912 adherens junction
1.32 1.48e-06 GO:0031981 nuclear lumen
1.32 4.03e-04 GO:0005654 nucleoplasm
1.28 5.79e-06 GO:0044428 nuclear part
1.27 4.46e-06 GO:0031974 membrane-enclosed lumen
1.27 1.96e-05 GO:0070013 intracellular organelle lumen
1.27 3.74e-05 GO:0005829 cytosol
1.26 3.16e-05 GO:0043233 organelle lumen
1.22 2.19e-13 GO:0005634 nucleus
1.15 4.59e-13 GO:0043231 intracellular membrane-bounded organelle
1.15 5.33e-13 GO:0043227 membrane-bounded organelle
1.13 3.16e-08 GO:0005737 cytoplasm
1.13 3.93e-04 GO:0044444 cytoplasmic part
1.13 1.66e-03 GO:0044446 intracellular organelle part
1.12 1.72e-17 GO:0005622 intracellular
1.12 3.58e-17 GO:0044424 intracellular part
1.12 2.02e-10 GO:0043226 organelle
1.12 3.20e-10 GO:0043229 intracellular organelle
1.12 5.04e-03 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.66 3.26e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.65 1.22e-02 GO:0016881 acid-amino acid ligase activity
1.55 1.28e-03 GO:0016874 ligase activity
1.38 3.60e-04 GO:0030528 transcription regulator activity
1.38 1.29e-02 GO:0019899 enzyme binding
1.32 1.77e-02 GO:0001071 nucleic acid binding transcription factor activity
1.32 1.77e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.25 1.41e-04 GO:0003677 DNA binding
1.24 1.43e-02 GO:0016740 transferase activity
1.21 1.60e-05 GO:0003676 nucleic acid binding
1.17 2.13e-12 GO:0005515 protein binding
1.13 4.62e-03 GO:0003824 catalytic activity
1.10 5.74e-13 GO:0005488 binding