Motif ID: GTF2A1,2.p2

Z-value: 2.218


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2A1chr14_-_807570180.312.7e-01Click!
GTF2A2chr15_-_577368280.019.8e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_42641712 3.468 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr11_-_5487728 3.336 NM_017481
UBQLN3
ubiquilin 3
chr21_-_32879617 2.854 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_-_205186330 2.398 NM_002644
PIGR
polymeric immunoglobulin receptor
chr20_-_42457717 2.392


chr19_+_40895669 2.323 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr20_-_43889339 2.271 NM_003279
TNNC2
troponin C type 2 (fast)
chr16_+_56259657 2.259 NM_170776
GPR97
G protein-coupled receptor 97
chr7_-_75280962 2.239 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr11_-_73397929 2.235 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr8_-_145672525 2.219 NM_003923
FOXH1
forkhead box H1
chr17_-_35975227 2.207 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr16_+_48857962 2.189 ADCY7
adenylate cyclase 7
chr22_+_21852911 2.155 BCR
breakpoint cluster region
chr19_+_59777049 2.143 NM_001130917
NM_006866
LILRA2

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

chr22_+_21852699 2.097 BCR
breakpoint cluster region
chr18_+_606671 2.085 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_+_201541241 2.075 BTG2
BTG family, member 2
chr16_+_25135783 2.010 NM_001169
AQP8
aquaporin 8
chr12_+_56290229 1.975 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr14_-_23623657 1.931 NM_006177
NRL
neural retina leucine zipper
chr6_-_49712483 1.823 NM_000324
RHAG
Rh-associated glycoprotein
chr17_+_53769659 1.790 LOC100506779
hypothetical LOC100506779
chr6_-_32259974 1.785 NM_001136
NM_172197
AGER

advanced glycosylation end product-specific receptor

chr11_-_118722575 1.767 NM_015645
NM_031433
C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr7_-_149631001 1.742 NM_001164459
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr9_-_70780574 1.686


chr19_-_54093749 1.650 NM_003323
TULP2
tubby like protein 2
chr19_+_40465249 1.647 NM_021175
HAMP
hepcidin antimicrobial peptide
chr21_+_34112456 1.615 ITSN1
intersectin 1 (SH3 domain protein)
chr11_+_63864263 1.614 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr15_-_42756377 1.589 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr11_+_5610060 1.589 NM_130390
TRIM34
tripartite motif containing 34
chr12_-_107551744 1.586 SELPLG
selectin P ligand
chr2_+_27155197 1.578 EMILIN1
elastin microfibril interfacer 1
chr12_+_117067214 1.567 PEBP1
phosphatidylethanolamine binding protein 1
chr11_+_118269310 1.555 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr12_+_54910086 1.547 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr4_-_26100986 1.511 NM_000730
CCKAR
cholecystokinin A receptor
chr6_+_30212488 1.490 NM_138700
TRIM40
tripartite motif containing 40
chr1_-_205012348 1.485 NM_000572
IL10
interleukin 10
chr6_+_31976754 1.484 NM_001178063
C2
complement component 2
chr5_-_39238818 1.419 FYB
FYN binding protein
chr1_+_201541269 1.414 NM_006763
BTG2
BTG family, member 2
chr11_-_102001259 1.400 NM_004771
MMP20
matrix metallopeptidase 20
chr1_-_111848265 1.393 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr22_+_20068039 1.378 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr17_-_23721468 1.358 VTN
vitronectin
chr20_-_34635091 1.358


chr11_+_117982422 1.356 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr1_+_148496792 1.352 NM_012113
CA14
carbonic anhydrase XIV
chr4_+_24406283 1.347 SOD3
superoxide dismutase 3, extracellular
chr12_-_107551783 1.336 NM_003006
SELPLG
selectin P ligand
chr7_+_134567270 1.330 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr1_+_179164195 1.326


chr11_+_60765219 1.319 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr12_+_130004404 1.315 NM_198827
GPR133
G protein-coupled receptor 133
chr11_+_60727559 1.311 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr22_+_21359175 1.308 IGLV3-25
immunoglobulin lambda variable 3-25
chr1_-_205161821 1.308 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_-_65013070 1.302 LOC400958
hypothetical LOC400958
chr10_+_74323344 1.298 NM_152635
OIT3
oncoprotein induced transcript 3
chr7_-_128203079 1.295 NM_001708
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr1_+_31655607 1.290 NM_001199037
SERINC2
serine incorporator 2
chr19_+_59777085 1.281 LILRA2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
chr19_+_41085221 1.280 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr3_+_38282301 1.274 NM_004256
SLC22A13
solute carrier family 22 (organic anion transporter), member 13
chr12_-_50026689 1.269 NM_001971
CELA1
chymotrypsin-like elastase family, member 1
chr1_-_26266571 1.254 NM_032588
TRIM63
tripartite motif containing 63
chr15_-_75150574 1.236 NM_001168412
NM_005724
NM_198902
TSPAN3


tetraspanin 3


chr19_-_54618410 1.232 NM_178449
PTH2
parathyroid hormone 2
chr2_+_27154938 1.230 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr21_+_44597911 1.228 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr17_-_59312892 1.211 NM_002059
NM_022556
NM_022557
NM_022558
GH2



growth hormone 2



chr6_-_46401174 1.210 RCAN2
regulator of calcineurin 2
chr16_+_68765428 1.205 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr3_-_13032130 1.200


chr17_+_53769562 1.198 LOC100506779
hypothetical LOC100506779
chr6_+_31661934 1.196 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr17_+_4795128 1.192 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr2_+_190710730 1.188 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr1_-_91260357 1.179 ZNF644
zinc finger protein 644
chr16_-_727889 1.173 NARFL
nuclear prelamin A recognition factor-like
chr4_+_24406336 1.169 SOD3
superoxide dismutase 3, extracellular
chr16_+_31446703 1.149 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr1_+_6537924 1.138 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr17_+_35075124 1.131 NM_003673
TCAP
titin-cap (telethonin)
chr12_+_54700955 1.127 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr17_-_23721485 1.122 NM_000638
VTN
vitronectin
chr11_-_85074848 1.122 NM_152723
CCDC89
coiled-coil domain containing 89
chr6_-_46401363 1.122 NM_005822
RCAN2
regulator of calcineurin 2
chr22_+_21852743 1.119 BCR
breakpoint cluster region
chr17_-_59342319 1.113 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr22_+_21116283 1.113


chr1_+_52964609 1.111 NM_024646
ZYG11B
zyg-11 homolog B (C. elegans)
chr3_+_99733432 1.110 NM_005290
GPR15
G protein-coupled receptor 15
chr1_+_154351200 1.109 LMNA
lamin A/C
chr22_-_20419975 1.108 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr17_-_23721351 1.103 VTN
vitronectin
chr16_-_65781499 1.103 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr12_-_53065758 1.096 ZNF385A
zinc finger protein 385A
chr3_-_42818221 1.091


chr8_-_131097856 1.081 FAM49B
family with sequence similarity 49, member B
chr1_-_154665807 1.077 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr19_-_53868075 1.076 NM_145807
NTN5
netrin 5
chr19_+_5082230 1.065 KDM4B
lysine (K)-specific demethylase 4B
chr8_-_131097828 1.047 FAM49B
family with sequence similarity 49, member B
chr22_+_21065202 1.036


chr12_+_46802695 1.034 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr22_+_20067662 1.033 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr15_-_75150506 1.028 TSPAN3
tetraspanin 3
chr2_+_108751033 1.025 RANBP2
RAN binding protein 2
chr19_-_15421761 1.018 NM_021241
WIZ
widely interspaced zinc finger motifs
chr17_-_23721420 1.016 VTN
vitronectin
chr3_+_46423682 1.006 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr19_+_791963 0.996 PRTN3
proteinase 3
chr17_-_70220605 0.996 NM_139018
CD300LF
CD300 molecule-like family member f
chr11_-_64582568 0.995 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr11_+_6216905 0.991 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr12_-_54392328 0.990 NM_001144997
ITGA7
integrin, alpha 7
chr2_+_94900904 0.977 NM_144705
TEKT4
tektin 4
chr17_-_23721430 0.976 VTN
vitronectin
chr6_+_33495824 0.974 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr19_+_60487578 0.966 BRSK1
BR serine/threonine kinase 1
chr1_+_29086206 0.962 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr10_-_49152918 0.954 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr17_-_71404611 0.953 NM_173547
TRIM65
tripartite motif containing 65
chr17_-_44006808 0.952 NM_002146
HOXB3
homeobox B3
chr17_-_35774467 0.950 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr22_+_21852551 0.943 NM_004327
NM_021574
BCR

breakpoint cluster region

chr11_+_118561375 0.943 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr12_+_52103905 0.941 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr2_+_218929822 0.938 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr1_-_20179495 0.931 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr19_+_10083196 0.930 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chrX_-_70248022 0.925 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr1_+_32417846 0.921 TXLNA
taxilin alpha
chr12_-_74711474 0.919 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_+_29086156 0.918 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr2_+_176737050 0.912 NM_006898
HOXD3
homeobox D3
chr22_+_21065207 0.909 IGLJ3
immunoglobulin lambda joining 3
chr7_+_73826244 0.906 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr20_+_61337679 0.905 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr12_-_101396459 0.903 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_-_123816190 0.903 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr6_+_43247168 0.900 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr8_-_18585721 0.893 PSD3
pleckstrin and Sec7 domain containing 3
chr6_-_26038817 0.893 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chrX_+_148770598 0.892 NM_001166400
NM_001166401
NM_005364
MAGEA8


melanoma antigen family A, 8


chr11_+_2279812 0.890 NM_139022
TSPAN32
tetraspanin 32
chr1_-_154205675 0.889 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_-_60352369 0.885 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr9_+_138760432 0.881 LOC100128593
hypothetical LOC100128593
chr5_+_156628929 0.881 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr6_-_31977747 0.878 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr14_+_99859427 0.876 NM_207117
SLC25A47
solute carrier family 25, member 47
chr17_+_38259620 0.875 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_-_60379998 0.875 NM_004778
GPR44
G protein-coupled receptor 44
chr17_-_60988077 0.873 NM_004655
AXIN2
axin 2
chrX_-_130250715 0.867 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr17_-_58871906 0.858 NM_001017917
CYB561
cytochrome b-561
chr6_-_130578110 0.850 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr11_+_60746396 0.844 NM_001079808
PGA5
PGA3
PGA4
pepsinogen 5, group I (pepsinogen A)
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr6_-_49942147 0.843 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr1_+_154351162 0.841 LMNA
lamin A/C
chr17_+_76549658 0.838 RPTOR
regulatory associated protein of MTOR, complex 1
chr15_-_88150823 0.836 ANPEP
alanyl (membrane) aminopeptidase
chr8_-_145671947 0.833 FOXH1
forkhead box H1
chr1_+_85819004 0.831 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_60988226 0.831 AXIN2
axin 2
chr8_+_128817658 0.831 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr11_-_117718532 0.830 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr6_+_43247179 0.826 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr3_+_46514488 0.816 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr19_-_56549853 0.814 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr6_+_167504070 0.811 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chr17_-_39500512 0.808 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chrX_-_55074125 0.808 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr11_+_59279481 0.807 STX3
syntaxin 3
chr3_+_38007264 0.805 VILL
villin-like
chr1_-_207891264 0.802 NM_001017402
LAMB3
laminin, beta 3
chr2_+_113709553 0.798 LOC654433
hypothetical LOC654433
chr1_+_154351082 0.796 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr6_-_167717907 0.789 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr22_+_33792125 0.788 NM_001008494
ISX
intestine-specific homeobox
chr17_-_69869552 0.786 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr6_+_43246897 0.785 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr16_+_56616782 0.782 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr21_-_42247007 0.777 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr19_+_810658 0.777 NM_001928
CFD
complement factor D (adipsin)
chrX_-_130250880 0.775 IGSF1
immunoglobulin superfamily, member 1
chr12_+_108038774 0.775 ACACB
acetyl-CoA carboxylase beta
chr1_-_158883666 0.773 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr2_-_190635566 0.772 NM_005259
MSTN
myostatin
chr5_-_134397740 0.772 NM_002653
PITX1
paired-like homeodomain 1
chr1_+_32417909 0.770 NM_175852
TXLNA
taxilin alpha
chr16_+_82544327 0.756 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr11_+_64448628 0.754 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr19_+_54530458 0.752 CD37
CD37 molecule
chr2_+_28469275 0.746 NM_005253
FOSL2
FOS-like antigen 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.12 6.87e-04 GO:0002576 platelet degranulation
1.27 1.48e-02 GO:0006950 response to stress
1.64 3.61e-02 GO:0007599 hemostasis
1.59 4.14e-02 GO:0050878 regulation of body fluid levels
1.11 4.20e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.61 1.49e-04 GO:0031983 vesicle lumen
3.57 7.30e-04 GO:0031093 platelet alpha granule lumen
3.50 1.02e-03 GO:0034774 secretory granule lumen
3.36 1.95e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.07 4.43e-03 GO:0031091 platelet alpha granule
1.26 1.58e-02 GO:0005576 extracellular region

Nothing significant found in function category.