Motif ID: NRF1.p2

Z-value: 5.574


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1290387650.486.9e-02Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_64301807 4.324 NM_001178031
SF1
splicing factor 1
chr19_-_51097694 4.069 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr1_+_32251988 3.822 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr2_-_33677798 3.745 NM_015475
FAM98A
family with sequence similarity 98, member A
chr4_-_56107725 3.100 NM_004898
CLOCK
clock homolog (mouse)
chr6_-_163754903 2.998 LOC100526820
hypothetical LOC100526820
chr6_-_33787413 2.928 C6orf125
chromosome 6 open reading frame 125
chr14_+_22633728 2.909 C14orf119
chromosome 14 open reading frame 119
chr21_+_33619147 2.851 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr17_-_44794325 2.781 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr6_-_33787479 2.542 NM_032340
C6orf125
chromosome 6 open reading frame 125
chr17_-_35510074 2.510 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr21_+_33066281 2.509 C21orf49
chromosome 21 open reading frame 49
chr11_+_64785888 2.371 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr12_-_123023052 2.348 NM_025140
CCDC92
coiled-coil domain containing 92
chr3_+_43303005 2.332 NM_001100594
NM_017719
SNRK

SNF related kinase

chr1_-_19409328 2.331 NM_020765
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr1_-_16174859 2.330 NM_003443
ZBTB17
zinc finger and BTB domain containing 17
chr3_+_49424642 2.329 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr2_-_197499584 2.298 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr2_+_71149193 2.281 NAGK
N-acetylglucosamine kinase
chr18_-_12874140 2.227 NM_002828
NM_080422
NM_080423
PTPN2


protein tyrosine phosphatase, non-receptor type 2


chr1_-_201124848 2.221 NM_002871
RABIF
RAB interacting factor
chr16_+_48657381 2.214 NM_182922
HEATR3
HEAT repeat containing 3
chr17_-_24302597 2.204 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr16_+_4415805 2.198 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr6_+_33044353 2.185


chr9_+_132990834 2.158 NUP214
nucleoporin 214kDa
chr3_+_10132314 2.116 NM_018462
C3orf10
chromosome 3 open reading frame 10
chr22_+_22737753 2.097 NM_012295
CABIN1
calcineurin binding protein 1
chr21_-_33065849 2.093 NM_013329
NM_016631
GCFC1

GC-rich sequence DNA-binding factor 1

chr17_-_35510431 2.074 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr12_+_105275989 2.042 NM_001160708
POLR3B
polymerase (RNA) III (DNA directed) polypeptide B
chr1_+_3763704 2.038 NM_004402
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr6_+_33044378 2.020 NM_005104
BRD2
bromodomain containing 2
chr22_-_19543012 2.013 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr9_+_132990760 2.010 NM_005085
NUP214
nucleoporin 214kDa
chr16_+_48657408 1.952 HEATR3
HEAT repeat containing 3
chr1_+_148603208 1.903 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr2_+_28828112 1.899 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr19_-_4351470 1.875 NM_003025
SH3GL1
SH3-domain GRB2-like 1
chr22_-_21193037 1.873 ZNF280B
zinc finger protein 280B
chr6_-_150011450 1.853 KATNA1
katanin p60 (ATPase containing) subunit A 1
chr1_+_91739241 1.849 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr17_-_45110339 1.836 NM_001007226
NM_001007227
NM_001007228
NM_001007229
NM_001007230
NM_003563
SPOP





speckle-type POZ protein





chr12_-_107775400 1.818 SSH1
slingshot homolog 1 (Drosophila)
chr6_-_43651578 1.797 XPO5
exportin 5
chr4_+_6768682 1.790 NM_018366
CNO
cappuccino homolog (mouse)
chr3_+_15222747 1.789 CAPN7
calpain 7
chr21_-_46703020 1.787


chr22_-_19543069 1.784 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr4_+_6768800 1.773 CNO
cappuccino homolog (mouse)
chr20_-_48163071 1.772 NM_001032288
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr20_-_30003386 1.769 PDRG1
p53 and DNA-damage regulated 1
chr17_-_24302450 1.757 PHF12
PHD finger protein 12
chr3_+_151803755 1.755 NM_016275
SELT
selenoprotein T
chr10_+_133995587 1.737 NM_001143758
NM_001143759
NM_030626
LRRC27


leucine rich repeat containing 27


chr5_-_132101042 1.721 NM_007054
KIF3A
kinesin family member 3A
chr6_-_36623038 1.716 STK38
serine/threonine kinase 38
chr5_-_271235 1.714 NM_145265
CCDC127
coiled-coil domain containing 127
chr1_+_46041870 1.712 NM_015112
MAST2
microtubule associated serine/threonine kinase 2
chr2_-_37164962 1.700 NM_019024
HEATR5B
HEAT repeat containing 5B
chr22_-_21814208 1.685 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr1_+_91738953 1.671 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr20_-_34807882 1.659 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr19_+_61607505 1.651 NM_152478
NM_001159861
ZNF583

zinc finger protein 583

chr3_-_184180985 1.648 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr6_-_39190728 1.639 NM_018322
C6orf64
chromosome 6 open reading frame 64
chr17_-_23244499 1.638 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr2_-_37164919 1.638 HEATR5B
HEAT repeat containing 5B
chr22_-_19686351 1.624 NM_001008695
NM_030573
THAP7

THAP domain containing 7

chr8_-_42870779 1.615 NM_001160223
NM_001160224
NM_001160225
NM_030954
RNF170



ring finger protein 170



chr1_+_35507197 1.608 ZMYM4
zinc finger, MYM-type 4
chr17_+_72648580 1.579 NM_001039573
NM_001143998
NM_001143999
NM_003003
SEC14L1



SEC14-like 1 (S. cerevisiae)



chr5_-_176365971 1.566 NM_016290
UIMC1
ubiquitin interaction motif containing 1
chr19_-_44032202 1.564 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr21_+_37367432 1.563 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr1_-_16551514 1.546 NM_018994
FBXO42
F-box protein 42
chr10_+_86078136 1.546 NM_018999
FAM190B
family with sequence similarity 190, member B
chr19_+_1358664 1.544 DAZAP1
DAZ associated protein 1
chr5_+_134209628 1.543 C5orf24
chromosome 5 open reading frame 24
chr10_+_133995629 1.543 NM_001143757
LRRC27
leucine rich repeat containing 27
chr19_-_7874426 1.536


chr22_-_19543099 1.518 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr9_+_138959518 1.518 NM_000606
C8G
complement component 8, gamma polypeptide
chr7_+_99865340 1.516 MEPCE
methylphosphate capping enzyme
chr6_-_36623223 1.509 NM_007271
STK38
serine/threonine kinase 38
chr7_+_12217343 1.509 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr19_-_48815853 1.490 NM_182498
ZNF428
zinc finger protein 428
chr10_+_27833167 1.489 NM_021252
RAB18
RAB18, member RAS oncogene family
chr5_+_134209444 1.485 NM_001135586
C5orf24
chromosome 5 open reading frame 24
chr4_+_26471410 1.483 NM_001169117
NM_001169118
NM_020860
STIM2


stromal interaction molecule 2


chr3_+_44354594 1.482 NM_001029840
C3orf23
chromosome 3 open reading frame 23
chr5_+_112071087 1.467 NM_001127511
APC
adenomatous polyposis coli
chr5_+_134209268 1.465 NM_152409
C5orf24
chromosome 5 open reading frame 24
chrX_-_30817329 1.464 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr1_-_247119516 1.458 NM_001136036
ZNF692
zinc finger protein 692
chr3_-_14963943 1.458


chr20_+_36534871 1.458 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr22_+_19078397 1.458 NM_003426
ZNF74
zinc finger protein 74
chr6_+_13682628 1.447 NM_001193267
NM_031244
NM_012241
SIRT5


sirtuin 5


chr15_+_57067141 1.440 NM_017610
RNF111
ring finger protein 111
chr1_-_3763620 1.430 NM_014704
KIAA0562
KIAA0562
chrX_+_151860870 1.429 NM_001178115
ZNF185
zinc finger protein 185 (LIM domain)
chr11_+_63205444 1.427 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr6_+_2710602 1.426 NM_020135
NM_130395
WRNIP1

Werner helicase interacting protein 1

chr2_-_112729072 1.424 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr12_+_68418829 1.424 NM_022456
NM_175624
RAB3IP

RAB3A interacting protein (rabin3)

chr12_-_26982144 1.420 C12orf11
chromosome 12 open reading frame 11
chr16_+_27122307 1.418 NM_024773
JMJD5
jumonji domain containing 5
chr12_+_47810915 1.414


chr1_-_3763480 1.414 KIAA0562
KIAA0562
chr16_+_29892714 1.401 NM_004783
NM_016151
TAOK2

TAO kinase 2

chr10_-_16899395 1.400 RSU1
Ras suppressor protein 1
chr17_+_4683280 1.397 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr16_+_30876959 1.390


chr3_+_44355007 1.388 C3orf23
chromosome 3 open reading frame 23
chr7_-_124357272 1.379 NM_001042594
NM_015450
POT1

protection of telomeres 1 homolog (S. pombe)

chr19_+_47480445 1.375 NM_015125
CIC
capicua homolog (Drosophila)
chr6_+_44463418 1.375 CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr2_+_118562499 1.366 NM_016133
INSIG2
insulin induced gene 2
chr9_+_107496638 1.365 NM_018112
TMEM38B
transmembrane protein 38B
chr7_+_116289833 1.363 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_+_56202874 1.363 NM_052897
MBD6
methyl-CpG binding domain protein 6
chr2_+_98427737 1.363 NM_001134224
NM_001134225
NM_001566
NM_004027
INPP4A



inositol polyphosphate-4-phosphatase, type I, 107kDa



chr12_+_81604752 1.358 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr11_+_18374388 1.358 NM_001165414
LDHA
lactate dehydrogenase A
chr1_+_27972269 1.338 NM_177424
STX12
syntaxin 12
chr12_-_116112495 1.337 NM_015002
NM_033624
FBXO21

F-box protein 21

chr7_-_104816487 1.337


chr4_-_121207338 1.329 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr16_+_86542449 1.322 NM_001173539
NM_001173540
NM_001173541
NM_017869
NM_079837
BANP




BTG3 associated nuclear protein




chr22_+_19686434 1.320 FLJ39582
hypothetical LOC439931
chr3_-_17759100 1.319 NM_001134380
TBC1D5
TBC1 domain family, member 5
chr2_-_106177166 1.318 UXS1
UDP-glucuronate decarboxylase 1
chr1_+_196138304 1.317 NM_001024594
C1orf53
chromosome 1 open reading frame 53
chr6_+_44463265 1.315 NM_001253
CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr16_-_30288988 1.313 NM_015527
TBC1D10B
TBC1 domain family, member 10B
chr14_+_101500650 1.308 DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr7_+_158341961 1.306 NM_018051
WDR60
WD repeat domain 60
chr19_+_47416338 1.302 ZNF526
zinc finger protein 526
chr3_+_44354927 1.299 NM_001029839
NM_173826
C3orf23

chromosome 3 open reading frame 23

chr6_-_150011542 1.294 KATNA1
katanin p60 (ATPase containing) subunit A 1
chr10_+_59698891 1.292 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr22_+_22737814 1.290 CABIN1
calcineurin binding protein 1
chr9_-_37894098 1.288 MCART1
mitochondrial carrier triple repeat 1
chr21_-_37366684 1.278 NM_153681
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_+_79593679 1.277 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr10_-_71663076 1.276 NM_021129
PPA1
pyrophosphatase (inorganic) 1
chr22_+_22737870 1.276 CABIN1
calcineurin binding protein 1
chr6_+_2710560 1.275 WRNIP1
Werner helicase interacting protein 1
chr2_+_37165097 1.268 NM_174931
CCDC75
coiled-coil domain containing 75
chr17_-_7458574 1.266 FXR2
fragile X mental retardation, autosomal homolog 2
chr14_+_63924779 1.265 MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr19_+_47416271 1.260 NM_133444
ZNF526
zinc finger protein 526
chr22_-_19685998 1.256 THAP7
THAP domain containing 7
chr5_+_112340326 1.255 NM_152624
DCP2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr17_+_35531742 1.255 MSL1
male-specific lethal 1 homolog (Drosophila)
chr2_+_42249896 1.250 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr2_+_196230096 1.246 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr18_-_5286013 1.245 NM_001143823
NM_003409
ZFP161

zinc finger protein 161 homolog (mouse)

chr11_-_75769514 1.243 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr17_-_40750109 1.241 NM_003954
MAP3K14
mitogen-activated protein kinase kinase kinase 14
chr1_-_52604405 1.241 NM_032449
CC2D1B
coiled-coil and C2 domain containing 1B
chr12_-_123023312 1.239 CCDC92
coiled-coil domain containing 92
chr14_-_22127902 1.238 DAD1
defender against cell death 1
chr22_+_19543350 1.238 SNAP29
synaptosomal-associated protein, 29kDa
chr11_-_59193064 1.237 NM_152716
PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr6_-_39190925 1.229 C6orf64
chromosome 6 open reading frame 64
chr6_-_35996794 1.227 SRPK1
SRSF protein kinase 1
chrX_-_152517629 1.226 FAM58A
family with sequence similarity 58, member A
chr14_-_23981493 1.224 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr22_+_19543248 1.220 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chr7_-_44588365 1.219 TMED4
transmembrane emp24 protein transport domain containing 4
chr19_+_54280211 1.219 NM_003089
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr3_+_44355217 1.214 C3orf23
chromosome 3 open reading frame 23
chr16_+_28741873 1.212 ATXN2L
ataxin 2-like
chr5_+_170747312 1.210 NM_001037738
NM_002520
NM_199185
NPM1


nucleophosmin (nucleolar phosphoprotein B23, numatrin)


chr6_-_43651745 1.210 NM_020750
XPO5
exportin 5
chrX_-_152517815 1.209 NM_001130997
NM_152274
FAM58A

family with sequence similarity 58, member A

chr5_+_170747543 1.207 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr11_-_65382226 1.205


chr6_-_150011551 1.204 KATNA1
katanin p60 (ATPase containing) subunit A 1
chr3_-_47492320 1.201 SCAP
SREBF chaperone
chr3_-_198839026 1.199 LOC220729
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene
chr6_-_43651727 1.192 XPO5
exportin 5
chr2_+_100545827 1.189 NM_024065
PDCL3
phosducin-like 3
chr1_+_229540304 1.183 NM_001010984
NM_032018
C1orf124

chromosome 1 open reading frame 124

chr1_-_39111422 1.182 NM_012333
MYCBP
c-myc binding protein
chr21_+_33619067 1.181 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr11_-_65382228 1.180 CFL1
cofilin 1 (non-muscle)
chr6_-_153346283 1.179 NM_001142522
FBXO5
F-box protein 5
chr1_-_247119908 1.178 NM_001193328
NM_017865
ZNF692

zinc finger protein 692

chr1_+_20081510 1.175


chr7_+_116289827 1.167 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr9_+_114182216 1.167 HSDL2
hydroxysteroid dehydrogenase like 2
chr2_+_71148915 1.164 NM_017567
NAGK
N-acetylglucosamine kinase
chr21_-_34209897 1.162 NM_001697
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr14_-_22634134 1.161 ACIN1
apoptotic chromatin condensation inducer 1
chrX_+_47305459 1.158 NM_001654
ARAF
v-raf murine sarcoma 3611 viral oncogene homolog

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.54 8.26e-46 GO:0044260 cellular macromolecule metabolic process
1.44 2.99e-36 GO:0043170 macromolecule metabolic process
1.37 5.13e-36 GO:0044237 cellular metabolic process
1.32 4.22e-28 GO:0044238 primary metabolic process
1.29 2.87e-27 GO:0008152 metabolic process
1.65 2.35e-26 GO:0090304 nucleic acid metabolic process
1.56 1.24e-25 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.58 1.91e-24 GO:0044267 cellular protein metabolic process
1.47 2.25e-21 GO:0034641 cellular nitrogen compound metabolic process
1.45 5.35e-21 GO:0006807 nitrogen compound metabolic process
1.58 7.58e-17 GO:0010467 gene expression
1.43 3.29e-16 GO:0019538 protein metabolic process
1.59 7.53e-16 GO:0016070 RNA metabolic process
1.98 2.43e-14 GO:0006396 RNA processing
1.94 1.14e-12 GO:0051276 chromosome organization
2.03 3.08e-12 GO:0006974 response to DNA damage stimulus
1.48 5.73e-12 GO:0043412 macromolecule modification
1.94 6.75e-12 GO:0006259 DNA metabolic process
1.53 7.99e-12 GO:0006996 organelle organization
1.76 2.05e-11 GO:0033554 cellular response to stress
1.48 4.05e-11 GO:0006464 protein modification process
2.16 6.68e-10 GO:0006281 DNA repair
1.76 4.71e-09 GO:0022403 cell cycle phase
1.46 1.17e-08 GO:0034645 cellular macromolecule biosynthetic process
1.11 1.59e-08 GO:0009987 cellular process
1.86 1.78e-08 GO:0044265 cellular macromolecule catabolic process
1.45 1.82e-08 GO:0009059 macromolecule biosynthetic process
1.84 2.26e-08 GO:0016071 mRNA metabolic process
1.58 4.98e-08 GO:0007049 cell cycle
1.91 9.42e-08 GO:0000279 M phase
1.66 1.22e-07 GO:0046907 intracellular transport
1.32 1.87e-07 GO:0071841 cellular component organization or biogenesis at cellular level
2.06 3.26e-07 GO:0006412 translation
2.14 3.30e-07 GO:0034660 ncRNA metabolic process
1.63 3.46e-07 GO:0022402 cell cycle process
1.73 3.57e-07 GO:0009057 macromolecule catabolic process
1.51 5.74e-07 GO:0044248 cellular catabolic process
1.82 1.01e-06 GO:0006325 chromatin organization
2.08 1.28e-06 GO:0032446 protein modification by small protein conjugation
1.73 1.48e-06 GO:0000278 mitotic cell cycle
1.58 2.19e-06 GO:0045184 establishment of protein localization
1.96 2.55e-06 GO:0070647 protein modification by small protein conjugation or removal
1.31 2.64e-06 GO:0071842 cellular component organization at cellular level
1.58 3.19e-06 GO:0015031 protein transport
2.08 4.92e-06 GO:0016567 protein ubiquitination
2.48 8.23e-06 GO:0006310 DNA recombination
1.88 8.94e-06 GO:0016568 chromatin modification
1.49 1.18e-05 GO:0008104 protein localization
1.24 1.93e-05 GO:0071840 cellular component organization or biogenesis
3.08 2.14e-05 GO:0006302 double-strand break repair
1.95 2.47e-05 GO:0000087 M phase of mitotic cell cycle
1.30 4.01e-05 GO:0044249 cellular biosynthetic process
1.81 5.58e-05 GO:0006397 mRNA processing
1.42 5.78e-05 GO:0033036 macromolecule localization
2.17 7.02e-05 GO:0034470 ncRNA processing
2.81 8.76e-05 GO:0051168 nuclear export
2.55 9.11e-05 GO:0051028 mRNA transport
3.04 9.68e-05 GO:0006405 RNA export from nucleus
2.44 1.04e-04 GO:0006403 RNA localization
2.46 1.20e-04 GO:0050657 nucleic acid transport
2.46 1.20e-04 GO:0050658 RNA transport
2.46 1.20e-04 GO:0051236 establishment of RNA localization
1.89 1.32e-04 GO:0008380 RNA splicing
1.28 1.41e-04 GO:0009058 biosynthetic process
1.23 1.97e-04 GO:0016043 cellular component organization
1.89 1.98e-04 GO:0000280 nuclear division
1.89 1.98e-04 GO:0007067 mitosis
1.38 2.57e-04 GO:0009056 catabolic process
1.40 2.61e-04 GO:0051641 cellular localization
1.86 3.44e-04 GO:0048285 organelle fission
1.81 4.53e-04 GO:0044257 cellular protein catabolic process
2.12 4.95e-04 GO:0051169 nuclear transport
3.03 6.33e-04 GO:0006406 mRNA export from nucleus
1.80 8.33e-04 GO:0043632 modification-dependent macromolecule catabolic process
2.10 8.84e-04 GO:0006913 nucleocytoplasmic transport
1.79 8.95e-04 GO:0051603 proteolysis involved in cellular protein catabolic process
1.75 9.44e-04 GO:0030163 protein catabolic process
2.23 1.18e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.41 1.24e-03 GO:0051649 establishment of localization in cell
1.80 1.25e-03 GO:0006511 ubiquitin-dependent protein catabolic process
1.79 1.34e-03 GO:0019941 modification-dependent protein catabolic process
2.35 1.40e-03 GO:0006399 tRNA metabolic process
1.73 1.92e-03 GO:0044419 interspecies interaction between organisms
1.95 2.27e-03 GO:0009203 ribonucleoside triphosphate catabolic process
1.95 2.27e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.94 2.68e-03 GO:0009146 purine nucleoside triphosphate catabolic process
2.06 2.77e-03 GO:0043687 post-translational protein modification
1.91 4.34e-03 GO:0009143 nucleoside triphosphate catabolic process
1.91 4.34e-03 GO:0009154 purine ribonucleotide catabolic process
1.71 5.73e-03 GO:0018193 peptidyl-amino acid modification
1.89 5.93e-03 GO:0009261 ribonucleotide catabolic process
1.94 7.07e-03 GO:0000375 RNA splicing, via transesterification reactions
2.63 1.29e-02 GO:0006200 ATP catabolic process
2.51 1.35e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
1.91 1.71e-02 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.91 1.71e-02 GO:0000398 nuclear mRNA splicing, via spliceosome
2.42 1.98e-02 GO:0006402 mRNA catabolic process
1.75 2.39e-02 GO:0010608 posttranscriptional regulation of gene expression
1.79 2.60e-02 GO:0072523 purine-containing compound catabolic process
1.70 4.33e-02 GO:0009199 ribonucleoside triphosphate metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 2.24e-61 GO:0005622 intracellular
1.24 2.53e-59 GO:0044424 intracellular part
1.33 1.22e-57 GO:0043231 intracellular membrane-bounded organelle
1.33 1.40e-57 GO:0043227 membrane-bounded organelle
1.28 3.47e-54 GO:0043229 intracellular organelle
1.28 1.58e-53 GO:0043226 organelle
1.45 2.35e-46 GO:0005634 nucleus
1.74 9.10e-36 GO:0044428 nuclear part
1.38 1.03e-33 GO:0044446 intracellular organelle part
1.37 6.00e-32 GO:0044422 organelle part
1.74 1.67e-29 GO:0031981 nuclear lumen
1.65 1.44e-28 GO:0070013 intracellular organelle lumen
1.62 1.10e-27 GO:0031974 membrane-enclosed lumen
1.62 4.91e-27 GO:0043233 organelle lumen
1.80 1.13e-23 GO:0005654 nucleoplasm
1.21 2.33e-21 GO:0005737 cytoplasm
1.40 2.98e-19 GO:0032991 macromolecular complex
2.00 4.71e-14 GO:0005694 chromosome
1.23 8.06e-14 GO:0044444 cytoplasmic part
1.43 3.57e-11 GO:0005829 cytosol
1.96 1.03e-10 GO:0044427 chromosomal part
1.33 1.89e-10 GO:0043234 protein complex
1.90 2.24e-10 GO:0030529 ribonucleoprotein complex
1.34 3.75e-10 GO:0043228 non-membrane-bounded organelle
1.34 3.75e-10 GO:0043232 intracellular non-membrane-bounded organelle
1.72 1.13e-09 GO:0044451 nucleoplasm part
1.05 4.10e-08 GO:0044464 cell part
1.05 4.33e-08 GO:0005623 cell
1.45 2.05e-07 GO:0005739 mitochondrion
1.88 3.08e-06 GO:0005815 microtubule organizing center
1.71 4.28e-06 GO:0005730 nucleolus
2.18 1.07e-05 GO:0005819 spindle
1.99 6.73e-05 GO:0005813 centrosome
1.53 1.35e-04 GO:0015630 microtubule cytoskeleton
1.98 1.45e-04 GO:0000228 nuclear chromosome
2.10 1.65e-04 GO:0044454 nuclear chromosome part
2.32 1.89e-04 GO:0044455 mitochondrial membrane part
1.92 2.05e-04 GO:0000785 chromatin
2.78 4.67e-04 GO:0000922 spindle pole
1.50 6.69e-04 GO:0044429 mitochondrial part
1.48 7.53e-04 GO:0031967 organelle envelope
2.54 1.27e-03 GO:0031461 cullin-RING ubiquitin ligase complex
2.89 1.61e-03 GO:0034708 methyltransferase complex
2.89 1.61e-03 GO:0035097 histone methyltransferase complex
1.45 1.97e-03 GO:0031975 envelope
2.09 2.44e-03 GO:0000151 ubiquitin ligase complex
1.61 1.32e-02 GO:0019866 organelle inner membrane
1.63 1.63e-02 GO:0005743 mitochondrial inner membrane
4.96 1.79e-02 GO:0032300 mismatch repair complex
2.90 2.30e-02 GO:0008287 protein serine/threonine phosphatase complex
1.22 2.32e-02 GO:0031090 organelle membrane
2.01 2.89e-02 GO:0016607 nuclear speck
1.91 4.31e-02 GO:0000793 condensed chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.24 3.29e-21 GO:0005515 protein binding
1.41 1.05e-18 GO:0003676 nucleic acid binding
1.88 6.82e-17 GO:0003723 RNA binding
1.10 1.75e-10 GO:0005488 binding
1.23 1.77e-10 GO:0003824 catalytic activity
1.36 1.31e-08 GO:0000166 nucleotide binding
1.86 3.72e-08 GO:0016874 ligase activity
1.99 7.68e-07 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.02 2.60e-06 GO:0016881 acid-amino acid ligase activity
2.04 1.27e-05 GO:0019787 small conjugating protein ligase activity
1.29 2.76e-05 GO:0003677 DNA binding
1.31 8.35e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.99 1.17e-04 GO:0004842 ubiquitin-protein ligase activity
1.30 1.69e-04 GO:0017076 purine nucleotide binding
1.30 2.01e-04 GO:0032553 ribonucleotide binding
1.30 2.01e-04 GO:0032555 purine ribonucleotide binding
1.34 3.00e-04 GO:0005524 ATP binding
1.32 5.54e-04 GO:0030554 adenyl nucleotide binding
1.32 7.41e-04 GO:0032559 adenyl ribonucleotide binding
1.99 8.15e-04 GO:0003682 chromatin binding
1.43 3.38e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.44 3.66e-03 GO:0017111 nucleoside-triphosphatase activity
2.03 4.09e-03 GO:0004518 nuclease activity
1.43 4.22e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.43 4.29e-03 GO:0016462 pyrophosphatase activity
4.78 1.21e-02 GO:0030983 mismatched DNA binding
1.62 1.55e-02 GO:0016887 ATPase activity
1.25 2.57e-02 GO:0016740 transferase activity
1.87 4.31e-02 GO:0004721 phosphoprotein phosphatase activity
2.34 4.38e-02 GO:0042393 histone binding
2.34 4.38e-02 GO:0047485 protein N-terminus binding