Motif ID: EGR1..3.p2

Z-value: 1.568


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_642489320.459.2e-02Click!
EGR1chr5_+_137829065-0.441.0e-01Click!
EGR3chr8_-_226064010.039.2e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_18081968 1.074 NM_002688
 SEPT5
septin 5
chr6_+_36272506 1.071 NM_015695
 BRPF3
bromodomain and PHD finger containing, 3
chr22_+_20101661 1.058 NM_015094
 HIC2
hypermethylated in cancer 2
chrX_-_135161185 1.013 NM_001173517
NM_024597
 MAP7D3

MAP7 domain containing 3

chr17_+_35587767 1.004 NM_016339
 RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chrX_-_16798383 0.887 NM_002893
 RBBP7
retinoblastoma binding protein 7
chr4_-_809879 0.827 NM_006651
 CPLX1
complexin 1
chrX_-_16798363 0.799 RBBP7
retinoblastoma binding protein 7
chr7_-_526005 0.776 NM_002607
NM_033023
 PDGFA

platelet-derived growth factor alpha polypeptide

chr19_+_40325993 0.757 NM_022006
 FXYD7
FXYD domain containing ion transport regulator 7
chr11_+_2422747 0.756 NM_000218
 KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr19_-_45888259 0.741 NM_004756
 NUMBL
numb homolog (Drosophila)-like
chr15_-_76720598 0.726 NM_000750
 CHRNB4
cholinergic receptor, nicotinic, beta 4
chr7_+_49783774 0.700 NM_198570
 VWC2
von Willebrand factor C domain containing 2
chr8_-_111056099 0.696 NM_014379
 KCNV1
potassium channel, subfamily V, member 1
chr22_+_38720881 0.688 NM_138435
 FAM83F
family with sequence similarity 83, member F
chr10_+_69314347 0.664 NM_012238
 SIRT1
sirtuin 1
chr16_+_88305743 0.653 LOC100128881
hypothetical LOC100128881
chr12_-_107775400 0.646 SSH1
slingshot homolog 1 (Drosophila)
chr19_-_56260135 0.637 NM_015596
 KLK13
kallikrein-related peptidase 13

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 149 entries
enrichment   p-value GO term description
4.71 8.23e-04 GO:0045815 positive regulation of gene expression, epigenetic
3.14 4.19e-02 GO:0043489 RNA stabilization
3.14 4.19e-02 GO:0048255 mRNA stabilization
2.28 5.72e-03 GO:0016458 gene silencing
2.26 1.76e-05 GO:0040029 regulation of gene expression, epigenetic
2.13 3.42e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.01 1.28e-05 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.93 5.36e-06 GO:0032582 negative regulation of gene-specific transcription
1.89 6.89e-05 GO:0016570 histone modification
1.88 6.26e-05 GO:0016569 covalent chromatin modification
1.88 1.10e-02 GO:0010975 regulation of neuron projection development
1.87 9.06e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.86 3.83e-05 GO:0045664 regulation of neuron differentiation
1.85 1.26e-11 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.81 4.63e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.80 2.19e-16 GO:0010629 negative regulation of gene expression
1.78 4.27e-02 GO:0016055 Wnt receptor signaling pathway
1.76 5.81e-13 GO:0051253 negative regulation of RNA metabolic process
1.76 6.51e-13 GO:0045892 negative regulation of transcription, DNA-dependent
1.76 6.79e-05 GO:0050767 regulation of neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
2.40 1.16e-03 GO:0035770 RNA granule
2.04 1.38e-03 GO:0016585 chromatin remodeling complex
1.90 8.13e-03 GO:0019717 synaptosome
1.74 3.19e-04 GO:0030425 dendrite
1.74 2.85e-03 GO:0030136 clathrin-coated vesicle
1.74 5.71e-03 GO:0005912 adherens junction
1.72 2.57e-02 GO:0005938 cell cortex
1.68 3.77e-03 GO:0031252 cell leading edge
1.68 8.53e-03 GO:0070161 anchoring junction
1.67 5.49e-08 GO:0045202 synapse
1.66 3.10e-03 GO:0030135 coated vesicle
1.61 1.87e-04 GO:0044456 synapse part
1.60 2.36e-03 GO:0005667 transcription factor complex
1.53 1.01e-04 GO:0043005 neuron projection
1.48 3.84e-03 GO:0048471 perinuclear region of cytoplasm
1.44 6.03e-05 GO:0030054 cell junction
1.41 3.55e-05 GO:0044451 nucleoplasm part
1.34 9.97e-04 GO:0031982 vesicle
1.33 2.38e-03 GO:0031410 cytoplasmic vesicle
1.32 6.45e-03 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
2.57 3.33e-02 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
2.30 4.29e-02 GO:0046332 SMAD binding
1.87 4.87e-06 GO:0010843 promoter binding
1.87 3.67e-04 GO:0003714 transcription corepressor activity
1.84 6.80e-06 GO:0000975 regulatory region DNA binding
1.84 6.80e-06 GO:0001067 regulatory region nucleic acid binding
1.84 6.80e-06 GO:0044212 transcription regulatory region DNA binding
1.76 1.03e-02 GO:0022843 voltage-gated cation channel activity
1.75 6.44e-05 GO:0003713 transcription coactivator activity
1.74 2.80e-09 GO:0000988 protein binding transcription factor activity
1.74 2.80e-09 GO:0000989 transcription factor binding transcription factor activity
1.74 4.97e-09 GO:0003712 transcription cofactor activity
1.73 2.84e-07 GO:0016563 transcription activator activity
1.73 1.42e-06 GO:0008134 transcription factor binding
1.69 3.35e-06 GO:0016564 transcription repressor activity
1.63 1.16e-03 GO:0003702 RNA polymerase II transcription factor activity
1.61 3.33e-02 GO:0005244 voltage-gated ion channel activity
1.61 3.33e-02 GO:0022832 voltage-gated channel activity
1.58 1.52e-16 GO:0030528 transcription regulator activity
1.57 4.10e-10 GO:0043565 sequence-specific DNA binding