Motif ID: EGR1..3.p2

Z-value: 1.568


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_642489320.459.2e-02Click!
EGR1chr5_+_137829065-0.441.0e-01Click!
EGR3chr8_-_226064010.039.2e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_18081968 1.074 NM_002688
SEPT5
septin 5
chr6_+_36272506 1.071 NM_015695
BRPF3
bromodomain and PHD finger containing, 3
chr22_+_20101661 1.058 NM_015094
HIC2
hypermethylated in cancer 2
chrX_-_135161185 1.013 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr17_+_35587767 1.004 NM_016339
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chrX_-_16798383 0.887 NM_002893
RBBP7
retinoblastoma binding protein 7
chr4_-_809879 0.827 NM_006651
CPLX1
complexin 1
chrX_-_16798363 0.799 RBBP7
retinoblastoma binding protein 7
chr7_-_526005 0.776 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr19_+_40325993 0.757 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr11_+_2422747 0.756 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr19_-_45888259 0.741 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr15_-_76720598 0.726 NM_000750
CHRNB4
cholinergic receptor, nicotinic, beta 4
chr7_+_49783774 0.700 NM_198570
VWC2
von Willebrand factor C domain containing 2
chr8_-_111056099 0.696 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr22_+_38720881 0.688 NM_138435
FAM83F
family with sequence similarity 83, member F
chr10_+_69314347 0.664 NM_012238
SIRT1
sirtuin 1
chr16_+_88305743 0.653 LOC100128881
hypothetical LOC100128881
chr12_-_107775400 0.646 SSH1
slingshot homolog 1 (Drosophila)
chr19_-_56260135 0.637 NM_015596
KLK13
kallikrein-related peptidase 13
chrX_-_16798096 0.628 RBBP7
retinoblastoma binding protein 7
chr1_+_41022066 0.627 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr3_-_39170105 0.621 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr19_+_45799060 0.613 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chrX_-_152592450 0.611 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr3_-_13896618 0.592 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr11_-_2863536 0.576 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr17_-_44010543 0.554 NM_024015
HOXB4
homeobox B4
chrX_+_9392980 0.535 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr19_+_1704661 0.522 NM_001080488
ONECUT3
one cut homeobox 3
chr9_+_133259330 0.518 PRRC2B
proline-rich coiled-coil 2B
chr22_+_38183262 0.516 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chrX_-_47364173 0.514 NM_006950
NM_133499
SYN1

synapsin I

chr19_-_54267932 0.511 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chrX_+_16874651 0.510 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr9_-_122679387 0.508 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr12_-_53071285 0.507 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr9_-_139316523 0.505 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr1_+_6407403 0.503 NM_031475
ESPN
espin
chr7_-_106088565 0.503 NM_175884
FLJ36031
hypothetical protein FLJ36031
chr1_+_32992131 0.502


chrX_-_152853402 0.484 NM_003491
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr18_+_12397894 0.474 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr18_-_51406359 0.465 TCF4
transcription factor 4
chr1_+_35031185 0.464 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr22_-_20551722 0.462 MAPK1
mitogen-activated protein kinase 1
chr11_+_113815317 0.459 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr19_+_7834124 0.452 EVI5L
ecotropic viral integration site 5-like
chr19_-_1518875 0.442 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chrX_-_47364039 0.439


chr6_-_84197573 0.439 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr5_+_60663842 0.437 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr11_-_112851051 0.434 NM_000795
NM_016574
DRD2

dopamine receptor D2

chr14_+_51850754 0.434 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr19_-_14951349 0.430 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr18_-_68685789 0.428 NM_138966
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr10_+_45189617 0.427 NM_000698
ALOX5
arachidonate 5-lipoxygenase
chr9_-_139027435 0.424 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr10_+_134893766 0.423 NM_003577
UTF1
undifferentiated embryonic cell transcription factor 1
chr10_-_64248932 0.419 NM_001136178
EGR2
early growth response 2
chr1_-_32574185 0.418 NM_023009
MARCKSL1
MARCKS-like 1
chr1_-_33420213 0.417 NM_018207
TRIM62
tripartite motif containing 62
chrX_+_134383533 0.415 NCRNA00086
non-protein coding RNA 86
chrX_+_117745551 0.413 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr5_+_56146656 0.409 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr1_+_39229474 0.408 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr1_-_154318412 0.407 NM_001093725
MEX3A
mex-3 homolog A (C. elegans)
chr15_+_65145248 0.405 NM_005902
SMAD3
SMAD family member 3
chr19_-_18409788 0.403 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr12_-_107775462 0.401 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr3_-_39170038 0.399 CSRNP1
cysteine-serine-rich nuclear protein 1
chr3_-_24511456 0.396 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr15_-_70399551 0.396 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr16_-_47201588 0.395 NM_153029
N4BP1
NEDD4 binding protein 1
chr1_-_21375939 0.389 NM_001198801
NM_001198802
EIF4G3

eukaryotic translation initiation factor 4 gamma, 3

chr20_-_48980858 0.387 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr5_-_158569067 0.387 RNF145
ring finger protein 145
chrX_-_152592958 0.386 NM_001039582
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr1_+_2149993 0.382 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr19_+_8180179 0.381 NM_024552
LASS4
LAG1 homolog, ceramide synthase 4
chr7_+_150387686 0.378 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr4_-_40911212 0.377 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr13_+_24940965 0.377 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr5_+_176493488 0.376 NSD1
nuclear receptor binding SET domain protein 1
chr7_+_150414704 0.375 NM_001042535
NM_031946
AGAP3

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

chr15_-_70399523 0.373 CELF6
CUGBP, Elav-like family member 6
chr17_-_24940521 0.372 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr20_+_54637714 0.367 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr1_-_149698272 0.366 POGZ
pogo transposable element with ZNF domain
chr5_+_61637822 0.365 KIF2A
kinesin heavy chain member 2A
chr1_-_68071635 0.364 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr12_-_102413875 0.364 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chr7_+_128257698 0.364 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr1_+_153317887 0.361 NM_004952
EFNA3
ephrin-A3
chr19_+_12810258 0.360 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr1_-_198645788 0.358 NM_012482
ZNF281
zinc finger protein 281
chr7_-_32897934 0.357 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr20_-_930806 0.356 NM_001029871
NM_001040007
RSPO4

R-spondin family, member 4

chr21_+_45888001 0.356 PCBP3
poly(rC) binding protein 3
chr21_+_46473494 0.354 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr12_-_55310261 0.353 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr16_+_1604641 0.353 NM_020825
CRAMP1L
Crm, cramped-like (Drosophila)
chr5_-_177950161 0.350 NM_173465
COL23A1
collagen, type XXIII, alpha 1
chr11_-_10272256 0.348 NM_030962
SBF2
SET binding factor 2
chr2_+_104838177 0.347 NM_006236
POU3F3
POU class 3 homeobox 3
chr1_+_231816372 0.347 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr13_+_24940917 0.343 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr7_-_156125876 0.343 C7orf13
chromosome 7 open reading frame 13
chr7_-_3049872 0.341 NM_032415
CARD11
caspase recruitment domain family, member 11
chrX_+_151557292 0.341 NM_018558
GABRQ
gamma-aminobutyric acid (GABA) receptor, theta
chr16_-_695719 0.341 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr1_-_6468600 0.338 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr2_+_102602579 0.338 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr9_-_85622366 0.338 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr10_+_99463468 0.338 MARVELD1
MARVEL domain containing 1
chr17_+_77582774 0.338 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chrX_-_16797895 0.337 NM_001198719
RBBP7
retinoblastoma binding protein 7
chr19_-_18409971 0.335 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr2_-_100305626 0.335 NM_198461
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr6_+_99389300 0.333 NM_005604
POU3F2
POU class 3 homeobox 2
chr10_+_99463446 0.332 NM_031484
MARVELD1
MARVEL domain containing 1
chr7_+_156126157 0.330 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr1_+_167342493 0.330 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr15_+_31390454 0.330 NM_001036
RYR3
ryanodine receptor 3
chr7_-_124192265 0.329 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr11_-_63770716 0.325 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_123023052 0.325 NM_025140
CCDC92
coiled-coil domain containing 92
chr3_-_45242808 0.324 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr3_+_185538998 0.323 FAM131A
family with sequence similarity 131, member A
chr5_-_45731976 0.321 NM_021072
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr21_-_45532176 0.320 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr6_+_99389318 0.319 POU3F2
POU class 3 homeobox 2
chr1_-_16174859 0.319 NM_003443
ZBTB17
zinc finger and BTB domain containing 17
chrX_-_23835868 0.318 NM_024122
APOO
apolipoprotein O
chr19_-_47438384 0.318 GSK3A
glycogen synthase kinase 3 alpha
chr4_+_3264509 0.318 RGS12
regulator of G-protein signaling 12
chr19_+_17253453 0.317 NM_152363
ANKLE1
ankyrin repeat and LEM domain containing 1
chr7_+_24290331 0.317 NM_000905
NPY
neuropeptide Y
chr17_+_72827185 0.317 NM_006640
SEPT9
septin 9
chr20_-_538909 0.316 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr5_+_61637701 0.315 NM_001098511
NM_004520
KIF2A

kinesin heavy chain member 2A

chr10_+_98582005 0.315 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr22_+_27798887 0.314 NM_001039570
NM_032045
KREMEN1

kringle containing transmembrane protein 1

chr17_+_69939806 0.313 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr7_+_150387649 0.313 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr5_+_176493233 0.312 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr6_+_137185441 0.311 PEX7
peroxisomal biogenesis factor 7
chr22_-_20551937 0.308 MAPK1
mitogen-activated protein kinase 1
chr1_-_227545310 0.307 NM_145257
C1orf96
chromosome 1 open reading frame 96
chr9_-_122679283 0.307 PHF19
PHD finger protein 19
chrX_-_72215949 0.306 NM_001012977
PABPC1L2A
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2A
poly(A) binding protein, cytoplasmic 1-like 2B
chr2_+_233927892 0.303 DGKD
diacylglycerol kinase, delta 130kDa
chr1_+_226261374 0.302 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr11_-_63770840 0.302 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_43118721 0.301 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr19_-_60383280 0.301 NM_003180
SYT5
synaptotagmin V
chr7_+_154720547 0.299 INSIG1
insulin induced gene 1
chr17_-_47591123 0.299 NM_020178
CA10
carbonic anhydrase X
chr10_+_69314714 0.298 SIRT1
sirtuin 1
chr4_-_10068055 0.296 NM_053042
ZNF518B
zinc finger protein 518B
chr1_-_196011152 0.296 NM_001195215
NM_001195216
NM_144977
DENND1B


DENN/MADD domain containing 1B


chr5_-_45731588 0.295 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr1_-_21375891 0.295 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_+_52215982 0.295 NM_002517
NPAS1
neuronal PAS domain protein 1
chr11_+_107304344 0.295 NM_017516
RAB39
RAB39, member RAS oncogene family
chr19_+_16296632 0.294 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr14_-_90789919 0.294 NM_003485
GPR68
G protein-coupled receptor 68
chr10_+_45189673 0.293 ALOX5
arachidonate 5-lipoxygenase
chrX_-_19815370 0.286 SH3KBP1
SH3-domain kinase binding protein 1
chr5_-_172687798 0.286 STC2
stanniocalcin 2
chr11_+_117812282 0.286 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr20_+_41976831 0.286 NM_001098797
TOX2
TOX high mobility group box family member 2
chr13_-_37341859 0.285 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr1_-_85131439 0.285 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr18_+_12244317 0.285 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr11_-_118582098 0.284 CCDC153
coiled-coil domain containing 153
chr3_-_38046034 0.283 NM_006225
PLCD1
phospholipase C, delta 1
chr5_+_3649167 0.282 NM_024337
IRX1
iroquois homeobox 1
chr19_-_11317887 0.282 NM_001145416
NM_033408
NM_198536
TMEM205


transmembrane protein 205


chr2_-_182253457 0.280 NM_002500
NEUROD1
neurogenic differentiation 1
chr19_-_9908014 0.278 NM_058164
OLFM2
olfactomedin 2
chr6_+_41856466 0.277 NM_013397
PRICKLE4
prickle homolog 4 (Drosophila)
chrX_-_19815526 0.277 SH3KBP1
SH3-domain kinase binding protein 1
chr9_+_139892049 0.277 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr1_+_32530289 0.277 HDAC1
histone deacetylase 1
chr19_+_2220529 0.277 OAZ1
ornithine decarboxylase antizyme 1
chr1_+_154389945 0.277 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr19_-_50963942 0.276


chr22_-_18384251 0.276 NM_001670
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr3_-_187025501 0.276 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr22_+_40724674 0.276 NM_152613
WBP2NL
WBP2 N-terminal like
chr7_-_27108826 0.276 NM_006735
HOXA2
homeobox A2
chr7_-_129038701 0.275


chr1_+_246087230 0.275 TRIM58
tripartite motif containing 58
chr8_+_17824631 0.275 NM_006197
PCM1
pericentriolar material 1
chr7_+_44754700 0.275 ZMIZ2
zinc finger, MIZ-type containing 2
chr10_+_76541351 0.273 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chr1_+_32530298 0.272 HDAC1
histone deacetylase 1
chr1_-_9806377 0.271 CLSTN1
calsyntenin 1
chr19_-_60611136 0.270 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 2.05e-21 GO:0050794 regulation of cellular process
1.19 1.29e-20 GO:0050789 regulation of biological process
1.17 5.55e-19 GO:0065007 biological regulation
1.64 1.28e-17 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.80 2.19e-16 GO:0010629 negative regulation of gene expression
1.49 2.62e-16 GO:0007399 nervous system development
1.35 1.25e-15 GO:0010468 regulation of gene expression
1.10 2.76e-15 GO:0009987 cellular process
1.37 7.30e-15 GO:0051252 regulation of RNA metabolic process
1.59 4.92e-14 GO:0022008 neurogenesis
1.61 1.21e-13 GO:0048699 generation of neurons
1.33 3.72e-13 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.27 4.36e-13 GO:0060255 regulation of macromolecule metabolic process
1.24 5.68e-13 GO:0019222 regulation of metabolic process
1.76 5.81e-13 GO:0051253 negative regulation of RNA metabolic process
1.35 6.09e-13 GO:0006355 regulation of transcription, DNA-dependent
1.76 6.51e-13 GO:0045892 negative regulation of transcription, DNA-dependent
1.32 1.36e-12 GO:0010556 regulation of macromolecule biosynthetic process
1.30 2.54e-12 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 3.04e-12 GO:0031323 regulation of cellular metabolic process
1.65 3.27e-12 GO:0009890 negative regulation of biosynthetic process
1.65 4.44e-12 GO:0031327 negative regulation of cellular biosynthetic process
1.22 5.04e-12 GO:0044260 cellular macromolecule metabolic process
1.52 1.22e-11 GO:0009892 negative regulation of metabolic process
1.25 1.23e-11 GO:0080090 regulation of primary metabolic process
1.85 1.26e-11 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.65 2.07e-11 GO:0010558 negative regulation of macromolecule biosynthetic process
1.66 3.79e-11 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.29 5.15e-11 GO:0009889 regulation of biosynthetic process
1.53 5.26e-11 GO:0010605 negative regulation of macromolecule metabolic process
1.63 5.59e-11 GO:0051254 positive regulation of RNA metabolic process
1.29 6.52e-11 GO:0031326 regulation of cellular biosynthetic process
1.28 1.08e-10 GO:0051171 regulation of nitrogen compound metabolic process
1.32 1.51e-10 GO:0048523 negative regulation of cellular process
1.65 1.59e-10 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.61 1.75e-10 GO:0010628 positive regulation of gene expression
1.64 1.97e-10 GO:0045893 positive regulation of transcription, DNA-dependent
1.16 2.96e-10 GO:0044237 cellular metabolic process
1.57 3.93e-10 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.71 4.27e-10 GO:0031175 neuron projection development
1.30 5.56e-10 GO:0048519 negative regulation of biological process
1.63 6.25e-10 GO:0051172 negative regulation of nitrogen compound metabolic process
1.59 6.25e-10 GO:0030182 neuron differentiation
1.57 6.57e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
1.34 1.09e-09 GO:0006464 protein modification process
1.54 2.03e-09 GO:0051173 positive regulation of nitrogen compound metabolic process
1.28 3.73e-09 GO:0048522 positive regulation of cellular process
1.22 4.45e-09 GO:0023052 signaling
1.72 5.00e-09 GO:0048812 neuron projection morphogenesis
1.67 5.68e-09 GO:0000904 cell morphogenesis involved in differentiation
1.23 7.21e-09 GO:0007275 multicellular organismal development
1.49 7.77e-09 GO:0031324 negative regulation of cellular metabolic process
1.71 1.11e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.72 1.15e-08 GO:0007409 axonogenesis
1.32 1.16e-08 GO:0043412 macromolecule modification
1.61 1.30e-08 GO:0048666 neuron development
1.18 1.39e-08 GO:0043170 macromolecule metabolic process
1.42 2.31e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.36 3.17e-08 GO:0009653 anatomical structure morphogenesis
1.25 4.18e-08 GO:0048518 positive regulation of biological process
1.21 4.23e-08 GO:0032502 developmental process
1.49 4.96e-08 GO:0031328 positive regulation of cellular biosynthetic process
1.48 6.11e-08 GO:0009891 positive regulation of biosynthetic process
1.25 7.30e-08 GO:0071842 cellular component organization at cellular level
1.46 7.89e-08 GO:0048468 cell development
1.55 1.65e-07 GO:0030030 cell projection organization
1.33 2.30e-07 GO:0023051 regulation of signaling
1.63 2.46e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.23 5.93e-07 GO:0048731 system development
1.21 6.79e-07 GO:0016043 cellular component organization
1.22 7.12e-07 GO:0048856 anatomical structure development
1.28 7.83e-07 GO:0030154 cell differentiation
1.59 1.67e-06 GO:0048858 cell projection morphogenesis
1.44 1.69e-06 GO:0006351 transcription, DNA-dependent
1.58 1.76e-06 GO:0032990 cell part morphogenesis
1.52 1.78e-06 GO:0032989 cellular component morphogenesis
1.72 2.64e-06 GO:0007411 axon guidance
1.23 3.20e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.53 3.43e-06 GO:0000902 cell morphogenesis
1.26 3.72e-06 GO:0048869 cellular developmental process
1.36 3.76e-06 GO:0031325 positive regulation of cellular metabolic process
1.50 4.20e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.19 5.31e-06 GO:0051179 localization
1.93 5.36e-06 GO:0032582 negative regulation of gene-specific transcription
1.19 8.42e-06 GO:0007165 signal transduction
1.19 1.22e-05 GO:0071840 cellular component organization or biogenesis
2.01 1.28e-05 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.23 1.44e-05 GO:0044267 cellular protein metabolic process
1.46 1.60e-05 GO:0009790 embryo development
1.34 1.69e-05 GO:0009893 positive regulation of metabolic process
2.26 1.76e-05 GO:0040029 regulation of gene expression, epigenetic
1.63 2.82e-05 GO:0016568 chromatin modification
1.39 3.44e-05 GO:0050793 regulation of developmental process
1.86 3.83e-05 GO:0045664 regulation of neuron differentiation
1.20 4.56e-05 GO:0006810 transport
1.12 4.79e-05 GO:0044238 primary metabolic process
1.54 4.96e-05 GO:0019226 transmission of nerve impulse
1.54 4.96e-05 GO:0035637 multicellular organismal signaling
1.20 5.12e-05 GO:0051234 establishment of localization
1.88 6.26e-05 GO:0016569 covalent chromatin modification
1.45 6.63e-05 GO:0045595 regulation of cell differentiation
1.76 6.79e-05 GO:0050767 regulation of neurogenesis
1.89 6.89e-05 GO:0016570 histone modification
1.35 1.06e-04 GO:0010646 regulation of cell communication
1.51 1.07e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.65 1.47e-04 GO:0060284 regulation of cell development
1.51 1.60e-04 GO:0007417 central nervous system development
1.10 2.70e-04 GO:0008152 metabolic process
1.29 2.83e-04 GO:0009966 regulation of signal transduction
1.40 3.44e-04 GO:2000026 regulation of multicellular organismal development
1.67 3.76e-04 GO:0051960 regulation of nervous system development
1.19 7.70e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.15 7.73e-04 GO:0051716 cellular response to stimulus
1.29 7.77e-04 GO:0051641 cellular localization
4.71 8.23e-04 GO:0045815 positive regulation of gene expression, epigenetic
1.51 1.04e-03 GO:0007268 synaptic transmission
1.24 1.23e-03 GO:0016070 RNA metabolic process
1.25 1.34e-03 GO:0006996 organelle organization
1.55 2.12e-03 GO:0018193 peptidyl-amino acid modification
1.30 2.18e-03 GO:0051649 establishment of localization in cell
1.17 2.46e-03 GO:0019538 protein metabolic process
1.32 3.12e-03 GO:0032774 RNA biosynthetic process
1.42 3.30e-03 GO:0009887 organ morphogenesis
2.13 3.42e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.47 3.47e-03 GO:0006325 chromatin organization
1.37 3.49e-03 GO:0016192 vesicle-mediated transport
1.55 4.13e-03 GO:0007389 pattern specification process
1.61 4.65e-03 GO:0032446 protein modification by small protein conjugation
2.28 5.72e-03 GO:0016458 gene silencing
1.52 5.86e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.52 6.06e-03 GO:0048598 embryonic morphogenesis
1.52 6.64e-03 GO:0007420 brain development
1.47 6.68e-03 GO:0032583 regulation of gene-specific transcription
1.87 9.06e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.88 1.10e-02 GO:0010975 regulation of neuron projection development
1.33 1.15e-02 GO:0051128 regulation of cellular component organization
1.59 1.92e-02 GO:0016567 protein ubiquitination
1.61 2.34e-02 GO:0003002 regionalization
1.74 2.44e-02 GO:0009952 anterior/posterior pattern formation
1.37 2.47e-02 GO:0051276 chromosome organization
1.44 2.65e-02 GO:0051094 positive regulation of developmental process
1.15 2.92e-02 GO:0034641 cellular nitrogen compound metabolic process
1.18 3.24e-02 GO:0090304 nucleic acid metabolic process
1.50 3.75e-02 GO:0070647 protein modification by small protein conjugation or removal
3.14 4.19e-02 GO:0043489 RNA stabilization
3.14 4.19e-02 GO:0048255 mRNA stabilization
1.78 4.27e-02 GO:0016055 Wnt receptor signaling pathway
1.28 4.62e-02 GO:0007154 cell communication
1.81 4.63e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 1.92e-29 GO:0005622 intracellular
1.13 3.24e-29 GO:0044424 intracellular part
1.14 8.58e-22 GO:0043226 organelle
1.14 2.42e-21 GO:0043229 intracellular organelle
1.15 2.43e-18 GO:0043227 membrane-bounded organelle
1.14 5.10e-18 GO:0043231 intracellular membrane-bounded organelle
1.21 5.76e-18 GO:0005634 nucleus
1.05 1.45e-12 GO:0005623 cell
1.05 2.13e-12 GO:0044464 cell part
1.12 9.68e-11 GO:0005737 cytoplasm
1.67 5.49e-08 GO:0045202 synapse
1.20 3.28e-06 GO:0043234 protein complex
1.24 5.15e-06 GO:0044428 nuclear part
1.41 3.55e-05 GO:0044451 nucleoplasm part
1.24 4.26e-05 GO:0031981 nuclear lumen
1.29 5.29e-05 GO:0005654 nucleoplasm
1.44 6.03e-05 GO:0030054 cell junction
1.12 6.09e-05 GO:0044446 intracellular organelle part
1.11 7.10e-05 GO:0044444 cytoplasmic part
1.53 1.01e-04 GO:0043005 neuron projection
1.12 1.04e-04 GO:0044422 organelle part
1.61 1.87e-04 GO:0044456 synapse part
1.21 2.70e-04 GO:0005829 cytosol
1.74 3.19e-04 GO:0030425 dendrite
1.34 9.97e-04 GO:0031982 vesicle
2.40 1.16e-03 GO:0035770 RNA granule
2.04 1.38e-03 GO:0016585 chromatin remodeling complex
1.14 2.05e-03 GO:0032991 macromolecular complex
1.60 2.36e-03 GO:0005667 transcription factor complex
1.33 2.38e-03 GO:0031410 cytoplasmic vesicle
1.18 2.70e-03 GO:0070013 intracellular organelle lumen
1.74 2.85e-03 GO:0030136 clathrin-coated vesicle
1.66 3.10e-03 GO:0030135 coated vesicle
1.68 3.77e-03 GO:0031252 cell leading edge
1.48 3.84e-03 GO:0048471 perinuclear region of cytoplasm
1.18 5.21e-03 GO:0043233 organelle lumen
1.74 5.71e-03 GO:0005912 adherens junction
1.30 5.97e-03 GO:0042995 cell projection
1.32 6.45e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.32 6.92e-03 GO:0031988 membrane-bounded vesicle
1.90 8.13e-03 GO:0019717 synaptosome
1.17 8.47e-03 GO:0031974 membrane-enclosed lumen
1.68 8.53e-03 GO:0070161 anchoring junction
1.21 1.03e-02 GO:0005856 cytoskeleton
1.72 2.57e-02 GO:0005938 cell cortex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.99e-32 GO:0005515 protein binding
1.10 3.16e-20 GO:0005488 binding
1.58 1.52e-16 GO:0030528 transcription regulator activity
1.51 4.52e-12 GO:0001071 nucleic acid binding transcription factor activity
1.51 4.52e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.30 8.98e-11 GO:0003677 DNA binding
1.57 4.10e-10 GO:0043565 sequence-specific DNA binding
1.23 2.54e-09 GO:0003676 nucleic acid binding
1.74 2.80e-09 GO:0000988 protein binding transcription factor activity
1.74 2.80e-09 GO:0000989 transcription factor binding transcription factor activity
1.74 4.97e-09 GO:0003712 transcription cofactor activity
1.73 2.84e-07 GO:0016563 transcription activator activity
1.73 1.42e-06 GO:0008134 transcription factor binding
1.69 3.35e-06 GO:0016564 transcription repressor activity
1.87 4.87e-06 GO:0010843 promoter binding
1.84 6.80e-06 GO:0000975 regulatory region DNA binding
1.84 6.80e-06 GO:0001067 regulatory region nucleic acid binding
1.84 6.80e-06 GO:0044212 transcription regulatory region DNA binding
1.22 4.33e-05 GO:0000166 nucleotide binding
1.75 6.44e-05 GO:0003713 transcription coactivator activity
1.38 2.11e-04 GO:0019899 enzyme binding
1.87 3.67e-04 GO:0003714 transcription corepressor activity
1.44 4.40e-04 GO:0008092 cytoskeletal protein binding
1.21 5.07e-04 GO:0008270 zinc ion binding
1.63 1.16e-03 GO:0003702 RNA polymerase II transcription factor activity
1.46 1.99e-03 GO:0019904 protein domain specific binding
1.32 6.23e-03 GO:0016301 kinase activity
1.36 8.15e-03 GO:0004672 protein kinase activity
1.13 8.30e-03 GO:0046872 metal ion binding
1.76 1.03e-02 GO:0022843 voltage-gated cation channel activity
1.33 1.05e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.19 1.06e-02 GO:0032553 ribonucleotide binding
1.19 1.06e-02 GO:0032555 purine ribonucleotide binding
1.19 1.15e-02 GO:0017076 purine nucleotide binding
1.49 1.19e-02 GO:0003779 actin binding
1.12 1.54e-02 GO:0043167 ion binding
1.12 1.88e-02 GO:0043169 cation binding
1.18 3.25e-02 GO:0035639 purine ribonucleoside triphosphate binding
2.57 3.33e-02 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
1.61 3.33e-02 GO:0005244 voltage-gated ion channel activity
1.61 3.33e-02 GO:0022832 voltage-gated channel activity
2.30 4.29e-02 GO:0046332 SMAD binding