Motif ID: ZIC1..3.p2

Z-value: 3.006


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486105160.777.1e-04Click!
ZIC3chrX_+_1364763530.611.6e-02Click!
ZIC2chr13_+_994322580.381.7e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_85169615 6.303 NM_005250
FOXL1
forkhead box L1
chr10_-_90702490 5.907 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_-_13910167 5.031 NM_024825
PODNL1
podocan-like 1
chr3_-_73756668 5.002 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr12_-_50871953 4.330 NM_001081492
NM_182507
KRT80

keratin 80

chr3_+_64645819 3.745 LOC100507098
hypothetical LOC100507098
chr17_-_72045218 3.182 NM_134268
CYGB
cytoglobin
chr16_+_66244314 3.172 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr21_-_26867138 3.164 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr7_-_27191287 2.932 NM_005523
HOXA11
homeobox A11
chr5_+_131437383 2.921 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr22_-_36153449 2.897 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr7_-_27180398 2.887 NM_018951
HOXA10
homeobox A10
chr3_+_50281582 2.852 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_-_168660293 2.832 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr6_-_112001590 2.817 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr10_+_75343352 2.719 PLAU
plasminogen activator, urokinase
chr1_-_21478571 2.711 NM_001113347
ECE1
endothelin converting enzyme 1
chr5_+_175725050 2.677 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr22_-_49063088 2.620 PLXNB2
plexin B2
chr7_+_44110527 2.561 AEBP1
AE binding protein 1
chr19_-_53912025 2.519 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_+_199519202 2.430 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr2_-_133144094 2.414 LYPD1
LY6/PLAUR domain containing 1
chr17_+_36515166 2.396 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr8_-_22070208 2.379 NM_139278
LGI3
leucine-rich repeat LGI family, member 3
chr17_+_76549658 2.356 RPTOR
regulatory associated protein of MTOR, complex 1
chr3_+_50281309 2.309 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr17_+_45703765 2.258 NM_001168215
TMEM92
transmembrane protein 92
chr6_-_169392771 2.204


chr3_-_124893875 2.198 MYLK
myosin light chain kinase
chr5_+_150008030 2.185 SYNPO
synaptopodin
chr3_+_189353502 2.170 LPP
LIM domain containing preferred translocation partner in lipoma
chr19_-_13808101 2.136 LOC284454
hypothetical LOC284454
chr20_+_19903778 2.136 RIN2
Ras and Rab interactor 2
chr11_+_57547928 2.126 NM_001005212
OR9Q1
olfactory receptor, family 9, subfamily Q, member 1
chr16_+_54070302 2.113 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_+_31616809 2.103 NM_013962
NRG1
neuregulin 1
chr10_+_80672842 2.100 ZMIZ1
zinc finger, MIZ-type containing 1
chrX_+_51653348 2.053 NM_001005333
NM_006986
MAGED1

melanoma antigen family D, 1

chr8_+_75899326 2.011 NM_015886
PI15
peptidase inhibitor 15
chr12_+_54400417 2.007 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr6_+_160102978 2.003 NM_005891
ACAT2
acetyl-CoA acetyltransferase 2
chr19_-_60573552 1.993 NM_000641
IL11
interleukin 11
chr17_-_28644118 1.990 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr16_-_66827449 1.986 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr22_-_26527469 1.967 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr11_+_111288686 1.958 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chrX_-_107866262 1.944 NM_003604
IRS4
insulin receptor substrate 4
chr8_-_22044463 1.929 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr12_+_5411534 1.920 NM_001102654
NTF3
neurotrophin 3
chr10_+_52421120 1.902 PRKG1
protein kinase, cGMP-dependent, type I
chr6_+_101948102 1.901


chr20_+_35583020 1.895 NM_005386
NM_181689
NNAT

neuronatin

chr4_+_72271218 1.895 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr17_-_15185623 1.885 NM_031898
TEKT3
tektin 3
chr11_-_126375864 1.868 KIRREL3
kin of IRRE like 3 (Drosophila)
chr11_-_11986704 1.858 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_-_35948150 1.852 NM_019897
OR2S2
olfactory receptor, family 2, subfamily S, member 2
chr20_+_61798512 1.847 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr20_+_61798446 1.846 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_+_201363458 1.839 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr19_+_54837181 1.834 NM_021228
SCAF1
SR-related CTD-associated factor 1
chr1_-_154484341 1.800 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr17_-_40674883 1.789


chr15_+_87540238 1.789 ABHD2
abhydrolase domain containing 2
chr9_+_135389698 1.774 NM_014694
ADAMTSL2
ADAMTS-like 2
chr13_+_30378311 1.760 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr11_+_111288669 1.747 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr6_+_160103052 1.737 ACAT2
acetyl-CoA acetyltransferase 2
chr12_-_42231990 1.713 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr9_+_112470871 1.702 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr5_-_92982927 1.689


chr11_+_19328846 1.671 NM_001111018
NAV2
neuron navigator 2
chr1_+_17817397 1.668 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_-_72228427 1.665 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr14_+_100362236 1.644 MEG3
maternally expressed 3 (non-protein coding)
chr7_+_27191534 1.640 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr11_-_126375895 1.634 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr1_-_12599934 1.625 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr22_+_35290271 1.624


chr10_-_71575953 1.620 TYSND1
trypsin domain containing 1
chr14_+_100362204 1.617 MEG3
maternally expressed 3 (non-protein coding)
chr15_+_71953020 1.610 NM_153356
TBC1D21
TBC1 domain family, member 21
chr14_+_28306633 1.606 FOXG1
forkhead box G1
chr17_-_39632845 1.600 ATXN7L3
ataxin 7-like 3
chr3_-_113841200 1.593 CCDC80
coiled-coil domain containing 80
chr1_-_152202574 1.592 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr9_+_132002692 1.585 NM_001128826
NCS1
neuronal calcium sensor 1
chr22_-_49317408 1.581 ODF3B
outer dense fiber of sperm tails 3B
chr11_+_113155727 1.580 NM_001101389
CLDN25
claudin 25
chr2_+_220033777 1.569 NM_001173476
SPEG
SPEG complex locus
chr11_-_117200618 1.560 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr15_+_58083798 1.557 FOXB1
forkhead box B1
chr12_+_52653176 1.544 NM_014212
HOXC11
homeobox C11
chr19_-_13909877 1.542 PODNL1
podocan-like 1
chr14_+_104218487 1.522


chr9_+_78824390 1.508 NM_001013735
FOXB2
forkhead box B2
chr20_-_3713509 1.496 CENPB
centromere protein B, 80kDa
chr9_+_134026836 1.493 NTNG2
netrin G2
chr4_+_76077229 1.489 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr1_-_38285033 1.464 NM_002699
POU3F1
POU class 3 homeobox 1
chrX_-_30237403 1.464 NM_000475
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr10_-_95350949 1.464 NM_006744
RBP4
retinol binding protein 4, plasma
chr17_-_34811377 1.464 NM_001184906
NM_032875
FBXL20

F-box and leucine-rich repeat protein 20

chr7_+_44110470 1.461 NM_001129
AEBP1
AE binding protein 1
chrX_-_114374860 1.460 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr5_+_147775652 1.459 FBXO38
F-box protein 38
chr2_+_233605625 1.435 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr6_+_41714171 1.431 NM_005586
MDFI
MyoD family inhibitor
chr17_-_19231049 1.428 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr7_+_47661366 1.427 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr17_-_45629401 1.427


chr13_-_98202884 1.422 NM_005073
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr12_-_131697109 1.415 NM_001195520
LOC645277
hypothetical LOC645277
chr18_+_17076166 1.412 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr11_-_65082705 1.404 LTBP3
latent transforming growth factor beta binding protein 3
chr4_-_174686918 1.383 HAND2
heart and neural crest derivatives expressed 2
chr19_-_53808505 1.377 NM_017708
FAM83E
family with sequence similarity 83, member E
chr20_-_22978141 1.376 NM_000361
THBD
thrombomodulin
chr1_+_148788410 1.370 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr9_+_123101926 1.367 GSN
gelsolin
chr12_-_3732478 1.363 EFCAB4B
EF-hand calcium binding domain 4B
chr16_+_85158357 1.358 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr11_-_27697768 1.354 NM_001143807
BDNF
brain-derived neurotrophic factor
chr15_+_98960277 1.351 NM_024708
NM_198243
ASB7

ankyrin repeat and SOCS box containing 7

chr12_-_2814410 1.350 NM_031474
NRIP2
nuclear receptor interacting protein 2
chr9_-_121171400 1.347 NM_014618
DBC1
deleted in bladder cancer 1
chr2_+_15999599 1.344 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr11_+_122806196 1.330 LOC100128242
hypothetical LOC100128242
chr3_+_45042754 1.325 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr8_-_93144366 1.310 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_-_174687104 1.295 HAND2
heart and neural crest derivatives expressed 2
chr9_+_111850698 1.290 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr21_-_27139143 1.281 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_-_66877519 1.279 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr9_-_72673753 1.272 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr8_+_70541631 1.269 SULF1
sulfatase 1
chr16_+_65790514 1.267 NM_024712
ELMO3
engulfment and cell motility 3
chr11_+_131285747 1.266 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr15_+_38520594 1.262 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr3_-_130761967 1.261 PLXND1
plexin D1
chr19_+_50004134 1.251 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr1_+_26986996 1.249 NM_017837
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr1_+_116181927 1.245 NHLH2
nescient helix loop helix 2
chr5_-_58607673 1.242 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_111287657 1.231 NM_001885
CRYAB
crystallin, alpha B
chr11_-_132318741 1.226 OPCML
opioid binding protein/cell adhesion molecule-like
chr11_-_75057062 1.226 NM_033063
NM_207577
MAP6

microtubule-associated protein 6

chr5_+_167889123 1.222


chr17_+_7549138 1.220 NM_001406
EFNB3
ephrin-B3
chr11_+_1897374 1.204 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr5_+_170779664 1.200 FGF18
fibroblast growth factor 18
chr6_+_142664490 1.198 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr17_-_77474597 1.190 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr9_-_103289154 1.187 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr15_+_58083737 1.187


chr8_-_93144039 1.185


chr2_-_236837726 1.185 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr17_+_4784524 1.177 RNF167
ring finger protein 167
chrX_+_101887562 1.172 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chr19_-_12747263 1.171 HOOK2
hook homolog 2 (Drosophila)
chr12_-_3732614 1.168 NM_001144958
NM_001144959
NM_032680
EFCAB4B


EF-hand calcium binding domain 4B


chr14_-_50631407 1.168 TRIM9
tripartite motif containing 9
chr12_-_80677223 1.167 NM_003625
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr21_-_27139563 1.167 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_217206450 1.165 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr8_-_17599438 1.164 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chrX_-_43717864 1.160 NM_000266
NDP
Norrie disease (pseudoglioma)
chr12_+_52733927 1.160 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr11_-_110917632 1.158


chr9_+_4480193 1.156 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr16_+_51722285 1.150 CHD9
chromodomain helicase DNA binding protein 9
chr12_-_51734434 1.146 LOC283335
hypothetical LOC283335
chr1_-_203657803 1.145 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr2_+_176695658 1.142 NM_014213
HOXD9
homeobox D9
chr3_+_50272648 1.139


chr10_+_119292699 1.138


chr9_+_134027154 1.137 NM_032536
NTNG2
netrin G2
chr1_+_113038202 1.136 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr3_-_166397142 1.135 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr1_+_176748834 1.134 NM_001170722
NM_001170723
NM_001170724
NM_032126
C1orf49



chromosome 1 open reading frame 49



chr21_+_39117064 1.129 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr17_-_36507900 1.129 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr14_+_102662416 1.116 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr17_+_56884560 1.112 TBX4
T-box 4
chr9_+_123101701 1.111 NM_000177
GSN
gelsolin
chr11_+_7491789 1.110 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_54786723 1.107 NM_020719
PRR12
proline rich 12
chr2_+_217206327 1.101 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr7_-_112513379 1.096 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr3_+_185580554 1.096 NM_003741
CHRD
chordin
chr15_+_72253940 1.093 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr22_-_42589543 1.086 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr12_-_80676562 1.085 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr5_+_139473873 1.084 NM_005859
PURA
purine-rich element binding protein A
chr2_+_235525355 1.078 NM_014521
SH3BP4
SH3-domain binding protein 4
chr7_-_27120015 1.075 HOXA3
homeobox A3
chr8_+_39084206 1.073 NM_145004
ADAM32
ADAM metallopeptidase domain 32
chr11_-_122571046 1.072 CLMP
CXADR-like membrane protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 8.37e-14 GO:0048856 anatomical structure development
1.42 2.40e-13 GO:0048731 system development
1.34 7.13e-13 GO:0032502 developmental process
1.60 1.38e-12 GO:0007399 nervous system development
1.57 2.00e-11 GO:0009653 anatomical structure morphogenesis
1.47 2.07e-11 GO:0048869 cellular developmental process
1.34 2.63e-11 GO:0007275 multicellular organismal development
1.47 3.72e-11 GO:0030154 cell differentiation
1.12 5.88e-10 GO:0009987 cellular process
1.71 3.81e-09 GO:0048699 generation of neurons
1.66 2.41e-08 GO:0022008 neurogenesis
1.18 3.38e-08 GO:0050794 regulation of cellular process
1.72 3.57e-07 GO:0030182 neuron differentiation
1.15 5.60e-07 GO:0065007 biological regulation
1.16 1.77e-06 GO:0050789 regulation of biological process
1.35 5.72e-06 GO:0048523 negative regulation of cellular process
1.57 6.61e-06 GO:0050793 regulation of developmental process
1.27 7.06e-06 GO:0016043 cellular component organization
1.54 8.07e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.30 1.47e-05 GO:0071842 cellular component organization at cellular level
1.94 1.59e-05 GO:0007389 pattern specification process
1.97 1.88e-05 GO:0001501 skeletal system development
1.53 4.15e-05 GO:0048468 cell development
1.59 6.67e-05 GO:2000026 regulation of multicellular organismal development
1.31 9.19e-05 GO:0048519 negative regulation of biological process
1.24 9.76e-05 GO:0071840 cellular component organization or biogenesis
1.61 1.06e-04 GO:0009790 embryo development
1.67 1.33e-04 GO:0048666 neuron development
1.27 2.00e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.23 2.03e-04 GO:0023052 signaling
1.18 2.17e-04 GO:0032501 multicellular organismal process
1.59 3.29e-04 GO:0045595 regulation of cell differentiation
1.80 4.16e-04 GO:0009792 embryo development ending in birth or egg hatching
2.02 4.46e-04 GO:0003002 regionalization
1.51 5.14e-04 GO:0009888 tissue development
1.80 5.24e-04 GO:0043009 chordate embryonic development
1.80 5.24e-04 GO:0048598 embryonic morphogenesis
2.28 5.95e-04 GO:0043062 extracellular structure organization
1.54 6.92e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.57 7.25e-04 GO:0010628 positive regulation of gene expression
1.61 7.47e-04 GO:0009887 organ morphogenesis
1.53 8.19e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.59 9.45e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.85 9.77e-04 GO:0060284 regulation of cell development
1.50 1.37e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.77 1.37e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.49 1.38e-03 GO:0009891 positive regulation of biosynthetic process
1.25 1.74e-03 GO:0048518 positive regulation of biological process
1.27 1.87e-03 GO:0048522 positive regulation of cellular process
1.34 1.89e-03 GO:0023051 regulation of signaling
1.69 1.92e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.56 2.13e-03 GO:0030030 cell projection organization
1.52 2.16e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.55 2.30e-03 GO:0051254 positive regulation of RNA metabolic process
1.69 2.98e-03 GO:0007409 axonogenesis
1.42 3.00e-03 GO:0010646 regulation of cell communication
2.14 3.55e-03 GO:0009952 anterior/posterior pattern formation
1.30 3.59e-03 GO:0048513 organ development
1.70 3.72e-03 GO:0009968 negative regulation of signal transduction
1.63 3.88e-03 GO:0031175 neuron projection development
1.85 4.14e-03 GO:0051960 regulation of nervous system development
1.85 4.14e-03 GO:0061061 muscle structure development
1.77 4.65e-03 GO:0015672 monovalent inorganic cation transport
1.62 5.18e-03 GO:0048585 negative regulation of response to stimulus
1.77 5.26e-03 GO:0007411 axon guidance
1.62 5.88e-03 GO:0030001 metal ion transport
2.25 6.29e-03 GO:0042692 muscle cell differentiation
1.65 6.33e-03 GO:0023057 negative regulation of signaling
1.99 7.00e-03 GO:0045664 regulation of neuron differentiation
1.65 7.02e-03 GO:0010648 negative regulation of cell communication
1.66 7.08e-03 GO:0032583 regulation of gene-specific transcription
1.65 7.79e-03 GO:0048812 neuron projection morphogenesis
1.88 8.30e-03 GO:0050767 regulation of neurogenesis
1.56 8.98e-03 GO:0006812 cation transport
1.62 9.12e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.00 9.52e-03 GO:0048732 gland development
2.59 9.69e-03 GO:0048706 embryonic skeletal system development
1.44 1.16e-02 GO:0006811 ion transport
1.60 1.16e-02 GO:0000904 cell morphogenesis involved in differentiation
1.34 1.41e-02 GO:0009966 regulation of signal transduction
1.66 1.55e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.35 2.21e-02 GO:0051239 regulation of multicellular organismal process
1.57 2.46e-02 GO:0032990 cell part morphogenesis
1.59 2.74e-02 GO:0072358 cardiovascular system development
1.59 2.74e-02 GO:0072359 circulatory system development
4.32 2.74e-02 GO:0060425 lung morphogenesis
1.50 2.79e-02 GO:0032989 cellular component morphogenesis
3.78 2.79e-02 GO:0009954 proximal/distal pattern formation
2.13 3.10e-02 GO:0060537 muscle tissue development
1.57 3.79e-02 GO:0019226 transmission of nerve impulse
1.57 3.79e-02 GO:0035637 multicellular organismal signaling
2.05 4.74e-02 GO:0045165 cell fate commitment
1.82 4.79e-02 GO:0048568 embryonic organ development
3.14 4.96e-02 GO:0051149 positive regulation of muscle cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.69 1.81e-06 GO:0030054 cell junction
1.31 2.14e-05 GO:0044459 plasma membrane part
2.00 2.45e-04 GO:0034702 ion channel complex
2.27 2.71e-04 GO:0034703 cation channel complex
2.11 1.52e-03 GO:0005912 adherens junction
2.05 1.53e-03 GO:0070161 anchoring junction
2.45 2.21e-03 GO:0016585 chromatin remodeling complex
1.63 3.92e-03 GO:0045202 synapse
1.20 6.08e-03 GO:0043234 protein complex
1.61 1.15e-02 GO:0031012 extracellular matrix
1.65 1.93e-02 GO:0005578 proteinaceous extracellular matrix
1.64 3.72e-02 GO:0044456 synapse part
2.14 4.43e-02 GO:0005925 focal adhesion

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.66 8.27e-07 GO:0043565 sequence-specific DNA binding
1.49 1.95e-05 GO:0030528 transcription regulator activity
1.46 9.79e-05 GO:0001071 nucleic acid binding transcription factor activity
1.46 9.79e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.13 1.01e-04 GO:0005515 protein binding
1.08 1.45e-04 GO:0005488 binding
2.21 6.52e-04 GO:0022843 voltage-gated cation channel activity
1.75 1.92e-03 GO:0016563 transcription activator activity
1.89 1.41e-02 GO:0005244 voltage-gated ion channel activity
1.89 1.41e-02 GO:0022832 voltage-gated channel activity
1.48 3.26e-02 GO:0008324 cation transmembrane transporter activity
1.70 3.56e-02 GO:0005261 cation channel activity
1.65 3.90e-02 GO:0022836 gated channel activity