Motif ID: ZIC1..3.p2

Z-value: 3.006


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486105160.777.1e-04Click!
ZIC3chrX_+_1364763530.611.6e-02Click!
ZIC2chr13_+_994322580.381.7e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_85169615 6.303 NM_005250
 FOXL1
forkhead box L1
chr10_-_90702490 5.907 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_-_13910167 5.031 NM_024825
 PODNL1
podocan-like 1
chr3_-_73756668 5.002 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr12_-_50871953 4.330 NM_001081492
NM_182507
 KRT80

keratin 80

chr3_+_64645819 3.745 LOC100507098
hypothetical LOC100507098
chr17_-_72045218 3.182 NM_134268
 CYGB
cytoglobin
chr16_+_66244314 3.172 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr21_-_26867138 3.164 NM_052954
 CYYR1
cysteine/tyrosine-rich 1
chr7_-_27191287 2.932 NM_005523
 HOXA11
homeobox A11
chr5_+_131437383 2.921 NM_000758
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr22_-_36153449 2.897 NM_052906
 ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr7_-_27180398 2.887 NM_018951
 HOXA10
homeobox A10
chr3_+_50281582 2.852 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_-_168660293 2.832 NM_003062
 SLIT3
slit homolog 3 (Drosophila)
chr6_-_112001590 2.817 NM_001164282
 TRAF3IP2
TRAF3 interacting protein 2
chr10_+_75343352 2.719 PLAU
plasminogen activator, urokinase
chr1_-_21478571 2.711 NM_001113347
 ECE1
endothelin converting enzyme 1
chr5_+_175725050 2.677 NM_173664
 ARL10
ADP-ribosylation factor-like 10
chr22_-_49063088 2.620 PLXNB2
plexin B2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 94 entries
enrichment   p-value GO term description
4.32 2.74e-02 GO:0060425 lung morphogenesis
3.78 2.79e-02 GO:0009954 proximal/distal pattern formation
3.14 4.96e-02 GO:0051149 positive regulation of muscle cell differentiation
2.59 9.69e-03 GO:0048706 embryonic skeletal system development
2.28 5.95e-04 GO:0043062 extracellular structure organization
2.25 6.29e-03 GO:0042692 muscle cell differentiation
2.14 3.55e-03 GO:0009952 anterior/posterior pattern formation
2.13 3.10e-02 GO:0060537 muscle tissue development
2.05 4.74e-02 GO:0045165 cell fate commitment
2.02 4.46e-04 GO:0003002 regionalization
2.00 9.52e-03 GO:0048732 gland development
1.99 7.00e-03 GO:0045664 regulation of neuron differentiation
1.97 1.88e-05 GO:0001501 skeletal system development
1.94 1.59e-05 GO:0007389 pattern specification process
1.88 8.30e-03 GO:0050767 regulation of neurogenesis
1.85 9.77e-04 GO:0060284 regulation of cell development
1.85 4.14e-03 GO:0051960 regulation of nervous system development
1.85 4.14e-03 GO:0061061 muscle structure development
1.82 4.79e-02 GO:0048568 embryonic organ development
1.80 4.16e-04 GO:0009792 embryo development ending in birth or egg hatching

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.45 2.21e-03 GO:0016585 chromatin remodeling complex
2.27 2.71e-04 GO:0034703 cation channel complex
2.14 4.43e-02 GO:0005925 focal adhesion
2.11 1.52e-03 GO:0005912 adherens junction
2.05 1.53e-03 GO:0070161 anchoring junction
2.00 2.45e-04 GO:0034702 ion channel complex
1.69 1.81e-06 GO:0030054 cell junction
1.65 1.93e-02 GO:0005578 proteinaceous extracellular matrix
1.64 3.72e-02 GO:0044456 synapse part
1.63 3.92e-03 GO:0045202 synapse
1.61 1.15e-02 GO:0031012 extracellular matrix
1.31 2.14e-05 GO:0044459 plasma membrane part
1.20 6.08e-03 GO:0043234 protein complex

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.21 6.52e-04 GO:0022843 voltage-gated cation channel activity
1.89 1.41e-02 GO:0005244 voltage-gated ion channel activity
1.89 1.41e-02 GO:0022832 voltage-gated channel activity
1.75 1.92e-03 GO:0016563 transcription activator activity
1.70 3.56e-02 GO:0005261 cation channel activity
1.66 8.27e-07 GO:0043565 sequence-specific DNA binding
1.65 3.90e-02 GO:0022836 gated channel activity
1.49 1.95e-05 GO:0030528 transcription regulator activity
1.48 3.26e-02 GO:0008324 cation transmembrane transporter activity
1.46 9.79e-05 GO:0001071 nucleic acid binding transcription factor activity
1.46 9.79e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.13 1.01e-04 GO:0005515 protein binding
1.08 1.45e-04 GO:0005488 binding