Motif ID: ZNF423.p2

Z-value: 1.921


Transcription factors associated with ZNF423.p2:

Gene SymbolEntrez IDGene Name
ZNF423 23090 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZNF423chr16_-_48418418-0.468.4e-02Click!


Activity profile for motif ZNF423.p2.

activity profile for motif ZNF423.p2


Sorted Z-values histogram for motif ZNF423.p2

Sorted Z-values for motif ZNF423.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_1993022 1.820 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr19_-_1992862 1.696 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr10_-_134940315 1.593 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr9_-_139068269 1.391 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr19_+_19510056 1.257 NM_153221
CILP2
cartilage intermediate layer protein 2
chr17_-_975809 1.243 ABR
active BCR-related gene
chr11_-_60819273 1.230 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr20_-_21326046 1.186 NM_033176
NKX2-4
NK2 homeobox 4
chrX_-_102205736 1.142 BEX1
brain expressed, X-linked 1
chr21_+_45699830 1.135 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr11_-_60819110 1.082 VWCE
von Willebrand factor C and EGF domains
chr19_+_19510098 1.079 CILP2
cartilage intermediate layer protein 2
chr22_-_49062461 1.063 PLXNB2
plexin B2
chr11_-_431956 1.045 ANO9
anoctamin 9
chr10_+_135190855 1.029 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr3_+_13496714 1.015 NM_024827
NM_001136041
HDAC11

histone deacetylase 11

chr16_+_170334 0.966 NM_005331
HBQ1
hemoglobin, theta 1
chr1_-_38285033 0.958 NM_002699
POU3F1
POU class 3 homeobox 1
chr1_+_226261374 0.948 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr10_+_3099708 0.943 NM_002627
PFKP
phosphofructokinase, platelet
chr19_-_18409971 0.931 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chrX_+_122922058 0.920 NM_001042749
STAG2
stromal antigen 2
chr20_+_61838479 0.915 LIME1
Lck interacting transmembrane adaptor 1
chr10_-_108914277 0.911 NM_001013031
NM_052918
SORCS1

sortilin-related VPS10 domain containing receptor 1

chr11_-_431995 0.911 NM_001012302
ANO9
anoctamin 9
chr19_-_41083288 0.908 NM_139239
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr17_-_33178987 0.902 HNF1B
HNF1 homeobox B
chr19_-_18409788 0.900 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr18_+_12244317 0.885 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr16_+_2954217 0.879 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr11_-_2248374 0.874 ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr19_-_4017739 0.866 NM_015898
ZBTB7A
zinc finger and BTB domain containing 7A
chr15_-_81113676 0.863 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr8_+_22479115 0.857 NM_001018003
SORBS3
sorbin and SH3 domain containing 3
chr20_-_25010756 0.854 NM_014588
NM_199425
VSX1

visual system homeobox 1

chr17_-_35017650 0.842 NEUROD2
neurogenic differentiation 2
chr6_-_3172775 0.840 NM_178012
TUBB2B
tubulin, beta 2B
chr5_+_170668892 0.827 NM_021025
TLX3
T-cell leukemia homeobox 3
chr9_+_134027154 0.816 NM_032536
NTNG2
netrin G2
chr19_-_5291700 0.815 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr17_-_35017691 0.808 NM_006160
NEUROD2
neurogenic differentiation 2
chr17_-_10042579 0.803 NM_201433
GAS7
growth arrest-specific 7
chr11_+_92342436 0.801 NM_005959
MTNR1B
melatonin receptor 1B
chr22_-_36153449 0.795 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr20_+_61838389 0.790 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr4_+_61749540 0.779 LPHN3
latrophilin 3
chr17_+_69950782 0.774 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_-_144991386 0.772 ZEB2
zinc finger E-box binding homeobox 2
chr10_+_88770025 0.772 NM_001146157
FAM25A
family with sequence similarity 25, member A
chr11_+_72696963 0.764 ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr19_-_44214707 0.762


chr4_-_154929657 0.760 NM_003013
SFRP2
secreted frizzled-related protein 2
chr13_+_95541093 0.755 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr22_-_42589543 0.753 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr1_-_6502655 0.749 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_226530350 0.745


chr1_-_27825178 0.743 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr7_+_75977680 0.735 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr11_+_65536037 0.735 NM_001323
CST6
cystatin E/M
chr21_-_45786709 0.718 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr19_+_11770360 0.717 NM_152356
ZNF491
zinc finger protein 491
chr20_+_43531806 0.715 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr16_+_53915971 0.715 NM_024335
IRX6
iroquois homeobox 6
chr5_-_179162480 0.706 NM_054013
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr11_+_61352348 0.701 FADS2
fatty acid desaturase 2
chr3_+_185430910 0.698 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr3_+_123385870 0.692 NM_001178065
CASR
calcium-sensing receptor
chr19_-_44214972 0.691 NM_178820
FBXO27
F-box protein 27
chr19_-_11550576 0.691 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr19_-_60557875 0.691 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr3_+_198214173 0.690 LOC100507057
MFI2
hypothetical LOC100507057
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr9_+_134026836 0.688 NTNG2
netrin G2
chr14_-_22891865 0.678 NM_016609
SLC22A17
solute carrier family 22, member 17
chr14_-_76807302 0.678 NM_021257
NGB
neuroglobin
chr11_-_44928803 0.676 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr16_+_2461500 0.674 NM_006181
NTN3
netrin 3
chr11_+_72697310 0.672 NM_014786
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr7_-_1562272 0.670 NM_001097620
TMEM184A
transmembrane protein 184A
chr5_+_68823874 0.670 NM_002538
OCLN
occludin
chr8_-_11742668 0.669


chr15_+_62230962 0.666 NM_024798
SNX22
sorting nexin 22
chr17_+_74531873 0.665 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr5_-_79901838 0.663 ANKRD34B
ankyrin repeat domain 34B
chr19_-_11550765 0.662 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr10_-_121286034 0.660 NM_002925
RGS10
regulator of G-protein signaling 10
chr19_+_14108974 0.658


chr16_+_2071631 0.657 TSC2
tuberous sclerosis 2
chr3_-_49732062 0.655 NM_198722
AMIGO3
adhesion molecule with Ig-like domain 3
chr9_-_109290107 0.645 KLF4
Kruppel-like factor 4 (gut)
chr2_+_14690260 0.636 NM_145175
FAM84A
family with sequence similarity 84, member A
chr4_+_4438883 0.634 NM_001040101
NM_014392
D4S234E

DNA segment on chromosome 4 (unique) 234 expressed sequence

chr7_+_6622051 0.628 NM_017560
ZNF853
zinc finger protein 853
chr4_-_44145266 0.624 KCTD8
potassium channel tetramerisation domain containing 8
chr17_-_18848713 0.624 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr2_-_144991556 0.622 ZEB2
zinc finger E-box binding homeobox 2
chr9_+_139239464 0.622 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr20_+_61654816 0.619 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr19_-_1763198 0.611 NM_001178002
NM_138813
ATP8B3

ATPase, aminophospholipid transporter, class I, type 8B, member 3

chr8_+_65656164 0.607 BHLHE22
basic helix-loop-helix family, member e22
chr8_-_65873658 0.603 NM_004820
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr1_+_1256585 0.598 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr16_+_69950116 0.598 NM_001740
NM_007088
CALB2

calbindin 2

chr15_-_88095363 0.597 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr22_+_20067662 0.595 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr15_-_77169894 0.595 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr7_+_103756339 0.590 NM_199000
LHFPL3
lipoma HMGIC fusion partner-like 3
chr1_-_2333800 0.589 PEX10
peroxisomal biogenesis factor 10
chr11_+_61352209 0.589 NM_004265
FADS2
fatty acid desaturase 2
chr17_+_1574583 0.584 NM_001163811
WDR81
WD repeat domain 81
chr19_+_40716153 0.583 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr17_+_45993338 0.575 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr19_-_5573794 0.575 NM_014649
SAFB2
scaffold attachment factor B2
chr1_-_23623713 0.573 NM_003196
TCEA3
transcription elongation factor A (SII), 3
chr3_-_48569213 0.571 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr8_+_145137354 0.571 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr19_-_51081147 0.570 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr17_+_7402788 0.566 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_117173004 0.565 DSCAML1
Down syndrome cell adhesion molecule like 1
chr7_-_5536783 0.562 ACTB
actin, beta
chr11_+_17714070 0.559 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr19_-_1997229 0.559 MKNK2
MAP kinase interacting serine/threonine kinase 2
chrX_-_3274680 0.559 NM_015419
MXRA5
matrix-remodelling associated 5
chr6_-_88932485 0.555 NM_001160226
NM_001160258
NM_001160259
NM_016083
CNR1



cannabinoid receptor 1 (brain)



chr5_+_68824143 0.552 OCLN
occludin
chr7_-_5536704 0.552 NM_001101
ACTB
actin, beta
chr1_-_2333863 0.552 NM_002617
NM_153818
PEX10

peroxisomal biogenesis factor 10

chr2_-_42574587 0.551 NM_133329
NM_172344
KCNG3

potassium voltage-gated channel, subfamily G, member 3

chr17_+_73738985 0.549 NM_001145529
TMEM235
transmembrane protein 235
chr16_-_56389176 0.547 NM_001130099
KIFC3
kinesin family member C3
chr1_-_202387767 0.546 NM_018208
ETNK2
ethanolamine kinase 2
chr16_+_639278 0.545 NM_145294
WDR90
WD repeat domain 90
chr14_+_103674812 0.542 NM_015656
KIF26A
kinesin family member 26A
chr1_-_181826086 0.540 NCF2
neutrophil cytosolic factor 2
chr11_-_494887 0.540 RNH1
ribonuclease/angiogenin inhibitor 1
chr17_-_37144408 0.539 NM_001079870
NM_001079871
NM_177977
HAP1


huntingtin-associated protein 1


chr9_+_139892049 0.534 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr14_-_67051773 0.534 NM_182526
TMEM229B
transmembrane protein 229B
chr1_+_14797764 0.530 NM_015209
NM_201628
KAZN

kazrin, periplakin interacting protein

chr11_-_67028415 0.528 PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr5_-_1498510 0.527 NM_001044
SLC6A3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
chr22_+_35586950 0.526 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr10_-_120345148 0.525 NM_004248
PRLHR
prolactin releasing hormone receptor
chr9_-_16860719 0.525 NM_017637
BNC2
basonuclin 2
chr17_+_8865547 0.522 NM_004822
NTN1
netrin 1
chr11_+_65792603 0.516 NM_030981
RAB1B
RAB1B, member RAS oncogene family
chr19_+_6415259 0.516 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr16_+_69950138 0.515 CALB2
calbindin 2
chr6_+_39868126 0.514 DAAM2
dishevelled associated activator of morphogenesis 2
chr19_-_4054200 0.510 MAP2K2
mitogen-activated protein kinase kinase 2
chr22_+_48740432 0.508 PIM3
pim-3 oncogene
chr7_-_156495985 0.507 NM_005515
MNX1
motor neuron and pancreas homeobox 1
chr20_-_61600834 0.506 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr17_-_33179118 0.506 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr11_+_60448487 0.505 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr2_-_120697441 0.504 TMEM185B
transmembrane protein 185B (pseudogene)
chr1_+_35019376 0.504 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr16_-_2186465 0.502 NM_020764
CASKIN1
CASK interacting protein 1
chr19_+_49866563 0.500 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr19_-_6410735 0.498 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr20_+_41978195 0.498 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr17_-_77394872 0.498 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr22_+_28446288 0.497 NM_182527
CABP7
calcium binding protein 7
chr16_-_626293 0.496 NM_001040160
NM_001040161
NM_001040162
NM_001040165
NM_032366
C16orf13




chromosome 16 open reading frame 13




chr6_+_39868116 0.495


chr19_+_4591028 0.495 NM_001167942
TNFAIP8L1
tumor necrosis factor, alpha-induced protein 8-like 1
chr11_-_61415429 0.489 NM_021727
FADS3
fatty acid desaturase 3
chr6_+_30238961 0.489 NM_033229
TRIM15
tripartite motif containing 15
chr10_-_118022965 0.487 NM_005264
GFRA1
GDNF family receptor alpha 1
chr2_+_202607554 0.485 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr20_-_61356247 0.483 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr12_-_42231990 0.482 NM_025003
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr11_+_834111 0.481 TSPAN4
tetraspanin 4
chr19_+_17440577 0.478 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr22_-_18841785 0.475 NM_015672
RIMBP3
RIMS binding protein 3
chr2_-_120697382 0.474 TMEM185B
transmembrane protein 185B (pseudogene)
chr10_-_46601687 0.473 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr10_+_47867667 0.469 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr8_-_11361594 0.468 NM_053279
FAM167A
family with sequence similarity 167, member A
chr2_-_233060774 0.467 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr10_-_76538859 0.466 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr17_+_74531820 0.463 NM_030968
NM_198594
C1QTNF1

C1q and tumor necrosis factor related protein 1

chr22_-_20235749 0.460 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr19_+_2792432 0.457 NM_001172775
NM_152791
ZNF555

zinc finger protein 555

chr9_-_139043035 0.457 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr19_+_18391423 0.457


chr22_-_41375232 0.456 CYB5R3
cytochrome b5 reductase 3
chr17_-_2187427 0.452 NM_018128
TSR1
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
chr20_-_55274497 0.452 BMP7
bone morphogenetic protein 7
chr13_+_113587674 0.452 GAS6
growth arrest-specific 6
chr16_-_31135895 0.448 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr2_-_230641862 0.448 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr14_+_23508922 0.447 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr3_-_129024665 0.447 NM_001003794
MGLL
monoglyceride lipase
chr4_+_4439618 0.446 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr5_+_32747194 0.442 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr10_-_76665691 0.442 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr11_+_46359855 0.435 MDK
midkine (neurite growth-promoting factor 2)
chr3_-_129690056 0.434 NM_001145661
GATA2
GATA binding protein 2
chr14_+_91859904 0.432 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr13_-_27572646 0.431 NM_004119
FLT3
fms-related tyrosine kinase 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.67 3.36e-09 GO:0007399 nervous system development
1.33 1.01e-06 GO:0032502 developmental process
1.18 3.07e-06 GO:0065007 biological regulation
1.38 4.27e-06 GO:0048731 system development
1.33 5.38e-06 GO:0007275 multicellular organismal development
1.20 7.60e-06 GO:0050794 regulation of cellular process
1.34 1.48e-05 GO:0048856 anatomical structure development
1.19 2.13e-05 GO:0050789 regulation of biological process
1.41 2.50e-04 GO:0030154 cell differentiation
1.39 4.03e-04 GO:0048869 cellular developmental process
1.25 3.19e-03 GO:0023052 signaling
1.39 3.32e-03 GO:0007166 cell surface receptor linked signaling pathway
1.58 3.64e-03 GO:0022008 neurogenesis
1.27 4.23e-03 GO:0007165 signal transduction
1.23 8.58e-03 GO:0051716 cellular response to stimulus
1.42 9.97e-03 GO:0009653 anatomical structure morphogenesis
1.18 3.67e-02 GO:0032501 multicellular organismal process
1.59 4.66e-02 GO:0030182 neuron differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 4.99e-06 GO:0005886 plasma membrane
1.27 5.25e-06 GO:0071944 cell periphery
1.40 1.27e-05 GO:0044459 plasma membrane part
1.72 2.14e-02 GO:0045202 synapse
1.74 2.28e-02 GO:0031012 extracellular matrix
1.12 4.44e-02 GO:0016020 membrane

Nothing significant found in function category.