Motif ID: HMX1.p2

Z-value: 1.719


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_131286513 2.420 NTM
neurotrimin
chr19_+_58750305 2.309 NM_001079907
ZNF331
zinc finger protein 331
chr18_+_12244317 2.174 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr11_+_69602055 1.877 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr14_+_62740878 1.733 NM_020663
RHOJ
ras homolog gene family, member J
chr3_-_112796855 1.673 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr1_+_154478574 1.599 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr5_-_172594691 1.562 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr11_-_407324 1.550 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr17_-_72045218 1.485 NM_134268
CYGB
cytoglobin
chr8_+_120497732 1.374 NM_002514
NOV
nephroblastoma overexpressed gene
chr17_-_7106497 1.301 CLDN7
claudin 7
chr12_-_47604930 1.300 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chrX_-_131918905 1.275 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr1_+_17719405 1.269 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr18_-_44189625 1.247 ZBTB7C
zinc finger and BTB domain containing 7C
chr17_-_40695216 1.246 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr5_-_139992621 1.240 NM_000591
CD14
CD14 molecule
chr8_+_31616809 1.235 NM_013962
NRG1
neuregulin 1
chr20_+_13150417 1.214 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr8_+_24828359 1.199 NM_001105541
NEFM
neurofilament, medium polypeptide
chr14_+_73073570 1.193 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr21_-_38954433 1.191 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr2_-_133144094 1.186 LYPD1
LY6/PLAUR domain containing 1
chr20_-_21442663 1.182 NM_002509
NKX2-2
NK2 homeobox 2
chr17_-_45427565 1.177 NM_005220
DLX3
distal-less homeobox 3
chr7_-_16811131 1.174 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr1_-_86394695 1.172 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr16_-_85099941 1.166 LOC400550
hypothetical LOC400550
chr5_-_81082699 1.163 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr1_+_151917674 1.147 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr17_+_77582774 1.115 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr11_+_7574992 1.107 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr14_-_50631407 1.099 TRIM9
tripartite motif containing 9
chr9_-_109290107 1.088 KLF4
Kruppel-like factor 4 (gut)
chr19_+_58733144 1.066 NM_001079906
ZNF331
zinc finger protein 331
chr17_-_7106987 1.060 NM_001185023
NM_001307
CLDN7

claudin 7

chr19_-_11352850 1.060 EPOR
erythropoietin receptor
chr2_-_219633481 1.053 NM_002181
IHH
Indian hedgehog
chr3_-_173648896 1.044 NM_004122
NM_198407
GHSR

growth hormone secretagogue receptor

chr13_+_42046182 1.041 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr11_-_117305277 1.036 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr4_-_17392232 1.033 NM_015688
FAM184B
family with sequence similarity 184, member B
chr5_-_168660293 1.023 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr16_+_84204424 1.023 NM_014615
KIAA0182
KIAA0182
chr21_-_31853160 1.022 NM_003253
TIAM1
T-cell lymphoma invasion and metastasis 1
chr16_+_23101538 1.012 NM_001039
SCNN1G
sodium channel, nonvoltage-gated 1, gamma
chr8_-_24828134 0.999 NEFM
neurofilament, medium polypeptide
chr6_+_36752244 0.979 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr5_-_115180221 0.977 NM_001801
CDO1
cysteine dioxygenase, type I
chr13_+_24152548 0.974 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr22_-_49063088 0.970 PLXNB2
plexin B2
chr16_+_666075 0.965 NM_003961
RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr14_-_100104014 0.965 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr6_+_30002084 0.960


chr21_-_27261276 0.946 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr15_-_66511488 0.946 NM_001004439
ITGA11
integrin, alpha 11
chr8_-_26780665 0.938 ADRA1A
adrenergic, alpha-1A-, receptor
chr11_+_66827563 0.933 SSH3
slingshot homolog 3 (Drosophila)
chr15_+_82113813 0.922 NM_207517
ADAMTSL3
ADAMTS-like 3
chr3_+_10832867 0.907 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr9_-_139068269 0.886 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr7_-_155294518 0.880 SHH
sonic hedgehog
chr3_-_11736946 0.878 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr18_-_55091596 0.875 NM_013435
RAX
retina and anterior neural fold homeobox
chr8_-_26780645 0.859


chr20_+_43531806 0.858 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr11_+_128751044 0.855 NM_003658
BARX2
BARX homeobox 2
chr1_-_215377718 0.843 NM_001134285
ESRRG
estrogen-related receptor gamma
chr2_-_73350103 0.842 NM_001080410
FBXO41
F-box protein 41
chr19_-_63643400 0.836 NM_003433
ZNF132
zinc finger protein 132
chr22_-_37598176 0.828 NM_014292
CBX6
chromobox homolog 6
chr22_-_37598160 0.827 CBX6
chromobox homolog 6
chr2_-_26717713 0.826 NM_001029881
CIB4
calcium and integrin binding family member 4
chr1_+_201711578 0.825 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr11_+_93394025 0.823 NM_001098672
HEPHL1
hephaestin-like 1
chr2_-_53940571 0.821 NM_001164165
NM_006794
GPR75-ASB3
GPR75
GPR75-ASB3 read-through transcript
G protein-coupled receptor 75
chr19_-_62912347 0.814 NM_001085384
ZNF154
zinc finger protein 154
chr15_+_30797466 0.811 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr16_-_66827449 0.808 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr6_-_150253729 0.800 NM_139165
RAET1E
retinoic acid early transcript 1E
chr17_+_19255083 0.797 NM_007148
RNF112
ring finger protein 112
chr11_-_128399218 0.795 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr10_-_105604942 0.792 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr14_+_61653827 0.792 FLJ43390
hypothetical LOC646113
chr11_+_66827494 0.773 NM_017857
SSH3
slingshot homolog 3 (Drosophila)
chr19_-_50977586 0.769 DMPK
dystrophia myotonica-protein kinase
chr4_-_78038025 0.769 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr8_-_74167886 0.766 NM_153225
C8orf84
chromosome 8 open reading frame 84
chr17_+_19853200 0.757 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr9_-_34554800 0.753 CNTFR
ciliary neurotrophic factor receptor
chr22_-_37598115 0.753 CBX6
chromobox homolog 6
chr9_-_84867604 0.751 RASEF
RAS and EF-hand domain containing
chr6_-_40663089 0.746 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr19_-_50977592 0.738 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr15_-_80123935 0.737 MEX3B
mex-3 homolog B (C. elegans)
chr12_-_15265490 0.734 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr17_+_21220260 0.730 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr14_+_41146513 0.728 NM_152447
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr6_-_112001590 0.727 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr19_-_360138 0.727 NM_001136263
C2CD4C
C2 calcium-dependent domain containing 4C
chr1_+_15446354 0.722 NM_052929
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr20_-_9767406 0.720 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr11_+_66547391 0.718 NM_177963
SYT12
synaptotagmin XII
chr8_+_121206478 0.713 NM_021110
COL14A1
collagen, type XIV, alpha 1
chr13_-_37341859 0.712 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr11_+_1367665 0.706 NM_003957
BRSK2
BR serine/threonine kinase 2
chr13_-_83354425 0.705 SLITRK1
SLIT and NTRK-like family, member 1
chr4_+_91267706 0.700 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr8_+_26427378 0.700 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr5_-_115938305 0.696 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr9_-_10602722 0.688 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr11_-_67032125 0.687 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr7_+_80145461 0.686 CD36
CD36 molecule (thrombospondin receptor)
chr19_-_5802420 0.685 NM_000149
NM_001097639
NM_001097640
NM_001097641
FUT3



fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)



chr13_-_83354474 0.683 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr12_+_52634950 0.679 NM_173860
HOXC12
homeobox C12
chr1_+_226937732 0.673 RHOU
ras homolog gene family, member U
chrX_-_69186506 0.672 NM_001002254
AWAT2
acyl-CoA wax alcohol acyltransferase 2
chr3_+_54131613 0.670 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr7_-_143523582 0.668 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr8_-_23619866 0.664 NM_001136271
NKX2-6
NK2 transcription factor related, locus 6 (Drosophila)
chr2_-_135193011 0.662 NM_030923
TMEM163
transmembrane protein 163
chr17_-_76064842 0.661 NM_002522
NPTX1
neuronal pentraxin I
chr6_-_41781655 0.657 TFEB
transcription factor EB
chr5_+_170779664 0.650 FGF18
fibroblast growth factor 18
chr6_-_166641860 0.649 NM_175922
PRR18
proline rich 18
chr1_+_201711505 0.644 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr1_-_236120844 0.640 NM_021186
ZP4
zona pellucida glycoprotein 4
chr1_-_55039458 0.638 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr9_-_23811477 0.636 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_-_126414252 0.633 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr21_+_45699830 0.628 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr17_-_6887965 0.628 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr12_+_99712504 0.625 NM_178826
ANO4
anoctamin 4
chr10_+_94811010 0.621 NM_183374
CYP26C1
cytochrome P450, family 26, subfamily C, polypeptide 1
chr17_-_35911340 0.620 NM_032865
TNS4
tensin 4
chr4_+_81325447 0.619 NM_020226
PRDM8
PR domain containing 8
chr4_+_148621694 0.618 EDNRA
endothelin receptor type A
chr15_+_45263517 0.618 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr11_+_66381077 0.618 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr12_+_93066370 0.610 NM_005761
PLXNC1
plexin C1
chr5_-_24680841 0.610 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr17_+_7402788 0.606 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr14_-_76807302 0.605 NM_021257
NGB
neuroglobin
chr1_-_159325977 0.603 NM_030916
PVRL4
poliovirus receptor-related 4
chr5_+_146594718 0.603 NM_001112724
NM_145001
STK32A

serine/threonine kinase 32A

chr12_-_29827952 0.602 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr4_+_156900053 0.601 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr12_+_120840829 0.601 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr6_+_41714171 0.601 NM_005586
MDFI
MyoD family inhibitor
chr5_+_68746694 0.599 NM_001038603
MARVELD2
MARVEL domain containing 2
chr4_-_73653331 0.598 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr12_-_94708477 0.593 NTN4
netrin 4
chr13_+_40929525 0.593 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr16_-_17472238 0.591 NM_022166
XYLT1
xylosyltransferase I
chr21_-_41801946 0.591 TMPRSS2
transmembrane protease, serine 2
chr14_-_24173205 0.591 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr13_+_40929690 0.591 C13orf15
chromosome 13 open reading frame 15
chr7_-_131911768 0.587 PLXNA4
plexin A4
chr1_+_31855873 0.581 NM_001525
HCRTR1
hypocretin (orexin) receptor 1
chr7_-_155297576 0.581 NM_000193
SHH
sonic hedgehog
chr5_-_141981083 0.579 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr15_+_87147667 0.576 NM_001135
NM_013227
ACAN

aggrecan

chr6_+_7672009 0.573 NM_001718
BMP6
bone morphogenetic protein 6
chr18_+_54682261 0.572 ZNF532
zinc finger protein 532
chr10_+_83625049 0.568 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr15_-_50869379 0.568 NM_004498
ONECUT1
one cut homeobox 1
chr2_-_101370355 0.566 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr3_+_11171213 0.565 NM_001098212
HRH1
histamine receptor H1
chr19_-_50977485 0.562 DMPK
dystrophia myotonica-protein kinase
chr19_-_61874934 0.562 ZNF835
zinc finger protein 835
chr21_-_41801778 0.561 NM_001135099
TMPRSS2
transmembrane protease, serine 2
chr19_+_63599268 0.560 NM_001195135
LOC646862
hypothetical protein LOC646862
chr7_+_96473225 0.558 NM_005222
DLX6
distal-less homeobox 6
chr13_+_40929679 0.557 C13orf15
chromosome 13 open reading frame 15
chr1_+_32703225 0.556 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chr7_+_129919330 0.554 MEST
mesoderm specific transcript homolog (mouse)
chr12_-_47679176 0.552 NM_015086
DDN
dendrin
chr11_+_66580861 0.549 NM_014578
RHOD
ras homolog gene family, member D
chr4_-_8211335 0.547 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr17_-_15185623 0.546 NM_031898
TEKT3
tektin 3
chr7_-_19151509 0.545 NM_152898
FERD3L
Fer3-like (Drosophila)
chr3_+_214668 0.545


chr19_+_52215982 0.542 NM_002517
NPAS1
neuronal PAS domain protein 1
chr15_-_86600658 0.538 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr4_-_142273881 0.537 NM_020724
RNF150
ring finger protein 150
chr21_-_41801950 0.537 NM_005656
TMPRSS2
transmembrane protease, serine 2
chr2_-_101370291 0.536 CREG2
cellular repressor of E1A-stimulated genes 2
chr22_+_49128639 0.535 PPP6R2
protein phosphatase 6, regulatory subunit 2
chr19_+_53747233 0.531 NM_177973
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr19_-_10558906 0.528 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr14_-_73106243 0.526


chr4_+_54660954 0.525 NM_133267
GSX2
GS homeobox 2
chr8_-_119703361 0.525 NM_001101676
NM_207506
SAMD12

sterile alpha motif domain containing 12

chr4_-_177950658 0.524 NM_005429
VEGFC
vascular endothelial growth factor C
chrX_-_19815370 0.524 SH3KBP1
SH3-domain kinase binding protein 1
chr7_+_143683365 0.524 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr6_+_19946591 0.523


chr4_+_94969064 0.521 NM_005172
ATOH1
atonal homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.53 2.68e-10 GO:0030154 cell differentiation
1.50 2.65e-09 GO:0048869 cellular developmental process
1.59 9.81e-09 GO:0007399 nervous system development
1.77 1.55e-08 GO:0022008 neurogenesis
1.76 1.12e-07 GO:0048699 generation of neurons
1.73 1.41e-07 GO:0048468 cell development
1.99 6.85e-07 GO:0000904 cell morphogenesis involved in differentiation
2.03 1.29e-06 GO:0051094 positive regulation of developmental process
2.20 1.55e-06 GO:0045597 positive regulation of cell differentiation
2.05 2.08e-06 GO:0007409 axonogenesis
1.35 2.53e-06 GO:0048731 system development
1.99 4.92e-06 GO:0048812 neuron projection morphogenesis
2.00 4.94e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.77 6.26e-06 GO:0030182 neuron differentiation
2.89 1.00e-05 GO:0042692 muscle cell differentiation
1.76 1.40e-05 GO:0045595 regulation of cell differentiation
1.82 1.55e-05 GO:0000902 cell morphogenesis
1.79 1.57e-05 GO:0032989 cellular component morphogenesis
1.89 1.90e-05 GO:0032990 cell part morphogenesis
1.90 2.24e-05 GO:0031175 neuron projection development
1.31 2.27e-05 GO:0048856 anatomical structure development
1.88 2.69e-05 GO:0048858 cell projection morphogenesis
1.29 2.73e-05 GO:0007275 multicellular organismal development
1.81 3.66e-05 GO:0048666 neuron development
1.62 4.39e-05 GO:0050793 regulation of developmental process
1.40 1.02e-04 GO:0048513 organ development
1.73 1.30e-04 GO:0030030 cell projection organization
1.43 1.52e-04 GO:0023051 regulation of signaling
1.65 2.35e-04 GO:2000026 regulation of multicellular organismal development
2.01 3.15e-04 GO:0007411 axon guidance
1.44 3.48e-04 GO:0009653 anatomical structure morphogenesis
1.25 4.86e-04 GO:0032502 developmental process
1.44 8.31e-04 GO:0009966 regulation of signal transduction
1.99 8.32e-04 GO:0060284 regulation of cell development
1.31 1.42e-03 GO:0048522 positive regulation of cellular process
1.99 1.52e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.99 4.56e-03 GO:0061061 muscle structure development
5.05 7.13e-03 GO:0008038 neuron recognition
1.34 9.34e-03 GO:0048583 regulation of response to stimulus
1.22 1.14e-02 GO:0023052 signaling
1.30 2.19e-02 GO:0048523 negative regulation of cellular process
1.26 2.53e-02 GO:0048518 positive regulation of biological process
1.12 2.60e-02 GO:0065007 biological regulation
1.49 2.68e-02 GO:0040011 locomotion
1.13 3.71e-02 GO:0050794 regulation of cellular process
1.43 4.70e-02 GO:0010646 regulation of cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 2.81e-05 GO:0044459 plasma membrane part
1.71 5.75e-05 GO:0030054 cell junction
1.82 6.47e-04 GO:0031012 extracellular matrix
1.20 1.12e-03 GO:0005886 plasma membrane
1.19 2.50e-03 GO:0071944 cell periphery
1.76 1.59e-02 GO:0005578 proteinaceous extracellular matrix

Nothing significant found in function category.