Motif ID: PRDM1.p3

Z-value: 1.668


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_1066408810.391.5e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16717887 5.560 BNC2
basonuclin 2
chr9_-_116608113 5.013 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr11_-_104344473 3.210 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr4_+_187227302 2.945 NM_003265
TLR3
toll-like receptor 3
chr4_+_14985272 2.895 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_-_112682573 2.558 LAMA4
laminin, alpha 4
chr17_-_45626364 2.518


chr10_-_44200458 2.481 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr5_-_142795269 2.473 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr9_-_8723893 2.454 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr6_-_112682459 2.395 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr17_+_6600080 2.369 XAF1
XIAP associated factor 1
chr3_-_115825742 2.304 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_112682401 2.302 LAMA4
laminin, alpha 4
chr17_+_17339059 2.182


chr4_+_142777172 2.150 NM_000585
NM_172174
IL15

interleukin 15

chr8_+_134272463 2.131 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr16_+_55580910 2.099 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr17_+_6599879 1.999 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr15_-_40537002 1.963 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr14_+_101297887 1.951 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr22_-_34886727 1.809 NM_145640
APOL3
apolipoprotein L, 3
chr10_-_131652007 1.757 NM_001005463
EBF3
early B-cell factor 3
chr4_-_153523113 1.723 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr4_+_37569093 1.689 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr8_-_79880095 1.602 NM_000880
IL7
interleukin 7
chr1_-_242073094 1.594 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr20_+_13924263 1.567 MACROD2
MACRO domain containing 2
chr4_-_186815116 1.520 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr3_-_102888090 1.450 NM_000986
RPL24
ribosomal protein L24
chr1_-_7998265 1.393 ERRFI1
ERBB receptor feedback inhibitor 1
chr12_-_69289889 1.372 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_+_2975590 1.323 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr11_-_40272239 1.308 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr9_-_34700062 1.306 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr10_+_18469611 1.280 NM_201593
NM_201596
NM_201597
NM_001167945
NM_201571
NM_201572
CACNB2





calcium channel, voltage-dependent, beta 2 subunit





chrX_-_62921937 1.261 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr11_+_32069183 1.227 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr2_+_230900121 1.177 NM_138402
SP140L
SP140 nuclear body protein-like
chr4_-_186814852 1.147 SORBS2
sorbin and SH3 domain containing 2
chr11_+_28088406 1.134 METTL15
methyltransferase like 15
chr11_-_40271086 1.125 LRRC4C
leucine rich repeat containing 4C
chr15_+_72620570 1.096 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr11_+_28086373 1.082 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr6_+_127481740 1.078 NM_032784
RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr6_-_99904251 1.064 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr21_+_25856311 1.058 MIR155HG
MIR155 host gene (non-protein coding)
chr8_-_23596346 1.037 NM_006167
NKX3-1
NK3 homeobox 1
chr22_-_28972683 1.020 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr14_+_23982017 1.014


chr12_+_6431437 1.013 NM_018009
TAPBPL
TAP binding protein-like
chr9_+_136673464 1.004 NM_000093
COL5A1
collagen, type V, alpha 1
chr21_-_42219849 0.995 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr20_+_56904042 0.985 GNAS
GNAS complex locus
chr6_-_112682038 0.980 LAMA4
laminin, alpha 4
chr3_-_11598829 0.937 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr9_-_14858974 0.936 FREM1
FRAS1 related extracellular matrix 1
chr4_+_88075176 0.934 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr17_+_29621352 0.922 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr9_+_18464138 0.882 ADAMTSL1
ADAMTS-like 1
chr7_+_154943466 0.877 NM_001427
EN2
engrailed homeobox 2
chr6_+_127481496 0.869 RSPO3
R-spondin 3 homolog (Xenopus laevis)
chr15_-_53996597 0.867 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_+_51951314 0.865 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr3_-_49826221 0.857 UBA7
ubiquitin-like modifier activating enzyme 7
chr15_+_65245546 0.843 NM_001145104
SMAD3
SMAD family member 3
chr10_+_91051685 0.843 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr20_+_13924014 0.837 NM_080676
MACROD2
MACRO domain containing 2
chr6_-_105691675 0.835 BVES
blood vessel epicardial substance
chr3_-_8518327 0.829 LOC100288428
hypothetical LOC100288428
chr8_+_144711619 0.825 NM_024736
GSDMD
gasdermin D
chr3_+_8518539 0.825 LMCD1
LIM and cysteine-rich domains 1
chr6_-_10520592 0.810 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr11_-_28086263 0.804 KIF18A
kinesin family member 18A
chr5_-_34078991 0.797 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr20_-_5048443 0.794 NM_182649
PCNA
proliferating cell nuclear antigen
chr17_+_3326045 0.792 NM_000049
ASPA
aspartoacylase
chr11_-_28086277 0.789 NM_031217
KIF18A
kinesin family member 18A
chr2_-_19421852 0.779 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr11_-_104411065 0.778 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr8_-_29176490 0.766 NM_015254
KIF13B
kinesin family member 13B
chr21_-_38955487 0.760 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr4_-_20594645 0.743 KCNIP4
Kv channel interacting protein 4
chr2_-_189752575 0.742 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_-_181540631 0.737 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr11_-_85107569 0.724 NM_206929
SYTL2
synaptotagmin-like 2
chr17_+_7406040 0.724 NM_015670
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr2_+_230989114 0.722 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr2_-_45648608 0.721 SRBD1
S1 RNA binding domain 1
chr11_-_28086222 0.713 KIF18A
kinesin family member 18A
chr2_+_230989177 0.710 SP100
SP100 nuclear antigen
chr13_-_109600709 0.705 COL4A1
collagen, type IV, alpha 1
chr3_+_176059763 0.704 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr1_+_159435728 0.699 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr7_+_134114701 0.698 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_-_230792844 0.693 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr7_+_42938463 0.690 NM_031903
MRPL32
mitochondrial ribosomal protein L32
chr3_+_189354167 0.669 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_114125955 0.668 ACSL5
acyl-CoA synthetase long-chain family member 5
chr9_+_119506428 0.666 TLR4
toll-like receptor 4
chr13_+_30207690 0.663 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr6_-_10520264 0.650 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr14_-_23685629 0.644 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_220884257 0.638 MIA3
melanoma inhibitory activity family, member 3
chr1_-_159435440 0.635 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr4_+_146623405 0.624 NM_001003688
SMAD1
SMAD family member 1
chr4_-_100461530 0.623 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chrX_-_106248674 0.622 RBM41
RNA binding motif protein 41
chr8_-_23768242 0.620 NM_003155
STC1
stanniocalcin 1
chr10_+_69539255 0.618 NM_032578
MYPN
myopalladin
chr8_-_93144366 0.609 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_105691235 0.602 NM_007073
BVES
blood vessel epicardial substance
chr3_+_8518508 0.601 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr3_+_51952326 0.594 PARP3
poly (ADP-ribose) polymerase family, member 3
chr10_+_114125927 0.593 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_42184350 0.568 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr5_+_6799100 0.564 NM_001171806
PAPD7
PAP associated domain containing 7
chr11_+_63765106 0.555 NM_001135208
FKBP2
FK506 binding protein 2, 13kDa
chr3_-_189354510 0.553 LOC339929
hypothetical LOC339929
chr2_+_205118801 0.540 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr8_+_97575052 0.537 NM_002998
SDC2
syndecan 2
chr6_-_101018271 0.531 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr2_+_230989150 0.529 SP100
SP100 nuclear antigen
chr6_+_126282078 0.529 NCOA7
nuclear receptor coactivator 7
chr13_+_30207668 0.528 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_-_42938255 0.513 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr10_+_114126004 0.511 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_49826360 0.509 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr11_-_85108030 0.507 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chrX_-_106248706 0.506 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr5_-_96169329 0.503 ERAP1
endoplasmic reticulum aminopeptidase 1
chr12_+_120055013 0.496 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr2_+_205118961 0.496 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr8_+_56848733 0.495


chr5_+_131774478 0.490 NM_001013717
C5orf56
chromosome 5 open reading frame 56
chr8_+_97575071 0.488 SDC2
syndecan 2
chr19_-_52427698 0.469 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr9_+_108665168 0.463 NM_021224
ZNF462
zinc finger protein 462
chr8_+_39890484 0.460 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr8_-_145132551 0.458 PARP10
poly (ADP-ribose) polymerase family, member 10
chr5_+_96237923 0.451 ERAP2
endoplasmic reticulum aminopeptidase 2
chr3_+_120495906 0.444 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr14_-_23981493 0.435 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr11_+_5602782 0.430 NM_021616
TRIM34
tripartite motif containing 34
chr4_+_154824844 0.420


chr5_+_139869819 0.419


chr14_+_57781308 0.411 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr2_-_224611568 0.407 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr11_-_4371463 0.401 NM_003141
TRIM21
tripartite motif containing 21
chr1_+_158063102 0.400 NM_020125
SLAMF8
SLAM family member 8
chr14_+_57781352 0.399 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr6_+_116889248 0.392 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr9_+_111582317 0.392 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr1_+_103961476 0.389 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr14_+_57781210 0.384 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_205118710 0.383 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr17_+_7405944 0.380 SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr1_-_203867402 0.378 ELK4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr7_+_89681069 0.377 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr12_-_47605478 0.373 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr1_-_197173159 0.371 LOC100131234
familial acute myelogenous leukemia related factor
chr20_+_337346 0.363 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr9_-_112139908 0.360 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr11_+_58668827 0.357 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr10_+_122600843 0.350 WDR11
WD repeat domain 11
chr4_+_154824871 0.349 NM_003264
TLR2
toll-like receptor 2
chr9_+_119506446 0.348 TLR4
toll-like receptor 4
chr10_+_91077581 0.345 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr15_+_68971835 0.332 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr12_+_53809731 0.330 NM_001005243
OR9K2
olfactory receptor, family 9, subfamily K, member 2
chr10_-_73167586 0.324 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr2_+_37165097 0.319 NM_174931
CCDC75
coiled-coil domain containing 75
chr3_-_161584137 0.315 NM_001190242
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr11_+_60366004 0.314 NM_024098
CCDC86
coiled-coil domain containing 86
chr11_-_58099884 0.312 NM_004811
LPXN
leupaxin
chr7_-_42938304 0.308 NM_002787
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr8_-_42184194 0.301 PLAT
plasminogen activator, tissue
chr7_+_134114957 0.299 CALD1
caldesmon 1
chrX_+_102770303 0.297 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr11_-_65138323 0.294


chr14_+_72594985 0.293 RBM25
RNA binding motif protein 25
chr1_+_158063130 0.287 SLAMF8
SLAM family member 8
chr7_+_5220342 0.284 NM_001033520
WIPI2
WD repeat domain, phosphoinositide interacting 2
chr20_+_336941 0.282 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr14_+_72595020 0.279 RBM25
RNA binding motif protein 25
chr8_-_145132582 0.277 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr9_-_72926333 0.276 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr10_-_13789628 0.275 FRMD4A
FERM domain containing 4A
chr3_+_46423682 0.274 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr5_-_16670085 0.272 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr2_+_165858586 0.266 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr6_-_28663045 0.259 NM_052923
SCAND3
SCAN domain containing 3
chr5_+_152850276 0.259 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr10_-_27569269 0.258 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr13_+_107720475 0.252 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr7_-_51351825 0.247 COBL
cordon-bleu homolog (mouse)
chr20_+_336963 0.245 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr19_-_11500912 0.241 NM_001142464
NM_001142465
NM_016581
ECSIT


ECSIT homolog (Drosophila)


chr4_+_154824891 0.237 TLR2
toll-like receptor 2
chr12_+_68923043 0.236 NM_014515
CNOT2
CCR4-NOT transcription complex, subunit 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.30 2.08e-03 GO:0002376 immune system process
2.50 6.11e-03 GO:0051704 multi-organism process
2.64 7.74e-03 GO:0006955 immune response
13.96 2.83e-02 GO:0042993 positive regulation of transcription factor import into nucleus
41.87 3.31e-02 GO:0002483 antigen processing and presentation of endogenous peptide antigen
41.87 3.31e-02 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
7.88 3.32e-02 GO:0060337 type I interferon-mediated signaling pathway
7.88 3.32e-02 GO:0071357 cellular response to type I interferon
7.76 3.69e-02 GO:0034340 response to type I interferon
19.94 4.28e-02 GO:0032728 positive regulation of interferon-beta production

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.53 3.39e-03 GO:0005126 cytokine receptor binding
21.47 6.06e-03 GO:0001530 lipopolysaccharide binding